Despite the place-name ending in "-holme" (which is normally from Old Norse holmr "island, water-meadow"), it is not from this word. Instead the ending is Old English ham "homestead", rather than the similar Old English hamm "river-meadow, bend in river", despite the village's proximity to the River Humber. The name was recorded as Wexnem in 1162.
In 1823 inhabitants in the village numbered 72. Occupations included seven farmers.
- Mills, Anthony David (2003); A Dictionary of British Place Names, Oxford University Press, revised edition (2011), p.486. ISBN 019960908X
- Ekwall, Eilert (1960). The concise Oxford dictionary of English place-names (4 ed.). Oxford: Clarendon Press. p. 502. ISBN 0-19-869103-3.
- Baines, Edward; History, Directory & Gazetteer of the County of York (1823), p.397. ISBN 1230139141
- Gazetteer — A–Z of Towns Villages and Hamlets. East Riding of Yorkshire Council. 2006. p. 11.
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