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|Ab urbe condita||2253|
|Balinese saka calendar||1421–1422|
|English Regnal year||15 Hen. 7 – 16 Hen. 7|
|Chinese calendar||己未年 (Earth Goat)|
4196 or 4136
— to —
庚申年 (Metal Monkey)
4197 or 4137
|- Vikram Samvat||1556–1557|
|- Shaka Samvat||1421–1422|
|- Kali Yuga||4600–4601|
|Japanese calendar||Meiō 9|
|Minguo calendar||412 before ROC|
|Thai solar calendar||2042–2043|
1626 or 1245 or 473
— to —
1627 or 1246 or 474
|Wikimedia Commons has media related to 1500.|
The year was seen as being especially important by many Christians in Europe, who thought it would bring the beginning of the end of the world. Their belief was based on the phrase "half-time after the time", when the apocalypse was due to occur, which appears in the Book of Revelation and was seen as referring to 1500. This time was also just after the Old World's discovery of the Americas in 1492, and therefore was influenced greatly by the New World.
The end of this year marked the halfway point of the 2nd millennium, as there were 500 years before it and 500 years after it.
- January 5 – Duke Ludovico Sforza recaptures Milan, but is soon driven out again by the French.
- January 26 – Spanish navigator Vicente Yáñez Pinzón reaches the northern coast of Brazil.
- February 17 – Battle of Hemmingstedt: The Danish army fails to conquer the peasants' republic of Dithmarschen.
- April 22 – Portuguese navigator Pedro Álvares Cabral officially discovers Brazil, and claims the land for the Kingdom of Portugal. He had 13 vessels with him.
- July 14 – The Muscovites defeat the Lithuanians and the Poles in the Battle of Vedrosha.
- August – : The Turkish fleet of Kemal Reis defeats the Venetians in the Second Battle of Lepanto. The Turks proceed to capture Modon and Coron, the "two eyes of the Republic".
- August 10 – Diogo Dias discovers an island which he names St Lawrence (after the saint's day on which it was first sighted), later to be known as Madagascar.
- November 11 – Treaty of Granada: Louis XII of France and Ferdinand II of Aragon agree to divide the Kingdom of Naples between them.
- November 16 – Emperor Go-Kashiwabara accedes to the throne of Meiō era Japan.
- December 24 – The Siege of the Castle of St. George ends, and the island of Cephalonia is captured by a joint Venetian–Spanish fleet.
- December 31 – The last incunable is printed in Venice.
- Europe's population is estimated at 56.7 million people (Spielvogel).
- Saxony's mint at Annaberg begins producing guldengroschens.
- Although other reports exist, it is thought that the last wolf in England was killed this year, making the species extinct in that country. The wolf is thought to have been killed in Allithwaite, in Cumbria. However, reports of wolf sightings and laws concerning wolf bounties existed in rural areas of the north until the 18th century.
- A group of Māori migrated east from modern day New Zealand to the Rēkohu islands, developing a distinct pacificist culture known as the Moriori (approx date)
- January 1 – Solomon Molcho, Portuguese mystic (d. 1532)
- January 6 – John of Ávila, Spanish mystic and saint (d. 1569)
- January 20 – Jean Quintin, French priest, knight and writer (d. 1561)
- February 7 – João de Castro, Portuguese nobleman and fourth viceroy of Portuguese India (d. 1548)
- February 22 – Cardinal Rodolfo Pio da Carpi, Italian humanist (d. 1564)
- February 24 – Charles V, Holy Roman Emperor (d. 1558)
- March 12 – Reginald Pole, Archbishop of Canterbury (d. 1558)
- April 12 – Joachim Camerarius, German classical scholar (d. 1574)
- April 23
- April 27 – Louis, Count of Vaudémont, Italian bishop (d. 1528)
- May 17 – Federico II Gonzaga, Duke of Mantua (d. 1540)
- June 13 – Ernest of Bavaria, pledge lord of the County of Glatz (d. 1560)
- July 2 – Federico Cesi (cardinal), Italian cardinal (d. 1565)
- July 20 – Lorenzo Cybo, Italian condottiero (d. 1549)
- August 16 – Louis Gonzaga (Rodomonte), Italian-French dignitary and diplomat (d. 1532)
- September 5 – Maria of Jever, last ruler of the Lordship of Jever (d. 1575)
- September 7 – Sebastian Newdigate, Carthusian monk and martyr (d. 1535)
- September 17 – Sebastiano Antonio Pighini, Italian cardinal (d. 1553)
- September 26 – Ludovica Torelli, Count of Guastalla (d. 1569)
- October 17 – Alonso de Orozco Mena, Spanish Roman Catholic priest (d. 1591)
- November 3 – Benvenuto Cellini, Italian goldsmith and sculptor (d. 1571)
- December 6 – Nicolaus Mameranus, Luxembourgian soldier and historian (d. 1567)
- Johannes Aal, Swiss theologian and composer (d. 1553)
- Charles Dumoulin, French jurist (d. 1566)
- Wu Cheng'en, Chinese novelist (d. 1582)
- Heinrich Faber, German music theorist (d. 1552)
- Francisco de Moraes, Portuguese writer (d. 1572)
- Mem de Sá, Governor-General of Brazil (d. 1572)
- Jeanne de la Font, French poet and culture patron (d. 1532)
- Ming the clam, longest living ocean quahog was born (d. 2006)
- February 17 – William III, Landgrave of Hesse (b. 1471)
- April 10 – Michael Tarchaniota Marullus, Greek scholar, poet and soldier (b. c. 1453)
- April 12 – Leonhard of Gorizia, Count of Gorz (b. 1440)
- May 29
- June 19 – Edmund Tudor, Duke of Somerset, English nobleman (b. 1499)
- June 23 – Lodovico Lazzarelli, Italian poet (b. 1447)
- July 14 – Íñigo López de Mendoza y Luna, 2nd Duke of the Infantado, Spanish noble (b. 1438)
- July 19 – Miguel da Paz, Prince of Portugal (b. 1498)
- August 18 – Alfonso of Aragon, prince (b. 1481)
- August 26 – Philipp I, Count of Hanau-Münzenberg, German noble (b. 1449)
- August 30 – Victor, Duke of Münsterberg and Opava, Count of Glatz (b. 1443)
- September 12 – Albert III, Duke of Saxony (b. 1443)
- September 15 – John Morton, English Archbishop of Canterbury (b. c. 1420)
- October 1 – John Alcock, English Bishop of Ely (b. c. 1430)
- October 21 – Emperor Go-Tsuchimikado of Japan (b. 1442)
- November 13 – Philip, Prince of Anhalt-Köthen, German prince (b. 1468)
- date unknown – Antonia of Savoy, Lady Consort of Monaco
- Andrew Graham-Dixon, Art of Germany (2011), United Kingdom: British Broadcasting Corporation[need quotation to verify]
- "History of Europe - The Middle Ages". Encyclopedia Britannica. Retrieved January 14, 2021.
- "Pinzon discovers Brazil". HISTORY. Retrieved October 11, 2019.
- Robert James Bast; Andrew Colin Gow; Heiko Augustinus Oberman (2000). Continuity and Change: The Harvest of Late Medieval and Reformation History : Essays Presented to Heiko A. Oberman on His 70th Birthday. Brill. p. 122. ISBN 90-04-11633-8.
- Raphaël Louis Oechslin (1962). Louis of Granada. Herder. p. 24.
- Vella, Horatio C. R. (2003). "Jean Quintin's Insulae Melitae Descriptio (1536) : an anniversary and a discussion on its sources" (PDF). Humanitas: Journal of the Faculty of Arts. University of Malta. 2: 155–171. Archived from the original (PDF) on September 19, 2020.
- Benjamin Eli Smith (1895). The Century Cyclopedia of Names: A Pronouncing and Etymological Dictionary of Names in Geography, Biography, Mythology, History, Ethnology, Art, Archæology, Fiction, Etc. ... Century Company. p. 224.
- "Charles V | Accomplishments, Reign, Abdication, & Facts". Encyclopedia Britannica. Retrieved January 14, 2021.
- Johnson's New Universal Cyclopaedia: a Scientific and Popular Treasury of Useful Knowledge. A.J. Johnson & Son. 1879. p. 740.
- John McClintock; James Strong (1981). Cyclopedia of Biblical, Theological, and Ecclesiastical Literature. Baker Publishing Group. p. 138. ISBN 978-0-8010-6123-3.
- Robert W. Karrow (1993). Mapmakers of the Sixteenth Century and Their Maps: Bio-bibliographies of the Cartographers of Abraham Ortelius, 1570 : Based on Leo Bagrow's A. Ortelii Catalogus Cartographorum. Newberry Library. p. 510. ISBN 978-0-932757-05-0.
- Titus Lucretius Carus (1864). Titi Lucreti Cari De Rerum Natura Libri Sex: With a translation and notes. Bell. p. 6.
- Rebecca Stefoff (1995). The British Library Companion to Maps and Mapmaking. British Library. p. 111. ISBN 978-0-7123-0650-8.
- Wouter J. Hanegraaff and Ruud M. Bouthoorn, Lodovico Lazzarelli (1447-1500): The Hermetic Writings and Related Documents, Arizona Center for Medieval and Renaissance Studies, Tempe 2005.
- Leicestershire Architectural and Archaeological Society (1874). Transactions. p. 214.