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Orthocoronavirinae is one of two subfamilies in the family Coronaviridae. It is subdivided into the genera Alphacoronavirus, Betacoronavirus, Gammacoronavirus, and Deltacoronavirus. These include phylogenetically compact genogroups of enveloped, positive-sense, single-stranded RNA and with a nucleocapsid of helical symmetry. The genomic size of coronaviruses ranges from approximately 26 to 32 kilobases, extraordinarily large for an RNA virus. Their numbers are growing rapidly with several novel coronaviruses being recently discovered including Middle East respiratory syndrome coronavirus MERS-CoV discovered in 2012.[3][4]

Virus classification e
(unranked): Virus
Realm: Riboviria
Phylum: incertae sedis
Order: Nidovirales
Family: Coronaviridae
Subfamily: Orthocoronavirinae
  • Coronavirinae

The genus Alphacoronavirus(formerly known as Coronavirus group 1 (CoV-1)) includes subgroups 1a and 1b, which are prototyped by human coronavirus 229E (HCoV-229E) and HCoV-NL63, as well as the newly established species alphacoronavirus 1 (including porcine transmissible gastroenteritis virus [TGEV]), respectively. The genus Betacoronavirus (formerly Betacoronavirus group 2 (Cov-2)) includes several subgroups, with the most prominent (subgroups 2a and 2b) being prototyped by the species Murine coronavirus (including mouse hepatitis virus [MHV]) and severe acute respiratory syndrome-related coronavirus, respectively. The genus Alphacoronavirus and Betacoronavirus derive from the bat gene pool. The genus Gammacoronavirus includes all avian coronaviruses identified until 2009.[5][6]


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  1. ^ "Virus Taxonomy: 2018 Release" (html). International Committee on Taxonomy of Viruses (ICTV). October 2018. Retrieved 25 January 2019.
  2. ^ "ICTV Taxonomy history: Orthocoronavirinae" (html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 26 January 2019.
  3. ^ Thiel V, ed. (2007). Coronaviruses: Molecular and Cellular Biology (1st ed.). Caister Academic Press. ISBN 978-1-904455-16-5.[page needed]
  4. ^ Gorbalenya, A. E.; Snijder, E. J.; Spaan, W. J. M. (2004). "Severe Acute Respiratory Syndrome Coronavirus Phylogeny: Toward Consensus". Journal of Virology. 78 (15): 7863–6. doi:10.1128/JVI.78.15.7863-7866.2004. PMC 446116. PMID 15254158.
  5. ^ Lai, M. M. C.; Holmes, K. V. (2001). "Coronaviridae". In Knipe, D. M.; Howley, P. M.; Griffin, D. E.; Lamb, R. A.; Martin, M. A.; Roizman, B.; Straus, S. E. (eds.). Fields virology (4th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 1163–85.
  6. ^ Woo, P. C. Y.; Lau, S. K. P.; Lam, C. S. F.; Lau, C. C. Y.; Tsang, A. K. L.; Lau, J. H. N.; Bai, R.; Teng, J. L. L.; Tsang, C. C. C.; Wang, M.; Zheng, B.-J.; Chan, K.-H.; Yuen, K.-Y. (2012). "Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus". Journal of Virology. 86 (7): 3995–4008. doi:10.1128/JVI.06540-11. PMC 3302495. PMID 22278237.