|Ab urbe condita||2246|
|Balinese saka calendar||1414–1415|
|English Regnal year||8 Hen. 7 – 9 Hen. 7|
|Chinese calendar||壬子年 (Water Rat)|
4189 or 4129
— to —
癸丑年 (Water Ox)
4190 or 4130
|- Vikram Samvat||1549–1550|
|- Shaka Samvat||1414–1415|
|- Kali Yuga||4593–4594|
|Japanese calendar||Meiō 2|
|Minguo calendar||419 before ROC|
|Thai solar calendar||2035–2036|
1619 or 1238 or 466
— to —
1620 or 1239 or 467
|Wikimedia Commons has media related to 1493.|
- January 19 – Treaty of Barcelona: Charles VIII of France returns Cerdagne and Roussillon to Ferdinand of Aragon.
- March 1 – Martín Alonso Pinzón returns to the city of Bayona in Spain from the voyage of discovery, sending the first notice about the discovery to the Catholic Monarchs (Christopher Columbus is delayed by a storm in the Azores).
- March 15 – Christopher Columbus and Martín Alonso Pinzón return to Palos de la Frontera, the original port in Spain from where they started the first voyage of discovery.
- April 12 – Askia Mohammad I defeats Sonni Baru at the Battle of Anfao and usurps the throne of the Songhai Empire.
- May 4 – In the papal bull Inter caetera, Pope Alexander VI decrees that all lands discovered 100 leagues (or further west) of the Azores are Spanish.
- August 19 – Maximilian I succeeds his father, Frederick III, as Holy Roman Emperor.
- September 9 – Battle of Krbava Field in southern Croatia: Forces of the Ottoman Empire defeat those of the Kingdom of Croatia.
- September 26 – Pope Alexander VI issues the bull Dudum siquidem to the Catholic Monarchs, extending the grant of newly discovered lands he made them in Inter caetera.
- September 29 – Christopher Columbus leaves Cádiz on his second voyage of exploration.
- November 19 – Christopher Columbus lands on the coast of the island of Borinquen, which he renames San Juan (modern-day Puerto Rico).
- England imposes sanctions on Burgundy for supporting Perkin Warbeck, the pretender to the English throne.
- James IV of Scotland seizes lands of John MacDonald II, putting an end to the Lord of the Isles.
- Huayna Capac becomes emperor of the Inca Empire.
- Leonardo Da Vinci draws the first known helicopter.
- January 2 – Louis de Bourbon de Vendôme, French cardinal (d. 1557)
- January 6 – Olaus Petri, Swedish clergyman (d. 1552)
- January 9 – Johann of Brandenburg-Ansbach, Viceroy of Valencia, German noble (d. 1525)
- January 25 – Maximilian Sforza, Duke of Milan (d. 1530)
- January 26
- February 9 – Helen of the Palatinate, Duchess of Pomerania (d. 1524)
- March 15 – Anne de Montmorency, Constable of France (d. 1567)
- April 11 – George I, Duke of Pomerania from the House of Griffins (d. 1531)
- April 25 – Giovanni Gaddi, Italian priest (d. 1542)
- May 5 – Alessandro Pasqualini, Italian architect (d. 1559)
- May 6 – Girolamo Seripando, Catholic cardinal (d. 1563)
- June 5 – Justus Jonas, German Protestant reformer (d. 1555)
- June 10 – Anton Fugger, German merchant (d. 1560)
- September 28 – Agnolo Firenzuola, Italian poet and litterateur (d. 1543)
- September 29 – Yi Gwang-sik, Korean politician and general (d. 1563)
- October 14 – Shimazu Tadayoshi, Japanese warlord (d. 1568)
- October 17 – Bartolommeo Bandinelli, Renaissance Italian sculptor (d. 1560)
- November 11 – Bernardo Tasso, Italian courtier and poet (d. 1569)
- November 11 or December 17 – Paracelsus, born Philippus von Hohenheim, Swiss physician and scientist (d. 1541)
- November 17 – John Neville, 3rd Baron Latimer, English politician (d. 1543)
- November 25 – Osanna of Cattaro, Dominican visionary and anchoress (d. 1565)
- December 9 – Íñigo López de Mendoza, 4th Duke of the Infantado (d. 1566)
- December 25 – Antoinette de Bourbon, French noblewoman (d. 1583)
- December 27 – Johann Pfeffinger, German theologian (d. 1573)
- December 31 – Eleonora Gonzaga, Duchess of Urbino, Italian politically active duchess (d. 1570)
- date unknown
- May – Pietro Antonio Solari, Italian architect (b. 1450)
- May 10 – Colin Campbell, 1st Earl of Argyll, Scottish politician (b. c. 1433)
- May 14 – Nannina de' Medici, member of de' Medici family (b. 1448)
- June 14 – Ermolao Barbaro, Italian scholar (b. 1454)
- August 19 – Frederick III, Holy Roman Emperor (b. 1415)
- September 9 – Mirko Derenčin, Croatian leader
- October 11 – Eleanor of Naples, Duchess of Ferrara (b. 1450)
- October 22 – James Douglas, 1st Earl of Morton
- November 6 – Andrey Bolshoy, Russian prince (b. 1446)
- date unknown
- Ahmad Zarruq, Moroccan scholar and Sufi sheikh (b. 1442)
- James Blount, English soldier
- Isabel Bras Williamson, Scottish merchant (b. 1430)
- Kim Si-seup, Korean scholar and author (b. 1435)
- Martín Alonso Pinzón, Spanish navigator and explorer (b. c. 1441)
- Tupac Inca Yupanqui, Inca ruler of Tahuantinsuyu
- "Historical Events for Year 1493 | OnThisDay.com". Historyorb.com. Retrieved April 22, 2017.
- Williams, Neville (1999). "1493". The Hutchinson Chronology of World History: 1492-1775 - The Expanding World. Abington, UK: Helicon Books. ISBN 978-1-85-986282-7.
- Palmer, Alan; Veronica (1992). The Chronology of British History. London: Century Ltd. pp. 135–138. ISBN 0-7126-5616-2.