2022: Maiden Challenger title, ATP debut & first final, top 150 debutedit
Ranked No. 301, Misolic won the ATP Challenger singles title at the 2022 Zagreb Open.[3] As a result he reached the top 250 climbing 76 positions up in the rankings to No. 225 on 16 May 2022.[4]
Ranked No. 205, he made his ATP debut at the 2022 Generali Open Kitzbühel as a wildcard where he reached the quarterfinals defeating Daniel Dutra da Silva and Pablo Andujar.[5] Next he defeated Dusan Lajovic to reach the first ATP semifinal in his career.[6][7] He reached his maiden ATP final defeating Yannick Hanfmann in a final set tiebreak.[8] As a result he moved close to 70 positions up the rankings in the top 150 to a new career-high of world No. 137 and became the Austrian player No. 1 on 1 August 2022.[9]