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|Ab urbe condita||2318|
|Balinese saka calendar||1486–1487|
|English Regnal year||7 Eliz. 1 – 8 Eliz. 1|
|Chinese calendar||甲子年 (Wood Rat)|
4261 or 4201
— to —
乙丑年 (Wood Ox)
4262 or 4202
|- Vikram Samvat||1621–1622|
|- Shaka Samvat||1486–1487|
|- Kali Yuga||4665–4666|
|Japanese calendar||Eiroku 8|
|Minguo calendar||347 before ROC|
|Thai solar calendar||2107–2108|
1691 or 1310 or 538
— to —
1692 or 1311 or 539
|Wikimedia Commons has media related to 1565.|
- January – In Russia, it is the beginning of the Oprichnina, under Ivan the Terrible.
- January 23 – Battle of Talikota: The Vijayanagara Empire, the last Hindu kingdom in South India, is greatly weakened by the Deccan sultanates.
- February 13 – Spanish Conquistador Miguel López de Legazpi lands with his troops on the shores of Cebu Island, in the Philippines.
- March 1 – The city of Rio de Janeiro, Brazil, is founded as São Sebastião do Rio de Janeiro by Estácio de Sá.
- March 16 – Spanish Conquistador Miguel Lopez de Legazpi makes a Sandugan with the Datu Sikatuna, in the island of Bohol Philippines.
- April 27 – Cebu City is established as San Miguel by López de Legazpi, becoming the first Spanish settlement in the Philippines.
- May 18 – Ottoman troops land on the island of Malta, beginning the Siege of Malta.
- June 17 – Matsunaga Hisahide assassinates the 13th Ashikaga shōgun, Ashikaga Yoshiteru.
- July 29 – Mary, Queen of Scots, widowed, marries Henry Stuart, Lord Darnley.
- August 6 – Sark is granted as a Fief, by Elizabeth I, to Hellier de Carteret, Seigneur of Saint Ouen.
- August 28 – St. Augustine, Florida (named after St. Augustine), is established. It is the oldest remaining European settlement in the United States.
- September 4 – The Spanish fleet of Pedro Menéndez de Avilés lands on modern-day Florida, to oust the French under Jean Ribault. He later destroys the French colony of Fort Caroline.
- September 8 – Pedro Menéndez de Avilés settles in St. Augustine, Florida.
- September 11 – The Knights of Malta lift the Siege of Malta, after four months.
- October – The first Martello tower, the Tour de Mortella, designed by Giovan Giacomo Paleari Fratino (el Fratin), is completed as part of the Genovese defence system at Mortella (Myrtle) Point, in Upper Corsica.
- October 18 – Battle of Fukuda Bay: Ships belonging to the Matsura clan of Japan fail to capture the Portuguese trading carrack, in the first recorded naval battle between Japan and the West.
- The pencil is first documented by Conrad Gesner; it is becoming common in England.
- John Beddoes School is founded at Presteigne, Wales.
- Herlufsholm School is founded in Denmark.
- Huntingdon Grammar School is established in England.
- January 17 – Mariana Navarro de Guevarra Romero, Spanish Roman Catholic nun, member of the Mercedarian Tertiaries (d. 1624)
- February 13 – Willem Baudartius, Dutch theologian (d. 1640)
- March 23 – Eilhard Lubinus, German theologian (d. 1621)
- April 2 – Cornelis de Houtman, Dutch explorer (d. 1599)
- April 3 – Anna III, Abbess of Quedlinburg (d. 1601)
- May 15 – Hendrick de Keyser, Dutch sculptor and architect born in Utrecht (d. 1621)
- June 2 – Francisco Ribalta, Spanish painter (d. 1628)
- July 6 – Hugh Hamersley, Lord Mayor of London, 1627–1628 (d. 1636)
- August 5 - Paola Massarenghi, Italian composer (d. unknown)
- August 9 – Louis II, Count of Nassau-Weilburg (d. 1627)
- August 16 – Christina, Grand Duchess of Tuscany (d. 1637)
- August 20 – Margaretha van Valckenburch, Dutch shipowner, only female member of the VOC (d. 1650)
- August 29 – Agostino Ciampelli, Italian painter (d. 1630)
- September 17 – Edward Fortunatus, German nobleman (d. 1600)
- September 28 – Alessandro Tassoni, Italian poet and writer (d. 1635)
- October 6 – Marie de Gournay, French writer (d. 1645)
- October 12 – Ippolito Galantini, Italian founder of the Congregation of Christian Doctrine of Florence (d. 1619)
- October 22 – Benedikt Carpzov the elder, German legal scholar (d. 1624)
- November 10
- November 14 – Petrus Bertius, Flemish theologian and scientist (d. 1629)
- December 2 – Toby Caulfeild, 1st Baron Caulfeild, Northern Irish politician (d. 1627)
- date unknown
- Reza Abbasi, Persian painter and calligrapher (d. 1635)
- Ferdinando Gorges, English colonial entrepreneur (d. 1647)
- John Davies of Hereford, Welsh poet (d. 1618)
- Francis Meres, English churchman and author (d. 1647)
- Pedro Fernandes de Queirós, Portuguese seaman and explorer (d. 1614)
- John Spottiswoode, Archbishop of St. Andrews (d. 1639)
- Francis Tanfield, English governor of the South Falkland colony
- Edmund Whitelocke, English soldier and courtier (d. 1608)
- Robert Wintour, English conspirator (d. 1606)
- Maria Pita, Spanish heroine (d. 1643)
- January 19 – Diego Laynez, Spanish Jesuit theologian (b. 1512)
- January 28 – Francisco Cesi, Italian Catholic cardinal (b. 1500)
- February 28 – John, Duke of Münsterberg-Oels and Count of Glatz (b. 1509)
- March 17 – Alexander Ales, Scottish theologian (b. 1500)
- April 2 – Elisabeth Parr, Marchioness of Northampton, English noble (b. 1526)
- April 27 – Osanna of Cattaro, Dominican visionary and anchoress (b. 1493)
- May 14 – Nicolaus von Amsdorf, German Protestant reformer (b. 1483)
- May 5 – Queen Munjeong, Korean queen (b. 1501)
- May 28 – Mikołaj "the Black" Radziwiłł, Polish magnate (b. 1515)
- June 12 – Adrianus Turnebus, French classical scholar (b. 1512)
- June 17 – Ashikaga Yoshiteru, Japanese shogun (b. 1536)
- June 19 – Wolfgang Lazius, Austrian historian (b. 1514)
- June 23 – Turgut Reis, Ottoman naval commander (b. 1485)
- August – Jacques Buus, Flemish composer and organist (b. 1500)
- August 29 – Alfonso Carafa, Italian cardinal (b. 1540)
- June 25 – Herluf Trolle, Danish Admiral of the Fleet and co-founder of Herlufsholm School (b. 1516)
- September 13 – William Farel, French evangelist (b. 1489)
- September 20 – Cipriano de Rore, Flemish composer and teacher (b. 1515)
- October 4 – Pier Paolo Vergerio, Italian reformer (b. 1498)
- October 5 – Lodovico Ferrari, Italian mathematician (b. 1522)
- October 7 – Johannes Mathesius, German theologian (b. 1504)
- October 12 – Jean Ribault, French explorer and colonizer (b. 1520)
- October 14 – Thomas Chaloner, English statesman and poet (b. 1521)
- October 21 – John Frederick III, Duke of Saxony and nominal Duke of Saxe-Gotha (b. 1538)
- October 22 – Jean, Vicomte d'Aguisy Grolier de Servieres, French bibliophile (b. 1479)
- October 29 – Ranuccio Farnese, Italian prelate (b. 1530)
- November 2 – Mechthild of Bavaria, German duchess (b. 1532)
- November 25 – Hu Zongxian, Chinese general (b. 1512)
- December 9 – Pope Pius IV (b. 1499)
- December 12 – Johan Rantzau, German general (b. 1492)
- December 13 – Conrad Gessner, Swiss naturalist (b. 1516)
- date unknown