The 49ers traded their first- and a seventh-round selection (13th and 245th overall) to Tampa Bay Buccaneers in exchange for a first- and a fourth-round pick (14th and 117th overall).[51]
The 49ers traded their first-, fourth- and fifth-round selections (31st, 117th and 176th overall) to Minnesota Vikings in exchange for a first-round pick (No. 25th overall).[52]
The 49ers traded their WRMarquise Goodwin and a sixth-round selection (No. 210th overall) to Philadelphia Eagles in exchange for a sixth-round selection (No. 190th overall).[56]
Networks and times from Weeks 8–17 are subject to change as a result of flexible scheduling.
As the result of Saturday flexible scheduling during Week 16, the date, time, and network for that week's game at the Arizona Cardinals will be finalized at a later date—by no later than four weeks prior to game day.[58]
Game summaries
Week 1: vs. Arizona Cardinals
Week One: Arizona Cardinals at San Francisco 49ers – Game summary
With this loss, the 49ers dropped to 2–2. Nick Mullens struggled mightily in the game with two interceptions, one of which was returned by Alex Singleton for a touchdown, and was benched afterwards for C. J. Beathard. The 49ers drove all the way to within field goal range down by 5, but the clock ran out.
Week 5: vs. Miami Dolphins
Week Five: Miami Dolphins at San Francisco 49ers – Game summary
With this embarrasing loss, the 49ers dropped to 2–3, already matching last season's loss total. Jimmy Garoppolo returned from injury but struggled mightily with 2 interceptions, leading to him being benched at halftime for C.J. Beathard.
Week 6: vs. Los Angeles Rams
Week Six: Los Angeles Rams at San Francisco 49ers – Game summary
Period
1
2
3
4
Total
Rams
0
6
3
7
16
49ers
7
14
0
3
24
at Levi's Stadium, Santa Clara, California
Date: October 18
Game time: 5:20 p.m. PDT
Game weather: Sunny, 86 °F (30 °C)
Game attendance: 0
Referee: Carl Cheffers
TV announcers (NBC): Al Michaels, Cris Collinsworth and Michele Tafoya
The 49ers bounced back from the previous week. Jimmy Garoppolo threw 3 touchdowns and 268 yards and the 49ers defense was able to hold a red-hot Rams offense in check. With this win, they improved to 3–3, and won their third straight meeting against the Rams.
Week 7: at New England Patriots
Week Seven: San Francisco 49ers at New England Patriots – Game summary
This was quarterback Jimmy Garoppolo's first return to Foxboro since the Patriots traded him to 49ers in October 2017. Garoppolo played for the Patriots from 2014-2017, and was part of the their 2014 and 2016 Super Bowl-winning teams.
Week 8: at Seattle Seahawks
Week Eight: San Francisco 49ers at Seattle Seahawks – Game summary
^ abNew Orleans finished ahead of Seattle based on conference record.
^ abChicago finished and clinched the 7th and final playoff spot ahead of Arizona based on better win percentage in common games (against Detroit, the NY Giants, Carolina, and the LA Rams, Chicago finished 3–2, while Arizona finished 1–4).
^ abSan Francisco finished ahead of the NY Giants based on head-to-head victory. Division tie break was initially used to eliminate Dallas (see below).
^ abNY Giants won tiebreaker over Dallas based on division record.
^ abCarolina finished ahead of Detroit based on head-to-head victory.
^When breaking ties for three or more teams under the NFL's rules, they are first broken within divisions, then comparing only the highest-ranked remaining team from each division.