|Ab urbe condita||2250|
|Balinese saka calendar||1418–1419|
|English Regnal year||12 Hen. 7 – 13 Hen. 7|
|Chinese calendar||丙辰年 (Fire Dragon)|
4193 or 4133
— to —
丁巳年 (Fire Snake)
4194 or 4134
|- Vikram Samvat||1553–1554|
|- Shaka Samvat||1418–1419|
|- Kali Yuga||4597–4598|
|Japanese calendar||Meiō 6|
|Minguo calendar||415 before ROC|
|Thai solar calendar||2039–2040|
1623 or 1242 or 470
— to —
1624 or 1243 or 471
- February 7 (Shrove Tuesday) – Followers of Girolamo Savonarola burn thousands of "immoral" objects, at the Bonfire of the Vanities in Florence.
- May – The Cornish Rebellion breaks out in England, incited by war taxes.
- May 10 – Amerigo Vespucci allegedly leaves Cádiz, for his first voyage to the New World.
- May 12 – Pope Alexander VI excommunicates Girolamo Savonarola.
- May 20 – John Cabot sets sail from Bristol, on the ship Matthew (principally owned by Richard Amerike), looking for new lands to the west (some sources give a May 2 date).
- June 13 – The Catholic Monarchs issue the ordinance of Medina del Campo, creating a money system based on the copper maravedí, creating the peso of 34 maravedis. In the next three centuries, this system will dominate international payments. It will be used in almost all parts of the Americas and large parts of Asia. It is the basis for a number of modern currencies, including the U.S. dollar.
- June 17 – Battle of Deptford Bridge near London: Cornish rebels under Michael An Gof are soundly defeated by Henry VII. 
- June 24 – John Cabot lands in North America (near present day Bonavista, Newfoundland).
- July 8 – Vasco da Gama's fleet departs from Lisbon, beginning his expedition to India.
- September 7 – Second Cornish Uprising in England: Perkin Warbeck lands near Land's End; on September 10 he is proclaimed as King in Bodmin.
- September 28 –Battle of Rotebro: John, King of Denmark, defeats Sten Sture the Elder.
- September 30 – The Treaty of Ayton establishes a seven-year peace between England and Scotland.
- October 4 – Leaders of the Second Cornish Uprising surrender to the King at Taunton; the following day, Warbeck, having deserted his army, is captured at Beaulieu Abbey in Hampshire.
- October 6 – Sten Sture the Elder is forced to resign and end his 27-year term as Regent of Sweden. King John of Denmark and Norway is acknowledged by the estates as King of Sweden and formally elected on October 18, restoring the power of the Kalmar Union.
- December 5 – King Manuel I of Portugal proclaims an edict in which he demands that Jews convert to Christianity or leave the country.
- December 23 – Sheen Palace is destroyed by fire. Henry VII of England rebuilds it as Richmond Palace.
- Babur takes Samarkand at the age of fifteen after a seven-month siege. He will hold the city for 100 days.
- Ivan the Great issues his law code, the Sudebnik.
- The Ottomans give Russian merchants freedom of trade within the empire.
- Iamblichus De mysteriis Aegyptorum edited by Marsilio Ficino is published.
- February 16 – Philip Melanchthon, German humanist and reformer (d. 1560)
- February 19 – Matthäus Schwarz, German fashion writer (d. 1574)
- March – Giovanni Paolo I Sforza, Italian condottiero (d. 1535)
- April 2 – Georg Giese, German merchant (d. 1562)
- April 16 – Mōri Motonari, Japanese daimyō (d. 1571)
- April 17 – Pedro de Valdivia, Spanish conquistador (d. 1553)
- May 3 – Wilhelm IV of Eberstein, President of the Reichskammergericht (d. 1562)
- May 21 – Al-Hattab, Tripolitanian Muslim jurist (d. 1547)
- June 27 – Ernest I, Duke of Brunswick-Lüneburg (d. 1546)
- July 15 – Francis of Denmark, Danish prince (d. 1511)
- August 18 – Francesco Canova da Milano, Italian composer (d. 1543)
- September 10 – Wolfgang Musculus, German theologian (d. 1563)
- October 29 – Benedetto Accolti the Younger, Italian cardinal (d. 1549)
- date unknown
- January 3 – Beatrice d'Este, Duchess of Milan (b. 1475)
- January 30 – Lê Thánh Tông, Emperor of Vietnam (b. 1442)
- February 6 – Johannes Ockeghem, Flemish composer (b. c. 1410)
- May 26 – Antonio Manetti, Italian mathematician and architect (b. 1423)
- June 14 – Giovanni Borgia, 2nd Duke of Gandía (assassinated) (b.1474)
- June 27
- June 28 – James Tuchet, 7th Baron Audley (b. c. 1463)
- July – Estêvão da Gama, Portuguese explorer ( b. c. 1430)
- July 23 – Barbara Fugger, German banker (b. 1419)
- August 24 – Sophie of Pomerania, Duchess of Pomerania (b. 1435)
- October 4 – John, Prince of Asturias, only son of Ferdinand II of Aragon and Isabella I of Castile (b. 1478)
- November 7 – Philip II, Duke of Savoy (b. 1443)
- November 30 – Anna Sforza, Italian noble (b. 1476)
- date unknown
- probable – Elia del Medigo, Italian philosopher (b. 1460)
- Williams, Hywel (2005). Cassell's Chronology of World History. London: Weidenfeld & Nicolson. pp. 189–192. ISBN 0-304-35730-8.
- Palmer, Alan; Veronica (1992). The Chronology of British History. London: Century Ltd. pp. 135–138. ISBN 0-7126-5616-2.
- Annals of the Four Masters - Part 13. Annals of the Four Masters. Retrieved April 17, 2018.
Great famine prevailed through all Ireland in this and the following year, so that people ate of food unbecoming to mention, and never before heard of as having been introduced on human dishes.
- Timothy Wengert; M. Patrick Graham (October 1, 1997). Philip Melanchthon (1497-1560) and the Commentary. Bloomsbury Academic. p. 7. ISBN 978-1-85075-684-2.
- BONO, JAMES J.; SCHMITT, CHARLES B. (1979). "AN UNKNOWN LETTER OF JACQUES DALÉCHAMPS TO JEAN FERNEL: LOCAL AUTONOMY VERSUS CENTRALIZED GOVERNMENT" (PDF). Bulletin of the History of Medicine. 53 (1): 100–127. ISSN 0007-5140. JSTOR 44451300. PMID 387127.
- Studies in the History of Art. National Gallery of Art. 1972. p. 140. ISBN 978-0-89468-106-6.