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Transgender people have a gender identity or gender expression that differs from their assigned sex. Some transgender people who desire medical assistance to transition from one sex to another identify as transsexual. Transgender – often shortened as trans – is also an umbrella term: in addition to including people whose gender identity is the opposite of their assigned sex (trans men and trans women), it may include people who are not exclusively masculine or feminine (people who are genderqueer or non-binary, including bigender, pangender, genderfluid, or agender). Other definitions of transgender also include people who belong to a third gender, or else conceptualize transgender people as a third gender. Infrequently, the term transgender is defined very broadly to include cross-dressers, regardless of their gender identity.

Being transgender is independent of sexual orientation: transgender people may identify as heterosexual, homosexual, bisexual, asexual, or may decline to label their sexual orientation. The term transgender is also distinguished from intersex, a term that describes people born with physical sex characteristics "that do not fit typical binary notions of male or female bodies". The opposite of transgender is cisgender, which describes persons whose gender identity or expression matches their assigned sex.

The degree to which individuals feel genuine, authentic, and comfortable within their external appearance and accept their genuine identity has been called transgender congruence. Many transgender people experience gender dysphoria, and some seek medical treatments such as hormone replacement therapy, sex reassignment surgery, or psychotherapy. Not all transgender people desire these treatments, and some cannot undergo them for financial or medical reasons.

Many transgender people face discrimination in the workplace and in accessing public accommodations, and healthcare. In many places they are not legally protected from discrimination.

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A trans man (sometimes trans-man or transman) is a man who was assigned female at birth. The label of transgender man is not always interchangeable with that of transsexual man, although the two labels are often used in this way. Transgender is an umbrella term that includes different types of gender variant people (including transsexual people). Many trans men choose to undergo surgical or hormonal transition, or both (see sex reassignment therapy), to alter their appearance in a way that aligns with their gender identity or alleviates gender dysphoria.

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Having an opinion about transsexuality is about as useful as having an opinion on blindness. You can think whatever you like about it, but in the end, your friend is still blind and surely deserves to see.

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Christine Jorgensen (born George William Jorgensen, Jr. 30 May 1926 in The Bronx, New York City, USA; died 3 May 1989) was famous in the USA for having been the first widely-known individual to have sex reassignment surgery—in this case, male to female.

The second child of George William Jorgensen Sr., a carpenter and contractor, and his wife, the former Florence Davis Hansen, Jorgensen grew up in the Bronx and later described herself as having been a "frail, tow-headed, introverted little boy [sic] who ran from fistfights and rough-and-tumble games".

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