An outline of the participation of Panamanian football teams in the different regional tournaments offered by the CONCACAF. Since 1988, Panama has been sending at least one team to the competitions, the first appearance by a Panamanian team was in 1988 CONCACAF Champions' Cup when Plaza Amador played in the first round.
The best runs for a Panamanian team in competitions was when in 2002 when Árabe Unido finished runner-up in that year's competition of Copa Interclubes UNCAF.
Teams from Panama have participated in every edition of the CONCACAF Champions League (2008–present). The best results being runs to the quarterfinals on five separate occasions. Arabe Unido (x3: 2010, 2014, and 2017), Tauro FC (2018), and Indepediente (2019).
Panamanian teams have also competed in every edition of the CONCACAF League tournament which began in 2017 and ended in 2021. With four teams reaching the semifinals. Arabe Unido (x2 2017, and 2018), Plaza Amador (2017), and Tauro FC (2018).
Panamanian teams now compete in the new CONCACAF Central American Cup which began in 2023.
CONCACAF Champions Cup era (1962–2008, 2024–present) edit
| Season | Team | Round | Opponent | 1st leg | 2nd leg | Aggregate |
|---|---|---|---|---|---|---|
| 1988 | Plaza Amador | 1st Round |  Alajuelense
|
0–2 | 1–2 | 1–4 |
| 1989 | Plaza Amador | 1st Round |  Coke Milpross
|
1–1 | 4–1 | 5–1 |
| 2nd Round |  Pumas UNAM
|
0–4 | 0–6 | 0–10 | ||
| Deportivo La Previsora | Preliminary Round |  America Managua
|
1–1 | 2–0 | 3–1 | |
| 1st Round | Duurly's
|
3–0 | 6–2 | 9–2 | ||
| 2nd Round | UDG
|
0–1 | 5–5 | 5–6 | ||
| 1990 | Tauro FC | 1st Round |  Firpo
|
1–1 | 0–3 | 1–4 |
| Deportivo La Previsora | 1st Round | Alianza
|
1–10 | 0–2 | 1–12 | |
| 1991 | Plaza Amador | 1st Round | Alajuelense
|
1–4 | 0–7 | 1–11 |
| Tauro FC | 1st Round | America Managua
|
5–0 | 0–0 | 5–0 | |
| 2nd Round | Saprissa
|
1–3 | 0–2 | 1–5 | ||
| 1992 | Eurokickers F.C | 1st Round |  SF Bay Blackhawks
|
0–10 | 0–1 | 0–11 |
| Tauro FC | 1st Round | Real Esteli
|
2–0 | 5–1 | 7–1 | |
| 2nd Round | Dallas Rockets
|
1–3 | 2–2 | 3–5 | ||
| 1993 | Sporting Colon | Preliminary Round |  Comunicaciones
|
0–1 | 1–3 | 1–4 |
| Plaza Amador | Preliminary Round | Juventus Managua
|
5–0 | 4–0 | 9–0 | |
| 1st Round | Firpo
|
2–2 | 0–6 | 2–8 | ||
| 1995 | Árabe Unido | 1st Round | FAS
|
0–4 | 1–1 | 1–5 |
| PROJUSA | 1st Round | Juventus Managua
|
1–1 | 2–1 | 3–1 | |
| 2nd Round | Guadalajara
|
0–5 | 0–10 | 0–15 | ||
| 1996 | Cosmos | 1st Round | Comunicaciones
|
0–2 | 0–4 | 0–6 |
| Árabe Unido | 1st Round | Real Esteli
|
1–1 | 1–0 | 2–1 | |
| 2nd Round |  Victoria
|
0–1 | 1–2 | 1–3 | ||
| 1997 | Euro Kickers | Preliminary Round | Dariangen FC
|
4–2 | 1–4 | 5–6 |
| Tauro | 1st Round | CS Cartagines
|
0–5 | 2–4 | 2–9 | |
| Return to Campions Cup format (2024–present) | ||||||
| 2024 | Independiente | Round one | New England Revolution
|
0–1 | 0–3 | 0–4 |
CONCACAF Champions League era (2008–2023) edit
| Season | Team | Round | Opponent | Home | Away | Aggregate |
|---|---|---|---|---|---|---|
| 2008–09 | San Francisco | Preliminary Round | Jalapa
|
5–0 | 0–1 | 5–1 |
| Group Stage | Pumas UNAM
|
1–1 | 0–6 | 4th | ||
| Houston Dynamo
|
0–0 | 1–2 | ||||
| Firpo
|
2–3 | 0–1 | ||||
| Tauro FC | Preliminary Round | Chivas USA
|
2–0 | 1–1 | 3–1 | |
| Group Stage |  Puerto Rico Islanders
|
2–2 | 1–2 | 3rd | ||
| Municipal
|
2–1 | 2–2 | ||||
| Santos Laguna
|
2–0 | 0–3 | ||||
| 2009–10 | San Francisco | Preliminary Round |  San Juan Jabloteh
|
2–0 | 0–3 | 2–3 |
| Arabe Unido | Preliminary Round | Olimpia
|
1–0 | 1–2 | 2–2 (a) | |
| Group Stage | Pachuca
|
4–1 | 0–2 | 2nd | ||
| Houston Dynamo
|
1–1 | 1–5 | ||||
| Isidro Metapán
|
6–0 | 1–0 | ||||
| Quarterfinals | Cruz Azul
|
0–1 | 0–3 | 0–4 | ||
| 2010–11 | Tauro FC | Preliminary Round | Marathón
|
0–3 | 2–1 | 2–4 |
| San Francisco | Preliminary Round | Cruz Azul
|
2–3 | 0–6 | 2–9 | |
| Arabe Unido | Group Stage | Real Salt Lake
|
2–3 | 1–2 | 4th | |
 Toronto FC
|
1–0 | 0–1 | ||||
| Cruz Azul
|
0–6 | 0–2 | ||||
| 2011–12 | San Francisco | Preliminary Round | Seattle Sounders FC
|
1–0 | 0–2 | 1–2 |
| Tauro FC | Group Stage | Toronto FC
|
1–2 | 0–1 | 4th | |
| Pumas UNAM
|
0–0 | 0–1 | ||||
| FC Dallas
|
5–3 | 1–1 | ||||
| 2012–13 | Tauro FC | Group Stage | Real Salt Lake
|
0–1 | 0–2 | 3rd |
| Herediano
|
0–1 | 1–2 | ||||
| Chorrillo | Group Stage | Monterrey
|
0–6 | 0–5 | 3rd | |
| Municipal
|
1–2 | 1–2 | ||||
| Season | Team | Round | Opponent | Home | Away | Aggregate |
| 2013–14 | Sporting
San Miguelito |
Group Stage | Club América
|
0–1 | 0–3 | 3rd |
| Alajuelense
|
1–0 | 0–2 | ||||
| Arabe Unido | Group Stage | W Connection
|
3–1 | 2–0 | 1st | |
| Houston Dynamo
|
1–0 | 1–2 | ||||
| Quarterfinals | Alajuelense
|
0–2 | 0–0 | 0–2 | ||
| 2014–15 | Tauro FC | Group Stage |  Waterhouse
|
1–2 | 1–4 | 3rd |
| D.C. United
|
0–1 | 0–2 | ||||
| Chorrillo | Group Stage | Cruz Azul
|
1–0 | 0–3 | 3rd | |
| Alajuelense
|
1–1 | 0–1 | ||||
| 2015–16 | San Francisco | Group Stage | Querétaro
|
2–1 | 0–2 | 2nd |
| Verdes
|
8–0 | 1–2 | ||||
| Arabe Unido | Group Stage | Montego Bay United
|
3–0 | 2–1 | 2nd | |
| D.C. United
|
0–1 | 0–2 | ||||
| 2016–17 | Plaza Amador | Group Stage | Herediano
|
1–1 | 0–2 | 3rd |
| Tigres UANL
|
1–0 | 1–3 | ||||
| Arabe Unido | Group Stage | Monterrey
|
2–1 | 3–2 | 1st | |
 Don Bosco
|
2–0 | 5–2 | ||||
| Quarterfinals | FC Dallas
|
2–1 | 0–4 | 2–5 | ||
| 2018 | Tauro FC | Round of 16 | FC Dallas
|
1–0 | 2–3 | 3–3 (a) |
| Quarterfinals | Club América
|
1–3 | 0–4 | 1–7 | ||
| 2019 | Independiente | Round of 16 | Toronto FC
|
4–0 | 1–1 | 5–1 |
| Quarterfinals | Sporting Kansas City
|
2–1 | 0–3 | 2–4 |
CONCACAF League (2017–2021) edit
| Season | Team | Round | Opponent | Home | Away | Aggregate |
|---|---|---|---|---|---|---|
| 2017 | Chorrillo | Round of 16 | Honduras Progresso
|
1–0 | 1–0 | 2–0 |
| Quarterfinals | Santos de Guápiles
|
0–1 | 1–0 | 0–2 | ||
| Plaza Amador | Round of 16 | Portmore United
|
1–0 | 0–1 | 1–1 (5–4 p) | |
| Quarterfinals | Walter Ferreti
|
2–1 | 0–0 | 2–1 | ||
| Semifinals | Olimpia
|
1–7 | 1–1 | 2–8 | ||
| Árabe Unido | Round of 16 | Central
|
3–0 | 2–1 | 5–1 | |
| Quarterfinals | Águila
|
0–1 | 2–0 | 2–1 | ||
| Semifinals | Santos de Guápiles
|
0–0 | 0–1 | 0–1 | ||
| 2018 | Universitario | Round of 16 | Diriangén
|
3–1 | 4–0 | 7–1 |
| Quarterfinals | Herediano
|
1–2 | 0–3 | 1–4 | ||
| Tauro | Round of 16 | Real España
|
1–0 | 1–1 | 2–1 | |
| Quarterfinals | Walter Ferreti
|
3–1 | 4–0 | 7–1 | ||
| Semifinals | Motagua
|
2–1 | 0–2 | 2–3 | ||
| Árabe Unido | Round of 16 | Arnett Gardens
|
3–0 | 1–2 | 4–2 | |
| Quarterfinals | FAS
|
3–1 | 1–0 | 4–1 | ||
| Semifinals | Herediano
|
1–0 | 0–2 | 1–2 | ||
| 2019 | Tauro | Round of 16 | Alianza
|
1–0 | 0–2 | 1–2 |
| Independiente | Round of 16 |  S.V. Robinhood
|
2–1 | 1–1 | 3–2 | |
| Quarterfinals | Saprissa
|
0–0 | 0–0 | 0–0 | ||
| San Francisco | Preliminary Round | Alianza
|
0–1 | 1–5 | 1–6 | |
| 2020 | Tauro | Round of 16 | Forge FC
|
1–2 | N/A | |
| Independiente | Preliminary Round | Antigua GFC
|
0–0 (2–4 p) | N/A | ||
| San Francisco | Round of 16 | Alajuelense
|
0–1 | N/A | ||
| 2021 | Independiente | Round of 16 | Forge FC
|
0–2 | 0–0 | 0–2 |
| Plaza Amador | Round of 16 | Santos de Guápiles
|
0–2 | 0–1 | 0–3 | |
| Universitario | Preliminary round |  Samaritaine
|
N/A | 3–0 (w/o) | ||
| Round of 16 | Motagua
|
2–2 | 0–1 | 2–3 | ||