In medicine, a prosthesis (plural: prostheses; from Ancient Greek: πρόσθεσις, romanized: prósthesis, lit. 'addition, application, attachment'), or a prosthetic implant, is an artificial device that replaces a missing body part, which may be lost through trauma, disease, or a condition present at birth (congenital disorder). Prostheses are intended to restore the normal functions of the missing body part. Amputee rehabilitation is primarily coordinated by a physiatrist as part of an inter-disciplinary team consisting of physiatrists, prosthetists, nurses, physical therapists, and occupational therapists. Prostheses can be created by hand or with computer-aided design (CAD), a software interface that helps creators design and analyze the creation with computer-generated 2-D and 3-D graphics as well as analysis and optimization tools.
A person's prosthesis should be designed and assembled according to the person's appearance and functional needs. For instance, a person may need a transradial prosthesis, but the person needs to choose between an aesthetic functional device, a myoelectric device, a body-powered device, or an activity specific device. The person's future goals and economical capabilities may help them choose between one or more devices.
Craniofacial prostheses include intra-oral and extra-oral prostheses. Extra-oral prostheses are further divided into hemifacial, auricular (ear), nasal, orbital and ocular. Intra-oral prostheses include dental prostheses, such as dentures, obturators, and dental implants.
Penile prostheses are used to treat erectile dysfunction, correct penile deformity, perform phalloplasty and metoidioplasty procedures in biological men, and to build a new penis in female-to-male gender reassignment surgeries.
Limb prostheses include both upper- and lower-extremity prostheses.
Upper-extremity prostheses are used at varying levels of amputation: forequarter, shoulder disarticulation, transhumeral prosthesis, elbow disarticulation, transradial prosthesis, wrist disarticulation, full hand, partial hand, finger, partial finger. A transradial prosthesis is an artificial limb that replaces an arm missing below the elbow.
Upper limb prostheses can be categorized in three main categories: Passive devices, Body Powered devices, and Externally Powered (myoelectric) devices. Passive devices can either be passive hands, mainly used for cosmetic purposes, or passive tools, mainly used for specific activities (e.g. leisure or vocational). An extensive overview and classification of passive devices can be found in a literature review by Maat et.al. A passive device can be static, meaning the device has no movable parts, or it can be adjustable, meaning its configuration can be adjusted (e.g. adjustable hand opening). Despite the absence of active grasping, passive devices are very useful in bimanual tasks that require fixation or support of an object, or for gesticulation in social interaction. According to scientific data a third of the upper limb amputees worldwide use a passive prosthetic hand. Body Powered or cable-operated limbs work by attaching a harness and cable around the opposite shoulder of the damaged arm. A recent body-powered approach has explored the utilization of the user's breathing to power and control the prosthetic hand to help eliminate actuation cable and harness. The third category of prosthetic devices available is myoelectric arms. These work by sensing, via electrodes, when the muscles in the upper arm move, causing an artificial hand to open or close. In the prosthetics industry, a trans-radial prosthetic arm is often referred to as a "BE" or below elbow prosthesis.
Lower-extremity prostheses provide replacements at varying levels of amputation. These include hip disarticulation, transfemoral prosthesis, knee disarticulation, transtibial prosthesis, Syme's amputation, foot, partial foot, and toe. The two main subcategories of lower extremity prosthetic devices are trans-tibial (any amputation transecting the tibia bone or a congenital anomaly resulting in a tibial deficiency) and trans-femoral (any amputation transecting the femur bone or a congenital anomaly resulting in a femoral deficiency).
A transfemoral prosthesis is an artificial limb that replaces a leg missing above the knee. Transfemoral amputees can have a very difficult time regaining normal movement. In general, a transfemoral amputee must use approximately 80% more energy to walk than a person with two whole legs. This is due to the complexities in movement associated with the knee. In newer and more improved designs, hydraulics, carbon fiber, mechanical linkages, motors, computer microprocessors, and innovative combinations of these technologies are employed to give more control to the user. In the prosthetics industry, a trans-femoral prosthetic leg is often referred to as an "AK" or above the knee prosthesis.
A transtibial prosthesis is an artificial limb that replaces a leg missing below the knee. A transtibial amputee is usually able to regain normal movement more readily than someone with a transfemoral amputation, due in large part to retaining the knee, which allows for easier movement. Lower extremity prosthetics describe artificially replaced limbs located at the hip level or lower. In the prosthetics industry, a trans-tibial prosthetic leg is often referred to as a "BK" or below the knee prosthesis.
Prostheses are manufactured and fit by clinical Prosthetists. Prosthetists are healthcare professionals responsible for making, fitting, and adjusting prostheses and for lower limb prostheses will assess both gait and prosthetic alignment. Once a prosthesis has been fit and adjusted by a Prosthetist, a rehabilitation Physiotherapist (called Physical Therapist in America) will help teach a new prosthetic user to walk with a leg prosthesis. To do so, the physical therapist may provide verbal instructions and may also help guide the person using touch or tactile cues. This may be done in a clinic or home. There is some research suggesting that such training in the home may be more successful if the treatment includes the use of a treadmill. Using a treadmill, along with the physical therapy treatment, helps the person to experience many of the challenges of walking with a prosthesis.
In the United Kingdom, 75% of lower limb amputations are performed due to inadequate circulation (dysvascularity). This condition is often associated with many other medical conditions (co-morbidities) including diabetes and heart disease that may make it a challenge to recover and use a prosthetic limb to regain mobility and independence. For people who have inadequate circulation and have lost a lower limb, there is insufficient evidence due to a lack of research, to inform them regarding their choice of prosthetic rehabilitation approaches.
- Transfemoral (Above-knee)
- Transtibial (Below-knee)
- Ankle disarticulation (more commonly known as Syme's amputation)
- Knee disarticulation
- Hip disarticulation
- Partial foot amputations (Pirogoff, Talo-Navicular and Calcaneo-cuboid (Chopart), Tarso-metatarsal (Lisfranc), Trans-metatarsal, Metatarsal-phalangeal, Ray amputations, toe amputations).
- Van Nes rotationplasty
Prosthetic raw materialsEdit
Prosthetic are made lightweight for better convenience for the amputee. Some of these materials include:
- Wood (early prosthetics)
- Rubber (early prosthetics)
- Lightweight metals:
- Carbon fiber reinforced polymers
Wheeled prostheses have also been used extensively in the rehabilitation of injured domestic animals, including dogs, cats, pigs, rabbits, and turtles.
Prosthetics originate from the ancient Near East circa 3000 BCE, with the earliest evidence of prosthetics appearing in ancient Egypt and Iran. The earliest recorded mention of eye prosthetics is from the Egyptian story of the Eye of Horus dates circa 3000 BC, which involves the left eye of Horus being plucked out and then restored by Thoth. Circa 3000-2800 BC, the earliest archaeological evidence of prosthetics is found in ancient Iran, where an eye prosthetic is found buried with a woman in Shahr-i Shōkhta. It was likely made of bitumen paste that was covered with a thin layer of gold. The Egyptians were also early pioneers of foot prosthetics, as shown by the wooden toe found on a body from the New Kingdom circa 1000 BC. Another early textual mention is found in South Asia circa 1200 BC, involving the warrior queen Vishpala in the Rigveda. Roman bronze crowns have also been found, but their use could have been more aesthetic than medical.
An early mention of a prosthetic comes from the Greek historian Herodotus, who tells the story of Hegesistratus, a Greek diviner who cut off his own foot to escape his Spartan captors and replaced it with a wooden one.
Wood and metal prostheticsEdit
Pliny the Elder also recorded the tale of a Roman general, Marcus Sergius, whose right hand was cut off while campaigning and had an iron hand made to hold his shield so that he could return to battle. A famous and quite refined historical prosthetic arm was that of Götz von Berlichingen, made at the beginning of the 16th century. The first confirmed use of a prosthetic device, however, is from 950 to 710 BC. In 2000, research pathologists discovered a mummy from this period buried in the Egyptian necropolis near ancient Thebes that possessed an artificial big toe. This toe, consisting of wood and leather, exhibited evidence of use. When reproduced by bio-mechanical engineers in 2011, researchers discovered that this ancient prosthetic enabled its wearer to walk both barefoot and in Egyptian style sandals. Previously, the earliest discovered prosthetic was an artificial leg from Capua.
Around the same time, François de la Noue is also reported to have had an iron hand, as is, in the 17th Century, René-Robert Cavalier de la Salle. Henri de Tonti had a prosthetic hook for a hand. During the Middle Ages, prosthetic remained quite basic in form. Debilitated knights would be fitted with prosthetics so they could hold up a shield, grasp a lance or a sword, or stabilize a mounted warrior. Only the wealthy could afford anything that would assist in daily life.
One notable prosthesis was that belonging to an Italian man, who scientists estimate replaced his amputated right hand with a knife. Scientists investigating the skeleton, which was found in a Longobard cemetery in Povegliano Veronese, estimated that the man had lived sometime between the 6th and 8th centuries AD. Materials found near the man's body suggest that the knife prosthesis was attached with a leather strap, which he repeatedly tightened with his teeth.
During the Renaissance, prosthetics developed with the use of iron, steel, copper, and wood. Functional prosthetics began to make an appearance in the 1500s.
Technology progress before the 20th centuryEdit
An Italian surgeon recorded the existence of an amputee who had an arm that allowed him to remove his hat, open his purse, and sign his name. Improvement in amputation surgery and prosthetic design came at the hands of Ambroise Paré. Among his inventions was an above-knee device that was a kneeling peg leg and foot prosthesis with a fixed position, adjustable harness, and knee lock control. The functionality of his advancements showed how future prosthetics could develop.
Other major improvements before the modern era:
- Pieter Verduyn – First non-locking below-knee (BK) prosthesis.
- James Potts – Prosthesis made of a wooden shank and socket, a steel knee joint and an articulated foot that was controlled by catgut tendons from the knee to the ankle. Came to be known as "Anglesey Leg" or "Selpho Leg".
- Sir James Syme – A new method of ankle amputation that did not involve amputating at the thigh.
- Benjamin Palmer – Improved upon the Selpho leg. Added an anterior spring and concealed tendons to simulate natural-looking movement.
- Dubois Parmlee – Created prosthetic with a suction socket, polycentric knee, and multi-articulated foot.
- Marcel Desoutter & Charles Desoutter – First aluminium prosthesis
- Henry Heather Bigg, and his son Henry Robert Heather Bigg, won the Queen's command to provide "surgical appliances" to wounded soldiers after Crimea War. They developed arms that allowed a double arm amputee to crochet, and a hand that felt natural to others based on ivory, felt and leather.
At the end of World War II, the NAS (National Academy of Sciences) began to advocate better research and development of prosthetics. Through government funding, a research and development program was developed within the Army, Navy, Air Force, and the Veterans Administration.
Lower extremity modern historyEdit
After the Second World War a team at the University of California, Berkeley including James Foort and C.W. Radcliff helped to develop the quadrilateral socket by developing a jig fitting system for amputations above the knee. Socket technology for lower extremity limbs saw a further revolution during the 1980s when John Sabolich C.P.O., invented the Contoured Adducted Trochanteric-Controlled Alignment Method (CATCAM) socket, later to evolve into the Sabolich Socket. He followed the direction of Ivan Long and Ossur Christensen as they developed alternatives to the quadrilateral socket, which in turn followed the open ended plug socket, created from wood. The advancement was due to the difference in the socket to patient contact model. Prior to this, sockets were made in the shape of a square shape with no specialized containment for muscular tissue. New designs thus help to lock in the bony anatomy, locking it into place and distributing the weight evenly over the existing limb as well as the musculature of the patient. Ischial containment is well known and used today by many prosthetist to help in patient care. Variations of the ischial containment socket thus exists and each socket is tailored to the specific needs of the patient. Others who contributed to socket development and changes over the years include Tim Staats, Chris Hoyt, and Frank Gottschalk. Gottschalk disputed the efficacy of the CAT-CAM socket- insisting the surgical procedure done by the amputation surgeon was most important to prepare the amputee for good use of a prosthesis of any type socket design.
The first microprocessor-controlled prosthetic knees became available in the early 1990s. The Intelligent Prosthesis was the first commercially available microprocessor-controlled prosthetic knee. It was released by Chas. A. Blatchford & Sons, Ltd., of Great Britain, in 1993 and made walking with the prosthesis feel and look more natural. An improved version was released in 1995 by the name Intelligent Prosthesis Plus. Blatchford released another prosthesis, the Adaptive Prosthesis, in 1998. The Adaptive Prosthesis utilized hydraulic controls, pneumatic controls, and a microprocessor to provide the amputee with a gait that was more responsive to changes in walking speed. Cost analysis reveals that a sophisticated above-knee prosthesis will be about $1 million in 45 years, given only annual cost of living adjustments.
In 2019, a project under AT2030 was launched in which bespoke sockets are made using a thermoplastic, rather than through a plaster cast. This is faster to do and significantly less expensive. The sockets were called Amparo Confidence sockets.
Upper extremity modern historyEdit
A prosthesis is a functional replacement for an amputated or congenitally malformed or missing limb. Prosthetists are responsible for the prescription, design, and management of a prosthetic device.
In most cases, the prosthetist begins by taking a plaster cast of the patient's affected limb. Lightweight, high-strength thermoplastics are custom-formed to this model of the patient. Cutting-edge materials such as carbon fiber, titanium and Kevlar provide strength and durability while making the new prosthesis lighter. More sophisticated prostheses are equipped with advanced electronics, providing additional stability and control.
Current technology and manufacturingEdit
Over the years, there have been advancements in artificial limbs. New plastics and other materials, such as carbon fiber, have allowed artificial limbs to be stronger and lighter, limiting the amount of extra energy necessary to operate the limb. This is especially important for trans-femoral amputees. Additional materials have allowed artificial limbs to look much more realistic, which is important to trans-radial and transhumeral amputees because they are more likely to have the artificial limb exposed.
In addition to new materials, the use of electronics has become very common in artificial limbs. Myoelectric limbs, which control the limbs by converting muscle movements to electrical signals, have become much more common than cable operated limbs. Myoelectric signals are picked up by electrodes, the signal gets integrated and once it exceeds a certain threshold, the prosthetic limb control signal is triggered which is why inherently, all myoelectric controls lag. Conversely, cable control is immediate and physical, and through that offers a certain degree of direct force feedback that myoelectric control does not. Computers are also used extensively in the manufacturing of limbs. Computer Aided Design and Computer Aided Manufacturing are often used to assist in the design and manufacture of artificial limbs.
Most modern artificial limbs are attached to the residual limb (stump) of the amputee by belts and cuffs or by suction. The residual limb either directly fits into a socket on the prosthetic, or—more commonly today—a liner is used that then is fixed to the socket either by vacuum (suction sockets) or a pin lock. Liners are soft and by that, they can create a far better suction fit than hard sockets. Silicone liners can be obtained in standard sizes, mostly with a circular (round) cross section, but for any other residual limb shape, custom liners can be made. The socket is custom made to fit the residual limb and to distribute the forces of the artificial limb across the area of the residual limb (rather than just one small spot), which helps reduce wear on the residual limb.
Production of prosthetic socketEdit
The production of a prosthetic socket begins with capturing the geometry of the residual limb, this process is called shape capture. The goal of this process is to create an accurate representation of the residual limb, which is critical to achieve good socket fit. The custom socket is created by taking a plaster cast of the residual limb or, more commonly today, of the liner worn over their residual limb, and then making a mold from the plaster cast. The commonly used compound is called Plaster of Paris. In recent years, various digital shape capture systems have been developed which can be input directly to a computer allowing for a more sophisticated design. In general, the shape capturing process begins with the digital acquisition of three-dimensional (3D) geometric data from the amputee's residual limb. Data are acquired with either a probe, laser scanner, structured light scanner, or a photographic-based 3D scanning system.
After shape capture, the second phase of the socket production is called rectification, which is the process of modifying the model of the residual limb by adding volume to bony prominence and potential pressure points and remove volume from load bearing area. This can be done manually by adding or removing plaster to the positive model, or virtually by manipulating the computerized model in the software. Lastly, the fabrication of the prosthetic socket begins once the model has been rectified and finalized. The prosthetists would wrap the positive model with a semi-molten plastic sheet or carbon fiber coated with epoxy resin to construct the prosthetic socket. For the computerized model, it can be 3D printed using a various of material with different flexibility and mechanical strength.
Optimal socket fit between the residual limb and socket is critical to the function and usage of the entire prosthesis. If the fit between the residual limb and socket attachment is too loose, this will reduce the area of contact between the residual limb and socket or liner, and increase pockets between residual limb skin and socket or liner. Pressure then is higher, which can be painful. Air pockets can allow sweat to accumulate that can soften the skin. Ultimately, this is a frequent cause for itchy skin rashes. Over time, this can lead to breakdown of the skin. On the other hand, a very tight fit may excessively increase the interface pressures that may also lead to skin breakdown after prolonged use.
Artificial limbs are typically manufactured using the following steps:
- Measurement of the residual limb
- Measurement of the body to determine the size required for the artificial limb
- Fitting of a silicone liner
- Creation of a model of the liner worn over the residual limb
- Formation of thermoplastic sheet around the model – This is then used to test the fit of the prosthetic
- Formation of permanent socket
- Formation of plastic parts of the artificial limb – Different methods are used, including vacuum forming and injection molding
- Creation of metal parts of the artificial limb using die casting
- Assembly of entire limb
Current technology allows body-powered arms to weigh around one-half to one-third of what a myoelectric arm does.
Current body-powered arms contain sockets that are built from hard epoxy or carbon fiber. These sockets or "interfaces" can be made more comfortable by lining them with a softer, compressible foam material that provides padding for the bone prominences. A self-suspending or supra-condylar socket design is useful for those with short to mid-range below elbow absence. Longer limbs may require the use of a locking roll-on type inner liner or more complex harnessing to help augment suspension.
Wrist units are either screw-on connectors featuring the UNF 1/2-20 thread (USA) or quick-release connector, of which there are different models.
Voluntary opening and voluntary closingEdit
Two types of body-powered systems exist, voluntary opening "pull to open" and voluntary closing "pull to close". Virtually all "split hook" prostheses operate with a voluntary opening type system.
More modern "prehensors" called GRIPS utilize voluntary closing systems. The differences are significant. Users of voluntary opening systems rely on elastic bands or springs for gripping force, while users of voluntary closing systems rely on their own body power and energy to create gripping force.
Voluntary closing users can generate prehension forces equivalent to the normal hand, up to or exceeding one hundred pounds. Voluntary closing GRIPS require constant tension to grip, like a human hand, and in that property, they do come closer to matching human hand performance. Voluntary opening split hook users are limited to forces their rubber or springs can generate which usually is below 20 pounds.
An additional difference exists in the biofeedback created that allows the user to "feel" what is being held. Voluntary opening systems once engaged provide the holding force so that they operate like a passive vice at the end of the arm. No gripping feedback is provided once the hook has closed around the object being held. Voluntary closing systems provide directly proportional control and biofeedback so that the user can feel how much force that they are applying.
In 1997, the Colombian Prof. Álvaro Ríos Poveda, a researcher in bionics in Latin America, developed an upper limb and hand prosthesis with sensory feedback. This technology allows amputee patients to handle prosthetic hand systems in a more natural way.
A recent study showed that by stimulating the median and ulnar nerves, according to the information provided by the artificial sensors from a hand prosthesis, physiologically appropriate (near-natural) sensory information could be provided to an amputee. This feedback enabled the participant to effectively modulate the grasping force of the prosthesis with no visual or auditory feedback.
In February 2013, researchers from École Polytechnique Fédérale de Lausanne in Switzerland and the Scuola Superiore Sant'Anna in Italy, implanted electrodes into an amputee's arm, which gave the patient sensory feedback and allowed for real time control of the prosthetic. With wires linked to nerves in his upper arm, the Danish patient was able to handle objects and instantly receive a sense of touch through the special artificial hand that was created by Silvestro Micera and researchers both in Switzerland and Italy.
In July 2019, this technology was expanded on even further by researchers from the University of Utah, led by Jacob George. The group of researchers implanted electrodes into the patient's arm to map out several sensory precepts. They would then stimulate each electrode to figure out how each sensory precept was triggered, then proceed to map the sensory information onto the prosthetic. This would allow the researchers to get a good approximation of the same kind of information that the patient would receive from their natural hand. Unfortunately, the arm is too expensive for the average user to acquire, however, Jacob mentioned that insurance companies could cover the costs of the prosthetic.
Terminal devices contain a range of hooks, prehensors, hands or other devices.
Voluntary opening split hook systems are simple, convenient, light, robust, versatile and relatively affordable.
A hook does not match a normal human hand for appearance or overall versatility, but its material tolerances can exceed and surpass the normal human hand for mechanical stress (one can even use a hook to slice open boxes or as a hammer whereas the same is not possible with a normal hand), for thermal stability (one can use a hook to grip items from boiling water, to turn meat on a grill, to hold a match until it has burned down completely) and for chemical hazards (as a metal hook withstands acids or lye, and does not react to solvents like a prosthetic glove or human skin).
Prosthetic hands are available in both voluntary opening and voluntary closing versions and because of their more complex mechanics and cosmetic glove covering require a relatively large activation force, which, depending on the type of harness used, may be uncomfortable. A recent study by the Delft University of Technology, The Netherlands, showed that the development of mechanical prosthetic hands has been neglected during the past decades. The study showed that the pinch force level of most current mechanical hands is too low for practical use. The best tested hand was a prosthetic hand developed around 1945. In 2017 however, a research has been started with bionic hands by Laura Hruby of the Medical University of Vienna. A few open-hardware 3-D printable bionic hands have also become available. Some companies are also producing robotic hands with integrated forearm, for fitting unto a patient's upper arm and in 2020, at the Italian Institute of Technology (IIT), another robotic hand with integrated forearm (Soft Hand Pro) was developed.
Commercial providers and materialsEdit
Hosmer and Otto Bock are major commercial hook providers. Mechanical hands are sold by Hosmer and Otto Bock as well; the Becker Hand is still manufactured by the Becker family. Prosthetic hands may be fitted with standard stock or custom-made cosmetic looking silicone gloves. But regular work gloves may be worn as well. Other terminal devices include the V2P Prehensor, a versatile robust gripper that allows customers to modify aspects of it, Texas Assist Devices (with a whole assortment of tools) and TRS that offers a range of terminal devices for sports. Cable harnesses can be built using aircraft steel cables, ball hinges, and self-lubricating cable sheaths. Some prosthetics have been designed specifically for use in salt water.
Lower-extremity prosthetics describes artificially replaced limbs located at the hip level or lower. Concerning all ages Ephraim et al. (2003) found a worldwide estimate of all-cause lower-extremity amputations of 2.0–5.9 per 10,000 inhabitants. For birth prevalence rates of congenital limb deficiency they found an estimate between 3.5 and 7.1 cases per 10,000 births.
The two main subcategories of lower extremity prosthetic devices are trans-tibial (any amputation transecting the tibia bone or a congenital anomaly resulting in a tibial deficiency), and trans-femoral (any amputation transecting the femur bone or a congenital anomaly resulting in a femoral deficiency). In the prosthetic industry, a trans-tibial prosthetic leg is often referred to as a "BK" or below the knee prosthesis while the trans-femoral prosthetic leg is often referred to as an "AK" or above the knee prosthesis.
Other, less prevalent lower extremity cases include the following:
- Hip disarticulations – This usually refers to when an amputee or congenitally challenged patient has either an amputation or anomaly at or in close proximity to the hip joint.
- Knee disarticulations – This usually refers to an amputation through the knee disarticulating the femur from the tibia.
- Symes – This is an ankle disarticulation while preserving the heel pad.
The socket serves as an interface between the residuum and the prosthesis, ideally allowing comfortable weight-bearing, movement control and proprioception. Socket problems, such as discomfort and skin breakdown, are rated among the most important issues faced by lower-limb amputees.
Shank and connectorsEdit
This part creates distance and support between the knee-joint and the foot (in case of an upper-leg prosthesis) or between the socket and the foot. The type of connectors that are used between the shank and the knee/foot determines whether the prosthesis is modular or not. Modular means that the angle and the displacement of the foot in respect to the socket can be changed after fitting. In developing countries prosthesis mostly are non-modular, in order to reduce cost. When considering children modularity of angle and height is important because of their average growth of 1.9 cm annually.
Providing contact to the ground, the foot provides shock absorption and stability during stance. Additionally it influences gait biomechanics by its shape and stiffness. This is because the trajectory of the center of pressure (COP) and the angle of the ground reaction forces is determined by the shape and stiffness of the foot and needs to match the subject's build in order to produce a normal gait pattern. Andrysek (2010) found 16 different types of feet, with greatly varying results concerning durability and biomechanics. The main problem found in current feet is durability, endurance ranging from 16 to 32 months These results are for adults and will probably be worse for children due to higher activity levels and scale effects. Evidence comparing different types of feet and ankle prosthetic devices is not strong enough to determine if one mechanism of ankle/foot is superior to another. When deciding on a device, the cost of the device, a person's functional need, and the availability of a particular device should be considered.
In case of a trans-femoral (above knee) amputation, there also is a need for a complex connector providing articulation, allowing flexion during swing-phase but not during stance. As its purpose is to replace the knee, the prosthetic knee joint is the most critical component of the prosthesis for trans-femoral amputees. The function of the good prosthetic knee joint is to mimic the function of the normal knee, such as providing structural support and stability during stance phase but able to flex in a controllable manner during swing phase. Hence it allows users to have a smooth and energy efficient gait and minimize the impact of amputation. The prosthetic knee is connected to the prosthetic foot by the shank, which is usually made of an aluminum or graphite tube.
One of the most important aspect of a prosthetic knee joint would be its stance-phase control mechanism. The function of stance-phase control is to prevent the leg from buckling when the limb is loaded during weight acceptance. This ensures the stability of the knee in order to support the single limb support task of stance phase and provides a smooth transition to the swing phase. Stance phase control can be achieved in several ways including the mechanical locks, relative alignment of prosthetic components, weight activated friction control, and polycentric mechanisms.
To mimic the knee's functionality during gait, microprocessor-controlled knee joints have been developed that control the flexion of the knee. Some examples are Otto Bock's C-leg, introduced in 1997, Ossur's Rheo Knee, released in 2005, the Power Knee by Ossur, introduced in 2006, the Plié Knee from Freedom Innovations and DAW Industries' Self Learning Knee (SLK).
A microprocessor is used to interpret and analyze signals from knee-angle sensors and moment sensors. The microprocessor receives signals from its sensors to determine the type of motion being employed by the amputee. Most microprocessor controlled knee-joints are powered by a battery housed inside the prosthesis.
The sensory signals computed by the microprocessor are used to control the resistance generated by hydraulic cylinders in the knee-joint. Small valves control the amount of hydraulic fluid that can pass into and out of the cylinder, thus regulating the extension and compression of a piston connected to the upper section of the knee.
The main advantage of a microprocessor-controlled prosthesis is a closer approximation to an amputee's natural gait. Some allow amputees to walk near walking speed or run. Variations in speed are also possible and are taken into account by sensors and communicated to the microprocessor, which adjusts to these changes accordingly. It also enables the amputees to walk downstairs with a step-over-step approach, rather than the one step at a time approach used with mechanical knees. There is some research suggesting that people with microprocessor-controlled prostheses report greater satisfaction and improvement in functionality, residual limb health, and safety. People may be able to perform everyday activities at greater speeds, even while multitasking, and reduce their risk of falls.
However, some have some significant drawbacks that impair its use. They can be susceptible to water damage and thus great care must be taken to ensure that the prosthesis remains dry.
A myoelectric prosthesis uses the electrical tension generated every time a muscle contracts, as information. This tension can be captured from voluntarily contracted muscles by electrodes applied on the skin to control the movements of the prosthesis, such as elbow flexion/extension, wrist supination/pronation (rotation) or opening/closing of the fingers. A prosthesis of this type utilizes the residual neuromuscular system of the human body to control the functions of an electric powered prosthetic hand, wrist, elbow or foot. This is different from an electric switch prosthesis, which requires straps and/or cables actuated by body movements to actuate or operate switches that control the movements of the prosthesis. There is no clear evidence concluding that myoelectric upper extremity prostheses function better than body-powered prostheses. Advantages to using a myoelectric upper extremity prosthesis include the potential for improvement in cosmetic appeal (this type of prosthesis may have a more natural look), may be better for light everyday activities, and may be beneficial for people experiencing phantom limb pain. When compared to a body-powered prosthesis, a myoelectric prosthesis may not be as durable, may have a longer training time, may require more adjustments, may need more maintenance, and does not provide feedback to the user.
Prof. Alvaro Ríos Poveda has been working for several years on a non-invasive and affordable solution to this feedback problem. He considers that: "Prosthetic limbs that can be controlled with thought hold great promise for the amputee, but without sensorial feedback from the signals returning to the brain, it can be difficult to achieve the level of control necessary to perform precise movements. When connecting the sense of touch from a mechanical hand directly to the brain, prosthetics can restore the function of the amputated limb in an almost natural-feeling way." He presented the first Myoelectric prosthetic hand with sensory feedback at the XVIII World Congress on Medical Physics and Biomedical Engineering, 1997, held in Nice, France.
The USSR was the first to develop a myoelectric arm in 1958, while the first myoelectric arm became commercial in 1964 by the Central Prosthetic Research Institute of the USSR, and distributed by the Hangar Limb Factory of the UK.
Robots can be used to generate objective measures of patient's impairment and therapy outcome, assist in diagnosis, customize therapies based on patient's motor abilities, and assure compliance with treatment regimens and maintain patient's records. It is shown in many studies that there is a significant improvement in upper limb motor function after stroke using robotics for upper limb rehabilitation. In order for a robotic prosthetic limb to work, it must have several components to integrate it into the body's function: Biosensors detect signals from the user's nervous or muscular systems. It then relays this information to a microcontroller located inside the device, and processes feedback from the limb and actuator, e.g., position or force, and sends it to the controller. Examples include surface electrodes that detect electrical activity on the skin, needle electrodes implanted in muscle, or solid-state electrode arrays with nerves growing through them. One type of these biosensors are employed in myoelectric prostheses.
A device known as the controller is connected to the user's nerve and muscular systems and the device itself. It sends intention commands from the user to the actuators of the device and interprets feedback from the mechanical and biosensors to the user. The controller is also responsible for the monitoring and control of the movements of the device.
An actuator mimics the actions of a muscle in producing force and movement. Examples include a motor that aids or replaces original muscle tissue.
Targeted muscle reinnervation (TMR) is a technique in which motor nerves, which previously controlled muscles on an amputated limb, are surgically rerouted such that they reinnervate a small region of a large, intact muscle, such as the pectoralis major. As a result, when a patient thinks about moving the thumb of their missing hand, a small area of muscle on their chest will contract instead. By placing sensors over the reinnervated muscle, these contractions can be made to control the movement of an appropriate part of the robotic prosthesis.
A variant of this technique is called targeted sensory reinnervation (TSR). This procedure is similar to TMR, except that sensory nerves are surgically rerouted to skin on the chest, rather than motor nerves rerouted to muscle. Recently, robotic limbs have improved in their ability to take signals from the human brain and translate those signals into motion in the artificial limb. DARPA, the Pentagon's research division, is working to make even more advancements in this area. Their desire is to create an artificial limb that ties directly into the nervous system.
Advancements in the processors used in myoelectric arms have allowed developers to make gains in fine-tuned control of the prosthetic. The Boston Digital Arm is a recent artificial limb that has taken advantage of these more advanced processors. The arm allows movement in five axes and allows the arm to be programmed for a more customized feel. Recently the I-LIMB Hand, invented in Edinburgh, Scotland, by David Gow has become the first commercially available hand prosthesis with five individually powered digits. The hand also possesses a manually rotatable thumb which is operated passively by the user and allows the hand to grip in precision, power, and key grip modes.
Another neural prosthetic is Johns Hopkins University Applied Physics Laboratory Proto 1. Besides the Proto 1, the university also finished the Proto 2 in 2010. Early in 2013, Max Ortiz Catalan and Rickard Brånemark of the Chalmers University of Technology, and Sahlgrenska University Hospital in Sweden, succeeded in making the first robotic arm which is mind-controlled and can be permanently attached to the body (using osseointegration).
An approach that is very useful is called arm rotation which is common for unilateral amputees which is an amputation that affects only one side of the body; and also essential for bilateral amputees, a person who is missing or has had amputated either both arms or legs, to carry out activities of daily living. This involves inserting a small permanent magnet into the distal end of the residual bone of subjects with upper limb amputations. When a subject rotates the residual arm, the magnet will rotate with the residual bone, causing a change in magnetic field distribution. EEG (electroencephalogram) signals, detected using small flat metal discs attached to the scalp, essentially decoding human brain activity used for physical movement, is used to control the robotic limbs. This allows the user to control the part directly.
Robotic transtibial prosthesesEdit
The research of robotic legs has made some advancement over time, allowing exact movement and control.
Researchers at the Rehabilitation Institute of Chicago announced in September 2013 that they have developed a robotic leg that translates neural impulses from the user's thigh muscles into movement, which is the first prosthetic leg to do so. It is currently in testing.
The Icelandic company Össur has also created a robotic transtibial leg with motorized ankle that moves through algorithms and sensors that automatically adjust the angle of the foot during different points in its wearer's stride. Also there are brain-controlled bionic legs that allow an individual to move his limbs with a wireless transmitter.
The main goal of a robotic prosthesis is to provide active actuation during gait to improve the biomechanics of gait, including, among other things, stability, symmetry, or energy expenditure for amputees. There are several powered prosthetic legs currently on the market, including fully powered legs, in which actuators directly drive the joints, and semi-active legs, which use small amounts of energy and a small actuator to change the mechanical properties of the leg but do not inject net positive energy into gait. Specific examples include The emPOWER from BionX, the Proprio Foot from Ossur, and the Elan Foot from Endolite. Various research groups have also experimented with robotic legs over the last decade. Central issues being researched include designing the behavior of the device during stance and swing phases, recognizing the current ambulation task, and various mechanical design problems such as robustness, weight, battery-life/efficiency, and noise-level. However, scientists from Stanford University and Seoul National University has developed artificial nerves system that will help prosthetic limbs feel. This synthetic nerve system enables prosthetic limbs sense braille, feel the sense of touch and respond to the environment.
Use of recycled materialsEdit
Attachment to the bodyEdit
Most prostheses can be attached to the exterior of the body, in a non-permanent way. Some others however can be attached in a permanent way. One such example are exoprostheses (see below).
Direct bone attachment and osseointegrationEdit
Osseointegration is a method of attaching the artificial limb to the body. This method is also sometimes referred to as exoprosthesis (attaching an artificial limb to the bone), or endo-exoprosthesis.
The stump and socket method can cause significant pain in the amputee, which is why the direct bone attachment has been explored extensively. The method works by inserting a titanium bolt into the bone at the end of the stump. After several months the bone attaches itself to the titanium bolt and an abutment is attached to the titanium bolt. The abutment extends out of the stump and the (removable) artificial limb is then attached to the abutment. Some of the benefits of this method include the following:
- Better muscle control of the prosthetic.
- The ability to wear the prosthetic for an extended period of time; with the stump and socket method this is not possible.
- The ability for transfemoral amputees to drive a car.
The main disadvantage of this method is that amputees with the direct bone attachment cannot have large impacts on the limb, such as those experienced during jogging, because of the potential for the bone to break.
Cosmetic prosthesis has long been used to disguise injuries and disfigurements. With advances in modern technology, cosmesis, the creation of lifelike limbs made from silicone or PVC, has been made possible. Such prosthetics, including artificial hands, can now be designed to simulate the appearance of real hands, complete with freckles, veins, hair, fingerprints and even tattoos. Custom-made cosmeses are generally more expensive (costing thousands of U.S. dollars, depending on the level of detail), while standard cosmeses come premade in a variety of sizes, although they are often not as realistic as their custom-made counterparts. Another option is the custom-made silicone cover, which can be made to match a person's skin tone but not details such as freckles or wrinkles. Cosmeses are attached to the body in any number of ways, using an adhesive, suction, form-fitting, stretchable skin, or a skin sleeve.
Unlike neuromotor prostheses, neurocognitive prostheses would sense or modulate neural function in order to physically reconstitute or augment cognitive processes such as executive function, attention, language, and memory. No neurocognitive prostheses are currently available but the development of implantable neurocognitive brain-computer interfaces has been proposed to help treat conditions such as stroke, traumatic brain injury, cerebral palsy, autism, and Alzheimer's disease. The recent field of Assistive Technology for Cognition concerns the development of technologies to augment human cognition. Scheduling devices such as Neuropage remind users with memory impairments when to perform certain activities, such as visiting the doctor. Micro-prompting devices such as PEAT, AbleLink and Guide have been used to aid users with memory and executive function problems perform activities of daily living.
In addition to the standard artificial limb for everyday use, many amputees or congenital patients have special limbs and devices to aid in the participation of sports and recreational activities.
Within science fiction, and, more recently, within the scientific community, there has been consideration given to using advanced prostheses to replace healthy body parts with artificial mechanisms and systems to improve function. The morality and desirability of such technologies are being debated by transhumanists, other ethicists, and others in general.[by whom?] Body parts such as legs, arms, hands, feet, and others can be replaced.
The first experiment with a healthy individual appears to have been that by the British scientist Kevin Warwick. In 2002, an implant was interfaced directly into Warwick's nervous system. The electrode array, which contained around a hundred electrodes, was placed in the median nerve. The signals produced were detailed enough that a robot arm was able to mimic the actions of Warwick's own arm and provide a form of touch feedback again via the implant.
The DEKA company of Dean Kamen developed the "Luke arm", an advanced nerve-controlled prosthetic. Clinical trials began in 2008, with FDA approval in 2014 and commercial manufacturing by the Universal Instruments Corporation expected in 2017. The price offered at retail by Mobius Bionics is expected to be around $100,000.
Further research in April 2019, there have been improvements towards prosthetic function and comfort of 3D-printed personalized wearable systems. Instead of manual integration after printing, integrating electronic sensors at the intersection between a prosthetic and the wearer's tissue can gather information such as pressure across wearer's tissue, that can help improve further iteration of these types of prosthetic.
In early 2008, Oscar Pistorius, the "Blade Runner" of South Africa, was briefly ruled ineligible to compete in the 2008 Summer Olympics because his transtibial prosthesis limbs were said to give him an unfair advantage over runners who had ankles. One researcher found that his limbs used twenty-five percent less energy than those of a non-disabled runner moving at the same speed. This ruling was overturned on appeal, with the appellate court stating that the overall set of advantages and disadvantages of Pistorius' limbs had not been considered.
Pistorius did not qualify for the South African team for the Olympics, but went on to sweep the 2008 Summer Paralympics, and has been ruled eligible to qualify for any future Olympics. He qualified for the 2011 World Championship in South Korea and reached the semi-final where he ended last timewise, he was 14th in the first round, his personal best at 400m would have given him 5th place in the finals. At the 2012 Summer Olympics in London, Pistorius became the first amputee runner to compete at an Olympic Games. He ran in the 400 metres race semi-finals, and the 4 × 400 metres relay race finals. He also competed in 5 events in the 2012 Summer Paralympics in London.
There are multiple factors to consider when designing a transtibial prosthesis. Manufacturers must make choices about their priorities regarding these factors.
Nonetheless, there are certain elements of socket and foot mechanics that are invaluable for the athlete, and these are the focus of today's high-tech prosthetics companies:
- Fit – athletic/active amputees, or those with bony residua, may require a carefully detailed socket fit; less-active patients may be comfortable with a 'total contact' fit and gel liner
- Energy storage and return – storage of energy acquired through ground contact and utilization of that stored energy for propulsion
- Energy absorption – minimizing the effect of high impact on the musculoskeletal system
- Ground compliance – stability independent of terrain type and angle
- Rotation – ease of changing direction
- Weight – maximizing comfort, balance and speed
- Suspension – how the socket will join and fit to the limb
The buyer is also concerned with numerous other factors:
- Ease of use
- Size availability
Cost and source freedomEdit
In the USA a typical prosthetic limb costs anywhere between $15,000 and $90,000, depending on the type of limb desired by the patient. With medical insurance, a patient will typically pay 10%–50% of the total cost of a prosthetic limb, while the insurance company will cover the rest of the cost. The percent that the patient pays varies on the type of insurance plan, as well as the limb requested by the patient. In the United Kingdom, much of Europe, Australia and New Zealand the entire cost of prosthetic limbs is met by state funding or statutory insurance. For example, in Australia prostheses are fully funded by state schemes in the case of amputation due to disease, and by workers compensation or traffic injury insurance in the case of most traumatic amputations. The National Disability Insurance Scheme, which is being rolled out nationally between 2017 and 2020 also pays for prostheses.
Transradial (below the elbow amputation) and transtibial prostheses (below the knee amputation) typically cost between US $6,000 and $8,000, while transfemoral (above the knee amputation) and transhumeral prosthetics (above the elbow amputation) cost approximately twice as much with a range of $10,000 to $15,000 and can sometimes reach costs of $35,000. The cost of an artificial limb often recurs, while a limb typically needs to be replaced every 3–4 years due to wear and tear of everyday use. In addition, if the socket has fit issues, the socket must be replaced within several months from the onset of pain. If height is an issue, components such as pylons can be changed.
Not only does the patient need to pay for their multiple prosthetic limbs, but they also need to pay for physical and occupational therapy that come along with adapting to living with an artificial limb. Unlike the reoccurring cost of the prosthetic limbs, the patient will typically only pay the $2000 to $5000 for therapy during the first year or two of living as an amputee. Once the patient is strong and comfortable with their new limb, they will not be required to go to therapy anymore. Throughout one's life, it is projected that a typical amputee will go through $1.4 million worth of treatment, including surgeries, prosthetics, as well as therapies.
Low-cost above-knee prostheses often provide only basic structural support with limited function. This function is often achieved with crude, non-articulating, unstable, or manually locking knee joints. A limited number of organizations, such as the International Committee of the Red Cross (ICRC), create devices for developing countries. Their device which is manufactured by CR Equipments is a single-axis, manually operated locking polymer prosthetic knee joint.
Table. List of knee joint technologies based on the literature review.
|Name of technology (country of origin)||Brief description||Highest level of
|ICRC knee (Switzerland)||Single-axis with manual lock||Independent field|
|ATLAS knee (UK)||Weight-activated friction||Independent field|
|POF/OTRC knee (US)||Single-axis with ext. assist||Field|
|DAV/Seattle knee (US)||Compliant polycentric||Field|
|LIMBS International M1 knee (US)||Four-bar||Field|
|LCKnee (Canada)||Single-axis with automatic lock||Field|
|None provided (Nepal)||Single-axis||Field|
|None provided (New Zealand)||Roto-molded single-axis||Field|
|None provided (India)||Six-bar with squatting||Technical development|
|Friction knee (US)||Weight-activated friction||Technical development|
|Wedgelock knee (Australia)||Weight-activated friction||Technical development|
|SATHI friction knee (India)||Weight-activated friction||Limited data available|
A plan for a low-cost artificial leg, designed by Sébastien Dubois, was featured at the 2007 International Design Exhibition and award show in Copenhagen, Denmark, where it won the Index: Award. It would be able to create an energy-return prosthetic leg for US $8.00, composed primarily of fiberglass.
Prior to the 1980s, foot prostheses merely restored basic walking capabilities. These early devices can be characterized by a simple artificial attachment connecting one's residual limb to the ground.
The introduction of the Seattle Foot (Seattle Limb Systems) in 1981 revolutionized the field, bringing the concept of an Energy Storing Prosthetic Foot (ESPF) to the fore. Other companies soon followed suit, and before long, there were multiple models of energy storing prostheses on the market. Each model utilized some variation of a compressible heel. The heel is compressed during initial ground contact, storing energy which is then returned during the latter phase of ground contact to help propel the body forward.
Since then, the foot prosthetics industry has been dominated by steady, small improvements in performance, comfort, and marketability.
Open-source robotic prothesisEdit
There is currently an open-design Prosthetics forum known as the "Open Prosthetics Project". The group employs collaborators and volunteers to advance Prosthetics technology while attempting to lower the costs of these necessary devices. Open Bionics is a company that is developing open-source robotic prosthetic hands. They utilize 3D printing to manufacture the devices and low-cost 3D scanners to fit them onto the residual limb of a specific patient. Open Bionics' use of 3D printing allows for more personalized designs, such as the "Hero Arm" which incorporates the users favourite colours, textures, and even aesthetics to look like superheroes or characters from Star Wars with the aim of lowering the cost. A review study on a wide range of printed prosthetic hands, found that although 3D printing technology holds a promise for individualised prosthesis design, and it is cheaper than commercial prostheses available on the market, yet more expensive than mass production processes such as injection molding. The same study also found that evidence on the functionality, durability and user acceptance of 3D printed hand prostheses is still lacking.
Low-cost prosthetics for childrenEdit
In the USA an estimate was found of 32,500 children (<21 years) had a major paediatric amputation, with 5,525 new cases each year, of which 3,315 congenital.
Carr et al. (1998) investigated amputations caused by landmines for Afghanistan, Bosnia and Herzegovina, Cambodia and Mozambique among children (<14 years), showing estimates of respectively 4.7, 0.19, 1.11 and 0.67 per 1000 children. Mohan (1986) indicated in India a total of 424,000 amputees (23,500 annually), of which 10.3% had an onset of disability below the age of 14, amounting to a total of about 43,700 limb deficient children in India alone.
Few low-cost solutions have been created specially for children. Examples of low-cost prosthetic devices include:
Pole and crutchEdit
This hand-held pole with leather support band or platform for the limb is one of the simplest and cheapest solutions found. It serves well as a short-term solution, but is prone to rapid contracture formation if the limb is not stretched daily through a series of range-of motion (RoM) sets.
Bamboo, PVC or plaster limbsEdit
This also fairly simple solution comprises a plaster socket with a bamboo or PVC pipe at the bottom, optionally attached to a prosthetic foot. This solution prevents contractures because the knee is moved through its full RoM. The David Werner Collection, an online database for the assistance of disabled village children, displays manuals of production of these solutions.
Adjustable bicycle limbEdit
This solution is built using a bicycle seat post up side down as foot, generating flexibility and (length) adjustability. It is a very cheap solution, using locally available materials.
It is an endoskeletal modular lower limb from India, which uses thermoplastic parts. Its main advantages are the small weight and adaptability.
Monolimbs are non-modular prostheses and thus require more experienced prosthetist for correct fitting, because alignment can barely be changed after production. However, their durability on average is better than low-cost modular solutions.
A number of theorists have explored the meaning and implications of prosthetic extension of the body. Elizabeth Grosz writes, "Creatures use tools, ornaments, and appliances to augment their bodily capacities. Are their bodies lacking something, which they need to replace with artificial or substitute organs?...Or conversely, should prostheses be understood, in terms of aesthetic reorganization and proliferation, as the consequence of an inventiveness that functions beyond and perhaps in defiance of pragmatic need?" Elaine Scarry argues that every artifact recreates and extends the body. Chairs supplement the skeleton, tools append the hands, clothing augments the skin. In Scarry's thinking, "furniture and houses are neither more nor less interior to the human body than the food it absorbs, nor are they fundamentally different from such sophisticated prosthetics as artificial lungs, eyes and kidneys. The consumption of manufactured things turns the body inside out, opening it up to and as the culture of objects." Mark Wigley, a professor of architecture, continues this line of thinking about how architecture supplements our natural capabilities, and argues that "a blurring of identity is produced by all prostheses." Some of this work relies on Freud's earlier characterization of man's relation to objects as one of extension.
Notable users of prosthetic devicesEdit
- πρόσθεσις. Liddell, Henry George; Scott, Robert; A Greek–English Lexicon at the Perseus Project
- Nathan, Stuart (28 November 2018). "Prosthetic implant provides realistic wrist movement to amputees". Retrieved 2019-01-30.
- "Prosthetic implants – Prosthetic limbs and body parts – Plastic surgery – Services A-Z – Services". www.royalfree.nhs.uk. Retrieved 2019-01-30.
- "How artificial limb is made – material, manufacture, making, used, parts, components, structure, procedure". www.madehow.com. Retrieved 2017-10-24.
- "Physical Medicine and Rehabilitation Treatment Team". Department of Rehabilitation and Regenerative Medicine. Retrieved 2019-02-24.
- "4: Prosthetic Management: Overview, Methods, and Materials | O&P Virtual Library". www.oandplibrary.org. Retrieved 2017-10-24.
- Maat, Bartjan; Smit, Gerwin; Plettenburg, Dick; Breedveld, Paul (1 March 2017). "Passive prosthetic hands and tools: A literature review". Prosthetics and Orthotics International. 42 (1): 66–74. doi:10.1177/0309364617691622. PMC 5810914. PMID 28190380.
- Nagaraja, Vikranth H.; da Ponte Lopes, Jhonatan; Bergmann, Jeroen H. M. (September 2022). "Reimagining Prosthetic Control: A Novel Body-Powered Prosthetic System for Simultaneous Control and Actuation". Prosthesis. 4 (3): 394–413. doi:10.3390/prosthesis4030032.
- Nagaraja, Vikranth H.; Moulic, Soikat Ghosh; D’souza, Jennifer V.; Limesh, M.; Walters, Peter; Bergmann, Jeroen H. M. (December 2022). "A Novel Respiratory Control and Actuation System for Upper-Limb Prosthesis Users: Clinical Evaluation Study". IEEE Access. 10: 128764–128778. doi:10.1109/ACCESS.2022.3226697.
- "Oxford researchers develop breathing-powered prosthetic hand". BBC News. 14 December 2022.
- "Getting an artificial leg up – Cathy Johnson". Australian Broadcasting Corporation. Retrieved 2010-10-03.
- Highsmith, M. Jason; Andrews, Casey R.; Millman, Claire; Fuller, Ashley; Kahle, Jason T.; Klenow, Tyler D.; Lewis, Katherine L.; Bradley, Rachel C.; Orriola, John J. (2016-09-16). "Gait Training Interventions for Lower Extremity Amputees: A Systematic Literature Review". Technology and Innovation. 18 (2–3): 99–113. doi:10.21300/18.2-3.2016.99. PMC 5218520. PMID 28066520.
- Barr, Steven; Howe, Tracey E. (2018). "Prosthetic rehabilitation for older dysvascular people following a unilateral transfemoral amputation". The Cochrane Database of Systematic Reviews. 2018 (10): CD005260. doi:10.1002/14651858.CD005260.pub4. ISSN 1469-493X. PMC 6517199. PMID 30350430.
- Bowker, John H.; Michael, John W. (2002). Atlas of limb prosthetics : surgical, prosthetic, and rehabilitation principles. American Academy of Orthopaedic Surgeons (2nd ed.). St. Louis: Mosby Year Book. pp. 389, 413, 429, 479, 501, 535, 885. ISBN 978-0892032754. OCLC 54693136.
- Söderberg, Bengt (2001). Partial foot amputations (2nd ed.). Sweden: Centre for Partial Foot Amputees. p. 21. ISBN 978-9163107566. OCLC 152577368.
- "An Amazing Menagerie of Animal Prostheses". Scientific American.
- Pine, Keith R.; Sloan, Brian H.; Jacobs, Robert J. (2015). Clinical Ocular Prosthetics. Springer. ISBN 9783319190570.
- "No. 1705: A 3000-Year-Old Toe". Uh.edu. 2004-08-01. Retrieved 2013-03-13.
- Vanderwerker, Earl E. Jr. (1976). "A Brief Review of the History of Amputations and Prostheses". ICIB. 15 (5): 15–16. Archived from the original on 2007-10-14.
- Rosenfeld, Amnon; Dvorachek, Michael; Rotstein, Ilan (July 2000). "Bronze Single Crown-like Prosthetic Restorations of Teeth from the Late Roman Period". Journal of Archaeological Science. 27 (7): 641–644. doi:10.1006/jasc.1999.0517.
- Herodotus, The Histories. 9.37
- "The Iron Hand of the Goetz von Berlichingen". Karlofgermany.com. Retrieved 2009-11-03.
- Finch, Jacqueline (February 2011). "The ancient origins of prosthetic medicine". The Lancet. 377 (9765): 548–9. doi:10.1016/s0140-6736(11)60190-6. PMID 21341402. S2CID 42637892.
- Bryce, Geore (1887). A Short History of the Canadian People. London: S. Low, Marston, Searle & Rivington.
- Friedman, Lawrence (1978). The Psychological Rehabilitation of the Amputee. Springfield, IL.: Charles C. Thomas.
- Starr, Michelle. "This Medieval Italian Man Replaced His Amputated Hand With a Weapon". ScienceAlert. Retrieved 2018-04-17.
- Micarelli, I; Paine, R; Giostra, C; Tafuri, MA; Profico, A; Boggioni, M; Di Vincenzo, F; Massani, D; Papini, A; Manzi, G (31 December 2018). "Survival to amputation in pre-antibiotic era: a case study from a Longobard necropolis (6th-8th centuries AD)". Journal of Anthropological Sciences. 96 (96): 185–200. doi:10.4436/JASS.96001. PMID 29717991.
- Killgrove, Kristina. "Archaeologists Find Ancient Knife-Hand Prosthesis on Medieval Warrior". Forbes. Retrieved 2018-04-17.
- "The History of Prosthetics". UNYQ. 2015-09-21. Retrieved 2018-04-17.
- Romm, Sharon (July 1989). "Arms by Design". Plastic and Reconstructive Surgery. 84 (1): 158–63. doi:10.1097/00006534-198907000-00029. PMID 2660173.
- "A Brief History of Prosthetics". inMotion: A Brief History of Prosthetics. November–December 2007. Retrieved 23 November 2010.
- Bigg, Henry Robert Heather (1885) Artificial Limbs and the Amputations which Afford the Most Appropriate Stumps in Civil and Military Surgery. London
- Long, Ivan A. (1985). "Normal Shape-Normal Alignment (NSNA) Above-Knee Prosthesis". Clinical Prosthetics & Orthotics. 9 (4): 9–14 – via O&P Virtual Library.
- Gottschalk, Frank A.; Kourosh, Sohrab; Stills, Melvin; McClellan, Bruce; Roberts, Jim (October 1989). "Does Socket Configuration Influence the Position of the Femur in Above-Knee Amputation?". Journal of Prosthetics and Orthotics. 2 (1): 94. doi:10.1097/00008526-198910000-00009.
- "Blatchford Company History", Blatchford Group.
- Pike, Alvin (May/June 1999). "The New High Tech Prostheses". InMotion Magazine 9 (3)
- One small step for an amputee and a giant leap for Amparo and GDI Hub
- Changing Prosthetic Service Delivery with Amparo
- Johannes, Matthew S.; Bigelow, John D.; Burck, James M.; Harshbarger, Stuart D.; Kozlowski, Matthew V.; Van Doren, Thomas (2011). "An Overview of the Developmental Process for the Modular Prosthetic Limb" (PDF). Johns Hopkins APL Technical Digest. 30 (3): 207–16.
- Adee, Sally (January 2009). "The revolution will be prosthetized". IEEE Spectrum. 46 (1): 44–8. doi:10.1109/MSPEC.2009.4734314. S2CID 34235585.
- Burck, James M.; Bigelow, John D.; Harshbarger, Stuart D. (2011). "Revolutionizing Prosthetics: Systems Engineering Challenges and Opportunities". Johns Hopkins APL Technical Digest. 30 (3): 186–97. CiteSeerX 10.1.1.685.6772.
- Bogue, Robert (21 August 2009). "Exoskeletons and robotic prosthetics: a review of recent developments". Industrial Robot. 36 (5): 421–427. doi:10.1108/01439910910980141.
- Miranda, Robbin A.; Casebeer, William D.; Hein, Amy M.; Judy, Jack W.; Krotkov, Eric P.; Laabs, Tracy L.; Manzo, Justin E.; Pankratz, Kent G.; Pratt, Gill A.; Sanchez, Justin C.; Weber, Douglas J.; Wheeler, Tracey L.; Ling, Geoffrey S.F. (April 2015). "DARPA-funded efforts in the development of novel brain–computer interface technologies". Journal of Neuroscience Methods. 244: 52–67. doi:10.1016/j.jneumeth.2014.07.019. PMID 25107852. S2CID 14678623.
- "The Pentagon's Bionic Arm". CBS News. Retrieved 9 May 2015.
- "Custom Prosthetics, Artificial Limbs LI, NY | Progressive O&P". Progoandp.com. Retrieved 2016-12-28.
- "How artificial limb is made – Background, Raw materials, The manufacturing process of artificial limb, Physical therapy, Quality control". Madehow.com. 1988-04-04. Retrieved 2010-10-03.
- Mamalis, AG; Ramsden, JJ; Grabchenko, AI; Lytvynov, LA; Filipenko, VA; Lavrynenko, SN (2006). "A novel concept for the manufacture of individual sapphire-metallic hip joint endoprostheses". Journal of Biological Physics and Chemistry. 6 (3): 113–117. doi:10.4024/30601.jbpc.06.03.
- Suyi Yang, Eddie; Aslani, Navid; McGarry, Anthony (October 2019). "Influences and trends of various shape-capture methods on outcomes in trans-tibial prosthetics: A systematic review". Prosthetics and Orthotics International. 43 (5): 540–555. doi:10.1177/0309364619865424. ISSN 1746-1553. PMID 31364475. S2CID 198999869.
- Sharma, Hemant; Prabu, Dhanasekara (September 2013). "Plaster of Paris: Past, present and future". Journal of Clinical Orthopaedics and Trauma. 4 (3): 107–109. doi:10.1016/j.jcot.2013.09.004. ISSN 0976-5662. PMC 3880430. PMID 26403547.
- Herbert, Nicholas; Simpson, David; Spence, William D.; Ion, William (March 2005). "A preliminary investigation into the development of 3-D printing of prosthetic sockets". Journal of Rehabilitation Research and Development. 42 (2): 141–146. doi:10.1682/jrrd.2004.08.0134. ISSN 1938-1352. PMID 15944878.
- Sewell, P.; Noroozi, S.; Vinney, J.; Andrews, S. (August 2000). "Developments in the trans-tibial prosthetic socket fitting process: a review of past and present research". Prosthetics and Orthotics International. 24 (2): 97–107. doi:10.1080/03093640008726532. ISSN 0309-3646. PMID 11061196. S2CID 20147798.
- Ribeiro, Danielle; Cimino, Stephanie R.; Mayo, Amanda L.; Ratto, Matt; Hitzig, Sander L. (2019-08-16). "3D printing and amputation: a scoping review". Disability & Rehabilitation: Assistive Technology. 16 (2): 221–240. doi:10.1080/17483107.2019.1646825. ISSN 1748-3115. PMID 31418306. S2CID 201018681.
- Mak, A. F.; Zhang, M.; Boone, D. A. (March 2001). "State-of-the-art research in lower-limb prosthetic biomechanics-socket interface: a review". Journal of Rehabilitation Research and Development. 38 (2): 161–174. ISSN 0748-7711. PMID 11392649.
- Rios Poveda, Alvaro (2002). Myoelectric Prostheses with Sensorial Feedback. Myoelectric Symposium. ISBN 978-1-55131-029-9.
- Raspopovic, Stanisa; Capogrosso, Marco; Petrini, Francesco Maria; Bonizzato, Marco; Rigosa, Jacopo; Di Pino, Giovanni; et al. (5 February 2014). "Restoring Natural Sensory Feedback in Real-Time Bidirectional Hand Prostheses". Science Translational Medicine. 6 (222): 222ra19. doi:10.1126/scitranslmed.3006820. PMID 24500407. S2CID 206682721.
- "With a new prosthetic, researchers have managed to restore the sense of touch for a Denmark man who lost his left hand nine years ago.", USA Today, February 5, 2014
- "Artificial hand offering immediate touch response a success", Channelnewsasia, February 7, 2014
- DelViscio, Jeffery. "A Robot Hand Helps Amputees "Feel" Again". Scientific American. Retrieved 2020-06-12.
- Smit G, Plettenburg DH (2010). "Efficiency of Voluntary Closing Hand and Hook Prostheses". Prosthetics and Orthotics International. 34 (4): 411–427. doi:10.3109/03093646.2010.486390. PMID 20849359. S2CID 22327910.
- Smit, G; Bongers, RM; Van der Sluis, CK; Plettenburg, DH (2012). "Efficiency of voluntary opening hand and hook prosthetic devices: 24 years of development?". Journal of Rehabilitation Research and Development. 49 (4): 523–534. doi:10.1682/JRRD.2011.07.0125. PMID 22773256.
- Robitzski, Dan (May 2017) [First published 18 April 2017 as "A Spare Hand"]. "Disabled Hands Successfully Replaced with Bionic Prosthetics". Scientific American. Vol. 316, no. 5. p. 17. doi:10.1038/scientificamerican0517-17.
- Hruby, Laura A.; Sturma, Agnes; Mayer, Johannes A.; Pittermann, Anna; Salminger, Stefan; Aszmann, Oskar C. (November 2017). "Algorithm for bionic hand reconstruction in patients with global brachial plexopathies". Journal of Neurosurgery. 127 (5): 1163–1171. doi:10.3171/2016.6.JNS16154. PMID 28093018.
- 3D bionic hands
- UK woman can ride bike for first time with 'world's most lifelike bionic hand'
- Bebionic robotic hand
- A helping hand: EU researchers develop bionic hand that imitates life
- Onken, Sarah. "Dive In". cityviewnc.com. Archived from the original on 10 September 2015. Retrieved 24 August 2015.
- Ephraim, P. L.; Dillingham, T. R.; Sector, M; Pezzin, L. E.; MacKenzie, E. J. (2003). "Epidemiology of limb loss and congenital limb deficiency: A review of the literature". Archives of Physical Medicine and Rehabilitation. 84 (5): 747–61. doi:10.1016/S0003-9993(02)04932-8. PMID 12736892.
- Mak, A. F.; Zhang, M; Boone, D. A. (2001). "State-of-the-art research in lower-limb prosthetic biomechanics-socket interface: A review". Journal of Rehabilitation Research and Development. 38 (2): 161–74. PMID 11392649.
- Legro, MW; Reiber, G; del Aguila, M; Ajax, MJ; Boone, DA; Larsen, JA; Smith, DG; Sangeorzan, B (July 1999). "Issues of importance reported by persons with lower limb amputations and prostheses". Journal of Rehabilitation Research and Development. 36 (3): 155–63. PMID 10659798.
- Strait, E. (2006) Prosthetics in Developing Countries. oandp.org Retrieved 2019-03-11
- Stark, Gerald (2005). "Perspectives on How and Why Feet are Prescribed". Journal of Prosthetics and Orthotics. 17: S18–S22. doi:10.1097/00008526-200510001-00007.
- Jian, Yuancheng; Winter, DA; Ishac, MG; Gilchrist, L (1993). "Trajectory of the body COG and COP during initiation and termination of gait". Gait & Posture. 1: 9–22. doi:10.1016/0966-6362(93)90038-3.
- Andrysek, Jan (December 2010). "Lower-limb prosthetic technologies in the developing world: A review of literature from 1994–2010". Prosthetics and Orthotics International. 34 (4): 378–398. doi:10.3109/03093646.2010.520060. PMID 21083505. S2CID 27233705.
- Hofstad, Cheriel J; van der Linde, Harmen; van Limbeek, Jacques; Postema, Klaas (26 January 2004). "Prescription of prosthetic ankle-foot mechanisms after lower limb amputation" (PDF). Cochrane Database of Systematic Reviews. 2010 (1): CD003978. doi:10.1002/14651858.CD003978.pub2. PMC 8762647. PMID 14974050.
- Andrysek, Jan; Naumann, Stephen; Cleghorn, William L. (December 2004). "Design characteristics of pediatric prosthetic knees". IEEE Transactions on Neural Systems and Rehabilitation Engineering. 12 (4): 369–378. doi:10.1109/TNSRE.2004.838444. ISSN 1534-4320. PMID 15614992. S2CID 1860735.
- Wyss, Dominik (2012-11-27). Evaluation and Design of a Globally Applicable Rear-locking Prosthetic Knee Mechanism (Thesis thesis).
- R. Stewart and A. Staros, "Selection and application of knee mechanisms," Bulletin of Prosthetics Research, vol. 18, pp. 90-158, 1972.
- M. Greene, "Four bar linkage knee analysis," Prosthetics and Orthotics International, vol. 37, pp. 15-24, 1983.
- "The SLK, The Self-Learning Knee" Archived 2012-04-25 at the Wayback Machine, DAW Industries. Retrieved 16 March 2008.
- Marriott, Michel (2005-06-20). "Titanium and Sensors Replace Ahab's Peg Leg". The New York Times. Retrieved 2008-10-30.
- Martin, Craig W. (November 2003) "Otto Bock C-leg: A review of its effectiveness" Archived 2016-12-28 at the Wayback Machine. WCB Evidence Based Group
- Kannenberg, Andreas; Zacharias, Britta; Pröbsting, Eva (2014). "Benefits of microprocessor-controlled prosthetic knees to limited community ambulators: Systematic review". Journal of Rehabilitation Research and Development. 51 (10): 1469–1496. doi:10.1682/JRRD.2014.05.0118. PMID 25856664.
- Highsmith, M. Jason; Kahle, Jason T.; Bongiorni, Dennis R.; Sutton, Bryce S.; Groer, Shirley; Kaufman, Kenton R. (December 2010). "Safety, Energy Efficiency, and Cost Efficacy of the C-Leg for Transfemoral Amputees: A Review of the Literature". Prosthetics and Orthotics International. 34 (4): 362–377. doi:10.3109/03093646.2010.520054. PMID 20969495. S2CID 23608311.
- "Amputees control bionic legs with their thoughts". Reuters. 20 May 2015.
- Carey, Stephanie L.; Lura, Derek J.; Highsmith, M. Jason; CP.; FAAOP. (2015). "Differences in myoelectric and body-powered upper-limb prostheses: Systematic literature review". Journal of Rehabilitation Research and Development. 52 (3): 247–262. doi:10.1682/JRRD.2014.08.0192. PMID 26230500.
- International Federation for Medical and Biological Engineering (17 December 2012). "World Congress on Medical Physics and Biomedical Engineering". IFMBE. Retrieved 19 March 2022.
- Rios, Alvaro (1997). Microcontroller system for myoelectric prosthesis with sensory feedback. World Congress on Medical Physics and Biomedical Engineering: XVIII International Conference on Medical and Biological Engineering and XI International Conference on Medical Physics. Nice, France.
- Wirta, R. W.; Taylor, D. R.; Finley, F. R. (1978). "Pattern-recognition arm prosthesis: A historical perspective-a final report" (PDF). Bulletin of Prosthetics Research: 8–35. PMID 365281.
- Sherman, E. David (1964). "A Russian Bioelectric-Controlled Prosthesis: Report of a Research Team from the Rehabilitation Institute of Montreal". Canadian Medical Association Journal. 91 (24): 1268–1270. PMC 1927453. PMID 14226106.
- Muzumdar, Ashok (2004). Powered Upper Limb Prostheses: Control, Implementation and Clinical Application. Springer. ISBN 978-3-540-40406-4.
- Reinkensmeyer David J (2009). "Robotic Assistance For Upper Extremity Training After Stroke" (PDF). Studies in Health Technology and Informatics. 145: 25–39. PMID 19592784. Archived from the original (PDF) on 2016-12-28. Retrieved 2016-12-28.
- Kuiken TA, Miller LA, Lipschutz RD, Lock BA, Stubblefield K, Marasco PD, Zhou P, Dumanian GA (February 3, 2007). "Targeted reinnervation for enhanced prosthetic arm function in a woman with a proximal amputation: a case study". Lancet. 369 (9559): 371–80. doi:10.1016/S0140-6736(07)60193-7. PMID 17276777. S2CID 20041254.
- "Blogs: TR Editors' blog: Patients Test an Advanced Prosthetic Arm". Technology Review. 2009-02-10. Retrieved 2010-10-03.
- "Defense Sciences Office". Darpa.mil. Archived from the original on 2009-04-26. Retrieved 2010-10-03.
- Binedell, Trevor; Meng, Eugene; Subburaj, Karupppasamy (2020-08-25). "Design and development of a novel 3D-printed non-metallic self-locking prosthetic arm for a forequarter amputation". Prosthetics and Orthotics International. 45: 94–99. doi:10.1177/0309364620948290. ISSN 1746-1553. PMID 32842869. S2CID 221326246.
- "Proto 1 and Proto 2". Ric.org. 2007-05-01. Archived from the original on 2011-07-27. Retrieved 2010-10-03.
- "World premiere of muscle and nerve controlled arm prosthesis". Sciencedaily.com. February 2013. Retrieved 2016-12-28.
- Williams, Adam (2012-11-30). "Mind-controlled permanently-attached prosthetic arm could revolutionize prosthetics". Gizmag.com. Retrieved 2016-12-28.
- Ford, Jason (2012-11-28). "Trials imminent for implantable thought-controlled robotic arm". Theengineer.co.uk. Retrieved 2016-12-28.
- Li, Guanglin; Kuiken, Todd A (2008). "Modeling of Prosthetic Limb Rotation Control by Sensing Rotation of Residual Arm Bone". IEEE Transactions on Biomedical Engineering. 55 (9): 2134–2142. doi:10.1109/tbme.2008.923914. PMC 3038244. PMID 18713682.
- Contreras-Vidal José L.; et al. (2012). "Restoration of Whole Body Movement: Toward a Noninvasive Brain-Machine Interface System". IEEE Pulse. 3 (1): 34–37. doi:10.1109/mpul.2011.2175635. PMC 3357625. PMID 22344949.
- "Rehabilitation Institute of Chicago First to Develop Thought Controlled Robotic Leg". Medgadget.com. September 2013. Retrieved 2016-12-28.
- Is This the Future of Robotic Legs?
- "Transtibial Powered Prostheses". Biomechatronics. MIT Media Lab.
- "Brain-Controlled Bionic Legs Are Finally Here". Popular Science. Retrieved 2018-12-01.
- Liacouras, Peter C.; Sahajwalla, Divya; Beachler, Mark D.; Sleeman, Todd; Ho, Vincent B.; Lichtenberger, John P. (2017). "Using computed tomography and 3D printing to construct custom prosthetics attachments and devices". 3D Printing in Medicine. 3 (1): 8. doi:10.1186/s41205-017-0016-1. ISSN 2365-6271. PMC 5954798. PMID 29782612.
- "Home – BionX Medical Technologies". www.bionxmed.com. Retrieved 2018-01-08.
- Össur. "PROPRIO FOOT". www.ossur.com. Retrieved 2018-01-08.
- "Elan – Carbon, Feet, Hydraulic – Endolite USA – Lower Limb Prosthetics". Endolite USA – Lower Limb Prosthetics. Retrieved 2018-01-08.
- Windrich, Michael; Grimmer, Martin; Christ, Oliver; Rinderknecht, Stephan; Beckerle, Philipp (19 December 2016). "Active lower limb prosthetics: a systematic review of design issues and solutions". BioMedical Engineering OnLine. 15 (S3): 140. doi:10.1186/s12938-016-0284-9. PMC 5249019. PMID 28105948.
- ENGINEERING.com. "Researchers Create Artificial Nerve System". www.engineering.com. Retrieved 2018-06-08.
- "Stanford researchers create artificial nerve system for robots – Xinhua | English.news.cn". www.xinhuanet.com. Archived from the original on June 7, 2018. Retrieved 2018-06-08.
- University, Stanford (2018-05-31). "An artificial nerve system gives prosthetic devices and robots a sense of touch | Stanford News". Stanford News. Retrieved 2018-06-08.
- "Affordable prosthetics made from recycled plastic waste". MaterialDistrict. 14 January 2019. Retrieved 3 November 2020.
- "These researchers are turning plastic bottles into prosthetic limbs". World Economic Forum. 4 October 2019. Retrieved 3 November 2020.
- Bell, Sarah Jane (21 April 2019). "Recycling shampoo bottles to make prosthetic limbs becomes retired hairdresser's dream". ABC News. Australian Broadcasting Corporation. Retrieved 3 November 2020.
- Conway, Elle (26 June 2019). "Canberra family turning bottle caps into plastic hands and arms for children". ABC News. Australian Broadcasting Corporation. Retrieved 3 November 2020.
- "Envision Hands". Envision. 19 February 2020. Retrieved 3 November 2020.
- Thomas, Daniel J.; Singh, Deepti (August 2020). "3D printing for developing patient specific cosmetic prosthetics at the point of care". International Journal of Surgery (London, England). 80: 241–242. doi:10.1016/j.ijsu.2020.04.023. ISSN 1743-9159. PMID 32311524. S2CID 216047962.
- Serruya MD, Kahana MJ (2008). "Techniques and devices to restore cognition". Behav Brain Res. 192 (2): 149–65. doi:10.1016/j.bbr.2008.04.007. PMC 3051349. PMID 18539345.
- "Enhancements, Oxford Uehiro Centre for Practical Ethics". Practicalethics.ox.ac.uk. Archived from the original on 2016-12-28. Retrieved 2016-12-28.
- Caplan, Arthur; Elliott, Carl (2004). "Is It Ethical to Use Enhancement Technologies to Make Us Better than Well?". PLOS Medicine. 1 (3): e52. doi:10.1371/journal.pmed.0010052. PMC 539045. PMID 15630464.
- Buchanan, Allen E. (2011). Beyond Humanity?. doi:10.1093/acprof:oso/9780199587810.001.0001. ISBN 9780199587810.
- Anomaly, Jonny (2012). "Beyond Humanity? The Ethics of Biomedical Enhancement – by Allen Buchanan". Bioethics. 26 (7): 391–392. doi:10.1111/j.1467-8519.2012.01964.x.
- Warwick K, Gasson M, Hutt B, Goodhew I, Kyberd P, Andrews B, Teddy P, Shad A (2003). "The Application of Implant Technology for Cybernetic Systems". Archives of Neurology. 60 (10): 1369–1373. doi:10.1001/archneur.60.10.1369. PMID 14568806.
- Adee, Sarah (2008-02-01). "Dean Kamen's "Luke Arm" Prosthesis Readies for Clinical Trials". IEEE Spectrum.
- "DARPA's Mind-Controlled Arm Prosthesis Preps for Commercial Launch".
- Garner, Courtney (2019-04-05). "Wearable system interfaces: How can electronic sensors be integrated into improved 3D printed prosthetics?". SciTech Europa. Retrieved 2019-05-06.
- Robert Klemko (10 August 2012), "Oscar Pistorius makes history, leaves without medal", USA Today, archived from the original on 11 August 2012
- Oscar Pistorius makes Olympic history in 400m at London 2012, BBC Sport, 4 August 2012
- Bill Chappell (4 August 2012), Oscar Pistorius makes Olympic history in 400 meters, and moves on to semi-final, NPR, archived from the original on 4 August 2012
- "Men's 400m – semi-finals", london2012.com, archived from the original on 16 December 2012, retrieved 4 August 2012
- Greenberg, Chris (10 August 2012), "Oscar Pistorius, South African 4×400m relay team finish 8th as Bahamas wins gold", Huffington Post, archived from the original on 10 August 2012
- "Hawking, Pistorius open London's Paralympics: Wheelchair-bound physicist Stephen Hawking challenged athletes to 'look to the stars' as he helped open a record-setting Paralympics Games that will run for 11 days in near sold-out venues". Yahoo! Sports. Reuters. 29 August 2012. Archived from the original on 2 September 2012.
- "Cost of a Prosthetic Limb". Cost Helper Health. Retrieved 13 April 2015.
- "Funding for your prosthesis". Limbs4life. Limbs4life. Retrieved 28 January 2018.
- "Cost of Prosthetics Stirs Debate", Boston Globe, 5 July 2005. Retrieved 11 February 2007.
- "ICRC: Trans-Femoral Prosthesis – Manufacturing Guidelines" (PDF). Retrieved 2010-10-03.
- INDEX:2007 INDEX: AWARD Archived February 2, 2009, at the Wayback Machine
- Nagata, Kazuaki (2015-05-10). "Robot arm startup taps 3-D printers in quest to make prosthetics affordable". The Japan Times Online. Japantimes.co.jp. Retrieved 2016-12-28.
- "Open Prosthetics Website". Openprosthetics.org. Retrieved 2016-12-28.
- ten Kate, Jelle; Smit, Gerwin; Breedveld, Paul (2 February 2017). "3D-printed upper limb prostheses: a review". Disability and Rehabilitation: Assistive Technology. 12 (3): 300–314. doi:10.1080/17483107.2016.1253117. PMID 28152642. S2CID 38036558.
- Krebs, D. E.; Edelstein, J. E.; Thornby, M. A. (1991). "Prosthetic management of children with limb deficiencies". Physical Therapy. 71 (12): 920–34. doi:10.1097/01241398-199205000-00033. PMID 1946626.
- Carr, D.B. (1998). "Pain and Rehabilitation from Landmine Injury" (PDF). Update in Anaesthesia. 6 (2): 91.
- Mohan, D. (1986) A Report on Amputees in India. oandplibrary.org
- Werner, David (1987). Disabled village children: A guide for community health workers, rehabilitation workers, and families (1st ed.). Palo Alto, CA, USA: Hesperian Foundation. ISBN 0-942364-06-6.
- Cheng, V. (2004) A victim assistance solution. School of Industrial Design, Carleton University.
- Lee, Winson C. C.; Zhang, Ming (2005-08-01). "Design of monolimb using finite element modelling and statistics-based Taguchi method" (PDF). Clinical Biomechanics. 20 (7): 759–766. doi:10.1016/j.clinbiomech.2005.03.015. ISSN 0268-0033. PMID 15963612.
- Grosz, Elizabeth (2003). "Prosthetic Objects" in The State of Architecture at the Beginning of the 21st Century. pp. 96–97. The Monacelli Press. ISBN 1580931340.
- Scarry, Elaine (1985). The Body in Pain: The Making and Unmaking of the World. Oxford University Press.
- Lupton and Miller (1992). "Streamlining: The Aesthetics of Waste" in Taylor, M. and Preston, J. (eds.) 2006. Intimus: Interior Design Theory Reader. pp. 204–212. ISBN 978-0-470-01570-4.
- Wigley, Mark (1991). "Prosthetic Theory: The Disciplining of Architecture". Assemblage (15): 6–29. doi:10.2307/3171122. JSTOR 3171122.
- Murdoch, George; Wilson, A. Bennett Jr. (1997). A Primer on Amputations and Artificial Limbs. United States of America: Charles C Thomas Publisher, Ltd. pp. 3–31. ISBN 978-0-398-06801-1.
- 'Biomechanics of running: from faulty movement patterns come injury.' Sports Injury Bulletin.
- Edelstein, J. E. Prosthetic feet. State of the Art. Physical Therapy 68(12) Dec 1988: 1874–1881.
- Gailey, Robert. The Biomechanics of Amputee Running. October 2002.
- Hafner B. J.; Sanders J. E.; Czerniecki J. M.; Ferguson J. (2002). "Transtibial energy-storage-and-return prosthetic devices: A review of energy concepts and a proposed nomenclature". Journal of Rehabilitation Research and Development. 39 (1): 1–11. PMID 11926321.
- Afghan amputees tell their stories at Texas gathering, Fayetteville Observer
- Can modern prosthetics actually help reclaim the sense of touch?, PBS Newshour
- A hand for Rick, Fayetteville Observer
- What is prosthesis, prosthetic limb and its various component
- I have one of the most advanced prosthetic arms in the world – and I hate it by Britt H. Young
- A systematic review of randomised controlled trials assessing effectiveness of prosthetic and orthotic interventions