SC 292 begins at an intersection with SC 290 (West Main Street) in Duncan, within Spartanburg County. It travels to the east-northeast, crosses railroad tracks, and curves to the northeast. It crosses over the Middle Tyger River and enters Lyman. The highway crosses railroad tracks before passing Lyman Park. At Groce Road, SC 292 turns left and travels to the north-northwest. Three blocks later, it intersects U.S. Route 29 (US 29). The two highways travel concurrently to the west for one block, crossing railroad tracks along the way. The two highways intersect the western terminus of SC 129. SC 129/SC 292 travels to the north-northeast and immediately begin curving to the northeast. The only intersection along their short concurrency is with the southern terminus of SC 358 (Holly Springs Road). SC 292 travels to the north-northeast and crosses the North Tyger River before leaving the city limits. It curves back to the north-northeast and crosses Lake Cooley. It crosses Lawsons Fork Creek and enters Inman Mills. The highway travels southeast of Inman Mills Park. At the intersection with US 176 (Asheville Highway), the highway leaves Inman Mills and enters Inman. It curves to the northwest and turns right onto Prospect Street. Just after leaving town, it crosses Greene Creek. It crosses over Meadow Creek just before an interchange with Interstate 26 (I-26). A short distance later, it meets its eastern terminus, an intersection with SC 9 (Boiling Springs Road).