|Synonyms||Yellow jack, yellow plague, bronze john|
|A TEM micrograph of the yellow fever virus (234,000X magnification)|
|Symptoms||Fever, chills, muscle pain, yellow skin|
|Causes||Yellow fever virus spread by mosquitoes|
|Diagnostic method||Blood test|
|Prevention||Yellow fever vaccine|
|Frequency||~127,000 severe cases (2013)|
Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains particularly in the back, and headaches. Symptoms typically improve within five days. In about 15% of people within a day of improving, the fever comes back, abdominal pain occurs, and liver damage begins causing yellow skin. If this occurs, the risk of bleeding and kidney problems is also increased.
The disease is caused by the yellow fever virus and is spread by the bite of an infected female mosquito. It infects only humans, other primates, and several species of mosquitoes. In cities, it is spread primarily by Aedes aegypti, a type of mosquito found throughout the tropics and subtropics. The virus is an RNA virus of the genus Flavivirus. The disease may be difficult to tell apart from other illnesses, especially in the early stages. To confirm a suspected case, blood sample testing with polymerase chain reaction is required.
A safe and effective vaccine against yellow fever exists and some countries require vaccinations for travelers. Other efforts to prevent infection include reducing the population of the transmitting mosquito. In areas where yellow fever is common and vaccination is uncommon, early diagnosis of cases and immunization of large parts of the population is important to prevent outbreaks. Once infected, management is symptomatic with no specific measures effective against the virus. Death occurs in up to half of those who get severe disease.
In 2013, yellow fever resulted in about 127,000 severe infections and 45,000 deaths, with nearly 90% of these occurring in Africa. Nearly a billion people live in an area of the world where the disease is common. It is common in tropical areas of South America and Africa, but not in Asia. Since the 1980s, the number of cases of yellow fever has been increasing. This is believed to be due to fewer people being immune, more people living in cities, people moving frequently, and changing climate. The disease originated in Africa, from where it spread to South America through the slave trade in the 17th century. Since the 17th century, several major outbreaks of the disease have occurred in the Americas, Africa, and Europe. In the 18th and 19th centuries, yellow fever was seen as one of the most dangerous infectious diseases. In 1927 yellow fever virus became the first human virus to be isolated.
Signs and symptomsEdit
Yellow fever begins after an incubation period of three to six days. Most cases only cause a mild infection with fever, headache, chills, back pain, fatigue, loss of appetite, muscle pain, nausea, and vomiting. In these cases, the infection lasts only three to four days.
In 15% of cases, however, people enter a second, toxic phase of the disease with recurring fever, this time accompanied by jaundice due to liver damage, as well as abdominal pain. Bleeding in the mouth, the eyes, and the gastrointestinal tract cause vomit containing blood, hence the Spanish name for yellow fever, vómito negro ("black vomit"). There may also be kidney failure, hiccups, and delirium.
The toxic phase is fatal in about 20 to 50% of cases, making the overall fatality rate for the disease about 3.0 to 7.5%. However, the fatality rate of those with the toxic phase of the disease may exceed 50%.
|Yellow fever virus|
|Group:||Group IV ((+)ssRNA)|
|Species:||Yellow fever virus|
Yellow fever is caused by the yellow fever virus, a 40- to 50-nm-wide enveloped RNA virus, the type species and namesake of the family Flaviviridae. It was the first illness shown to be transmissible by filtered human serum and transmitted by mosquitoes, by Walter Reed around 1900. The positive-sense, single-stranded RNA is around 11,000 nucleotides long and has a single open reading frame encoding a polyprotein. Host proteases cut this polyprotein into three structural (C, prM, E) and seven nonstructural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5); the enumeration corresponds to the arrangement of the protein coding genes in the genome. Minimal yellow fever virus (YFV) 3’UTR region is required for stalling of the host 5'-3' exonuclease XRN1. The UTR contains PKS3 pseudoknot structure which serves as a molecular signal to stall the exonuclease and is the only viral requirement for subgenomic flavivirus RNA (sfRNA) production. The sfRNAs are a result of incomplete degradation of the viral genome by the exonuclease and are important for viral pathogenicity. Yellow fever belongs to the group of hemorrhagic fevers.
The viruses infect, amongst others, monocytes, macrophages, and dendritic cells. They attach to the cell surface via specific receptors and are taken up by an endosomal vesicle. Inside the endosome, the decreased pH induces the fusion of the endosomal membrane with the virus envelope. The capsid enters the cytosol, decays, and releases the genome. Receptor binding, as well as membrane fusion, are catalyzed by the protein E, which changes its conformation at low pH, causing a rearrangement of the 90 homodimers to 60 homotrimers.
After entering the host cell, the viral genome is replicated in the rough endoplasmic reticulum (ER) and in the so-called vesicle packets. At first, an immature form of the virus particle is produced inside the ER, whose M-protein is not yet cleaved to its mature form and is therefore denoted as prM (precursor M) and forms a complex with protein E. The immature particles are processed in the Golgi apparatus by the host protein furin, which cleaves prM to M. This releases E from the complex which can now take its place in the mature, infectious virion.
Yellow fever virus is mainly transmitted through the bite of the yellow fever mosquito Aedes aegypti, but other mostly Aedes mosquitoes such as the tiger mosquito (Aedes albopictus) can also serve as a vector for this virus. Like other arboviruses which are transmitted by mosquitoes, the yellow fever virus is taken up by a female mosquito when it ingests the blood of an infected human or other primate. Viruses reach the stomach of the mosquito, and if the virus concentration is high enough, the virions can infect epithelial cells and replicate there. From there, they reach the haemocoel (the blood system of mosquitoes) and from there the salivary glands. When the mosquito next sucks blood, it injects its saliva into the wound, and the virus reaches the bloodstream of the bitten person. Transovarial and transstadial transmission of the yellow fever virus within A. aegypti, that is, the transmission from a female mosquito to her eggs and then larvae, are indicated. This infection of vectors without a previous blood meal seems to play a role in single, sudden breakouts of the disease.
Three epidemiologically different infectious cycles occur, in which the virus is transmitted from mosquitoes to humans or other primates. In the "urban cycle", only the yellow fever mosquito A. aegypti is involved. It is well adapted to urban areas and can also transmit other diseases, including Zika fever, dengue fever, and chikungunya. The urban cycle is responsible for the major outbreaks of yellow fever that occur in Africa. Except in an outbreak in 1999 in Bolivia, this urban cycle no longer exists in South America.
Besides the urban cycle, both in Africa and South America, a sylvatic cycle (forest or jungle cycle) is present, where Aedes africanus (in Africa) or mosquitoes of the genus Haemagogus and Sabethes (in South America) serve as vectors. In the jungle, the mosquitoes infect mainly non-human primates; the disease is mostly asymptomatic in African primates. In South America, the sylvatic cycle is currently the only way humans can become infected, which explains the low incidence of yellow fever cases on the continent. People who become infected in the jungle can carry the virus to urban areas, where A. aegypti acts as a vector. Because of this sylvatic cycle, the yellow fever cannot be eradicated.
In Africa, a third infectious cycle known as "savannah cycle" or intermediate cycle, occurs between the jungle and urban cycles. Different mosquitoes of the genus Aedes are involved. In recent years, this has been the most common form of transmission of yellow fever in Africa.
Concern exists about yellow fever spreading to southeast Asia, where its vector A. aegypti already occurs.
After transmission from a mosquito, the viruses replicate in the lymph nodes and infect dendritic cells in particular. From there, they reach the liver and infect hepatocytes (probably indirectly via Kupffer cells), which leads to eosinophilic degradation of these cells and to the release of cytokines. Apoptotic masses known as Councilman bodies appear in the cytoplasm of hepatocytes.
Yellow fever is most frequently a clinical diagnosis, made on the basis of symptoms and the diseased person's whereabouts prior to becoming ill. Mild courses of the disease can only be confirmed virologically. Since mild courses of yellow fever can also contribute significantly to regional outbreaks, every suspected case of yellow fever (involving symptoms of fever, pain, nausea and vomiting six to 10 days after leaving the affected area) is treated seriously.
If yellow fever is suspected, the virus cannot be confirmed until six to 10 days after the illness. A direct confirmation can be obtained by reverse transcription polymerase chain reaction where the genome of the virus is amplified. Another direct approach is the isolation of the virus and its growth in cell culture using blood plasma; this can take one to four weeks.
Serologically, an enzyme linked immunosorbent assay during the acute phase of the disease using specific IgM against yellow fever or an increase in specific IgG-titer (compared to an earlier sample) can confirm yellow fever. Together with clinical symptoms, the detection of IgM or a fourfold increase in IgG-titer is considered sufficient indication for yellow fever. Since these tests can cross-react with other flaviviruses, like dengue virus, these indirect methods cannot conclusively prove yellow fever infection.
Liver biopsy can verify inflammation and necrosis of hepatocytes and detect viral antigens. Because of the bleeding tendency of yellow fever patients, a biopsy is only advisable post mortem to confirm the cause of death.
In a differential diagnosis, infections with yellow fever must be distinguished from other feverish illnesses like malaria. Other viral hemorrhagic fevers, such as Ebola virus, Lassa virus, Marburg virus, and Junin virus, must be excluded as cause.
Personal prevention of yellow fever includes vaccination and avoidance of mosquito bites in areas where yellow fever is endemic. Institutional measures for prevention of yellow fever include vaccination programmes and measures of controlling mosquitoes. Programmes for distribution of mosquito nets for use in homes are providing reductions in cases of both malaria and yellow fever. Use of EPA-registered insect repellent is recommended when outdoors. Exposure for even a short time is enough for a potential mosquito bite. Long-sleeved clothing, long pants, and socks are useful for prevention. The awareness of peak mosquito exposure is from dusk to dawn. The application of larvicides to water-storage containers can help eliminate potential mosquito breeding sites. Adult mosquitos can be killed through insecticide spray usage, which decreases the transmission of yellow fever.
- Use insect repellent when outdoors such as those containing DEET, picaridin, IR3535, or oil of lemon eucalyptus on exposed skin.
- Wear proper clothing to reduce mosquito bites. When weather permits, wear long sleeves, long pants and socks when outdoors. Mosquitoes may bite through thin clothing, so spraying clothes with repellent containing permethrin or another EPA-registered repellent will give extra protection. Clothing treated with permethrin is commercially available. Mosquito repellents containing permethrin are not approved for application directly to skin.
- The peak biting times for many mosquito species are dusk to dawn. However, A. aegypti, one of the mosquitoes that transmits yellow fever virus, feeds during the daytime. Staying in accommodations with screened or air-conditioned rooms, particularly during peak biting times, also reduces risk of mosquito bites.
Vaccination is recommended for those traveling to affected areas, because non-native people tend to develop more severe illness when infected. Protection begins by the 10th day after vaccine administration in 95% of people, and had been reported to last for at least 10 years. WHO now states that a single dose of vaccination is sufficient to confer lifelong immunity against yellow fever disease." The attenuated live vaccine stem 17D was developed in 1937 by Max Theiler. The World Health Organization (WHO)recommends routine vaccinations for people living in affected areas between the 9th and 12th months after birth.
Up to one in four people experience fever, aches, and local soreness and redness at the site of injection. In rare cases (less than one in 200,000 to 300,000), the vaccination can cause yellow fever vaccine–associated viscerotropic disease, which is fatal in 60% of cases. It is probably due to the genetic morphology of the immune system. Another possible side effect is an infection of the nervous system, which occurs in one in 200,000 to 300,000 cases, causing yellow fever vaccine-associated neurotropic disease, which can lead to meningoencephalitis and is fatal in less than 5% of cases.
The Yellow Fever Initiative, launched by WHO in 2006, vaccinated more than 105 million people in 14 countries in West Africa. No outbreaks were reported during 2015. The campaign was supported by the GAVI Alliance, and governmental organizations in Europe and Africa. According to the WHO, mass vaccination cannot eliminate yellow fever because of the vast number of infected mosquitoes in urban areas of the target countries, but it will significantly reduce the number of people infected.
In March 2017, WHO launched a vaccination campaign in Brazil with 3.5 million doses from an emergency stockpile. In March 2017 the WHO recommended vaccination for travellers to certain parts of Brazil.
Some countries in Asia are theoretically in danger of yellow fever epidemics (mosquitoes with the capability to transmit yellow fever and susceptible monkeys are present), although the disease does not yet occur there. To prevent introduction of the virus, some countries demand previous vaccination of foreign visitors if they have passed through yellow fever areas. Vaccination has to be proven in a vaccination certificate which is valid 10 days after the vaccination and lasts for 10 years. Although the WHO on 17 May 2013 advised that subsequent booster vaccinations are unnecessary, an older (than 10 years) certificate may not be acceptable at all border posts in all affected countries. A list of the countries that require yellow fever vaccination is published by the WHO. If the vaccination cannot be conducted for some reasons, dispensation may be possible. In this case, an exemption certificate issued by a WHO-approved vaccination center is required. Although 32 of 44 countries where yellow fever occurs endemically do have vaccination programmes, in many of these countries, less than 50% of their population is vaccinated.
Control of the yellow fever mosquito A. aegypti is of major importance, especially because the same mosquito can also transmit dengue fever and chikungunya disease. A. aegypti breeds preferentially in water, for example in installations by inhabitants of areas with precarious drinking water supply, or in domestic waste, especially tires, cans, and plastic bottles. These conditions are common in urban areas in developing countries.
Two main strategies are employed to reduce mosquito populations. One approach is to kill the developing larvae. Measures are taken to reduce the water accumulations in which the larva develops. Larvicides are used, as well as larvae-eating fish and copepods, which reduce the number of larvae. For many years, copepods of the genus Mesocyclops have been used in Vietnam for preventing dengue fever. It eradicated the mosquito vector in several areas. Similar efforts may be effective against yellow fever. Pyriproxyfen is recommended as a chemical larvicide, mainly because it is safe for humans and effective even in small doses.
The second strategy is to reduce populations of the adult yellow fever mosquito. Lethal ovitraps can reduce Aedes populations, but with a decreased amount of pesticide because it targets the mosquitoes directly. Curtains and lids of water tanks can be sprayed with insecticides, but application inside houses is not recommended by the WHO. Insecticide-treated mosquito nets are effective, just as they are against the Anopheles mosquito that carries malaria.
As for other flavivirus infections, no cure is known for yellow fever. Hospitalization is advisable and intensive care may be necessary because of rapid deterioration in some cases. Different methods for acute treatment of the disease have been shown not to be very successful; passive immunisation after emergence of symptoms is probably without effect. Ribavirin and other antiviral drugs, as well as treatment with interferons, do not have a positive effect in patients. A symptomatic treatment includes rehydration and pain relief with drugs such as paracetamol (acetaminophen in the United States). Acetylsalicylic acid (aspirin) should not be given because of its anticoagulant effect, which can be devastating in the case of internal bleeding that can occur with yellow fever.
Yellow fever is common in tropical and subtropical areas of South America and Africa. Worldwide, about 600 million people live in endemic areas. The WHO estimates 200,000 cases of disease and 30,000 deaths a year occur; the number of officially reported cases is far lower.
An estimated 90% of the infections occur on the African continent. In 2008, the largest number of recorded cases was in Togo. In 2016, a large outbreak originated in Angola and spread to neighboring countries before being contained by a massive vaccination campaign. In March and April, 11 cases were reported in China, the first appearance of the disease in Asia in recorded history.
Phylogenetic analysis has identified seven genotypes of yellow fever viruses, and they are assumed to be differently adapted to humans and to the vector A. aegypti. Five genotypes (Angola, Central/East Africa, East Africa, West Africa I, and West Africa II) occur only in Africa. West Africa genotype I is found in Nigeria and the surrounding areas. This appears to be especially virulent or infectious, as this type is often associated with major outbreaks. The three genotypes in East and Central Africa occur in areas where outbreaks are rare. Two recent outbreaks in Kenya (1992–1993) and Sudan (2003 and 2005) involved the East African genotype, which had remained unknown until these outbreaks occurred.
In South America, two genotypes have been identified (South American genotypes I and II). Based on phylogenetic analysis these two genotypes appear to have originated in West Africa and were first introduced into Brazil. The date of introduction into South America appears to be 1822 (95% confidence interval 1701 to 1911). The historical record shows an outbreak of yellow fever occurred in Recife, Brazil, between 1685 and 1690. The disease seems to have disappeared, with the next outbreak occurring in 1849. It was likely introduced with the importation of slaves through the slave trade from Africa. Genotype I has been divided into five subclades, A through E.
In late 2016, a large outbreak began in Minas Gerais state of Brazil that was characterized as a sylvan or jungle epizootic. It began as an outbreak in brown howler monkeys, which serve as a sentinel species for yellow fever, that then spread to men working in the jungle. By mid-March 2017 there had been more than 1,000 suspected human cases with 424 confirmed and 137 deaths. In April, the sylvan outbreak continued moving toward the Brazilean coast where most people are unvaccinated. No cases had been transmitted to humans by the Aedes aegypti mosquito, which can sustain urban outbreaks that can spread rapidly. The Health Ministry launched a vaccination campaign and was concerned about spread during the Carnival season in February and March.
Though the main vector (A. aegypti) also occurs in tropical and subtropical regions of Asia, the Pacific, and Australia, yellow fever has never occurred in these parts of the globe until the introduction of 11 cases by jet travel from an outbreak in Africa in 2016. Proposed explanations include the idea that the strains of the mosquito in the east are less able to transmit the yellow fever virus, that immunity is present in the populations because of other diseases caused by related viruses (for example, dengue), and that the disease was never introduced because the shipping trade was insufficient, but none is considered satisfactory. Another proposal is the absence of a slave trade to Asia on the scale of that to the Americas. The trans-Atlantic slave trade was probably the means of introduction into the Western Hemisphere from Africa.
The evolutionary origins of yellow fever most likely lie in Africa, with transmission of the disease from nonhuman primates to humans. The virus is thought to have originated in East or Central Africa and spread from there to West Africa. As it was endemic in Africa, the natives had developed some immunity to it. When an outbreak of yellow fever would occur in an African village where colonists resided, most Europeans died, while the native population usually suffered nonlethal symptoms resembling influenza. This phenomenon, in which certain populations develop immunity to yellow fever due to prolonged exposure in their childhood, is known as acquired immunity. The virus, as well as the vector A. aegypti, were probably transferred to North and South America with the importation of slaves from Africa, part of the Columbian Exchange following European exploration and colonization.
The first definitive outbreak of yellow fever in the New World was in 1647 on the island of Barbados. An outbreak was recorded by Spanish colonists in 1648 in the Yucatán Peninsula, where the indigenous Mayan people called the illness xekik ("blood vomit"). In 1685, Brazil suffered its first epidemic, in Recife. The first mention of the disease by the name "yellow fever" occurred in 1744. McNeill argues that the environmental and ecological disruption caused by the introduction of sugar plantations created the conditions for mosquito and viral reproduction, and subsequent outbreaks of yellow fever. Deforestation reduced insectivorous bird populations and other creatures that fed on mosquitoes and their eggs.
Although yellow fever is most prevalent in tropical-like climates, the northern United States were not exempted from the fever. The first outbreak in English-speaking North America occurred in New York City in 1668, and a serious one afflicted Philadelphia in 1793. English colonists in Philadelphia and the French in the Mississippi River Valley recorded major outbreaks in 1669, as well as those occurring later in the 18th and 19th centuries.
The southern city of New Orleans was plagued with major epidemics during the 19th century, most notably in 1833 and 1853. At least 25 major outbreaks took place in the Americas during the 18th and 19th centuries, including particularly serious ones in Cartagena in 1741, Cuba in 1762 and 1900, Santo Domingo in 1803, and Memphis in 1878. Considerable debate existed over whether the number of deaths caused by disease in the Haitian Revolution of the 1780s was exaggerated.
Major outbreaks have also occurred in southern Europe. Gibraltar lost many to outbreaks in 1804, 1814, and 1828. Barcelona suffered the loss of several thousand citizens during an outbreak in 1821. Urban epidemics continued in the United States until 1905, with the last outbreak affecting New Orleans.
In Colonial times and during the Napoleonic Wars, the West Indies were known as a particularly dangerous posting for soldiers due to the presence of yellow fever. The mortality rate in British garrisons in Jamaica was seven times that of garrisons in Canada, mostly because of yellow fever and other tropical disease such as malaria. Both English and French forces posted there were seriously affected by the "yellow jack". Wanting to regain control of the lucrative sugar trade in Saint-Domingue (Hispaniola), and with an eye on regaining France's New World empire, Napoleon sent an army under the command of his brother-in-law to Saint-Domingue to seize control after a slave revolt. The historian J. R. McNeill asserts that yellow fever accounted for about 35,000 to 45,000 casualties of these forces during the fighting. Only one-third of the French troops survived for withdrawal and return to France. Napoleon gave up on the island, and in 1804, Haiti proclaimed its independence as the second republic in the Western Hemisphere.
The yellow fever epidemic of 1793 in Philadelphia, which was then the capital of the United States, resulted in the deaths of several thousand people, more than 9% of the population. The national government fled the city, including President George Washington. Additional yellow fever epidemics struck Philadelphia, Baltimore, and New York City in the 18th and 19th centuries, and traveled along steamboat routes from New Orleans. They caused some 100,000–150,000 deaths in total.
In 1853, Cloutierville, Louisiana, had a late-summer outbreak of yellow fever that quickly killed 68 of the 91 inhabitants. A local doctor concluded that some unspecified infectious agent had arrived in a package from New Orleans. In 1858, St. Matthew's German Evangelical Lutheran Church in Charleston, South Carolina, suffered 308 yellow fever deaths, reducing the congregation by half. A ship carrying persons infected with the virus arrived in Hampton Roads in southeastern Virginia in June 1855. The disease spread quickly through the community, eventually killing over 3,000 people, mostly residents of Norfolk and Portsmouth. In 1873, Shreveport, Louisiana, lost almost a quarter of its population to yellow fever. In 1878, about 20,000 people died in a widespread epidemic in the Mississippi River Valley. That year, Memphis had an unusually large amount of rain, which led to an increase in the mosquito population. The result was a huge epidemic of yellow fever. The steamship John D. Porter took people fleeing Memphis northward in hopes of escaping the disease, but passengers were not allowed to disembark due to concerns of spreading yellow fever. The ship roamed the Mississippi River for the next two months before unloading her passengers. The last major U.S. outbreak was in 1905 in New Orleans.
The planets were in the same line as the sun and earth and this produced, besides Cyclones, Earthquakes, etc., a denser atmosphere holding more carbon and creating microbes. Mars had an uncommonly dense atmosphere, but its inhabitants were probably protected from the fever by their newly discovered canals, which were perhaps made to absorb carbon and prevent the disease.
In 1848, Josiah C. Nott suggested that yellow fever was spread by insects such as moths or mosquitoes, basing his ideas on the pattern of transmission of the disease. Carlos Finlay, a Cuban doctor and scientist, proposed in 1881 that yellow fever might be transmitted by mosquitoes rather than direct human contact. Since the losses from yellow fever in the Spanish–American War in the 1890s were extremely high, Army doctors began research experiments with a team led by Walter Reed, composed of doctors James Carroll, Aristides Agramonte, and Jesse William Lazear. They successfully proved Finlay's ″mosquito hypothesis″. Yellow fever was the first virus shown to be transmitted by mosquitoes. The physician William Gorgas applied these insights and eradicated yellow fever from Havana. He also campaigned against yellow fever during the construction of the Panama Canal, after a previous effort on the part of the French failed (in part due to mortality from the high incidence of yellow fever and malaria, which killed many workers).
Although Dr. Reed has received much of the credit in United States history books for "beating" yellow fever, he had fully credited Dr. Finlay with the discovery of the yellow fever vector, and how it might be controlled. Reed often cited Finlay's papers in his own articles, and also gave him credit for the discovery in his personal correspondence. The acceptance of Finlay's work was one of the most important and far-reaching effects of the Walter Reed Commission of 1900. Applying methods first suggested by Finlay, the United States government and Army eradicated yellow fever in Cuba and later in Panama, allowing completion of the Panama Canal. While Reed built on the research of Carlos Finlay, historian François Delaporte notes that yellow fever research was a contentious issue. Scientists, including Finlay and Reed, became successful by building on the work of less prominent scientists, without always giving them the credit they were due. Reed's research was essential in the fight against yellow fever. He should also receive full credit for his use of the first type of medical consent form during his experiments in Cuba, an attempt to ensure that participants knew they were taking a risk by being part of testing.
During 1920–23, the Rockefeller Foundation’s International Health Board undertook an expensive and successful yellow fever eradication campaign in Mexico. The IHB gained the respect of Mexico’s federal government because of the success. The eradication of yellow fever strengthened the relationship between the US and Mexico, which had not been very good in the past. The eradication of yellow fever was also a major step toward better global health.
In 1927, scientists isolated the yellow fever virus in West Africa. Following this, two vaccines were developed in the 1930s. The vaccine 17D was developed by the South African microbiologist Max Theiler at the Rockefeller Institute in New York City. This vaccine was widely used by the U.S. Army during World War II. Following the work of Ernest Goodpasture, Theiler used chicken eggs to culture the virus and won a Nobel Prize in 1951 for this achievement. A French team developed the French neurotropic vaccine (FNV), which was extracted from mouse brain tissue. Since this vaccine was associated with a higher incidence of encephalitis, FNV was not recommended after 1961. Vaccine 17D is still in use, and more than 400 million doses have been distributed. Little research has been done to develop new vaccines. Some researchers worry that the 60-year-old technology for vaccine production may be too slow to stop a major new yellow-fever epidemic. Newer vaccines, based on vero cells, are in development and should replace 17D at some point.
Using vector control and strict vaccination programs, the urban cycle of yellow fever was nearly eradicated from South America. Since 1943, only a single urban outbreak in Santa Cruz de la Sierra, Bolivia, has occurred. Since the 1980s, though, the number of yellow fever cases has been increasing again, and A. aegypti has returned to the urban centers of South America. This is partly due to limitations on available insecticides, as well as habitat dislocations caused by climate change. It is also because the vector control program was abandoned. Although no new urban cycle has yet been established, scientists believe this could happen again at any point. An outbreak in Paraguay in 2008 was thought to be urban in nature, but this ultimately proved not to be the case.
In Africa, virus eradication programs have mostly relied upon vaccination. These programs have largely been unsuccessful because they were unable to break the sylvatic cycle involving wild primates. With few countries establishing regular vaccination programs, measures to fight yellow fever have been neglected, making the future spread of the virus more likely.
In the hamster model of yellow fever, early administration of the antiviral ribavirin is an effective early treatment of many pathological features of the disease. Ribavirin treatment during the first five days after virus infection improved survival rates, reduced tissue damage in the liver and spleen, prevented hepatocellular steatosis, and normalised levels of alanine aminotransferase, a liver damage marker. The mechanism of action of ribavirin in reducing liver pathology in yellow fever virus infection may be similar to its activity in treatment of hepatitis C, a related virus. Because ribavirin had failed to improve survival in a virulent rhesus model of yellow fever infection, it had been previously discounted as a possible therapy. Infection was reduced in mosquitoes with the wMel strain of Wolbachia.
- Oldstone, Michael (2009). Viruses, Plagues, and History: Past, Present and Future. Oxford University Press. pp. 102–4. ISBN 9780199758494.
- Bazin, Hervé (2011). Vaccination : a history from Lady Montagu to genetic engineering. Montrouge: J. Libbey Eurotext. p. 407. ISBN 9782742007752.
- "Yellow fever Fact sheet N°100". World Health Organization. May 2013. Retrieved 23 February 2014.
- Tolle MA (April 2009). "Mosquito-borne diseases". Curr Probl Pediatr Adolesc Health Care. 39 (4): 97–140. doi:10.1016/j.cppeds.2009.01.001. PMID 19327647.
- GBD 2015 Mortality and Causes of Death, Collaborators. (8 October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015.". Lancet (London, England). 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMID 27733281.
- Scully, Crispian (2014). Scully's Medical Problems in Dentistry. Elsevier Health Sciences. p. 572. ISBN 9780702059636.
- Lindenbach, B. D.; et al. (2007). "Flaviviridae: The Viruses and Their Replication". In Knipe, D. M.; P. M. Howley. Fields Virology (5th ed.). Philadelphia, PA: Lippincott Williams & Wilkins. p. 1101. ISBN 0-7817606-0-7.
- "Frequently Asked Questions About Yellow Fever". CDC. August 21, 2015. Retrieved 18 March 2016.
- "CDC Yellow Fever". Retrieved 2012-12-12.
- Barrett AD, Higgs S (2007). "Yellow fever: a disease that has yet to be conquered". Annu. Rev. Entomol. 52: 209–29. doi:10.1146/annurev.ento.52.110405.091454. PMID 16913829.
- Sfakianos, Jeffrey; Hecht, Alan (2009). Babcock, Hilary, ed. West Nile virus. Foreword by David Heymann (2nd ed.). New York: Chelsea House. p. 17. ISBN 9781604132540.
- "CDC: Yellow fever—Symptoms and treatment". Retrieved 2010-11-10.
- "Yellow fever". WHO. Retrieved 2009-08-13.
- Control of Communicable Diseases Manual (20th ed.). Amer Public Health Assn. ISBN 978-0875530185.
- Chastel C (August 2003). "[Centenary of the discovery of yellow fever virus and its transmission by a mosquito (Cuba 1900–1901)]". Bull Soc Pathol Exot (in French). 96 (3): 250–6. PMID 14582304.
- Dr. Irwin Sherman "Twelve Diseases that Changed Our World". P. 144. ASM Press. 2007. ISBN 978-1-55581-466-3. OCLC 141178241.
- Franklin, Jon; Sutherland, John. "Guinea Pig Doctors: The Drama of Medical Research Through Self-Experimentation" by Jon Franklin (Author), John Sutherland (Author) Publisher: William Morrow & Co (March 1984) ISBN 068-8-02666-4
- Monath TP (April 2008). "Treatment of yellow fever". Antiviral Res. 78 (1): 116–24. doi:10.1016/j.antiviral.2007.10.009. PMID 18061688.
- "Yellow fever, Complications," Mayo Clinic, 2014-08-20. Retrieved 2016-07-25.
- Tomori O (2004). "Yellow fever: the recurring plague". Crit Rev Clin Lab Sci. 41 (4): 391–427. doi:10.1080/10408360490497474. PMID 15487593.
- Modrow, S.; et al. (2002). Molekulare Virologie – Eine Einführung für Biologen und Mediziner (2nd ed.). Spektrum Akademischer Verlag. p. 182. ISBN 3-8274-1086-X.
- Rogers DJ, Wilson AJ, Hay SI, Graham AJ (2006). "The global distribution of yellow fever and dengue". Adv. Parasitol. 62: 181–220. doi:10.1016/S0065-308X(05)62006-4. PMC . PMID 16647971.
- Staples JE, Monath TP (Aug 27, 2008). "Yellow fever: 100 years of discovery". JAMA: The Journal of the American Medical Association. 300 (8): 960–2. doi:10.1001/jama.300.8.960. PMID 18728272.
- Sampath A, Padmanabhan R (January 2009). "Molecular targets for flavivirus drug discovery". Antiviral Research. 81 (1): 6–15. doi:10.1016/j.antiviral.2008.08.004. PMC . PMID 18796313.
- Silva, Patricia A. G. C. (2010). "An RNA Pseudoknot Is Required for Production of Yellow Fever Virus Subgenomic RNA by the Host Nuclease XRN1". Journal of Virology. 84: 11395–11406. doi:10.1128/jvi.01047-10. PMC . PMID 20739539.
- Fontenille D, Diallo M, Mondo M, Ndiaye M, Thonnon J (1997). "First evidence of natural vertical transmission of yellow fever virus in Aedes aegypti, its epidemic vector". Transactions of the Royal Society of Tropical Medicine and Hygiene. 91 (5): 533–5. doi:10.1016/S0035-9203(97)90013-4. PMID 9463659.
- "Infectious Diseases Related to Travel". Yellow Book. Centers for Disease Control and Prevention. Retrieved 20 March 2016.
- "Yellow fever fact sheet". WHO—Yellow fever. Retrieved 2006-04-18.
- "Ebola outbreak Alert and response operations Diseases Biorisk reduction Yellow fever : a current threat". WHO. Retrieved 4 August 2016.
- Ryan, K. J.; C. G. Ray., eds. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
- Quaresma JA, Barros VL, Pagliari C, Fernandes ER, Guedes F, Takakura CF, Andrade HF, Vasconcelos PF, Duarte MI (2006). "Revisiting the liver in human yellow fever: virus-induced apoptosis in hepatocytes associated with TGF-beta, TNF-alpha and NK cells activity". Virology. 345 (1): 22–30. doi:10.1016/j.virol.2005.09.058. PMID 16278000.
- "Prevention | Yellow Fever | CDC". www.cdc.gov. Retrieved 2016-10-26.
- Barrett AD, Teuwen DE (June 2009). "Yellow fever vaccine – how does it work and why do rare cases of serious adverse events take place?". Current Opinion in Immunology. 21 (3): 308–13. doi:10.1016/j.coi.2009.05.018. PMID 19520559.
- WHO | Yellow fever vaccination booster not needed. Who.int (2013-05-17). Retrieved on 2014-05-12.
- Yellow Fever Vaccine Information Statement. Centers for Disease Control and Prevention. March 30, 2011.
- "Yellow fever". World Health Organization. Retrieved 2 April 2017.
- "Twelve million West Africans get yellow fever vaccines". BBC News. 23 November 2009. Retrieved 23 November 2009.
- "WHO dispatched 3.5 million doses of yellow fever vaccine for outbreak response in Brazil". World Health Organization. Retrieved 2 April 2017.
- "Yellow fever – Brazil". World Health Organization. Retrieved 9 March 2017.
- "Country list: Yellow fever vaccination requirements and recommendations; malaria situation; and other vaccination requirements" (PDF). WHO. 2013. p. 32. Retrieved 2015-04-12.
- "Yellow Fever – China". World Health Organization. Retrieved 9 February 2017.
- Woodall, J.P.; Yuill, T.M. (July 2016). "Why is the yellow fever outbreak in Angola a 'threat to the entire world'?". International Journal of Infectious Diseases. 48: 96–97. doi:10.1016/j.ijid.2016.05.001.
- Mutebi JP, Barrett AD (2002). "The epidemiology of yellow fever in Africa". Microbes Infect. 4 (14): 1459–1468. doi:10.1016/S1286-4579(02)00028-X. PMID 12475636.
- Ellis BR, Barrett AD (2008). "The enigma of yellow fever in East Africa". Rev Med Virol. 18 (5): 331–346. doi:10.1002/rmv.584. PMID 18615782.
- Mutebi JP, Rijnbrand RC, Wang H, Ryman KD, Wang E, Fulop LD, Titball R, Barrett AD (2004). "Genetic relationships and evolution of genotypes of yellow fever virus and other members of the yellow fever virus group within the Flavivirus genus based on the 3' noncoding region". J Virol. 78 (18): 9652–9665. doi:10.1128/JVI.78.18.9652-9665.2004. PMC . PMID 15331698.
- Auguste AJ, Lemey P, Pybus OG, Suchard MA, Salas RA, Adesiyun AA, Barrett AD, Tesh RB, Weaver SC, Carrington CV (2010). "Yellow fever virus maintenance in Trinidad and its dispersal throughout the Americas". J Virol. 84 (19): 9967–9977. doi:10.1128/JVI.00588-10. PMC . PMID 20631128.
- de Souza RP, Foster PG, Sallum MA, Coimbra TL, Maeda AY, Silveira VR, Moreno ES, da Silva FG, Rocco IM, Ferreira IB, Suzuki A, Oshiro FM, Petrella SM, Pereira LE, Katz G, Tengan CH, Siciliano MM, Dos Santos CL (2010). "Detection of a new yellow fever virus lineage within the South American genotype I in Brazil". J Med Virol. 82 (1): 175–185. doi:10.1002/jmv.21606. PMID 19950229.
- "YELLOW FEVER - AMERICAS (01): PAHO/WHO 2016". www.promedmail.org. International Society for Infectious Diseases. Retrieved 16 February 2017.
- "Yellow fever killing thousands of monkeys in Brazil". www.sciencedaily.com. Retrieved 24 March 2017.
- "Yellow fever – Americas (23): Brazil, PAHO/WHO". www.promedmail.org. International Society for Infectious Diseases. Retrieved 19 February 2017.
- "Yellow fever kills at least 137 people in Brazil". Anadolu Agency. 17 March 2017.
- "Yellow fever – Brazil". World Health Organization. Retrieved 9 April 2017.
- Times, Global. "Yellow fever cases continue to rise in Brazil, 253 confirmed – Global Times". www.globaltimes.cn. Retrieved 19 February 2017.
- Vainio J.; F. Cutts, eds. (1998). Yellow Fever. WHO Division of Emerging and other Communicable Diseases Surveillance and Control.
- Monath, T. P. (1989). "The absence of yellow fever in Asia: hypotheses. A cause for concern?". Virus Inf Exch Newslett: 106–7.
- Cathey JT, Marr JS (2014). "Yellow fever, Asia and the East African slave trade". Trans R Soc Trop Med Hyg. 108 (5): 252–7. doi:10.1093/trstmh/tru043. PMID 24743951.
- Bryant JE, Holmes EC, Barrett AD (2007). "Out of Africa: a molecular perspective on the introduction of yellow fever virus into the Americas". PLoS Pathog. 3 (5): e75. doi:10.1371/journal.ppat.0030075. PMC . PMID 17511518.
- Gould EA, de Lamballerie X, Zanotto PM, Holmes EC (2003). "Origins, evolution, coadaptations within the genus Flavivirus". Advances in Virus Research. 59: 277–314. doi:10.1016/S0065-3527(03)59008-X. ISBN 9780120398591. PMID 14696332.
- Bryant, JE; Holmes, EC; Barrett, AD (18 May 2007). "Out of Africa: a molecular perspective on the introduction of yellow fever virus into the Americas.". PLOS Pathogens. 3 (5): e75. doi:10.1371/journal.ppat.0030075. PMC . PMID 17511518.
- Oldstone, M. (1998). Viruses, Plagues, and History, New York: Oxford University Press.
- McNeill, J. R. (2010). Mosquito Empires: Ecology and war in the greater Caribbean, 1620–1914. NY: Cambridge University Press. pp. 44–45.
- McNeill, J. R. (1 April 2004). "Yellow Jack and Geopolitics: Environment, Epidemics, and the Struggles for Empire in the American Tropics, 1650–1825". OAH Magazine of History. 18 (3): 9–13. doi:10.1093/maghis/18.3.9.
- The earliest mention of "yellow fever" appears in a manuscript of 1744 by Dr. John Mitchell of Virginia; copies of the manuscript were sent to Mr. Cadwallader Colden, a physician in New York, and to Dr. Benjamin Rush of Philadelphia; the manuscript was eventually printed (in large part) in 1805 and reprinted in 1814. See:
- (John Mitchell) (1805) (Mitchell's account of the Yellow Fever in Virginia in 1741–2), The Philadelphia Medical Museum, 1 (1) : 1–20.
- (John Mitchell) (1814) "Account of the Yellow fever which prevailed in Virginia in the years 1737, 1741, and 1742, in a letter to the late Cadwallader Colden, Esq. of New York, from the late John Mitchell, M.D.F.R.S. of Virginia," American Medical and Philosophical Register … , 4 : 181–215. The term "yellow fever" appears on p. 186. On p. 188, Mitchell mentions "… the distemper was what is generally called the yellow fever in America." However, on pages 191–192, he states "… I shall consider the cause of the yellowness which is so remarkable in this distemper, as to have given it the name of the Yellow Fever."
- McNeill, John (2010). Mosquito Empires: Ecology and War in the Greater Caribbean, 1620–1914. New York, NY: Cambridge University Press. ISBN 978-0-511-67268-2.
- Miller, Jacquelyn C (2005). "The Wages of Blackness: African American Workers and the Meanings of Race during Philadelphia's 1793 Yellow Fever Epidemic". The Pennsylvania Magazine of History and Biography. 129 (2): 163–194.
- John S. Marr, and John T. Cathey. "The 1802 Saint-Domingue yellow fever epidemic and the Louisiana Purchase." Journal of Public Health Management and Practice 19#.1 (2013): 77–82. online
- Philippe R. Girard (2011). The Slaves Who Defeated Napoleon: Toussaint Louverture and the Haitian War of Independence, 1801–1804. University of Alabama Press. pp. 179–80.
- "Gibraltar's 1804 Yellow Fever Scourge: The Search for Scapegoats". Oxford Journals—Journal of the History of Medicine and Allied Sciences. Retrieved 2013-04-05.
- John Pierce & Jim Writer (2005). Yellow Jack: How Yellow Fever ravaged America and Walter Reed Discovered Its Deadly Secrets. Hoboken: John Wiley & Sons. p. 3.
- McNeill, JR (2002). "Yellow fever and geopolitics: environment, epidemics, and the struggles for empire in the American tropics, 1650–1900.". History now (Christchurch, N.Z.). 8 (2): 10–6. PMID 20690235.
- McNeill, J.R. (2010). Moaquito Empires: Ecology and war in the greater Caribbean, 1620–1914. Cambridge University Press. p. 259.
- "Yellow Fever Attacks Philadelphia, 1793". EyeWitness to History. Retrieved 2009-08-14.
- Patterson KD (1992). "Yellow fever epidemics and mortality in the United States, 1693–1905". Social science & medicine (1982). 34 (8): 855–865. doi:10.1016/0277-9536(92)90255-O. PMID 1604377.
- The Transactions of the American Medical Association, Volume IX, TK and PG Collins, 1856, page 704, "Yellow Fever at the Village of Cloutierville, La, in the Years 1853 and 1854" by Samuel O. Scruggs, M.D.
- New Orleans Genesis June 1970, page 261-262, "Cloutierville Yellow Fever Deaths, 1853"
- St. Matthew's Evangelical Lutheran Church: 125 Years of Christian Service, 1967.
- Mauer HB. "Mosquito control ends fatal plague of yellow fever". etext.lib.virginia.edu. Retrieved 2007-06-11. (undated newspaper clipping).
- Crosby, Molly Caldwell (2006). The American Plague. New York: Berkley Publishing Group. p. 75.
- "Yellow Fever — the plague of Memphis". HistoricMemphis.com. Retrieved August 20, 2014.
- Barnes, E. (2005). Diseases and Human Evolution. Albuquerque: University of New Mexico. ISBN 0-8263-3065-7.
- "The Tennessee Encyclopedia of History and Culture:Yellow Fever Epidemics". Tennessee Historical Society. Retrieved June 20, 2013.
- John W. Cowart, "Yellow Jack in Jacksonville, Yellow Fever visited Duval County, Florida, in 1888", Historical Text Archive
- Josiah C. Nott (1848) "Yellow Fever contrasted with Bilious Fever – Reasons for believing it a disease sui generis – Its mode of Propagation – Remote Cause – Probable insect or animalcular origin" "The New Orleans Medical and Surgical Journal," "4" : 563–601.
- Carlos Juan Finlay (presented: August 14, 1881 ; published: 1882) "El mosquito hipoteticamente considerado como agente de trasmision de la fiebre amarilla" (The mosquito hypothetically considered as an agent in the transmission of yellow fever) Anales de la Real Academia de Ciencias Médicas, Físicas y Naturales de la Habana, 18 : 147–169. Available on-line in English at:
- Charles Finlay, with Rudolph Matas, translator (1881) "The mosquito hypothetically considered as an agent in the transmission of yellow fever poison," New Orleans Medical and Surgical Journal, 9 : 601–616.
- Delta Omega.org
- Chaves-Carballo E (2005). "Carlos Finlay and yellow fever: triumph over adversity". Mil Med. 170 (10): 881–5. doi:10.7205/milmed.170.10.881. PMID 16435764.
- Pierce, J.R.; Writer, J. (2005). Yellow Jack: How Yellow Fever Ravaged America and Walter Reed Discovered Its Deadly Secrets. Wiley. ISBN 0-471-47261-1.
- "Phillip S. Hench Walter Reed Yellow Fever Collection". UVA Health Sciences: Historical Collections. Retrieved 2006-05-06.
- Delaporte, Francois (1991). The History of Yellow Fever: An Essay on the Birth of Tropical Medicine. Cambridge: MIT Press. pp. 89–90.
- Crosby, Molly Caldwell (2006). The American Plague:. New York: Berkley Publishing Group. p. 177.
- Fosdick, Raymond B. (1952). The Story of the Rockefeller Foundation. New York: Harper & Brothers. pp. 58–79.
- Birn AE, Solórzano A (1999). "Public health policy paradoxes: science and politics in the Rockefeller Foundation's hookworm campaign in Mexico in the 1920s". Soc Sci Med. 49 (9): 1197–213. doi:10.1016/s0277-9536(99)00160-4. PMID 10501641.
- L. Bigon (2014), "Transnational Networks of Administrating Disease and Urban Planning in West Africa: The Inter-Colonial Conference on Yellow Fever, Dakar, 1928" GeoJournal, 79 (1):103–111.
- Sbrana E, Xiao SY, Guzman H, Ye M, Travassos da Rosa AP, Tesh RB (2004). "Efficacy of post-exposure treatment of yellow fever with ribavirin in a hamster model of the disease". Am J Trop Med Hyg. 71 (3): 306–12. PMID 15381811.
- Huggins JW (1989). "Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad-spectrum antiviral drug". Rev Infect Dis. 11 (Suppl 4): S750–61. doi:10.1093/clinids/11.Supplement_4.S750. PMID 2546248.
- http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0001892 Impact of Wolbachia on Infection with Chikungunya and Yellow Fever Viruses in the Mosquito Vector Aedes aegypti
- Endicott, S. L.; Hageman, E. (1998). The United States and Biological Warfare: Secrets from the Early Cold War and Korea. Indiana University Press. ISBN 0-253-33472-1.
- Crosby, M. (2006). The American Plague: The Untold Story of Yellow Fever, the Epidemic that Shaped Our History. New York: The Berkley Publishing Group. ISBN 0-425-21202-5.
- Espinosa, M. (2009). Epidemic Invasions: Yellow Fever and the Limits of Cuban Independence, 1878–1930. Chicago: University of Chicago Press. ISBN 978-0-226-21811-3.
- Murphy, J. (2003). An American Plague: The True and Terrifying Story of the Yellow Fever Epidemic of 1793. New York: Clarion Books. ISBN 0-395-77608-2.
- Nuwer, D. S. (2009). Plague Among the Magnolias: The 1878 Yellow Fever Epidemic in Mississippi. University of Alabama Press. ISBN 978-0-8173-1653-2.
|Wikivoyage has a travel guide for Yellow fever.|
- Yellow fever at DMOZ
- Finlay CJ (2012). "The Mosquito Hypothetically Considered as the Transmitting Agent of Yellow Fever". MEDICC Review. 14 (1): 56–9.
- "Philip S. Hench Walter Reed Yellow Fever Collection." Claude Moore Health Sciences Library, University of Virginia
- "Yellow Fever and the Reed Commission." Claude Moore Health Sciences Library, University of Virginia
- "Yellow fever virus". NCBI Taxonomy Browser. 11089.