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|Ab urbe condita||2263|
|Balinese saka calendar||1431–1432|
|English Regnal year||1 Hen. 8 – 2 Hen. 8|
|Chinese calendar||己巳年 (Earth Snake)|
4206 or 4146
— to —
庚午年 (Metal Horse)
4207 or 4147
|- Vikram Samvat||1566–1567|
|- Shaka Samvat||1431–1432|
|- Kali Yuga||4610–4611|
|Japanese calendar||Eishō 7|
|Minguo calendar||402 before ROC|
|Thai solar calendar||2052–2053|
1636 or 1255 or 483
— to —
1637 or 1256 or 484
- January – Catherine of Aragon gives birth to her first child, a stillborn daughter.
- January 23 – An 18-year-old Henry VIII of England jousts anonymously at Richmond, Surrey and draws applause, before revealing his identity.
- February 27–November 25 – Portuguese conquest of Goa: Afonso de Albuquerque of Portugal conquers Goa.
- March 1 – Battle of Salt River: Indigenous ǃUriǁʼaekua decisively defeat sailors of the Portuguese Empire in South Africa.
- May 12 – The Prince of Anhua rebellion begins when Zhu Zhifan, Prince of Anhua, kills all the officials invited to a banquet, and declares his intent on ousting the powerful Ming dynasty eunuch Liu Jin, during the reign of the Zhengde Emperor in China.
- May 30 – Rebel leader Zhu Zhifan is defeated and captured by commander Qiu Yue, ending the Prince of Anhua rebellion.
- July – The Holy League, formed to defend the Italian States, attacks French-occupied Genoa. The 1510 influenza pandemic reaches Sicily, where it is nicknamed coccolucio, before spreading to the Italian states and the rest of Europe.
- August 10 – The Royal Dano-Norwegian Navy is founded.
- October 16 – Mingyi Nyo declares independence from the Ava Kingdom in upper Burma, by establishing the Toungoo dynasty.
- December 2 – Battle of Marv: Shah Ismail I defeats the Uzbek forces of Shaybani Khan, in Khorasan. Shaybani flees the battle only to be captured and killed by Ismail I troops, his head is turned into a Skull cup used as a drinking goblet.
- The Grand Prince of Moscow Vasili III conquers Pskov.
- Sir Thomas More becomes undersheriff of the City of London.
- Paolo Cortese publishes De Cardinalatu, a manual for cardinals, including advice on palatial architecture – which inspires Thomas Wolsey in his construction work at Hampton Court Palace.
- Heinrich Cornelius Agrippa moves to Italy.
- Sunflowers are brought to Europe.
- The Mary Rose ship is laid out. The next year the ship is built and complete in 1512. By the time the battle sank the ship in England.
- February 24 – Costanzo II Sforza, Italian noble (d. 1512)
- March 25 – Guillaume Postel, French linguist (d. 1581)
- March 30 – Antonio de Cabezón, Spanish composer and organist (d. 1566)
- June 6 – Giovanni Battista Cicala, Italian Catholic cardinal (d. 1570)
- June 22 – Alessandro de' Medici, Duke of Florence (d. 1537)
- August 11 – Margaret Paleologa, Sovereign Marchioness of Montferrat (1531–1540) (d. 1566)
- August 24 – Elisabeth of Brandenburg, Duchess of Brunswick-Calenberg-Göttingen (1525–1540) (d. 1558)
- October 6
- October 25 – Renée of France, French princess (d. 1574)
- October 28 – Francis Borgia, Spanish General of the Jesuits (d. 1572)
- December 28 – Nicholas Bacon, English politician (d. 1579)
- date unknown
- Jan Matsys, Flemish painter (d. 1575)
- Jörg Breu the Younger, German painter (d. 1547)
- Ferenc Dávid, Hungarian founder of the Unitarian Church (d. 1579)
- Solomon Luria, Polish-born Kabbalist (d. 1574)
- Oda Nobuhide, Japanese warlord (d. 1551)
- Bernard Palissy, French potter and writer
- Elizabeth Lucar, English calligrapher (d. 1537)
- Ambroise Paré, French surgeon (d. 1590)
- Nicolas Durand de Villegaignon, French naval officer (d. 1571)
- Pierre de Manchicourt, Flemish composer (d. 1564)
- Gracia Mendes Nasi, Ottoman businessperson and philanthropist (d. 1569)
- Beatriz de la Cueva, Governor of Guatemala (d. 1541)
- Francisco Vázquez de Coronado, Spanish conquistador (d. 1554)
- Tullia d'Aragona, Italian poet, author and philosopher (d. 1556)
- Aloysius Lilius, Italian inventor of the Gregorian calendar (d. 1576)
- Luis de Morales, Spanish religious painter (d. 1586)
- Lope de Rueda, Spanish dramatist and author (d. 1565)
- Lawrence Sheriff, Elizabethan gentleman and grocer (d. 1567)
- Claudio Veggio, Italian composer
- John Knox, Scottish reformer (d. 1572 )
- February 1 – Sidonie of Poděbrady, Bohemian princess, duchess consort of Saxony (b. 1449)
- February 28 – Juan de la Cosa, Spanish cartographer and explorer (b. c. 1460)
- March 1 – Francisco de Almeida, Portuguese soldier and explorer (b. c. 1450)
- March 10 – Johann Geiler von Kaisersberg, German preacher (b. 1445)
- March 12 – Mihnea cel Rău, Prince of Wallachia (b. c.1460)
- May 17 – Sandro Botticelli, Italian painter (b. 1445)
- May 25 – Cardinal Georges d'Ambroise, aka Monseigneur le Ledat. Adviser to King Louis XII of France. (b. 1460)
- July 10 – Catherine Cornaro, Queen of Cyprus (b. 1454)
- July 14 – Arthur Stewart, Duke of Rothesay, heir to the Scottish throne (b. 1509)
- July 27 – Giovanni Sforza, Italian condottiere (b. 1466)
- August 17
- September 15 – Saint Catherine of Genoa (b. 1447)
- September 18 – Ursula of Brandenburg, Duchess of Mecklenburg-Schwerin (b. 1488)
- November 11 – Bohuslav Hasištejnský z Lobkovic, Bohemian writer (b. 1461)
- December 2 – Muhammad Shaybani, Khan of Bukhara (b. 1451)
- December 14 – Friedrich of Saxony (b. 1473)
- December 31 – Bianca Maria Sforza, Holy Roman Empress (b. 1472)
- date unknown
- Derrik Mercer (February 1993). Chronicle of the Royal Family. Chronicle Communications. p. 140. ISBN 978-1-872031-20-0.
- Standard Encyclopaedia of Southern Africa, Capetown. 1970. p. 312.
- José Nicolau da Fonseca (1878). An Historical and Archæological Sketch of the City of Goa: Preceded by a Short Statistical Account of the Territory of Goa. Thacker & Company, limited. p. 88.
- Alfred Friedrich Gottfried Albert Woltmann; Karl Woermann (1885). History of Painting: The painting of the renascence. Dodd, Mead, & Company. p. 294.