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|Ab urbe condita||2329|
|Balinese saka calendar||1497–1498|
|English Regnal year||18 Eliz. 1 – 19 Eliz. 1|
|Chinese calendar||乙亥年 (Wood Pig)|
4272 or 4212
— to —
丙子年 (Fire Rat)
4273 or 4213
|- Vikram Samvat||1632–1633|
|- Shaka Samvat||1497–1498|
|- Kali Yuga||4676–4677|
|Japanese calendar||Tenshō 4|
|Minguo calendar||336 before ROC|
|Thai solar calendar||2118–2119|
1702 or 1321 or 549
— to —
1703 or 1322 or 550
|Wikimedia Commons has media related to 1576.|
- January 20 – Viceroy Martín Enríquez de Almanza founds the settlement of León, Guanajuato in New Spain (modern-day Mexico).
- January 25 – Portuguese explorer Paulo Dias de Novais founds the settlement of São Paulo da Assumpção de Loanda on the western coast of Africa, which becomes Luanda.
- May 5 – The Edict of Beaulieu or Peace of Monsieur (after "Monsieur", the Duke of Anjou, brother of the King, Henry III of France, who negotiated it) ends the Fifth War of Religion in France. Protestants are again granted freedom of worship.
- June 18 – The Battle of Haldighati, Mughal forces led by Man Singh I of Amer decisively defeated the Mewar Kingdom led by Maharana Pratap and Mewar was occupied.
- July 11 – English navigator Martin Frobisher sights Greenland.
- July 12 – Mughal Empire annexes Bengal after defeating the Bengal Sultanate at the Battle of Raj Mahal.
- August 11 – English navigator Martin Frobisher, on his search for the Northwest Passage, enters the bay now named after him.
- October – the Siege of Takabaru occurs in Japan, when the forces of Shimazu Takahisa besiege and take the fortress of Takabaru, which belonged to the Itō clan.
- November 2 – Rudolf II becomes Holy Roman Emperor.
- November 4 – Eighty Years' War – Sack of Antwerp: In the Low Countries, mutinous Spanish soldiers sack Antwerp; after three days the city is nearly destroyed.
- November 8 – Eighty Years' War – Pacification of Ghent: The States General of the Netherlands meet and unite to oppose pillaging Spanish mutineers.
- December 14 – Hungarian Transylvanian Prince Stephen Báthory is elected king of Poland.
- The 1576 Cocoliztli epidemic causes millions of deaths in the territory of New Spain, in modern-day Mexico.
- An early example of autobiography is written in English, by Thomas Whythorne.
- The Loci Communes of Peter Martyr Vermigli (d. 1562), edited by Robert le Maçon, are published in London.
- The following schools are founded in England:
- Konstanty Wasyl Ostrogski founds Ostroh Academy, the first university-level school in Eastern Europe.
- January 4 – Archduchess Catherine Renata of Austria, Austrian archduchess (d. 1599)
- January 5 – Anne Turner, English murderer (d. 1615)
- January 12 – Petrus Scriverius, Dutch writer and scholar on the history of Holland and Belgium (d. 1660)
- February 2 – Alix Le Clerc, French Canoness Regular and foundress (d. 1622)
- February 10 – Festus Hommius, Dutch theologian (d. 1642)
- February 29 – Antonio Neri, Italian chemist (d. 1614)
- March 14 – Eric of Lorraine, Bishop of Verdun (d. 1623)
- March 31 – Countess Louise Juliana of Nassau, countess consort and a regent of the Palatinate (d. 1644)
- May 17 – Joam Mattheus Adami, Italian Jesuit missionary (d. 1633)
- May 24 – Elizabeth Carey, Lady Berkeley, English courtier (d. 1635)
- May 27 – Caspar Schoppe, German controversialist and scholar (d. 1649)
- June 6 – Giovanni Diodati, Swiss-born Italian Calvinist theologian and translator (d. 1649)
- June 16 – Giovanni Battista Viola, Italian painter (d. 1622)
- July 3 – Duchess Anna of Prussia, Electress consort of Brandenburg and Duchess consort of Prussia (d. 1625)
- September 22 – Philipp of Bavaria, German Catholic cardinal (d. 1598)
- October – Thomas Weelkes, English composer and organist (d. 1626)
- October 6 – Roger Manners, 5th Earl of Rutland, eldest surviving son of John Manners (d. 1612)
- October 7 – John Marston, English writer (d. 1634)
- October 12 – Thomas Dudley, Governor of Massachusetts Bay Colony (d. 1653)
- October 28 – Rudolph, Prince of Anhalt-Zerbst, Prince of Anhalt (1586–1603), then Prince of Anhalt-Zerbst (1603–1621) (d. 1621)
- October 30 – Enrico Caterino Davila, Italian historian and diplomat (d. 1631)
- November 6 – Charles Günther, Count of Schwarzburg-Rudolstadt (1605–1630) (d. 1630)
- November 17 – Roque Gonzales, Paraguayan missionary (d. 1628)
- November 18 – Philipp Ludwig II, Count of Hanau-Münzenberg (1580–1612) (d. 1612)
- November 27 – Shimazu Tadatsune, Japanese ruler of Satsuma (d. 1638)
- December 20 – Saint John Sarkander, Moravian priest (d. 1620)
- date unknown
- probable – Jesper Mattson Cruus af Edeby, Swedish soldier and politician (d. 1622)
- January 19 – Hans Sachs, German Meistersinger (b. 1494)
- January 27 – Mizuno Nobumoto, Japanese shōgun
- February 10 – Wilhelm/Guilielmus Xylander, German classical scholar (b. 1532)
- February 12 – John Albert I, Duke of Mecklenburg (b. 1525)
- March 5 – Luis de Requesens y Zúñiga, Spanish governor of the Netherlands (b. 1528)
- March 18 – Johann Stössel, German theologian (b. 1524)
- May 14 – Tahmasp I, Shah of Persia (b. 1514)
- May 30 – Harada Naomasa, Japanese samurai
- June 30 – Franciscus Sonnius, Dutch counter-Reformation theologian (b. 1506)
- July 2 – Josias Simler, Swiss scholar (b. 1530)
- July 11 – Eleonora di Garzia di Toledo, Italian noble (d. 1553)
- July 16 – Isabella de' Medici, Italian noble (d. 1542)
- August 15 or August 22 – Bálint Bakfark, Hungarian composer and lutenist (b. 1507)
- August 27 – Titian, Italian painter (b. c. 1489)
- September 21 – Gerolamo Cardano, Italian mathematician, physician, astrologer and gambler (b. 1502)
- September 22 – Walter Devereux, 1st Earl of Essex (b. 1541)
- October 12 – Maximilian II, Holy Roman Emperor (b. 1527)
- October 14 – Konrad Heresbach, German Calvinist (b. 1496)
- October 26 – Frederick III, Elector Palatine, ruler from the house of Wittelsbach (b. 1515)
- November 4 – John Paulet, 2nd Marquess of Winchester (b. c. 1510)
- November 9 – Chamaraja Wodeyar IV, King of Mysore (b. 1507)
- date unknown