1580 (MDLXXX) was a leap year starting on Friday (link will display the full calendar) in the Julian calendar, and a leap year starting on Tuesday (link will display the full calendar) in the Proleptic Gregorian calendar.
|Ab urbe condita||2333|
|Balinese saka calendar||1501–1502|
|English Regnal year||22 Eliz. 1 – 23 Eliz. 1|
|Chinese calendar||己卯年 (Earth Rabbit)|
4276 or 4216
— to —
庚辰年 (Metal Dragon)
4277 or 4217
|- Vikram Samvat||1636–1637|
|- Shaka Samvat||1501–1502|
|- Kali Yuga||4680–4681|
|Japanese calendar||Tenshō 8|
|Minguo calendar||332 before ROC|
|Thai solar calendar||2122–2123|
1706 or 1325 or 553
— to —
1707 or 1326 or 554
- January 31 – Portuguese succession crisis of 1580: The death of Henry, King of Portugal, with no direct heirs, leads to conflict between his potential successors, including King Philip II of Spain and Infanta Catherine, Duchess of Braganza.
- March 1 – Michel de Montaigne signs the preface to his most significant work, Essays. They are published later this year.
- March 25 – Iberian Union: King Philip II of Spain becomes King of Portugal under the name Philip I, following the death without heirs of King Henry of Portugal, in a personal union of the crowns, thus maintaining Portuguese independence (in Europe and throughout the Portuguese Empire). The Philippine Dynasty rule lasts until 1640.
- April 6 – The Dover Straits earthquake occurs.
- May – The Lipizzan stud is established by Charles II, Archduke of Austria.
- June – England signs a commercial treaty with the Ottoman Empire.
- June 11 – Juan de Garay founds Buenos Aires.
- June 25 – The Book of Concord, a collection of Lutheran confessional documents, is published.
- July 12 – The Ostrog Bible, the first complete printed Bible translation into a Slavic language (Old Church Slavonic), is first printed at Ostroh in the Polish–Lithuanian Commonwealth (modern-day Ukraine) by Ivan Fyodorov.
- August 25 – Battle of Alcântara: Spanish armies, led by Fernando Álvarez de Toledo, defending the claim of King Philip II of Spain to the Portuguese throne, defeat the armies of Portuguese claimant António, Prior of Crato.
- September 26 – Francis Drake returns to Plymouth, England from his voyage of circumnavigation (westabout) on the Golden Hind, the second completed in a continuous voyage, and the first under its original commander.
- The Billy Mitchell volcano, on the island of Bougainville, undergoes a catastrophic eruption (VEI 6).
- The first session of the Jewish Vaad (Council of Four Lands) is held in Lublin, Poland; 70 delegates of Jewish local qahals meet to discuss taxation, and other issues important to Jewish communities.
- The Old City of Zamość is established in Poland, by Jan Zamoyski.
- Jesuit missionaries arrive at the court of Akbar, ruler of the Mughal Empire.
- A group of English merchants gains the right to trade in Ottoman territory, in return for supplying the sultan with iron, steel, brass and tin for his war with Persia.
- An influenza pandemic sweeps the world, starting in Asia and moving rapidly through Africa, Europe, and eventually the Americas. More than 10% of the population of Rome dies, and whole towns in Spain are depopulated.
- January 8 – Jens Hermansson Juel, Danish governor of Norway (d. 1634)
- January 12
- January 20 – Stefano Amadei, Italian painter (d. 1644)
- January 29 – Willem Isaacsz Swanenburg, Dutch engraver (d. 1612)
- January 30 – Gundakar, Prince of Liechtenstein, court official in Vienna (d. 1658)
- January – John Smith, English explorer and Virginia settler (d. 1631)
- February – John Digby, 1st Earl of Bristol, English diplomat (d. 1653)
- February 1 – Francis Fane, 1st Earl of Westmorland, English noble (d. 1629)
- February 2 – Jens Bjelke, Norwegian noble (d. 1659)
- February 22 – Charles de l'Aubespine, marquis de Châteauneuf, French diplomat and government official (d. 1653)
- February 24 – Matthias Hoe von Hoenegg, German theologian (d. 1645)
- February 28
- March 31 – Bogislaw XIV, Duke of Pomerania (d. 1637)
- April 8
- April 18 – (baptism) Thomas Middleton, English playwright (d. 1627)
- April 24 – Miguel Avellán, Spanish Catholic prelate, Auxiliary Bishop of Toledo from 1633 (d. 1650)
- May 5
- May 6 – Charles Gonzaga, Duke of Mantua and Montferrat, French noble (d. 1637)
- May 14 – Bassam Al-Soukaria, Lebanese army commander (d. 1667)
- May 30 – Fadrique de Toledo, 1st Marquis of Villanueva de Valdueza, Spanish noble and admiral (d. 1634)
- June 6 – Godefroy Wendelin, Flemish astronomer (d. 1667)
- June 9 – Daniel Heinsius, Dutch scholar (d. 1655)
- June 12 – Adriaan van Stalbemt, Flemish Baroque painter (d. 1662)
- June 14 – Elisabeth Magdalena of Pomerania, German duchess (d. 1649)
- June 26
- July 5 – Carlo Contarini, Doge of Venice (d. 1656)
- July 6 – Johann Stobäus, German composer (d. 1646)
- July 10 – Humphrey Chetham, English merchant (d. 1653)
- July 18 – Giovanni Giacomo Semenza, Italian painter (d. 1638)
- July 29 – Francesco Mochi, Italian early-Baroque sculptor (d. 1654)
- August 2 – Prince Jeongwon, Korean prince (d. 1619)
- August 19 – Pierre Vernier, French mathematician (d. 1637)
- September 4 – George Percy, English explorer (d. 1632)
- September 14
- September 15
- September 17 – Countess Charlotte Brabantina of Nassau, Belgian noble (d. 1631)
- September 24 – Elisabeth of Schleswig-Holstein-Sonderburg, Duchess consort of Pomerania (d. 1653)
- October 8 – Gábor Esterházy (1580–1626), Hungarian noble (d. 1626)
- October 12 – Hortensio Félix Paravicino, Spanish preacher and poet from the noble house of Pallavicini (d. 1633)
- October 20 – Peter Crüger, German astronomer and mathematician (d. 1639)
- October 30 – Armand-Nompar de Caumont, duc de La Force, Marshal of France (d. 1675)
- November 9 – Johannes Narssius, Dutch physician and poet (d. 1637)
- December 1 – Nicolas-Claude Fabri de Peiresc, French astronomer (d. 1637)
- December 4
- date unknown
- Philipp Clüver, German geographer and historian (d. 1623)
- Francesco Fontana, Italian lawyer and astronomer (d. 1656)
- Dirk Hartog, Dutch ship's captain and explorer (d. 1621)
- Jean Jannon, Swiss-born typefounder (d. 1658)
- Robert Killigrew, English courtier, politician, ambassador and knight (d. 1633)
- Willebrord Snellius, Dutch astronomer and mathematician (d. 1626)
- Raphael Sobiehrd-Mnishovsky, Bohemian lawyer and writer (d. 1644)
- Pierre Vernier, French mathematician and instrument inventor (d. 1637)
- Krzysztof Zbaraski, Polish nobleman (d. 1627)
- George Calvert, 1st Baron Baltimore, English politician and colonizer (d. 1623)
- William Brabazon, 1st Earl of Meath, English noble (d. 1651)
- Edward Fairfax, English translator (d. 1635)
- Frans Hals, Dutch painter (d. 1666)
- Alexander Leslie, 1st Earl of Leven, Scottish soldier (d. 1661)
- Benjamin, Duke of Soubise, French Huguenot leader (d. 1642)
- Adriana Basile, Italian composer (d. 1640)
- January 5 – Anna Sibylle of Hanau-Lichtenberg, German noblewoman (b. 1542)
- January 18
- January 31 – King Henry of Portugal (b. 1512)
- February 2 – Bessho Nagaharu, Japanese retainer (b. 1558)
- February 24 – Henry FitzAlan, 19th Earl of Arundel, English nobleman (b. 1511)
- April 20 – Francesco Alciati, Italian Catholic cardinal (b. 1522)
- May 3 – Thomas Tusser, English poet and farmer (b. c. 1524)
- May 31 – Dorothea of Denmark, Electress Palatine, Princess of Denmark, Sweden and Norway (b. 1520)
- June 10 – Luís de Camões, Portuguese poet (b. c. 1524)
- June 18 – Juliana of Stolberg, German countess (b. 1506)
- August 1 – Albrecht Giese, German politician and diplomat (b. 1524)
- August 12 – Luca Longhi, Italian painter (b. 1507)
- August 15 – Vincenzo Borghini, Italian monk (b. 1515)
- August 19 – Andrea Palladio, Italian architect (b. 1508)
- August 20 – Jerónimo Osório, Portuguese historian (b. 1506)
- August 28 – Antonín Brus z Mohelnice, Moravian Catholic archbishop (b. 1518)
- August 30 – Emmanuel Philibert, Duke of Savoy (b. 1528)
- September 19 – Catherine Brandon, Duchess of Suffolk, English noblewoman (b. 1519)
- September 20 – Honorat II of Savoy, French Navy admiral (b. 1511)
- September – Anne de Pisseleu d'Heilly, French royal mistress and cultural patron (b. 1508)
- October 1 – John II, Duke of Schleswig-Holstein-Haderslev (b. 1521)
- October 5 – Matsudaira Shigeyoshi, Japanese general (b. 1493)
- October 8 – Hieronymus Wolf, German historian (b. 1516)
- October 26 – Anna of Austria, Queen of Spain (b. 1549)
- November 3 – Jerónimo Zurita y Castro, Spanish historian (b. 1512)
- November 16 – Marie of Baden-Sponheim, German noblewoman (b. 1507
- November 30 – Richard Farrant, English composer (b. 1530)
- December 1 – Giovanni Morone, Italian Catholic cardinal (b. 1509)
- date unknown
- possible date
- Dionysius Lardner, ed., The History of Spain and Portugal, vol. 5, part of the Cabinet Cyclopaedia. London: Longman, Rees, et al., 1832. See pages 208-209.
- Michel de Montaigne (1887). Works of Michael de Montaigne: Comprising His Essays, Journey Into Italy, and Letters. Houghton, Mifflin. p. 471.
- Palmer, Alan; Veronica (1992). The Chronology of British History. London: Century Ltd. pp. 160–162. ISBN 0-7126-5616-2.
- Williams, Hywel (2005). Cassell's Chronology of World History. London: Weidenfeld & Nicolson. pp. 230–233. ISBN 0-304-35730-8.
- Joze Krasovec (October 1, 1999). The Interpretation of the Bible: The International Symposium in Slovenia. A&C Black. p. 676. ISBN 978-0-567-34563-9.
- Portuguese Studies Review. Baywolf Press. 2005. p. 71.
- Penguin Pocket On This Day. Penguin Reference Library. 2006. ISBN 0-14-102715-0.
- Roberts, J. (1994). History of the World. Penguin.
- Beveridge, W.I.B. (1991). "The Chronicle of Influenza Epidemics". History and Philosophy of the Life Sciences.
- Michelle O'Callaghan (March 7, 2009). Thomas Middleton, Renaissance Dramatist. Edinburgh University Press. p. 5. ISBN 978-0-7486-3169-8.
- Myrtle Byram McGraw (1941). The Child in Painting. Greystone Press. p. 12.
- Dauril Alden (1996). The Making of an Enterprise: The Society of Jesus in Portugal, Its Empire, and Beyond, 1540-1750. Stanford University Press. p. 90. ISBN 978-0-8047-2271-1.
- Luís de Camões (1966). The Lusiads of Luiz de Camões. Hispanic Society of America. p. xxix.
- Dissertation Abstracts International: The humanities and social sciences. A. University Microfilms. 1978. p. 2628.