Talk:Ralph S. Baric

This article is probably being spammed.

I just now deleted an entire section (Early Career) because it made serious claims about the COVID-19 outbreak that weren’t backed up by any supporting evidence. Alexandernwalczak (talk) 08:06, 24 June 2021 (UTC)

Link to the edit: https://en.m.wikipedia.org/wiki/Special:MobileDiff/1030165693 Alexandernwalczak (talk) 08:09, 24 June 2021 (UTC)

Suggestions for improvement

Hello folks fellow Wikipedians! While i was working on the development of a German language de Wikipedia article on Ralph Baric, i found some things i want to suggest here: Authors who want to improve this article should consult the Chinese zh Wikipedia version. Even if You do not have access to Chinese language (or to an appropriate translation machine), You should at least view (cross-read) the references (they are all English). I believe Wikipedia should be a project of many authors, and as the main author of the de Wikipedia article it is not primarily me who should make these addition-edits. --Himbeerbläuling (talk) 12:37, 5 July 2021 (UTC) (now: some sentences deleted) --Himbeerbläuling (talk) 09:36, 27 November 2021 (UTC)

Suggested Edits for first section

Ralph Steven Baric (born 1954) is William R. Kenan Jr. Distinguished Professor in the Department of Epidemiology, and Professor in the Department of Microbiology and Immunology at The University of North Carolina at Chapel Hill.

As the leading expert in coronavirus, he has spent the past 3 decades as a world leader in the study of coronaviruses and is responsible for UNC-Chapel Hill’s coronavirus research efforts. He has led the world in recognizing the importance of zoonotic viruses as potentially rich source of new emerging pathogens in humans. Specifically, he works to decipher the complex interactions between the virion and cell surface molecules that function in the entry and cross species transmission of positive-strand RNA viruses. 1

Baric's work involves coronaviruses, including gain of function research aimed at devising effective vaccines against coronaviruses. 2 Baric has warned of emerging coronaviruses presenting as a significant threat to global health, due to zoonosis. 3 4 Sciencenerd47 (talk) 15:19, 10 October 2022 (UTC)

Suggest edits for career

In a research collaboration with scientists at Duke University and the University of North Carolina at Chapel Hill, an antibody has been identified and tested which limits the severity of infections from a variety of coronaviruses, including those that cause COVID-19 as well as the original SARS illness. The antibody was tested in animal models at UNC- Chapel Hill which was led by Dr. Baric. 5

Dr. Baric's work involves using coronaviruses as models to study the genetics of RNA virus transcription, replication, persistence and cross species transmission. Dr Baric has also uses alphavirus vaccine vectors to develop novel candidate vaccines.

Baric has published multiple articles and book chapters on the epidemiology and genetics of various viruses, including norovirus [6] [7] [8] , and coronaviruses, [9] [10]as well as potential treatments for viral diseases.[11] [12]

Key Publications include research on severe acute respiratory syndrome, recombination resistant coronaviruses, broad spectrum antivirals and zoonotic coronaviruses.

In 2000, he published several articles on the Development of Coronavirus Infections, Subgenomic negative strand function during MHV infection and Mechanisms of MHV persistence.  

In 2001, he published articles on Mucosal, systemic and cross immunity against Norwalk like viruses, Coronavirus Heterologous Expression Vectors, Evidence of protective immune response against Norwalk like virus and Coronavirus heterologous gene expression vectors

In 2002, he published articles on systemic, mucosal and heterotopic immune induction in mice inoculated with Venezuelan equine encephalitis replicons expressing Norwalk virus like particles and Systematic assembly of a full length infectious cDNA of mouse hepatitis virus strain A59

In 2004- 2005, he published articles on reverse genetic analysis of the transcription regulatory sequence of the coronavirus transmissible gastroenteritis, development of mouse hepatitis virus and SARS-CoV infectious cDNA constructs, the nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication.  

In 2006, he published articles on vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants, SARS coronavirus vaccine

In 2015, with Shi Zhengli of the Wuhan Institute of Virology, he published an article titled "A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence," which describes their work in generating and characterizing "a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone." [13]

In 2016, he published articles on SARS like cluster of circulating bat coronaviruses show potential, T cells mediate protective immunity against emerging respiratory coronavirus, the effect of inhibition of PP1 and TNFa signaling on pathogenesis of SARS coronavirus and mouse model of MERS coronavirus induced acute respiratory distress syndrome  

In 2017, he published articles on MERS Coronavirus Nonstructural Protein 16 is Necessary for Interferon Resistance and Viral Pathogenesis and Sydney norovirus strain with minor sequence variation leading to antibody escape.

In 2018, he published articles on Coronavirus Susceptibility to the Antiviral Remdesivir, an immunocompetent mouse model of zika virus infection, MERS replication In Vitro, modeling pathogenesis of emergent of pre-emergent human coronaviruses in mice and evaluation of recombination resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform

In 2019, he published articles on broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase, trypsin treatment unlocks barrier for zoonotic bat coronaviruses infection, receptor recognition by novel coronavirus from Wuhan and increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis.

In 2020, Baric contributed to establishing the official nomenclature and taxonomic classification of SARS-CoV-2. [14]

In 2021, he was elected member of the U. S. National Academy of Sciences. [15] Sciencenerd47 (talk) 16:40, 12 October 2022 (UTC)

Honors and Awards

Oliver Max Gardner Award – 2021 (UNC System)

Health Care Heroes Lifetime Achievement Award- 2021 (Triangle Business Journal)

William R. Kenan, Jr. Distinguished Professor of Epidemiology- 2019 (University of North Carolina at Chapel Hill)  

Innovation Award for Faculty Research- 2011 (University of North Carolina at Chapel Hill)

Established Investigator Award- 1994 (American Heart Association)  

Harvey Weaver Scholar- 1986 (National Multiple Sclerosis Society)   Sciencenerd47 (talk) 16:41, 12 October 2022 (UTC)

do you have independent secondary reliable sources which show these awards are notable? and due inclusion? — Shibbolethink ^{(♔ ♕)} 14:27, 15 October 2022 (UTC)

Hi Shibbolethink! Thank you so much for taking a look at these. I have included updated suggestions with sources below. Please let me know if you have any further questions.

Oliver Max Gardner Award – 2021 (UNC System) [1]

Health Care Heroes Lifetime Achievement Award- 2021 (Triangle Business Journal) [2]

William R. Kenan, Jr. Distinguished Professor of Epidemiology- 2019 (University of North Carolina at Chapel Hill)  [3]

Innovation Award for Faculty Research- 2011 (University of North Carolina at Chapel Hill) [4]

Established Investigator Award- 1994 (American Heart Association)  [5]

Harvey Weaver Scholar- 1986 (National Multiple Sclerosis Society) [6] Sciencenerd47 (talk) 21:27, 2 November 2022 (UTC)

Suggested Edits for Page:

Hello, I believe the line, “An article in the Proceedings of the National Academy of Sciences suggests that Baric's lab had the capability to create SARS-CoV-2, the coronavirus that causes Covid-19. [5][6] ” that is currently posted on the page inaccurately portrays the contents of the PNAS Proceedings. The cited proceedings do not mention Dr. Baric’s name at all within the content of the article. Sciencenerd47 (talk) 21:27, 2 November 2022 (UTC)

Absolutely right this is a massive WP:BLP violation — Shibbolethink ^{(♔ ♕)} 22:06, 2 November 2022 (UTC)

Thank you for you input on this! Sciencenerd47 (talk) 18:25, 3 November 2022 (UTC)