Effect of spaceflight on the human body
Humans venturing into the environment of space can have negative effects on the body. Significant adverse effects of long-term weightlessness include muscle atrophy and deterioration of the skeleton (spaceflight osteopenia). Other significant effects include a slowing of cardiovascular system functions, decreased production of red blood cells, balance disorders, eyesight disorders and a weakening of the immune system. Additional symptoms include fluid redistribution (causing the "moon-face" appearance typical in pictures of astronauts experiencing weightlessness), loss of body mass, nasal congestion, sleep disturbance, and excess flatulence.
The engineering problems associated with leaving Earth and developing space propulsion systems have been examined for over a century, and millions of man-hours of research have been spent on them. In recent years there has been an increase in research on the issue of how humans can survive and work in space for extended and possibly indefinite periods of time. This question requires input from the physical and biological sciences and has now become the greatest challenge (other than funding) facing human space exploration. A fundamental step in overcoming this challenge is trying to understand the effects and impact of long-term space travel on the human body.
Many of the environmental conditions experienced by humans during spaceflight are very different from those in which humans evolved; however, technology is able to shield people from the harshest conditions, such as that offered by a spaceship or spacesuit. The immediate needs for breathable air and drinkable water are addressed by a life support system, a group of devices that allow human beings to survive in outer space. The life support system supplies air, water and food. It must also maintain temperature and pressure within acceptable limits and deal with the body's waste products. Shielding against harmful external influences such as radiation and micro-meteorites is also necessary.
Of course, it is not possible to remove all hazards; the most important factor affecting human physical well-being in space is weightlessness, more accurately defined as Micro-g environment. Living in this type of environment impacts the body in three important ways: loss of proprioception, changes in fluid distribution, and deterioration of the musculoskeletal system.
Space medicine is a developing medical practice that studies the health of astronauts living in outer space. The main purpose of this academic pursuit is to discover how well and for how long people can survive the extreme conditions in space, and how fast they can re-adapt to the Earth's environment after returning from space. Space medicine also seeks to develop preventative and palliative measures to ease the suffering caused by living in an environment to which humans are not well adapted.
Ascent and reentryEdit
During takeoff and reentry space travelers can experience several times normal gravity. An untrained person can usually withstand about 3g, but can blackout at 4 to 6g. G-force in the vertical direction is more difficult to tolerate than a force perpendicular to the spine because blood flows away from the brain and eyes. First the person experiences temporary loss of vision and then at higher g-forces loses consciousness. G-force training and a G-suit which constricts the body to keep more blood in the head can mitigate the effects. Most spacecraft are designed to keep g-forces within comfortable limits.
The environment of space is lethal without appropriate protection: the greatest threat in the vacuum of space derives from the lack of oxygen and pressure, although temperature and radiation also pose risks.
Human physiology is adapted to living within the atmosphere of Earth, and a certain amount of oxygen is required in the air we breathe. The minimum concentration, or partial pressure, of oxygen that can be tolerated is 16 kPa (0.16 bar).[dubious ] Below this, the astronaut is at risk of becoming unconscious and dying from hypoxia. In the vacuum of space, gas exchange in the lungs continues as normal but results in the removal of all gases, including oxygen, from the bloodstream. After 9 to 12 seconds, the deoxygenated blood reaches the brain, and it results in the loss of consciousness. Death would gradually follow after two minutes of exposure—though the absolute limits are uncertain.
Humans and other animals exposed to vacuum lose consciousness after a few seconds and die of hypoxia within minutes. Blood and other body fluids do boil when their pressure drops below 6.3 kPa (47 Torr), the vapor pressure of water at body temperature. This condition is called ebullism. The steam may bloat the body to twice its normal size and slow circulation, but tissues are elastic and porous enough to prevent rupture. Ebullism is slowed by the pressure containment of blood vessels, so some blood remains liquid. Swelling and ebullism can be reduced by containment in a flight suit. Space Shuttle astronauts wore a fitted elastic garment called a Crew Altitude Protection Suit (CAPS) which prevented ebullism at pressures as low as 2 kPa (15 Torr). Spacesuits are necessary to prevent ebullism above 19 km. Most spacesuits use 20 kPa (150 Torr) of pure oxygen, just enough to sustain full consciousness. This pressure is high enough to prevent ebullism, but simple evaporation of blood, or of gases dissolved in the blood, can still cause decompression sickness (the bends) and gas embolisms if not managed.
A short-term exposure to vacuum of up to 30 seconds is unlikely to cause permanent physical damage. Animal experiments show that rapid and complete recovery is normal for exposures shorter than 90 seconds, while longer full-body exposures are fatal and resuscitation has never been successful. There is only a limited amount of data available from human accidents, but it is consistent with animal data. Limbs may be exposed for much longer if breathing is not impaired. Rapid decompression can be much more dangerous than vacuum exposure itself. Even if the victim does not hold their breath, venting through the windpipe may be too slow to prevent the fatal rupture of the delicate alveoli of the lungs. Eardrums and sinuses may be ruptured by rapid decompression, soft tissues may bruise and seep blood, and the stress of shock accelerates oxygen consumption, leading to hypoxia. Injuries caused by rapid decompression are called barotrauma, and are well known from scuba diving accidents. A pressure drop as small as 100 Torr (13 kPa), which produces no symptoms if it is gradual, may be fatal if it occurs suddenly.
Most of the information known about the way the human body reacts are due to accidental decompression, especially during experimental spaceflight projects. One such case is discussed in a NASA technical report: Rapid (Explosive) Decompression Emergencies in Pressure-Suited Subjects:[page needed]
- "At NASA's Manned Spacecraft Center (now renamed Johnson Space Center) we had a test subject accidentally exposed to a near vacuum (less than 1 psi) [7 kPa] in an incident involving a leaking space suit in a vacuum chamber back in '65. He remained conscious for about 14 seconds, which is about the time it takes for O2 deprived blood to go from the lungs to the brain. The suit probably did not reach a hard vacuum, and we began repressurizing the chamber within 15 seconds. The subject regained consciousness at around 15,000 feet [4600 m] equivalent altitude. The subject later reported that he could feel and hear the air leaking out, and his last conscious memory was of the water on his tongue beginning to boil."
There has been one recorded incident of death from decompression in spaceflight, the Soyuz 11 decompression accident in 1971, which resulted in the death of the three cosmonauts on board.
In a vacuum, there is no medium for removing heat from the body by conduction or convection. Loss of heat is by radiation from the 310 K temperature of a person to the 3 K of outer space. This is a slow process, especially in a clothed person, so there is no danger of immediately freezing. Rapid evaporative cooling of skin moisture in a vacuum may create frost, particularly in the mouth, but this is not a significant hazard.
Exposure to the intense radiation of direct, unfiltered sunlight would lead to local heating, though that would likely be well distributed by the body's conductivity and blood circulation. Other solar radiation, particularly ultraviolet rays, however, may cause severe sunburn.
Without the protection of Earth's atmosphere and magnetosphere astronauts are exposed to high levels of radiation. A year in low Earth orbit results in a dose of radiation 10 times that of the annual dose on earth. High levels of radiation damage lymphocytes, cells heavily involved in maintaining the immune system; this damage contributes to the lowered immunity experienced by astronauts. Radiation has also recently been linked to a higher incidence of cataracts in astronauts. Outside the protection of low Earth orbit, galactic cosmic rays present further challenges to human spaceflight, as the health threat from cosmic rays significantly increases the chances of cancer over a decade or more of exposure. A NASA-supported study reported that radiation may harm the brain of astronauts and accelerate the onset of Alzheimer's disease. Solar flare events (though rare) can give a fatal radiation dose in minutes. It is thought that protective shielding and protective drugs may ultimately lower the risks to an acceptable level.
Crew living on the International Space Station (ISS) are partially protected from the space environment by Earth's magnetic field, as the magnetosphere deflects solar wind around the earth and the ISS. Nevertheless, solar flares are powerful enough to warp and penetrate the magnetic defences, and so are still a hazard to the crew. The crew of Expedition 10 took shelter as a precaution in 2005 in a more heavily shielded part of the station designed for this purpose. However, beyond the limited protection of Earth's magnetosphere, interplanetary manned missions are much more vulnerable. Lawrence Townsend of the University of Tennessee and others have studied the most powerful solar flare ever recorded. Radiation doses astronauts would receive from a flare of this magnitude could cause acute radiation sickness and possibly even death.
There is scientific concern that extended spaceflight might slow down the body's ability to protect itself against diseases. Radiation can penetrate living tissue and cause both short and long-term damage to the bone marrow stem cells which create the blood and immune systems. In particular, it causes 'chromosomal aberrations' in lymphocytes. As these cells are central to the immune system, any damage weakens the immune system, which means that in addition to increased vulnerability to new exposures, viruses already present in the body—which would normally be suppressed—become active. In space, T-cells (a form of lymphocyte) are less able to reproduce properly, and the T-cells that do reproduce are less able to fight off infection. Over time immunodeficiency results in the rapid spread of infection among crew members, especially in the confined areas of space flight systems.
On 31 May 2013, The NASA scientists reported that a possible manned mission to Mars may involve a great radiation risk based on the amount of energetic particle radiation detected by the RAD on the Mars Science Laboratory while traveling from the Earth to Mars in 2011–2012.
In September 2017, NASA reported radiation levels on the surface of the planet Mars were temporarily doubled, and were associated with an aurora 25-times brighter than any observed earlier, due to a massive, and unexpected, solar storm in the middle of the month.
Following the advent of space stations that can be inhabited for long periods of time, exposure to weightlessness has been demonstrated to have some deleterious effects on human health. Humans are well-adapted to the physical conditions at the surface of the earth, and so in response to weightlessness, various physiological systems begin to change, and in some cases, atrophy. Though these changes are usually temporary, some do have a long-term impact on human health.
Short-term exposure to microgravity causes space adaptation syndrome, a self-limiting nausea caused by derangement of the vestibular system. Long-term exposure causes multiple health problems, one of the most significant being loss of bone and muscle mass. Over time these deconditioning effects can impair astronauts' performance, increase their risk of injury, reduce their aerobic capacity, and slow down their cardiovascular system. As the human body consists mostly of fluids, gravity tends to force them into the lower half of the body, and our bodies have many systems to balance this situation. When released from the pull of gravity, these systems continue to work, causing a general redistribution of fluids into the upper half of the body. This is the cause of the round-faced 'puffiness' seen in astronauts. Redistributing fluids around the body itself causes balance disorders, distorted vision, and a loss of taste and smell.
A 2006 Space Shuttle experiment found that Salmonella typhimurium, a bacterium that can cause food poisoning, became more virulent when cultivated in space. On April 29, 2013, scientists in Rensselaer Polytechnic Institute, funded by NASA, reported that, during spaceflight on the International Space Station, microbes seem to adapt to the space environment in ways "not observed on Earth" and in ways that "can lead to increases in growth and virulence". More recently, in 2017, bacteria were found to be more resistant to antibiotics and to thrive in the near-weightlessness of space. Microorganisms have been observed to survive the vacuum of outer space.
The most common problem experienced by humans in the initial hours of weightlessness is known as space adaptation syndrome or SAS, commonly referred to as space sickness. It is related to motion sickness, and arises as the vestibular system adapts to weightlessness. Symptoms of SAS include nausea and vomiting, vertigo, headaches, lethargy, and overall malaise. The first case of SAS was reported by cosmonaut Gherman Titov in 1961. Since then, roughly 45% of all people who have flown in space have suffered from this condition. The duration of space sickness varies, but rarely has it lasted for more than 72 hours, after which the body adjusts to the new environment.
On Earth, our bodies react automatically to gravity, maintaining both posture and locomotion in a downward pulling world. In microgravity environments, these constant signals are absent: the otolith organs in the inner ear are sensitive to linear acceleration and no longer perceive a downwards bias; muscles are no longer required to contract to maintain posture, and pressure receptors in the feet and ankles no longer signal the direction of "down". These changes can immediately result in visual-orientation illusions where the astronaut feels he has flipped 180 degrees. Over half of astronauts also experience symptoms of motion sickness for the first three days of travel due to the conflict between what the body expects and what the body actually perceives. Over time however the brain adapts and although these illusions can still occur, most astronauts begin to see "down" as where the feet are. People returning to Earth after extended weightless periods have to readjust to the force of gravity and may have problems standing up, focusing their gaze, walking and turning. This is just an initial problem, as they recover these abilities quickly.[vague]
NASA jokingly measures SAS using the "Garn scale", named for United States Senator Jake Garn, whose sickness during STS-51-D was the worst on record. Accordingly, one "Garn" is equivalent to the most severe possible case of space sickness. By studying how changes can affect balance in the human body—involving the senses, the brain, the inner ear, and blood pressure—NASA hopes to develop treatments that can be used on Earth and in space to correct balance disorders. Until then, astronauts rely on medication, such as midodrine and dimenhydrinate anti-nausea patches, as required (such as when space suits are worn, because vomiting into a space suit could be fatal).
Bone and muscle deteriorationEdit
A major effect of long-term weightlessness involves the loss of bone and muscle mass. Without the effects of gravity, skeletal muscle is no longer required to maintain posture and the muscle groups used in moving around in a weightless environment differ from those required in terrestrial locomotion. In a weightless environment, astronauts put almost no weight on the back muscles or leg muscles used for standing up. Those muscles then start to weaken and eventually get smaller. Consequently, some muscles atrophy rapidly, and without regular exercise astronauts can lose up to 20% of their muscle mass in just 5 to 11 days The types of muscle fibre prominent in muscles also change. Slow twitch endurance fibres used to maintain posture are replaced by fast twitch rapidly contracting fibres that are insufficient for any heavy labour. Advances in research on exercise, hormone supplements and medication may help maintain muscle and body mass.
Bone metabolism also changes. Normally, bone is laid down in the direction of mechanical stress. However, in a microgravity environment there is very little mechanical stress. This results in a loss of bone tissue approximately 1.5% per month especially from the lower vertebrae, hip and femur. Due to microgravity and the decreased load on the bones, there is a rapid increase in bone loss, from 3% cortical bone loss per decade to about 1% every month the body is exposed to microgravity, for an otherwise healthy adult. The rapid change in bone density is dramatic, making bones frail and resulting in symptoms which resemble those of osteoporosis. On Earth, the bones are constantly being shed and regenerated through a well-balanced system which involves signaling of osteoblasts and osteoclasts. These systems are coupled, so that whenever bone is broken down, newly formed layers take its place—neither should happen without the other, in a healthy adult. In space, however, there is an increase in osteoclast activity due to microgravity. This is a problem, because osteoclasts break down the bones into minerals that are reabsorbed by the body. Osteoblasts are not consecutively active with the osteoclasts, causing the bone to be constantly diminished with no recovery. This increase in osteoclasts activity has been seen particularly in the pelvic region, because this is the region which carries the biggest load with gravity present. A study demonstrated that in healthy mice, osteoclasts appearance increased by 197%, accompanied by a down-regulation of osteoblasts and growth factors that are known to help with the formation of new bone, after only sixteen days of exposure to microgravity. Elevated blood calcium levels from the lost bone result in dangerous calcification of soft tissues and potential kidney stone formation. It is still unknown whether bone recovers completely. Unlike people with osteoporosis, astronauts eventually regain their bone density. After a 3–4 month trip into space, it takes about 2–3 years to regain lost bone density. New techniques are being developed to help astronauts recover faster. Research on diet, exercise and medication may hold the potential to aid the process of growing new bone.
To prevent some of these adverse physiological effects, the ISS is equipped with two treadmills (including the COLBERT), and the aRED (advanced Resistive Exercise Device), which enable various weight-lifting exercises which add muscle but do nothing for bone density, and a stationary bicycle; each astronaut spends at least two hours per day exercising on the equipment. Astronauts use bungee cords to strap themselves to the treadmill. Astronauts subject to long periods of weightlessness wear pants with elastic bands attached between waistband and cuffs to compress the leg bones and reduce osteopenia.
Currently, NASA is using advanced computational tools to understand the how to best counteract the bone and muscle atrophy experienced by astronauts in microgravity environments for prolonged periods of time. The Human Research Program's Human Health Countermeasures Element chartered the Digital Astronaut Project to investigate targeted questions about exercise countermeasure regimes. NASA is focusing on integrating a model of the advanced Resistive Exercise Device (ARED) currently on board the International Space Station with OpenSim  musculoskeletal models of humans exercising with the device. The goal of this work is to use inverse dynamics to estimate joint torques and muscle forces resulting from using the ARED, and thus more accurately prescribe exercise regimens for the astronauts. These joint torques and muscle forces could be used in conjunction with more fundamental computational simulations of bone remodeling and muscle adaptation in order to more completely model the end effects of such countermeasures, and determine whether a proposed exercise regime would be sufficient to sustain astronaut musculoskeletal health.
The second effect of weightlessness takes place in human fluids. The body is made up of 60% water, much of it intra-vascular and inter-cellular. Within a few moments of entering a microgravity environment, fluid is immediately re-distributed to the upper body resulting in bulging neck veins, puffy face and sinus and nasal congestion which can last throughout the duration of the trip and is very much like the symptoms of the common cold. In space the autonomic reactions of the body to maintain blood pressure are not required and fluid is distributed more widely around the whole body. This results in a decrease in plasma volume of around 20%. These fluid shifts initiate a cascade of adaptive systemic effects that can be dangerous upon return to earth. Orthostatic intolerance results in astronauts returning to Earth after extended space missions being unable to stand unassisted for more than 10 minutes at a time without fainting. This is due in part to changes in the autonomic regulation of blood pressure and the loss of plasma volume. Although this effect becomes worse the longer the time spent in space, as yet all individuals have returned to normal within at most a few weeks of landing.
In space, astronauts lose fluid volume—including up to 22% of their blood volume. Because it has less blood to pump, the heart will atrophy. A weakened heart results in low blood pressure and can produce a problem with "orthostatic tolerance", or the body's ability to send enough oxygen to the brain without the astronaut's fainting or becoming dizzy. "Under the effects of the earth's gravity, blood and other body fluids are pulled towards the lower body. When gravity is taken away or reduced during space exploration, the blood tends to collect in the upper body instead, resulting in facial edema and other unwelcome side effects. Upon return to earth, the blood begins to pool in the lower extremities again, resulting in orthostatic hypotension."
Disruption of sensesEdit
In 2013 NASA published a study that found changes to the eyes and eyesight of monkeys with spaceflights longer than 6 months. Noted changes included a flattening of the eyeball and changes to the retina. Space traveler's eye-sight can become blurry after too much time in space. Another effect is known as Cosmic ray visual phenomena
...[a] NASA survey of 300 male and female astronauts, about 23 percent of short-flight and 49 percent of long-flight astronauts said they had experienced problems with both near and distance vision during their missions. Again, for some people vision problems persisted for years afterward.— NASA
- Intracranial pressure
Because weightlessness increases the amount of fluid in the upper part of the body, astronauts experience increased intracranial pressure. This appears to increase pressure on the backs of the eyeballs, affecting their shape and slightly crushing the optic nerve. This effect was noticed in 2012 in a study using MRI scans of astronauts who had returned to Earth following at least one month in space. Such eyesight problems could be a major concern for future deep space flight missions, including a manned mission to the planet Mars.
If indeed elevated intracranial pressure is the cause, artificial gravity might present one solution, as it would for many human health risks in space. However, such artificial gravitational systems have yet to be proven. More, even with sophisticated artificial gravity, a state of relative microgravity may remain, the risks of which remain unknown. 
One effect of weightlessness on humans is that some astronauts report a change in their sense of taste when in space. Some astronauts find that their food is bland, others find that their favorite foods no longer taste as good (one who enjoyed coffee disliked the taste so much on a mission that he stopped drinking it after returning to Earth); some astronauts enjoy eating certain foods that they would not normally eat, and some experience no change whatsoever. Multiple tests have not identified the cause, and several theories have been suggested, including food degradation, and psychological changes such as boredom. Astronauts often choose strong-tasting food to combat the loss of taste.
Additional physiological effectsEdit
After two months, calluses on the bottoms of feet molt and fall off from lack of use, leaving soft new skin. Tops of feet become, by contrast, raw and painfully sensitive. Tears cannot be shed while crying, as they stick together into a ball. In microgravity odors quickly permeate the environment, and NASA found in a test that the smell of cream sherry triggered the gag reflex. Various other physical discomforts such as back and abdominal pain are common because of the readjustment to gravity, where in space there was no gravity and these muscles could freely stretch. These may be part of the asthenization syndrome reported by cosmonauts living in space over an extended period of time, but regarded as anecdotal by astronauts. Fatigue, listlessness, and psychosomatic worries are also part of the syndrome. The data is inconclusive; however, the syndrome does appear to exist as a manifestation of all the internal and external stress crews in space must face.
Astronauts may not be able to quickly return to Earth or receive medical supplies, equipment or personnel if a medical emergency occurs. The astronauts may have to rely for long periods on their limited existing resources and medical advice from the ground.
The psychological effects of living in space have not been clearly analyzed but analogies on Earth do exist, such as Arctic research stations and submarines. The enormous stress on the crew, coupled with the body adapting to other environmental changes, can result in anxiety, insomnia and depression.
There has been considerable evidence that psychosocial stressors are among the most important impediments to optimal crew morale and performance. Cosmonaut Valery Ryumin, twice Hero of the Soviet Union, quotes this passage from The Handbook of Hymen by O. Henry in his autobiographical book about the Salyut 6 mission: "If you want to instigate the art of manslaughter just shut two men up in a eighteen by twenty-foot cabin for a month. Human nature won't stand it."
NASA's interest in psychological stress caused by space travel, initially studied when their manned missions began, was rekindled when astronauts joined cosmonauts on the Russian space station Mir. Common sources of stress in early American missions included maintaining high performance while under public scrutiny, as well as isolation from peers and family. On the ISS, the latter is still often a cause of stress, such as when NASA Astronaut Daniel Tani's mother died in a car accident, and when Michael Fincke was forced to miss the birth of his second child.
The amount and quality of sleep experienced in space is poor due to highly variable light and dark cycles on flight decks and poor illumination during daytime hours in the space craft. Even the habit of looking out of the window before retiring can send the wrong messages to the brain, resulting in poor sleep patterns. These disturbances in circadian rhythm have profound effects on the neurobehavioural responses of crew and aggravate the psychological stresses they already experience (see Fatigue and sleep loss during spaceflight for more information). Sleep is disturbed on the ISS regularly due to mission demands, such as the scheduling of incoming or departing space vehicles. Sound levels in the station are unavoidably high because the atmosphere is unable to thermosiphon; fans are required at all times to allow processing of the atmosphere, which would stagnate in the freefall (zero-g) environment. Fifty percent of space shuttle astronauts take sleeping pills and still get 2 hours less sleep each night in space than they do on the ground. NASA is researching two areas which may provide the keys to a better night’s sleep, as improved sleep decreases fatigue and increases daytime productivity. A variety of methods for combating this phenomenon are constantly under discussion.
Duration of space travelEdit
A study of the longest spaceflight concluded that the first three weeks represent a critical period where attention is adversely affected because of the demand to adjust to the extreme change of environment. While Skylab's three crews remained in space 1, 2, and 3 months respectively, long-term crews on Salyut 6, Salyut 7, and the ISS remain about 5–6 months, while MIR expeditions often lasted longer. The ISS working environment includes further stress caused by living and working in cramped conditions with people from very different cultures who speak different languages. First generation space stations had crews who spoke a single language, while 2nd and 3rd generation stations have a crew from many cultures who speak many languages. The ISS is unique because visitors are not classed automatically into 'host' or 'guest' categories as with previous stations and spacecraft, and may not suffer from feelings of isolation in the same way.
The sum of human experience has resulted in the accumulation of 58 solar years in space and a much better understanding of how the human body adapts. In the future, industrialisation of space and exploration of inner and outer planets will require humans to endure longer and longer periods in space. The majority of current data comes from missions of short duration and so some of the long-term physiological effects of living in space are still unknown. A round trip to Mars with current technology is estimated to involve at least 18 months in transit alone. Knowing how the human body reacts to such time periods in space is a vital part of the preparation for such journeys. On-board medical facilities need to be adequate for coping with any type of trauma or emergency as well as contain a huge variety of diagnostic and medical instruments in order to keep a crew healthy over a long period of time, as these will be the only facilities available on board a spacecraft for coping not only with trauma, but also with the adaptive responses of the human body in space.
At the moment only rigorously tested humans have experienced the conditions of space. If off-world colonization someday begins, many types of people will be exposed to these dangers, and the effects on the very young are completely unknown. On October 29, 1998, John Glenn, one of the original Mercury 7, returned to space at the age of 77. His space flight, which lasted 9 days, provided NASA with important information about the effects of space flight in older people. Factors such as nutritional requirements and physical environments which have so far not been examined will become important. Overall, there is little data on the manifold effects of living in space, and this makes attempts toward mitigating the risks during a lengthy space habitation difficult. Test beds such as the ISS are currently being utilized to research some of these risks.
The environment of space is still largely unknown, and there will likely be as-yet-unknown hazards. Meanwhile, future technologies such as artificial gravity and more complex bioregenerative life support systems may someday be capable of mitigating some risks.
- Fatigue and sleep loss during spaceflight
- Food systems on space exploration missions
- Intervertebral disc damage and spaceflight
- Locomotion in space
- Mars Analog Habitats
- Medical treatment during spaceflight
- Overview effect
- Reduced muscle mass, strength and performance in space
- Renal stone formation in space
- Space colonization
- Spaceflight radiation carcinogenesis
- Team composition and cohesion in spaceflight missions
- Visual impairment due to intracranial pressure
- Chang, Kenneth (27 January 2014). "Beings Not Made for Space". New York Times. Retrieved 27 January 2014.
- Kanas, Nick; Manzey, Dietrich (2008), "Basic Issues of Human Adaptation to Space Flight", Space Psychology and Psychiatry, Space Technology Library, 22: 15–48, ISBN 978-1-4020-6769-3, doi:10.1007/978-1-4020-6770-9_2
- "Health and Fitness". Space Future. Retrieved 2012-05-10.
- Toyohiro Akiyama (April 14, 1993). "The Pleasure of Spaceflight". Journal of Space Technology and Science. 9 (1): 21–23. Retrieved 2012-05-10.
- Dunn, Marcia (October 29, 2015). "Report: NASA needs better handle on health hazards for Mars". AP News. Retrieved October 30, 2015.
- Staff (October 29, 2015). "NASA's Efforts to Manage Health and Human Performance Risks for Space Exploration (IG-16-003)" (PDF). NASA. Retrieved October 29, 2015.
- "Breathing Easy on the Space Station". NASA. Archived from the original on 2008-09-21. Retrieved 2012-04-26.
- Landis, Geoffrey A. (7 August 2007). "Human Exposure to Vacuum". www.geoffreylandis.com. Archived from the original on 2009-07-21. Retrieved 2012-04-25.
- Harding, Richard M. (1989). Survival in Space: Medical Problems of Manned Spaceflight. London: Routledge. ISBN 0-415-00253-2.
- Czarnik, Tamarack R. (1999). "Ebullism at 1 Million Feet: Surviving Rapid/Explosive Decompressionn". Retrieved 2009-10-26.
- Billings, Charles E. (1973). "Chapter 1) Barometric Pressure". In Parker, James F.; West, Vita R. Bioastronautics Data Book (Second ed.). NASA. p. 5. NASA SP-3006. Retrieved 2012-09-23. 942 pages. "33.1 MB". 33.1 MB
- Webb, P. (1968). "The Space Activity Suit: An Elastic Leotard for Extravehicular Activity". Aerospace Medicine. 39 (4): 376–83. PMID 4872696.
- Author/s not stated (3 June 1997). "Ask an Astrophysicist: Human Body in a Vacuum". NASA(Goddard Space Flight Centre). Retrieved 2012-04-25.
- Cooke, J.P,; Bancroft, R.W. (1966). "Some Cardiovascular Responses in Anesthetized Dogs During Repeated Decompressions to a Near-Vacuum". Aerospace Medicine. 37: 1148–52. PMID 5297100.
- Greene, Nick (n.d.). "What Happens To The Human Body In A Vacuum?". About.com. Retrieved 2012-04-25.
- Roth (M.D.), Emanuel M. (November 1, 1968). "Rapid (Explosive) Decompression Emergencies in Pressure-suited Subjects". The Lovelace Foundation (for NASA). NASA-CR-1223. Retrieved 2012-09-23. 131 pages. "5.65 MB". 5.65 MB
- "Two MSC Employees Commended For Rescue in Chamber Emergency" (PDF). Roundup. Vol.6 No.6. Hoston, Texas: NASA Manned Spacecraft Center. 6 January 1967. p. 3. Retrieved 2012-09-23. "1.76 MB". 1.76 MB
- "Ask a scientist. Why is space cold?". Argonne National Laboratory, Division of Educational Programs. Retrieved 2008-11-27.
- Kerr, Richard (31 May 2013). "Radiation Will Make Astronauts' Trip to Mars Even Riskier". Science. 340 (6136): 1031. PMID 23723213. doi:10.1126/science.340.6136.1031. Retrieved 31 May 2013.
- Zeitlin, C. et al. (31 May 2013). "Measurements of Energetic Particle Radiation in Transit to Mars on the Mars Science Laboratory". Science. 340 (6136): 1080–84. Bibcode:2013Sci...340.1080Z. doi:10.1126/science.1235989. Retrieved 31 May 2013.
- Chang, Kenneth (30 May 2013). "Data Point to Radiation Risk for Travelers to Mars". New York Times. Retrieved 31 May 2013.
- Space Radiation Hazards and the Vision for Space Exploration. NAP. 2006. ISBN 0-309-10264-2.
- "The Right Stuff for Super Spaceships". NASA. 16 September 2002. Retrieved 2012-05-10.
- Cherry, Jonathan D.; Frost, Jeffrey L.; Lemere, Cynthia A.; Williams, Jacqueline P.; Olschowka, John A.; O'Banion, M. Kerry (2012). "Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer's Disease". PLOS ONE. 7 (12): e53275. Bibcode:2012PLoSO...753275C. PMC . PMID 23300905. doi:10.1371/journal.pone.0053275. Retrieved January 7, 2013.
- Vipan K. Parihar et. al., Cosmic radiation exposure and persistent cognitive dysfunction, Sci. Rep. 6, 34774; doi:10.1038/srep34774 (2016)
- Staff (January 1, 2013). "Study Shows that Space Travel is Harmful to the Brain and Could Accelerate Onset of Alzheimer's". SpaceRef. Retrieved January 7, 2013.
- Cowing, Keith (January 3, 2013). "Important Research Results NASA Is Not Talking About (Update)". NASA Watch. Retrieved January 7, 2013.
- Jay Buckey (23 February 2006). Space Physiology. Oxford University Press USA. ISBN 978-0-19-513725-5.
- Ker Than (23 February 2006). "Solar Flare Hits Earth and Mars". Space.com.
- "A new kind of solar storm". NASA. 10 June 2005.
- Stephen Battersby (21 March 2005). "Superflares could kill unprotected astronauts". New Scientist.
- Gueguinou, N.; Huin-Schohn, C.; Bascove, M.; Bueb, J.-L.; Tschirhart, E.; Legrand-Frossi, C.; Frippiat, J.-P. (2009). "Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit". Journal of Leukocyte Biology. 86 (5): 1027–38. PMID 19690292. doi:10.1189/jlb.0309167.
- Fong, MD, Kevin (12 February 2014). "The Strange, Deadly Effects Mars Would Have on Your Body". Wired. Retrieved 12 February 2014.
- Scott, Jim (30 September 2017). "Large solar storm sparks global aurora and doubles radiation levels on the martian surface". Phys.org. Retrieved 30 September 2017.
- "Exercise Physiology and Countermeasures Project (ExPC): Keeping Astronauts Healthy in Reduced Gravity". NASA. Archived from the original on 2012-05-04. Retrieved 2012-05-11.
- Caspermeyer, Joe (23 September 2007). "Space flight shown to alter ability of bacteria to cause disease". Arizona State University. Retrieved 14 September 2017.
- Kim W, et al. (April 29, 2013). "Spaceflight Promotes Biofilm Formation by Pseudomonas aeruginosa". PLOS ONE. 8 (4): e6237. Bibcode:2013PLoSO...862437K. doi:10.1371/journal.pone.0062437. Retrieved July 5, 2013.
- Dvorsky, George (13 September 2017). "Alarming Study Indicates Why Certain Bacteria Are More Resistant to Drugs in Space". Gizmodo. Retrieved 14 September 2017.
- Dose, K.; Bieger-Dose, A.; Dillmann, R.; Gill, M.; Kerz, O.; Klein, A.; Meinert, H.; Nawroth, T.; Risi, S.; Stridde, C. (1995). "ERA-experiment "space biochemistry"". Advances in Space Research. 16 (8): 119–129. Bibcode:1995AdSpR..16..119D. PMID 11542696. doi:10.1016/0273-1177(95)00280-R.
- Vaisberg, Horneck G.; Eschweiler, U.; Reitz, G.; Wehner, J.; Willimek, R.; Strauch, K. (1995). "Biological responses to space: results of the experiment "Exobiological Unit" of ERA on EURECA I". Adv Space Res. 16 (8): 105–18. Bibcode:1995AdSpR..16..105V. PMID 11542695. doi:10.1016/0273-1177(95)00279-N.
- "Why Do Astronauts Suffer From Space Sickness?". ScienceDaily. 2008-05-23.
- Bloomberg, Jacob J.; Kozlovskaya, Inessa B. (1996). "The Effects of Long-Duration Space Flight on Eye, Head, and Trunk Coordination During Locomotion (9307191)". NASA. Archived from the original on 2012-02-07. Retrieved 2012-05-10.
- Robert E. Stevenson; interviewed by Carol Butler (13 May 1999). "Oral History 2 Transcript" (PDF). Johnson Space Center Oral History Project. Retrieved 2012-05-10.
Jake Garn was sick, was pretty sick. I don't know whether we should tell stories like that. But anyway, Jake Garn, he has made a mark in the Astronaut Corps because he represents the maximum level of space sickness that anyone can ever attain, and so the mark of being totally sick and totally incompetent is one Garn. Most guys will get maybe to a tenth Garn, if that high. And within the Astronaut Corps, he forever will be remembered by that.
- "Muscle Atrophy" (PDF). NASA. Retrieved 2013-08-03.
- "Space Bones". NASA. October 1, 2001. Retrieved 2012-05-12.
- O'Flaherty EJ. Modeling Normal Aging Bone Loss, with Consideration of Bone Loss in Osteoporosis. Toxicol Sci 55 (1): 171–88, 2000.
- Rodan GA. Bone Homeostasis. P Natl A Sci USA 95 (23): 13361–62, 1998.
- Citation needed
- Blaber E, Dvorochkin N, Lee C, Alwood JS, Yousuf R, Pianetta P, Globus RK, Burns BP, Almeida EAC. Microgravity induces pelvic bone loss through osteocloastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21. PLoS ONE 8(4): e61372, 2013.
- Schneider SM, Amonette WE, Blazine K, Bentley J, Lee SM, Loehr JA, Moore AD Jr, Rapley M, Mulder ER, Smith SM (November 2003). "Training with the International Space Station interim resistive exercise device.". Medical Science Sports Exercise. 35 (11): 1935–45. PMID 14600562. doi:10.1249/01.MSS.0000093611.88198.08.
- "Daily life". ESA. 19 July 2004. Retrieved 28 October 2009.
- Cheryl L. Mansfield (7 November 2008). "Station Prepares for Expanding Crew". NASA. Retrieved 17 September 2009.
- "Bungee Cords Keep Astronauts Grounded While Running". NASA. 16 June 2009. Retrieved 23 August 2009.
- Amiko Kauderer (19 August 2009). "Do Tread on Me". NASA. Retrieved August 23, 2009.
- "Digital Astronaut Simulates Human Body in Space". Space Flight Systems @ GRC: Human Research Program, ISS and Human Health Office, Digital Astronaut. NASA Glenn Research Center: 23 Feb. 2013. http://spaceflightsystems.grc.nasa.gov/SOPO/ICHO/HRP/DA/
- White Ronald J., McPhee Jancy C. (2007). "The Digital Astronaut: An integrated modeling and database system for space biomedical research and operations". Acta Astronautica. 60 (4): 273–80. Bibcode:2007AcAau..60..273W. doi:10.1016/j.actaastro.2006.08.009.
- Lewandowski, B. E., et al. "Musculoskeletal Modeling Component of the NASA Digital Astronaut Project." (2011).
- Delp, Scott L., et al. "OpenSim: open-source software to create and analyze dynamic simulations of movement." Biomedical Engineering, IEEE Transactions on 54.11 (2007) 1940–1950.
- "When Space Makes You Dizzy". NASA. 2002. Retrieved 2012-04-25.
- Mader, T. H.; et al. (2011). "Optic Disc Edema, Globe Flattening, Choroidal Folds, and Hyperopic Shifts Observed in Astronauts after Long-duration Space Flight". Ophthalmology. 118 (10): 2058–69. PMID 21849212. doi:10.1016/j.ophtha.2011.06.021.
- Puiu, Tibi (November 9, 2011). "Astronauts’ vision severely affected during long space missions". zmescience.com. Retrieved February 9, 2012.
- "Male Astronauts Return With Eye Problems (video)". CNN News. 9 February 2012. Retrieved 2012-04-25.
- Space Staff (13 March 2012). "Spaceflight Bad for Astronauts' Vision, Study Suggests". Space.com. Retrieved 14 March 2012.
- Kramer, Larry A.; et al. (13 March 2012). "Orbital and Intracranial Effects of Microgravity: Findings at 3-T MR Imaging". Radiology. 263 (3): 819–827. doi:10.1148/radiol.12111986. Retrieved 14 March 2012.
- "Eye Problems Common in Astronauts". Discovery News. 13 March 2012. Retrieved 2012-04-25.
- "NASAexplores 5–8: A Matter Of Taste". NASAexplores. NASAexplores. May 29, 2003. Archived from the original on January 7, 2008.
- Bourland, Charles T. (2006-04-07). "Charles T. Bourland". NASA Johnson Space Center Oral History Project (Interview). Interview with Ross-Nazzal, Jennifer. Retrieved 24 December 2014.
- Pettit, Don (2012-05-04). "Toe Koozies". Air & Space/Smithsonian. Retrieved May 8, 2012.
- Garber, Megan (2013-01-14). "Why You Can't Cry in Space". The Atlantic. Retrieved January 15, 2013.
- The Body in Space
- Nick Kanas, MD, Vyacheslav Salnitskiy, Vadim Gushin, MD, Daniel S. Weiss, Ellen M. Grund, MS, Christopher Flynn, MD, Olga Kozerenko, MD, Alexander Sled, MS and Charles R. Marmar, MD (November 1, 2001). "Asthenia – Does It Exist in Space?". Psychosomatic Medicine. 63 (6): 874–80. PMID 11719624. doi:10.1097/00006842-200111000-00004.
- Dickens, Peter (March 2017). "Astronauts at Work: The Social Relations of Space Travel". Monthly Review.
- Peter Suedfeld1; Kasia E. Wilk; Lindi Cassel. Flying with Strangers: Postmission Reflections of Multinational Space Crews.
- Ryumin, Valery A Year off of Earth: A cosmonaut's journal. (In Russian). Moscow: Molodaya Gvardia Publishing, 1987. Retrieved 01.21.2013
- "Wide Awake in Outer Space". Retrieved 9 September 2013.
- Dietrich Manzey; Bernd Lorenz; Valeri Poljakov (1998). "Mental performance in extreme environments: results from a performance monitoring study during a 438-day spaceflight". Ergonomics. 41 (4): 537–559. PMID 9557591. doi:10.1080/001401398186991. Retrieved 2012-05-10.
- Nasa Report: Space Travel 'Inherently Hazardous' to Human Health. Leonard David. 2001
- Space Physiology and Medicine. Third edition. A. E. Nicogossian, C. L. Huntoon and S. L. Pool. Lea & Febiger, 1993.
- L.-F. Zhang. Vascular adaptation to microgravity: What have we learned?. Journal of Applied Physiology. 91(6) (pp 2415–2430), 2001.
- G. Carmeliet, Vico. L, Bouillon R. Critical Reviews in Eukaryotic Gene Expression. Vol 11(1–3) (pp 131–144), 2001.
- F.A. Cucinotta et al. Space radiation cancer risks and uncertainties for Mars missions. Radiation Research. Vol 156:5 II;pp 682–688, 2001.
- F.A. Cucinotta et al. Space radiation and cataracts in astronauts. Radiation Research. Vol 156(5 I) (pp 460–466), 2001.
- Styf, Jorma R. MD; Hutchinson, Karen BS; Carlsson, Sven G. PhD, and; Hargens, Alan R. Ph.D. Depression, Mood State, and Back Pain During
- Altitude Decompression Sickness Susceptibility, MacPherson, G; Aviation, Space, and Environmental Medicine, Volume 78, Number 6, June 2007, pp. 630–631(2)
- Decision Analysis in Aerospace Medicine: Costs and Benefits of a Hyperbaric Facility in Space, John-Baptiste, A; Cook, T; Straus, S; Naglie, G; et al. Aviation, Space, and Environmental Medicine, Volume 77, Number 4, April 2006, pp. 434–443(10)
- Incidence of Adverse Reactions from 23,000 Exposures to Simulated Terrestrial Altitudes up to 8900 m, DeGroot, D; Devine JA; Fulco CS; Aviation, Space, and Environmental Medicine, Volume 74, Number 9, September 2003, pp. 994–997(4)