Sex reassignment therapy
Sex reassignment therapy is the medical aspect of gender transitioning, that is, modifying one's sex characteristics to better suit one's gender identity. It can consist of hormone therapy to modify secondary sex characteristics, sex reassignment surgery to alter primary sex characteristics, and other procedures altering appearance, including permanent hair removal for trans women.
In appropriately evaluated cases of severe gender dysphoria, sex reassignment therapy is often the best when standards of care are followed.:1570:2108 There is academic concern over the low quality of the evidence supporting the efficacy of sex reassignment therapy as treatment for gender dysphoria, but more robust studies are impractical to carry out;:22 as well, there exists a broad clinical consensus, supplementing the academic research, that supports the effectiveness in terms of subjective improvement of sex reassignment therapy in appropriately selected patients.:2–3 Treatment of gender dysphoria does not involve attempting to correct the patient's gender identity, but to help the patient adapt.:1568
Major health organizations in the United States and UK have issued affirmative statements supporting sex reassignment therapy as comprising medically necessary treatments in certain appropriately evaluated cases.
In the International Classification of Diseases, the diagnosis is known as transsexualism. The US Diagnostic and Statistical Manual of Mental Disorders (DSM) names it gender dysphoria (in version 5). Some people who are validly diagnosed have no desire for all or some parts of sex reassignment therapy, particularly genital reassignment surgery, and/or are not appropriate candidates for such treatment.
The general standard for diagnosing, as well as treating, gender dysphoria is outlined in the WPATH Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People. As of February 2014, the most recent version of the standards is Version 7. According to the standards of care, "gender dysphoria refers to discomfort or distress that is caused by a discrepancy between a person's gender identity and that person's sex assigned at birth (and the associated gender role and/or primary and secondary sex characteristics). Only some gender-nonconforming people experience gender dysphoria at some point in their lives". Gender nonconformity is not the same as gender dysphoria; nonconformity, according to the standards of care, is not a pathology and does not require medical treatment.
The informed consent model is an alternative to the standard WPATH approach which does not require a person seeking transition related medical treatment to undergo formal assessment of their mental health or gender dysphoria. Arguments in favor of this model describe required assessments as gatekeeping, dehumanizing, pathologizing, and reinforcing a reductive perception of transgender experiences. Informed consent approaches include conversations between the medical provider and person seeking care on the details of risks and outcomes, current understandings of scientific research, and how the provider can best assist the person in making decisions.
Local standards of care exist in many countries.
Eligibility for different stages of treatmentEdit
While a mental health assessment is required by the standards of care, psychotherapy is not an absolute requirement but is highly recommended.
Hormone replacement therapy is to be initiated on referral from a qualified health professional. The general requirements, according to the WPATH standards, include:
- Persistent, well-documented gender dysphoria;
- Capacity to make a fully informed decision and to consent for treatment;
- Age of majority in a given country (however, the WPATH standards of care provide separate discussion of children and adolescents);
- If significant medical or mental health concerns are present, they must be reasonably well-controlled.
Often, at least a certain period of psychological counseling is required before initiating hormone replacement therapy, as is a period of living in the desired gender role, if possible, to ensure that they can psychologically function in that life-role. On the other hand, some clinics provide hormone therapy based on informed consent alone.
As surgery is a radical and irreversible intervention, more stringent standards are usually applied. Generally speaking, physicians who perform sex-reassignment surgery require the patient to live as the members of their target gender in all possible ways for at least a year, prior to the start of surgery, in order to assure that they can psychologically function in that life-role. This period is sometimes called the Real Life Test (RLT); it is part of a battery of requirements. Other frequent requirements are regular psychological counseling and letters of recommendation for this surgery.
The time period of "cross-living" is usually known as the Real-Life-Test (RLT) or Real-Life-Experience (RLE). It is sometimes required even before hormone therapy, but this is not always possible; transsexual men frequently cannot "pass" this period without hormones. Transsexual women may also require hormones to pass as women in society. Most trans women also require facial hair removal, voice training or voice surgery, and sometimes, facial feminization surgery, to be passable as females; these treatments are usually provided upon request with no requirements for psychotherapy or "cross-living".
Some surgeons who perform sex reassignment surgeries may require their patients to live as members of their target gender in as many ways as possible for a specified period of time, prior to any surgery. However, some surgeons recognize that this so-called real-life test for trans men, without breast removal and/or chest reconstruction, may be difficult. Therefore, many surgeons are willing to perform some or all elements of sex reassignment surgery without a real-life test. This is especially common amongst surgeons who practice in Asia. However, almost all surgeons practicing in North America and Europe who perform genital reassignment surgery require letters of approval from two psychotherapists; most Standards of Care recommend, and most therapists require, a one-year real-life test prior to genital reassignment surgery, though some therapists are willing to waive this requirement for certain patients.
The requirements for chest reconstruction surgery are different for trans men and trans women. The Standards of Care require trans men to undergo either 3 months of Real-life-test or psychological evaluation before surgery whereas trans women are required to undergo 18 months of hormone therapy. The requirement for trans men is due to the difficulty in presenting as male with female breasts, especially those of a C cup or larger. For very large breasts it can be impossible for the trans man to present as male before surgery. For trans women, the extra time is required to allow for complete breast development from hormone therapy. Having breast augmentation before that point can result in uneven breasts due to hormonal development, or removal of the implant if hormonal breast development is significant and results in larger breasts than desired.
Eligibility of minorsEdit
While the WPATH standards of care generally require the patient to have reached the age of majority, they include a separate section devoted to children and adolescents.
While there is anecdotal evidence of cases where a child firmly identified as another sex from a very early age, studies cited in the standards of care show that in the majority of cases such identification in childhood does not persist into adulthood.[better source needed] However, with adolescents, persistence is much more likely, and so reversible treatment by puberty blockers can be prescribed. This treatment is controversial as the use of puberty blockers involves a small risk of adverse physical effects.
A 2014 study made a longer-term evaluation of the effectiveness of this approach, looking at young transgender adults who had received puberty suppression during adolescence. It found that "After gender reassignment, in young adulthood, the [gender dysphoria] was alleviated and psychological functioning had steadily improved. Well-being was similar to or better than same-age young adults from the general population."[better source needed]
According to the WPATH SOC v7, "Psychotherapy (individual, couple, family, or group) for purposes such as exploring gender identity, role, and expression; addressing the negative impact of gender dysphoria and stigma on mental health; alleviating internalized transphobia; enhancing social and peer support; improving body image; or promoting resilience" is a treatment option.
Some transsexual people may suffer from co-morbid psychiatric conditions unrelated to their gender dysphoria. In cases of comorbid psychopathology, the standards are to manage the psychopathology "prior to, or concurrent with, treatment of gender dysphoria". Treatment may still be appropriate and necessary in cases of significant comorbid psychopathology, as cases have been reported in which the individual was both suffering from severe co-occurring psychopathology, and was a 'late-onset, gynephilic' trans woman, and yet experienced a long-term, positive outcome with hormonal and surgical gender transition.:22 The DSM-IV itself states that in rare instances, gender dysphoria may co-exist with schizophrenia, and that psychiatric disorders are not generally considered contraindications to sex reassignment therapy unless they are the primary cause of the patient's gender dysphoria.:108
For trans people, hormone therapy causes the development of many of the secondary sexual characteristics of their desired sex. However, many of the existing primary and secondary sexual characteristics cannot be reversed by hormone therapy. For example, hormone therapy can induce breast growth for trans women but can only minimally reduce breasts for trans men. HRT can prompt facial hair growth for transsexual men, but cannot regress facial hair for transsexual women. Hormone therapy may, however, reverse some characteristics, such as distribution of body fat and muscle, as well as menstruation in trans men.
Generally, those traits that are easily reversible will revert upon cessation of hormonal treatment, unless chemical or surgical castration has occurred, though for many trans people, surgery is required to obtain satisfactory physical characteristics. But in trans men, some hormonally-induced changes may become virtually irreversible within weeks, whereas trans women usually have to take hormones for many months before any irreversible changes will result.
As with all medical activities, health risks are associated with hormone replacement therapy, especially when high hormone doses are taken as is common for pre-operative or no-operative trans patients. It is always advised that all changes in therapeutic hormonal treatment should be supervised by a physician because starting, stopping or even changing dosage rates and levels can have physical and psychological health risks.
Although some trans women use herbal phytoestrogens as alternatives to pharmaceutical estrogens, little research has been performed with regards to the safety or effectiveness of such products. Anecdotal evidence suggests that the results of herbal treatments are minimal and very subtle, if at all noticeable, when compared to conventional hormone therapy.
Some trans people are able to avoid the medical community's requirements for hormone therapy altogether by either obtaining hormones from black market sources, such as internet pharmacies which ship from overseas, or more rarely, by synthesizing hormones themselves.
Testosterone therapy is typically used for masculinizing treatments. Effects can include thicker vocal cords, increased muscle mass, hair loss, and thicker skin. Intramuscular, subcutaneous, and transdermal options are available. These include cypionate (Depo-Testosterone®), and the longer acting testosterone undecanoate (Aveed®). Oral formulations are available in Europe, Andriol®, but are not available in the U.S. due to their pharmacokinetic properties.
Estrogen and anti-androgen therapy are typically used for feminizing treatments. Estrogen is available in oral, parenteral, and transdermal formulations. Often, estrogen alone is insufficient for androgen suppression, and appropriate therapy will call for additional anti-androgen medications. Anti-androgen medications include progesterone, medroxyprogesterone acetate, spironolactone, and finasteride.
Sex reassignment surgeryEdit
Sex reassignment surgery (SRS) refers to the surgical and medical procedures undertaken to align intersex and transsexual individuals' physical appearance and genital anatomy with their gender identity. SRS may encompass any surgical procedures which will reshape a male body into a body with a female appearance or vice versa, or more specifically refer to the procedures used to make male genitals into female genitals and vice versa.
Other proposed terms for SRS include "gender confirmation surgery," "gender realignment surgery," and "transsexual surgery." The aforementioned terms may also specifically refer to genital surgeries like vaginoplasty, metoidioplasty, and phalloplasty, even though more specific terms exist to refer exclusively to genital surgery, the most common of which is genital reassignment surgery (GRS). The term "genital reconstruction surgery" may also be used. There are significant medical risks associated with SRS that should be considered before undergoing the surgery.
Chest reconstruction surgeryEdit
For a lot of trans men, chest reconstruction is desired. Binding of the chest tissue can cause a variety of health issues, including reduced lung capacity and even broken ribs if improper techniques or materials are used. A mastectomy is performed, often including a nipple graft for those with a B or larger cup size.
For trans women, breast augmentation is done in a similar manner to those done for cisgender women. As with cisgender women, there is a limit on the size of implant that may be used, depending on the amount of pre-existing breast tissue.
Non invasive proceduresEdit
There are a number of non surgical procedures that can be administered instead of – or in addition to sex-reassignment surgery that contribute to gender affirming procedures.
History: Botox (onabotulinumtoxinA) was first discovered by Dr. Justinius Kerner in 1820 and was extracted to botulinum toxin, type A, in 1994 by Dr. Edward J. Schantz. It was found to relax overactive muscles in animals and was approved for human testing in the 1970s for muscle spasms, crossed eyes, and sweating.
It was approved by the FDA in 1989 for intramuscular, intradetrusor, and intradermal injection. There are a number of preparations for botulinum toxins, all of which can be used for the same treatments: Botox cosmetic, Dysport (Ipsen pharmaceuticals) (Botulinum toxin type A), Xeomin, Neurobloc, and Myobloc.
Function: Botox is typically used to paralyze or relax muscles in the face and neck, restricting muscle contractions, thus decreasing, preventing, and eliminating fine lines and wrinkles. Due to its paralyzing properties, it is also frequently used to relax larger muscles in the face (the masseters) to slim down a strong jawline. Because males tend to have stronger masseters and larger jaws, many transgender males receive botox treatments to decrease the appearance of a larger jaw.
Science: Botox blocks the release of the main neurotransmitter at the neuromuscular junction, acetylcholine, resulting in muscle paralysis. The paralysis and underactivity of the muscle typically lasts three months until it returns back to its original state. It has been used to treat strabismus and focal dystonias, hemifacial spasms, movement disorders, headaches, hypersalivation, hyperhidrosis, and other conditions.
Hyaluronic Acid Fillers:
History: Hyaluronic Acids have been used since the 1970s for the treatment of joint pains and other health conditions. It is a chemical naturally found in the body that has made its way into beauty industry and skin care products as well as an injectable commonly used for areas in the face to address loss of volume.
Function: Hyaluronic acids can be used to fill hollow areas of the face (under eye circles, deflated cheeks) or add volume to and contour to areas such as the nose, jaw, chin, and lips.
Science: Hyaluronic acid is a non-sulphated Glycosaminogycan (GAG) made up of polymeric disaccharides of D-glucuronic acid and N=acetyl=D-glucosamine linked by glucuronidic bonds. Due to its water retaining qualities, it adds volume to desired areas and can prevent aging.
History: Radiesse was FDA approved in December, 2006 for lipoatrophy in human immunodeficiency virus (HIV) patients. It originally was used to add volume to significant loss of fat in the faces of patients with HIV. Today it serves a variety of purposes, including dermal fillers.
Function: Radiesse can be used as a filler to fill hollow areas. It has also found its use as a “hand filler” to decrease the appearance of protruding veins in the hands.
Science: Hyperdiluted Calcium Hydroxyapatite (CaHA) stimulates collagen production, thus yielding volume to injected areas. When used as a dermal filler, Calcium Hydroxyapatite is hyperdiluted, significantly reducing the immediate volumizing effect and in turn causing only long term reshaping of tissue, making it ideal for superficial dermal rejuvenation.
History: Poly-L-Lactic Acid, manufactured by Dermik Laboratories, was FDA approved in August, 2004 and was originally intended for patients with HIV to address the loss of fat and volume in the face (facial lipoatrophy) despite complications reported to the FDA.
Function: Sculptra is primarility used as an injectable dermal filler for the face and buttock. Its collagen stimulating properties it allows for the gradual growth of the injected area. Results take 1–2 months to take full effect, and last up to 3–4 years.
Science: Poly-L-Lactic Acid (Sculptra) is a collagen stimulator. The increase in collagen production causes the collagen to wrap around particles in the body that would naturally break down, causing the area of injection.
The Merck Manual states, in regard to trans women, "In follow-up studies, genital surgery has helped some transsexual people live happier and more productive lives and so is justified in highly motivated, appropriately assessed and treated transsexual people, who have completed a 1- to 2-year real-life experience in a different gender role. Before surgery, transsexual people often need assistance with passing in public, including help with gestures and voice modulation. Participation in support groups, available in most large cities, is usually helpful.":1570 With regards to trans men, it states, "Surgery may help certain [trans men] patients achieve greater adaptation and life satisfaction. Similar to trans women, trans men should live in the male gender role for at least 1 yr before surgery. Anatomic results of neophallus surgical procedures are often less satisfactory in terms of function and appearance than neovaginal procedures for trans women. Complications are common, especially in procedures that involve extending the urethra into the neophallus.":1570
Kaplan and Sadock's Comprehensive Textbook of Psychiatry states, with regards to adults, "When patient gender dysphoria is severe and intractable, sex reassignment is often the best solution.":2108 Regret tends to occur in cases of misdiagnosis, no Real Life Experience, and poor surgical results. Risk factors for return to original gender role include history of transvestic fetishism, psychological instability, and social isolation. In adolescents, careful diagnosis and following strict criteria can ensure good post-operative outcomes. Many prepubescent children with cross-gender identities do not persist with gender dysphoria.:2109–2110 With regards to follow-up, it states that "Clinicians are less likely to report poor outcomes in their patients, thus shifting the reporting bias to positive results. However, some successful patients who wish to blend into the community as men or women do not make themselves available for follow-up. Also, some patients who are not happy with their reassignment may be more known to clinicians as they continue clinical contact.":2109
A 2009 systematic review looking at individual surgical procedures found that "[t]he evidence concerning gender reassignment surgery has several limitations in terms of: (a) lack of controlled studies, (b) evidence has not collected data prospectively, (c) high loss to follow up and (d) lack of validated assessment measures. Some satisfactory outcomes were reported, but the magnitude of benefit and harm for individual surgical procedures cannot be estimated accurately using the current available evidence."
A 2010 meta-analysis of follow-up studies reported "Pooling across studies shows that after sex reassignment, 80% of individuals with GID reported significant improvement in gender dysphoria (95% CI = 68–89%; 8 studies; I2 = 82%); 78% reported significant improvement in psychological symptoms (95% CI = 56–94%; 7 studies; I2 = 86%); 80% reported significant improvement in quality of life (95% CI = 72–88%; 16 studies; I2 = 78%); and 72% reported significant improvement in sexual function (95% CI = 60–81%; 15 studies; I2 = 78%)." The study concluded "Very low quality evidence suggests that sex reassignment that includes hormonal interventions in individuals with GID likely improves gender dysphoria, psychological functioning and comorbidities, sexual function and overall quality of life."
A study evaluating quality of life in female-to-male transgender individuals found "statistically significant (p<0.01) diminished quality of life among the FTM transgender participants as compared to the US male and female population, particularly in regard to mental health. FTM transgender participants who received testosterone (67%) reported statistically significant higher quality of life scores (p<0.01) than those who had not received hormone therapy."
A recent Swedish study (2010) found that “almost all patients were satisfied with sex reassignment at 5 years, and 86% were assessed by clinicians at follow-up as stable or improved in global functioning” A prospective study in the Netherlands that looked at the psychological and sexual functioning of 162 adult applicants of adult sex reassignment applicants before and after hormonal and surgical treatment found, "After treatment the group was no longer gender dysphoric. The vast majority functioned quite well psychologically, socially and sexually. Two non-homosexual male-to-female transsexuals expressed regrets."
A long-term follow-up study performed in Sweden over a long period of time (1973–2003) found that morbidity, suicidality, and mortality in post-operative trans people were still significantly higher than in the general population, suggesting that sex reassignment therapy is not enough to treat gender dysphoria, highlighting the need for improved health care following sex reassignment surgery. 10 controls were selected for each post-operative trans person, matched by birth year and sex; two control groups were used: one matching sex at birth, the other matching reassigned sex. The study states that "no inferences can be drawn [from this study] as to the effectiveness of sex reassignment as a treatment for transsexualism," citing studies showing the effectiveness of sex reassignment therapy, though noting their poor quality. The authors noted that the results suggested that those who received sex reassignment surgery before 1989 had worse mortality, suicidality, and crime rates than those who received surgery on or after 1989: mortality, suicidality, and crime rates for the 1989-2003 cohort were not statistically significant compared to healthy controls (though psychiatric morbidity was); it is not clear if this is because these negative factors tended to increase a decade after surgery or because in the 1990s and later improved treatment and social attitudes may have led to better outcomes.
The abstract of the American Psychiatric Association Task Force on GID's report from 2012 states, "The quality of evidence pertaining to most aspects of treatment in all subgroups was determined to be low; however, areas of broad clinical consensus were identified and were deemed sufficient to support recommendations for treatment in all subgroups." The APA Task Force states, with regard to the quality of studies, "For some important aspects of transgender care, it would be impossible or unwise to engage in more robust study designs due to ethical concerns and lack of volunteer enrollment. For example, it would be extremely problematic to include a 'long-term placebo treated control group' in an RCT of hormone therapy efficacy among gender variant adults desiring to use hormonal treatments.":22 The Royal College of Psychiatrists concurs with regards to SRS in trans women, stating, "There is no level 1 or 2 evidence (Oxford levels) supporting the use of feminising vaginoplasty in women but this is to be expected since a randomised controlled study for this scenario would be impossible to carry out."
Following up on the APA Task Force's report, the APA issued a statement stating that the APA recognizes that in "appropriately evaluated" cases, hormonal and surgical interventions may be medically necessary and opposes "categorical exclusions" of such treatment by third-party payers. The American Medical Association's Resolution 122 states, "An established body of medical research demonstrates the effectiveness and medical necessity of mental health care, hormone therapy and sex reassignment surgery as forms of therapeutic treatment for many people diagnosed with GID".
The need for treatment is emphasized by the higher rate of mental health problems, including depression, anxiety, and various addictions, as well as a higher suicide rate among untreated transsexual people than in the general population. Many of these problems, in the majority of cases, disappear or decrease significantly after a change of gender role and/or physical characteristics.
Ethical, cultural, and political considerationsEdit
Sex reassignment therapy is a controversial ethical subject. Notably, the Roman Catholic church, according to an unpublished Vatican document, holds that changing sex is not possible and, while in some cases treatment might be necessary, it does not change the person's sex in the eyes of the church. Some Catholic ethicists go further, proclaiming that a "sex change operation" is "mutilation" and therefore immoral.
Paul R. McHugh is a well-known opponent of sex reassignment therapy. According to his own article, when he joined Johns Hopkins University as director of the Department of Psychiatry and Behavioral Science, it was part of his intention to end sex reassignment surgery there. McHugh succeeded in ending it at the university during his time. However, a new gender clinic at Johns Hopkins has been opened in 2017.
Opposition was also expressed by several writers identifying as feminist, most famously Janice Raymond. Her paper was allegedly instrumental in removing Medicaid and Medicare support for sex reassignment therapy in the US.
Sex reassignment therapy, especially surgery, tends to be expensive and is not always covered by public or private health insurance. In many areas with comprehensive nationalized health care, such as some Canadian provinces and most European countries, SRT is covered under these plans. However, requirements for obtaining SRS and other transsexual services under these plans are sometimes more stringent than the requirements laid out in the WPATH Standards of Care for the Health of Transsexual, Transgender, and Gender Nonconforming People, and in Europe, many local Standards of Care exist. In other countries, such as the United States, no national health plan exists and the majority of private insurance companies do not cover SRS. The government of Iran, however, pays for such surgery because it is believed to be valid under Shi'ite Belief.
A significant and growing political movement exists, pushing to redefine the standards of care, asserting that they do not acknowledge the rights of self-determination and control over one's body, and that they expect (and even in many ways require) a monolithic transsexual experience. In opposition to this movement is a group of transsexual persons and caregivers who assert that the SOC are in place to protect others from "making a mistake" and causing irreversible changes to their bodies that will later be regretted – though few post-operative transsexuals believe that sexual reassignment surgery was a mistake for them.
The United StatesEdit
From 1981 until 2014, the Centers for Medicare and Medicaid Services (CMS) categorically excluded coverage of sex reassignment surgery by Medicare in its National Coverage Determination (NCD) "140.3 Transsexual Surgery," but that categorical exclusion came under challenge by an "aggrieved party" in an Acceptable NCD Complaint in 2013 and was subsequently struck down the following year by the Departmental Appeals Board (DAB), the administrative court of the U.S. Department of Health and Human Services (HHS). In late 2013, the DAB issued a ruling finding the evidence on record was "not complete and adequate to support the validity of the NCD" and then moved on to discovery to determine if the exclusion was valid. CMS did not defend its exclusion throughout the entire process. On May 30, 2014, HHS announced that the categorical exclusion was found by the DAB to not be valid "under the 'reasonableness standard,'" allowing for Medicare coverage of sex reassignment surgery to be decided on a case-by-case basis. HHS says it will move to implement the ruling. As Medicaid and private insurers often take their cues from Medicare on what to cover, this may lead to coverage of sex reassignment therapy by Medicaid and private insurers. The evidence in the case "outweighs the NCD record and demonstrates that transsexual surgery is safe and effective and not experimental," according to the DAB in its 2014 ruling.
Consent and the treatment of intersex peopleEdit
In 2011, Christiane Völling won the first successful case brought by an intersex person against a surgeon for non-consensual surgical intervention described by the International Commission of Jurists as "an example of an individual who was subjected to sex reassignment surgery without full knowledge or consent".
In 2015, the Council of Europe recognized, for the first time, a right for intersex persons to not undergo sex assignment treatment. In April 2015, Malta became the first country to recognize a right to bodily integrity and physical autonomy, and outlaw non-consensual modifications to sex characteristics. The Act was widely welcomed by civil society organizations.
- George R. Brown, MD (20 July 2011). "Chapter 165 Sexuality and Sexual Disorders". In Robert S. Porter, MD; et al. (eds.). The Merck Manual of Diagnosis and Therapy (19th ed.). Whitehouse Station, NJ, USA: Merck & Co., Inc. pp. 1567–1573. ISBN 978-0-911910-19-3.
- Richard M. Green, M.D., J.D. (June 8, 2009). "18.3 Gender Identity Disorders". In Benjamin Sadock; Virginia Alcott Sadock; Pedro Ruiz (eds.). Kaplan and Sadock's Comprehensive Textbook of Psychiatry (9th ed.). Lippincott Williams & Wilkins. pp. 2099–2111. ISBN 978-0781768993.CS1 maint: multiple names: authors list (link)[dead link]
- William Byne, Susan J. Bradley, Eli Coleman, A. Evan Eyler, Richard Green, Edgardo J. Menvielle, Heino F. L. Meyer-Bahlburg, Richard R. Pleak & D. Andrew Tompkins (August 2012). "Report of the American Psychiatric Association Task Force on Treatment of Gender Identity Disorder" (PDF). Archives of Sexual Behavior. 41 (4): 759–796 (pages cited as pages at link). doi:10.1007/s10508-012-9975-x. PMID 22736225. S2CID 26050161.CS1 maint: multiple names: authors list (link)
- Drescher, Jack; Haller, Ellen (July 2012). "Position Statement on Access to Care for Transgender and Gender Variant Individuals" (PDF). American Psychiatric Association. American Psychiatric Association. Retrieved 17 January 2014. External link in
- "AMA Resolution 122" (PDF). AMA House of Delegates May 2008 Report (showing that Resolution 122 was affirmed). American Medical Association. May 2008. Retrieved 17 January 2014. External link in
- "APA Policy Statement: Transgender, Gender Identity, & Gender Expression Non-Discrimination". American Psychological Association. American Psychological Association. August 2008. Retrieved 17 January 2014. External link in
- "Good practice guidelines for the assessment and treatment of adults with gender dysphoria" (PDF). Royal College of Psychiatrists. Royal College of Psychiatrists. October 2013. Retrieved 17 January 2014. External link in
- Whittle, Stephen; Bockting, Walter; Monstrey, Stan; Brown, George; Brownstein, Michael; DeCuypere, Griet; Ettner, Randi; Fraser, Lin; Green, Jamison; Rachlin, Katherine; Robinson, Beatrice. "WPATH Clarification on Medical Necessity of Treatment, Sex Reassignment, and Insurance Coverage for Transgender and Transsexual People Worldwide". WPATH. Archived from the original on 14 August 2015. Retrieved 27 August 2015.
- F64.0"Excerpt from ICD 10".
- "DSM 5 gender dysphoria fact sheet" (PDF).
- "Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7" (PDF). Archived from the original (PDF) on 2016-01-06.
- Ashley, Florence (2019-07-01). "Gatekeeping hormone replacement therapy for transgender patients is dehumanising". Journal of Medical Ethics. 45 (7): 480–482. doi:10.1136/medethics-2018-105293. ISSN 0306-6800. PMID 30988174.
- Lambert, Cei; Hopwood, Ruben; Cavanaugh, Timothy (2016-11-01). "Informed Consent in the Medical Care of Transgender and Gender-Nonconforming Patients". AMA Journal of Ethics. 18 (11): 1147–1155. doi:10.1001/journalofethics.2016.18.11.sect1-1611. ISSN 2376-6980. PMID 27883307.
- Steensma, Thomas D.; McGuire, Jenifer K.; Kreukels, Baudewijntje P. C.; Beekman, Anneke J.; Cohen-Kettenis, Peggy T. (June 2013). "Factors associated with desistence and persistence of childhood gender dysphoria: a quantitative follow-up study". Journal of the American Academy of Child and Adolescent Psychiatry. 52 (6): 582–590. doi:10.1016/j.jaac.2013.03.016. ISSN 1527-5418. PMID 23702447.
- de Vries, A. L. C.; McGuire, J. K.; Steensma, T. D.; Wagenaar, E. C. F.; Doreleijers, T. A. H.; Cohen-Kettenis, P. T. (8 September 2014). "Young Adult Psychological Outcome After Puberty Suppression and Gender Reassignment". Pediatrics. 134 (4): 696–704. doi:10.1542/peds.2013-2958. PMID 25201798. S2CID 18155489. Retrieved 27 August 2015.
- Mozes, Alan (10 September 2014). "Puberty Suppression Benefits Gender-Questioning Teens: Study". HealthDay. U.S. News & World Report. Retrieved 27 August 2015.
- Brown, Mildred (2003). True selves : understanding transsexualism-- for families, friends, coworkers, and helping professionals. San Francisco: Jossey-Bass. ISBN 978-0-7879-6702-4.
- "Transgender Health & Transitioning | Revel & Riot". www.revelandriot.com. Retrieved 2019-08-07.
- "Information on Testosterone Hormone Therapy | Transgender Care". transcare.ucsf.edu. Retrieved 2019-08-07.
- Hashemi, Leila; Weinreb, Jane; Weimer, Amy K.; Weiss, Rebecca Loren (July 2018). "Transgender Care in the Primary Care Setting: A Review of Guidelines and Literature". Federal Practitioner. 35 (7): 30–37. ISSN 1945-337X. PMC 6368014. PMID 30766372.
- Unger, Cécile A. (December 2016). "Hormone therapy for transgender patients". Translational Andrology and Urology. 5 (6): 877–884. doi:10.21037/tau.2016.09.04. ISSN 2223-4691. PMC 5182227. PMID 28078219.
- Deutsch, Madeline B.; Bhakri, Vipra; Kubicek, Katrina (March 2015). "Effects of cross-sex hormone treatment on transgender women and men". Obstetrics and Gynecology. 125 (3): 605–610. doi:10.1097/AOG.0000000000000692. ISSN 1873-233X. PMC 4442681. PMID 25730222.
- Hashemi, Leila; Weinreb, Jane; Weimer, Amy K.; Weiss, Rebecca Loren (July 2018). "Transgender Care in the Primary Care Setting: A Review of Guidelines and Literature". Federal Practitioner. 35 (7): 30–37. ISSN 1078-4497. PMC 6368014. PMID 30766372.
- Hembree, Wylie C.; Cohen-Kettenis, Peggy; Delemarre-van de Waal, Henriette A.; Gooren, Louis J.; Meyer, Walter J.; Spack, Norman P.; Tangpricha, Vin; Montori, Victor M. (2009-09-01). "Endocrine Treatment of Transsexual Persons:An Endocrine Society Clinical Practice Guideline". The Journal of Clinical Endocrinology & Metabolism. 94 (9): 3132–3154. doi:10.1210/jc.2009-0345. ISSN 0021-972X. PMID 19509099.
- Nigam, P K; Nigam, Anjana (2010). "BOTULINUM TOXIN". Indian Journal of Dermatology. 55 (1): 8–14. doi:10.4103/0019-5154.60343. ISSN 0019-5154. PMC 2856357. PMID 20418969.
- Gupta, Ramesh C.; Lall, Rajiv; Srivastava, Ajay; Sinha, Anita (2019-06-25). "Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory". Frontiers in Veterinary Science. 6: 192. doi:10.3389/fvets.2019.00192. ISSN 2297-1769. PMC 6603175. PMID 31294035.
- Papakonstantinou, Eleni; Roth, Michael; Karakiulakis, George (2012-07-01). "Hyaluronic acid: A key molecule in skin aging". Dermato-endocrinology. 4 (3): 253–258. doi:10.4161/derm.21923. ISSN 1938-1972. PMC 3583886. PMID 23467280.
- "FDA Approves Radiesse, Cosmetic Treatment for Facial Lipoatrophy". www.natap.org. Retrieved 2021-05-20.
- de Almeida, Ada Trindade; Figueredo, Vinicius; da Cunha, Ana Lúcia Gonzaga; Casabona, Gabriela; Costa de Faria, Joana Ribeiro; Alves, Emerson Vicente; Sato, Mauricio; Branco, Adeíza; Guarnieri, Christine; Palermo, Eliandre (2019-03-14). "Consensus Recommendations for the Use of Hyperdiluted Calcium Hydroxyapatite (Radiesse) as a Face and Body Biostimulatory Agent". Plastic and Reconstructive Surgery Global Open. 7 (3): e2160. doi:10.1097/GOX.0000000000002160. ISSN 2169-7574. PMC 6467620. PMID 31044123.
- Sickles, Christine K.; Nassereddin, Ali; Gross, Gary P. (2021), "Poly-L-Lactic Acid", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 29939648, retrieved 2021-05-20
- Simamora, Pahala; Chern, Wendy (May 2006). "Poly-L-lactic acid: an overview". Journal of Drugs in Dermatology: JDD. 5 (5): 436–440. ISSN 1545-9616. PMID 16703779.
- P. A. Sutcliffe, S. Dixon, R. L. Akehurst, A. Wilkinson, A. Shippam, S. White, R. Richards & C. M. Caddy (March 2009). "Evaluation of surgical procedures for sex reassignment: a systematic review". Journal of Plastic, Reconstructive & Aesthetic Surgery. 62 (3): 294–306. doi:10.1016/j.bjps.2007.12.009. PMID 18222742.CS1 maint: multiple names: authors list (link)
- Murad, Mohammad Hassan; Elamin, Mohamed B.; Garcia, Magaly Zumaeta; Mullan, Rebecca J.; Murad, Ayman; Erwin, Patricia J.; Montori, Victor M. (2010). "Hormonal therapy and sex reassignment: A systematic review and meta-analysis of quality of life and psychosocial outcomes". Clinical Endocrinology. 72 (2): 214–31. doi:10.1111/j.1365-2265.2009.03625.x. PMID 19473181. S2CID 19590739.
- Newfield, E; Hart, S; Dibble, S; Kohler, L (November 2006). "Female-to-male transgender quality of life". Quality of Life Research. 15 (9): 1447–57. CiteSeerX 10.1.1.468.9106. doi:10.1007/s11136-006-0002-3. PMID 16758113. S2CID 12727036.
- Johansson, Annika; Sundbom, Elisabet; Höjerback, Torvald; Bodlund, Owe (2009). "A Five-Year Follow-Up Study of Swedish Adults with Gender Identity Disorder". Archives of Sexual Behavior. 39 (6): 1429–37. doi:10.1007/s10508-009-9551-1. PMID 19816764. S2CID 22866694.
- Smith, YL; Van Goozen, SH; Kuiper, AJ; Cohen-Kettenis, PT (January 2005). "Sex reassignment: outcomes and predictors of treatment for adolescent and adult transsexuals" (PDF). Psychological Medicine. 35 (1): 89–99. doi:10.1017/S0033291704002776. PMID 15842032.
- Dhejne, Cecilia; Lichtenstein, Paul; Boman, Marcus; Johansson, Anna L. V.; Långström, Niklas; Landén, Mikael (2011). Scott, James (ed.). "Long-Term Follow-Up of Transsexual Persons Undergoing Sex Reassignment Surgery: Cohort Study in Sweden". PLOS ONE. 6 (2): e16885. Bibcode:2011PLoSO...616885D. doi:10.1371/journal.pone.0016885. PMC 3043071. PMID 21364939.
- Heylens, Gunter; Verroken, Charlotte; De Cock, Sanne; T'Sjoen, Guy; De Cuypere, Griet (2013). "Effects of Different Steps in Gender Reassignment Therapy on Psychopathology: A Prospective Study of Persons with a Gender Identity Disorder". The Journal of Sexual Medicine. 11 (1): 119–126. doi:10.1111/jsm.12363. ISSN 1743-6095. PMID 24344788.
- Yolanda L. S. Smith, Stephanie H. M. Van Goozen, Abraham J. Kuiper & Peggy T. Cohen-Kettenis (January 2005). "Sex reassignment: outcomes and predictors of treatment for adolescent and adult transsexuals" (PDF). Psychological Medicine. 35 (1): 89–99. doi:10.1017/S0033291704002776. PMID 15842032.CS1 maint: multiple names: authors list (link)
- "Vatican says 'sex-change' operation does not change person's gender". National Catholic Reporter. 2011-09-19.
- "FAQ on Gender Identity Disorder and "Sex Change" Operations". National Catholic Bioethics Center. Archived from the original on 2014-02-22.
- Paul McHugh. "Psychiatric misadventures".
- Richard P. Fitzgibbons, M.D., Philip M. Sutton, and Dale O’Leary, The Psychopathology of "Sex Reassignment" Surgery, Assessing Its Medical, Psychological, and Ethical Appropriateness, The National Catholic Bioethics Quarterly, Spring 2009, p. 100. Archived 2014-08-09 at the Wayback Machine
- Allen, Samantha (12 April 2017). "Can Trans People Trust Johns Hopkins's New Clinic?". The Daily Beast.
- "Why The Trans Community Hates Dr. Janice G. Raymond". TransGRiot. 2010-09-20.
- Iran's gay plan, Matthew Hays, Canadian Broadcasting Corporation, August 26, 2008; accessed August 13, 2009.
- Kuiper, A.J; P.T. Cohen-Kettenis (September 1998). "Gender Role Reversal among Postoperative Transsexuals". International Journal of Transgenderism. 2 (3). Archived from the original on 2007-02-04. Retrieved 2007-02-25.
- Wayne, Alex (30 May 2014). "Medicare Ordered to Consider Covering Sex-Change Surgery". Bloomberg. Retrieved 30 May 2014.
- McMorris-Santoro, Evan (30 May 2014). "Obama Administration Opens The Door To Medicare-Funded Sex Reassignment Surgery". BuzzFeed Politics. Retrieved 30 May 2014.
- Leslie A. Sussan; Constance B. Tobias; Sheila Ann Hegy (presiding) (2 Dec 2013). "NCD 140.3 Transsexual Surgery: NCD Ruling No. 2" (PDF). Acceptable National Coverage Determination Complaints (DAB). HHS.gov. Docket No. A-13-47. Retrieved 7 Feb 2014.
- Leslie A. Sussan; Constance B. Tobias; Sheila Ann Hegy (presiding) (30 May 2014). "NCD 140.3 Transsexual Surgery: Decision No. 2576" (PDF). Acceptable National Coverage Determination Complaints (DAB). HHS.gov. Docket No. A-13-87. Retrieved 4 Jul 2014.
- Daphna Stroumsa (January 2014). "The State of Transgender Health Care: Policy, Law, and Medical Frameworks". American Journal of Public Health. 104 (3): e31–8. doi:10.2105/AJPH.2013.301789. PMC 3953767. PMID 24432926.
- Sweden keeps sex-change sterilisation law, The Local, January 12, 2012
- International Commission of Jurists. "SOGI Casebook Introduction, Chapter six: Intersex". Retrieved 2015-12-27.
- Council of Europe; Commissioner for Human Rights (April 2015), Human rights and intersex people, Issue Paper
- Cabral, Mauro (April 8, 2015). "Making depathologization a matter of law. A comment from GATE on the Maltese Act on Gender Identity, Gender Expression and Sex Characteristics". Global Action for Trans Equality. Archived from the original on July 4, 2015. Retrieved 2015-07-03.
- OII Europe (April 1, 2015). "OII-Europe applauds Malta's Gender Identity, Gender Expression and Sex Characteristics Act. This is a landmark case for intersex rights within European law reform". Retrieved 2015-07-03.
- Carpenter, Morgan (April 2, 2015). "We celebrate Maltese protections for intersex people". Organisation Intersex International Australia. Retrieved 2015-07-03.
- Star Observer (2 April 2015). "Malta passes law outlawing forced surgical intervention on intersex minors". Star Observer.
- Reuters (1 April 2015). "Surgery and Sterilization Scrapped in Malta's Benchmark LGBTI Law". The New York Times.
- Brown, Mildred L.; Chloe Ann Rounsley (1996). True Selves: Understanding Transsexualism – For Families, Friends, Coworkers, and Helping Professionals. Jossey-Bass. ISBN 978-0-7879-6702-4.
- Dallas, Denny (2006). Transgender Rights: Transgender Communities of the United States in the Late Twentieth Century. University of Minnesota Press. ISBN 978-0-8166-4312-7.
- Feinberg, Leslie (1999). Trans Liberation : Beyond Pink or Blue. Beacon Press. ISBN 978-0-8070-7951-5.
- Kruijver, F. P. M. (2000). "Male-to-Female Transsexuals Have Female Neuron Numbers in a Limbic Nucleus". Journal of Clinical Endocrinology & Metabolism. 85 (5): 2034–41. doi:10.1210/jcem.85.5.6564. PMID 10843193.
- Coleman, E.; Bockting, W.; Botzer, M.; Cohen-Kettenis, P.; DeCuypere, G.; Feldman, J.; Fraser, L.; Green, J.; Knudson, G.; Meyer, W. J.; Monstrey, S.; Adler, R. K.; Brown, G. R.; Devor, A.H.; Ehrbar, R.; Ettner, R.; Eyler, E.; Garofalo, R.; Karasic, D. H.; Lev, A. I.; Mayer, G.; Meyer Bahlburg, H.; Hall, B.P.; Pfaefflin, F.; Rachlin, K.; Robinson, B.; Schechter, L. S.; Tangpricha, V.; van Trotsenburg, M.; Vitale, A.; Winter, S.; Whittle, S.; Wylie, K. R.; Zucker, K. (2012). "Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7" (PDF). International Journal of Transgenderism. 13 (4): 165–232. doi:10.1080/15532739.2011.700873. ISSN 1553-2739. S2CID 39664779. Archived from the original (PDF) on 2014-08-02.
- Pfäfflin, Friedemann & Astrid Junge -Sex Reassignment. Thirty Years of International Follow-up Studies After Sex Reassignment Surgery: A Comprehensive Review, 1961–1991 (translated from German into American English by Roberta B. Jacobson and Alf B. Meier)
- Rathus, Spencer A.; Jeffery S. Nevid; Lois Fichner-Rathus (2002). Human Sexuality in a World of Diversity. Allyn & Bacon. ISBN 978-0-205-40615-9.
- Schneider, H; Pickel, J; Stalla, G (2006). "Typical female 2nd–4th finger length (2D:4D) ratios in male-to-female transsexuals—possible implications for prenatal androgen exposure". Psychoneuroendocrinology. 31 (2): 265–9. doi:10.1016/j.psyneuen.2005.07.005. PMID 16140461. S2CID 33927715.
- Xavier, J., Simmons, R. (2000) – The Washington transgender needs assessment survey, Washington, DC: The Administration for HIV and AIDS of the District of Columbia Government