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|Ab urbe condita||2207|
|Balinese saka calendar||1375–1376|
|English Regnal year||32 Hen. 6 – 33 Hen. 6|
|Chinese calendar||癸酉年 (Water Rooster)|
4150 or 4090
— to —
甲戌年 (Wood Dog)
4151 or 4091
|- Vikram Samvat||1510–1511|
|- Shaka Samvat||1375–1376|
|- Kali Yuga||4554–4555|
|Japanese calendar||Kyōtoku 3|
|Minguo calendar||458 before ROC|
|Thai solar calendar||1996–1997|
1580 or 1199 or 427
— to —
1581 or 1200 or 428
|Wikimedia Commons has media related to 1454.|
- February 4 – Thirteen Years' War: The Secret Council of the Prussian Confederation sends a formal act of disobedience to the Grand Master, and the citizens of Toruń rebel against the Teutonic Knights, beginning the conflict.
- March 6 – Casimir IV of Poland renounces allegiance to the Teutonic Knights.
- March 27 – Richard Plantagenet, Duke of York becomes Protector for the insane King Henry VI of England.
- April 9 – Treaty of Lodi: Francesco Sforza forms a triple alliance between the Duchy of Milan, the Republic of Florence and Kingdom of Naples.
- August – In Moldavia, Petru Aron retakes the throne from Alexăndrel.
- September 18 – Thirteen Years' War – Battle of Chojnice: The Polish army is defeated by a smaller but more professional Teutonic army.
- December – King Henry of England having regained his sanity, the Duke of York is dismissed as Protector.
- The press of Johannes Gutenberg (at Mainz on the Rhine) produces the first printed documents bearing a date.
- Isaac Zarfati sends a circular letter to Rhineland, Swabia, Moravia and Hungary, praising the happy conditions of the Jews under the crescent, in contrast to the "great torture chamber" under the cross, and urging them to come to Turkey.
- The Statutes of Nieszawa are enacted in Poland.
- The drought of One Rabbit recorded in Aztec history.
- March 9 – Amerigo Vespucci, Italian explorer (d. 1512)
- June 3 – Bogislaw X, Duke of Pomerania (1474–1523) (d. 1523)
- June 16 – Joanna of Aragon, Queen of Naples (d. 1517)
- July 14 – Poliziano, Italian humanist (d. 1494)
- September 4 – Henry Stafford, 2nd Duke of Buckingham, English politician (d. 1483)
- September 24 – Gerold Edlibach, Swiss historian (d. 1530)
- November 25 – Catherine Cornaro, Queen of Cyprus (d. 1510)
- date unknown