Major intersections edit
| County | Location | Mile | Destinations | Notes |
|---|---|---|---|---|
| Fillmore | Prosper | 0.000 |  US 52
|
Continuation into Iowa |
| 1.048 |   MN 44 east
|
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| Harmony | 9.257 |   MN 139 south
|
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| Preston | 17.035 |  MN 16 east
|
South end of MN 16 concurrency | |
| 20.648 |  MN 16 west
|
North end of MN 16 concurrency | ||
| Fountain | 24.815 |  MN 80 west
|
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| Chatfield | 34.312 |    MN 30 east / MN 74 north
|
South end of MN 30 concurrency | |
| Olmsted | 34.811 | MN 30 west
|
North end of MN 30 concurrency | |
| Marion | 46.505 |  I-90 east – La Crosse
|
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| 47.625 |  CR 36 (Marion Rd)
|
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| Rochester | 50.400 |  CR 1 (11th Ave SE)
| ||
| 51.904 |  US 63 (Broadway) – Stewartville
|
6-lane freeway begins | ||
| 53.948 |  CR 25 (16th Street SW)
|
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| 54.297 |   US 14 east (12th Street SW) – Winona
|
No access northbound, south end of US 14 concurrency | ||
| 55.399 | 2nd Street SW | access to Mayo Clinic, Saint Marys Hospital | ||
| 56.077 |  US 14 west – Owatonna, Civic Center Drive NW
|
Partial cloverleaf, north end of US 14 concurrency | ||
| 56.956 | 19th Street NW, Elton Hills Dr NW | Single point urban interchange | ||
| 58.320 |  CR 22 east (37th Street NW)
| |||
| 59.663 | 55th Street NW | |||
| 61.670 |  CR 14 (75th Street NW)
|
6-lane freeways ends, remains a 4-lane freeway Partial cloverleaf | ||
| Oronoco | 64.244 |   CR 12 / CR 112 – Oronoco
|
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| Goodhue | Pine Island | 71.261 |  CR 11 – Pine Island
| |
| Zumbrota | 75.853 |  MN 60 east – Mazeppa, Zumbro Falls
|
South end of MN 60 concurrency | |
| 77.231 |   MN 58 / CR 10 – Zumbrota, Red Wing
| |||
| 78.280 | MN 60 west – Wanamingo, Kenyon
|
North end of MN 60 concurrency | ||
| Hader | 86.213 |   MN 57 / CR 8 – Wanamingo, Mantorville
| ||
| Wastedo | 89.420 |  CR 9 – Goodhue, Dennison
| ||
| 91.247 |  CR 1 south
| |||
| 91.472 |  CR 1 north
| |||
| Cannon Falls | 96.489 |  CR 24 north (65th Avenue)
| ||
| 96.897 | CR 24 west
| |||
| 98.060 |  MN 19 – Cannon Falls, Northfield
| |||
| Dakota | Hampton | 105.686 |    MN 50 / MN 56 / CR 47 – Farmington, Kenyon
| |
| Coates | 113.435 |  CR 46
| ||
| Rosemount | 115.573 |  CR 42 – Rosemount
| ||
| 117.501 |  MN 55 east – Hastings
|
Intersection northbound and Exit southbound | ||
| 118.174 | 117th St | |||
| Inver Grove Heights | 120.837 |  CR 56 (Concord Boulevard)
|
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| 121.679 | MN 55 west – Minneapolis
|
Northbound exit and southbound entrance | ||
| 122.677 |  To MN 55 west / 80th Street East
| |||
| 123.505 |  CR 26 (70th Street East)
| |||
| 124.735 | Upper 55th Street East | |||
| 125.379 |   I-494 / MN 110
| |||
| South St. Paul | 126.116 | Southview Boulevard, Mendota Road | ||
| South St. Paul/West St. Paul | 127.295 | Wentworth Avenue, Thompson Avenue | ||
| 128.048 | Butler Avenue | |||
| Ramsey | St. Paul | 129.155 |  MN 156 (Concord Street)
| |
| 129.469 | Eaton Street | Southbound exit and northbound entrance | ||
| 130.253 | Plato Boulevard, Fillmore Avenue | |||
| 130.858 |   I-94 east / US 10 east
|
Northbound exit | ||
| 130.937 |  I-94 west / US 10 west / US 52 north to I-35E
|
Southbound entrance | ||
| US 52 continues unsigned, overlapping Interstate 94. | ||||