Doctorwolfie

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Welcome to Wikipedia. This account was created for you.

Hey, if you need to ask me a question, E mail me at doctorwolfie@yahoo.com

My website is www.doctorwolfie.com

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Hello, Doctorwolfie. You have new messages at Jfdwolff's talk page.
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JFW | T@lk 21:20, 17 October 2011 (UTC)

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Autoimmune disease (check to confirm | fix with Dab solver)

was linked to TTP, ITP, NAIT, HUS

Any suggestions for improving this automated tool are welcome. Thanks, DPL bot (talk) 13:07, 16 November 2011 (UTC)

ATP: Ionization in biological systems

I greatly appreciated your comments on the talk page related to ATP. The last sentence in the "Ionization in biological systems" seems incomplete, and since you understand this page better than most, I hoped maybe you could help (I can't figure out what they're trying to say!)

As I read the talk page I was wondering if you might be the person that might help me finally understand; it seems as though biologists (and perhaps chemists) learn about thermodynamics, but there seems to be a disconnect with modern quantum mechanics. With reference to "high energy bonds" there was discussion about the energy being (or not) like energy stored in a spring. The page then goes on to describe the ionization state of ATP as being 4-. I'm probably ridiculously naive in my understanding, but is it that these electrons (the 4-) that are riding along on the ATP are in a high energy state (ie bearing photons) which will be yielded upon hydrolysis? Or do I totally have my head...er..up somewhere? doctorwolfie (talk) 21:12, 2 February 2012 (UTC)

The part you couldn't figure out was a simple vandalism (and a recent one) by an IP editor. If that happens when you read an article, go a few versions back to one by a username and see if the problem is gone. Then go up to see which IP added it (usually vandals are IPs or have red usernames, showing their TALK page is empty). To get rid of vandalisms, just go back to the last "good" version of an article, hit "edit this page" and then just save with the comment that you're "RVV" (reverting vandals). I did much the same. That wiped out your small "fix" but that was to a sentence that had been misplaced anyway (in physical properties).

The question of energy is complicated. All chemical bonds (a good article to read) require energy to break, or they wouldn't be bonds. You have to pull them apart, and that takes a force working through a distance. This doesn't change in QM. The "high energy bonds" in ATP still take energy to BREAK, but you get more energy BACK when new bonds are formed between the hydrolyzed phosphate and water molecules. So net energy is released. The same happens with gasoline and oxygen--- it takes energy to break them up, but you get more back when the new bonds form in CO2 and H2O.

ATP(4-) means most of the ATP rides around in a water solution ionized 4 times, so 4 of those protons are gone, leaving 4 oxygens with a pair of electrons and a negative charge. This is like any polyatomic anion (sulfate, nitrate, phosphate). THe counteranion here could be anything but there's a magnesium (2+) coiled up and physically associated with the polyionized ATP, so the best formula for it is really Mg-ATP(2-), which as a complex is really only twice ionized. When you get solid ATP in a bottle from some chem company, something else positive has to balance those charges, and it can be Na+, H+, or another Mg(2+). In the cell, these are counterions in solution.

These electrons are not particularly in a high energy state-- when salts or acids dissolve in water, they can liberate energy (get hot) or even suck energy up (get cold). Those self cooling ice packs called instant cold backs that are full of some salt and water, which absorb heat when the salt disolves (or when it crystallizes out). This is driven by the entropy term in the G = H-TS, so as long as S is in the right direction to drive G, the H can be positive or negative.

So to make this short, it's not the bond that is broken when the H+ or cation comes off the ATP as it dissolves that provides most of the free energy, although I suppose that would be possible to do, if the cell had a way to seqester solid salts from dissolved ones. As it doesn't, it is forced to use a reaction in which both products and reactants are already dissolved, and that's the hydrolysis of an already-ionized ATP. SBHarris 23:33, 2 February 2012 (UTC)

Not a good day

I was hoping to draw a little inspiration from Wikipedia today; trying to just review something neutral, I started to review Autoimmune_Diseases and was hurt by some of the Wikipedians poor opinions of physicians. Listen, I know we're not perfect, but unlike pure science, we are charged with the responsibility of interrupting disease processes before we fully understand them; people demand therapy before it's proven; I know....people ask me every day. Whenever I see really smart people trashing my profession I get defensive, but at the same time I have to agree; if it didn't pay well, nobody would do it. We're like a line of people trying to keep a huge crowd of people from falling off a cliff. When one slips through and crashes to their death, we're the ones they blame. Yet if they push us off the cliff, then they will be next in line. It's a long way down. doctorwolfie (talk) 12:14, 21 February 2012 (UTC)

Neutrophil NET

Can someone incorporate the information from https://en.wikipedia.org/wiki/Neutrophil_extracellular_traps ?

Disambiguation link notification for July 20

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Wikipedia study- Thank you

Hello DOctorwolfie, I hope you remember speaking to me in the summer of 2012 about your motivations for contributing to the health-related pages on Wikipedia. The great news is that the study got published this Wednesday in JMIR (Journal of Medical Internet Research). You can read it here: http://www.jmir.org/2014/12/e260 This would not have been possible without your contributions so once again, I would like to thank you for taking the time and sharing your experiences with me. I also wrote an entry about my own experience with the study, about additional observations and how I plan to further extend my research - published in the WMF blog today: https://blog.wikimedia.org.uk/2014/12/who-writes-wikipedias-health-and-medical-pages-and-why/If you have any comments or questions please get in touch.Perhaps see you at the next Wikimania conference in Mexico! Best Wishes Hydra Rain (talk) 21:15, 7 December 2014 (UTC)

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Housekeeping gene

Hi, I noticed that you have written Housekeeping gene. Unfortunately, the article has seven links to disambiguation pages. Usually I am quite able to solve these links but this article is so far outside my comfort zone that it is nearly Chinese for me. So trying to solve these seven links would be high stake gambling. So I admit defeat and hope that you can solve the links: AARS, DARS, KARS, MARS, NARS, PPID and TARS. Thanks in advance. The Banner talk 21:39, 23 February 2015 (UTC)

ArbCom elections are now open!

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ArbCom Elections 2016: Voting now open!

Hello, Doctorwolfie. Voting in the 2016 Arbitration Committee elections is open from Monday, 00:00, 21 November through Sunday, 23:59, 4 December to all unblocked users who have registered an account before Wednesday, 00:00, 28 October 2016 and have made at least 150 mainspace edits before Sunday, 00:00, 1 November 2016.

The Arbitration Committee is the panel of editors responsible for conducting the Wikipedia arbitration process. It has the authority to impose binding solutions to disputes between editors, primarily for serious conduct disputes the community has been unable to resolve. This includes the authority to impose site bans, topic bans, editing restrictions, and other measures needed to maintain our editing environment. The arbitration policy describes the Committee's roles and responsibilities in greater detail.

If you wish to participate in the 2016 election, please review the candidates' statements and submit your choices on the voting page. MediaWiki message delivery (talk) 22:08, 21 November 2016 (UTC)

AfC notification: User:Doctorwolfie/new article name here has a new comment

I've left a comment on your Articles for Creation submission, which can be viewed at User:Doctorwolfie/new article name here. Thanks! Robert McClenon (talk) 04:05, 27 October 2019 (UTC)

AfC notification: User:Doctorwolfie/new article name here has a new comment

I've left a comment on your Articles for Creation submission, which can be viewed at User:Doctorwolfie/new article name here. Thanks! Robert McClenon (talk) 12:46, 28 October 2019 (UTC)

Your submission at Articles for creation: new article name here (October 28)

Your recent article submission to Articles for Creation has been reviewed! Unfortunately, it has not been accepted at this time. The reasons left by Robert McClenon were: Please check the submission for any additional comments left by the reviewer. You are encouraged to edit the submission to address the issues raised and resubmit when they have been resolved.

• If you would like to continue working on the submission, go to User:Doctorwolfie/new article name here and click on the "Edit" tab at the top of the window.
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Robert McClenon (talk) 12:47, 28 October 2019 (UTC)

Hello, Doctorwolfie! Having an article declined at Articles for Creation can be disappointing. If you are wondering why your article submission was declined, please post a question at the Articles for creation help desk. If you have any other questions about your editing experience, we'd love to help you at the Teahouse, a friendly space on Wikipedia where experienced editors lend a hand to help new editors like yourself! See you there! Robert McClenon (talk) 12:47, 28 October 2019 (UTC)

Your submission at Articles for creation

Your recent article submission to Articles for Creation has been reviewed! Unfortunately, it has not been accepted at this time. Please check the submission for any additional comments left by the reviewer. You are encouraged to edit the submission to address the issues raised and resubmit when they have been resolved.

• If you would like to continue working on the submission, go to the submission and click on the "Edit" tab at the top of the window.
• If you now believe the draft cannot meet Wikipedia's standards or do not wish to progress it further, you may request deletion. Please go to the submission, click on the "Edit" tab at the top of the window, add "{{db-self}}" at the top of the draft text and click the blue "publish changes" button to save this edit.
• If you do not make any further changes to your draft, in 6 months, it will be considered abandoned and may be deleted.
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2600:100C:B20F:2741:31AD:CFF5:7B62:5669 (talk) 13:00, 28 October 2019 (UTC)

Dear Robert I haven’t proposed any new articles, at least not in years: have I been hacked? I used to do a lot of things with developmental disabilities, so either this was a very old proposal that I had forgotten about, or a bizarre case of spear-phishing?

Draft:Diagnosis of Neurodevelopmental Disorders concern

Hi there, I'm HasteurBot. I just wanted to let you know that Draft:Diagnosis of Neurodevelopmental Disorders, a page you created, has not been edited in 5 months. The Articles for Creation space is not an indefinite storage location for content that is not appropriate for articlespace.

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Your draft article, Draft:Diagnosis of Neurodevelopmental Disorders

Hello, Doctorwolfie. It has been over six months since you last edited the Articles for Creation submission or Draft page you started, "Diagnosis of Neurodevelopmental Disorders".

In accordance with our policy that Wikipedia is not for the indefinite hosting of material deemed unsuitable for the encyclopedia mainspace, the draft has been nominated for deletion. If you plan on working on it further, or editing it to address the issues raised if it was declined, simply and remove the {{db-afc}}, {{db-draft}}, or {{db-g13}} code.

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Thank you for your submission to Wikipedia! UnitedStatesian (talk) 23:09, 2 May 2020 (UTC)

Did we used to have something called a sandbox doctorwolfie (talk) 23:54, 11 August 2020 (UTC)