Mishra made his television debut with Star Plus's show Sanjivani, where he played the lead role of Dr. Rahul Mehra. After that he did various TV shows like Kumkum, Saat Phere - Saloni Ka Safar, Dil Se Diya Vachan, Ek Nayi Chhoti Si Zindagi. He was also the contestant of Nach Baliye 1. He has also done some episodic roles in C.I.D. and Adaalat. He was last seen in Dil Dosti Dance as Reyaansh's father on Channel V India. He played the role of Akash Roy in Star Plus's Ek Hasina Thi. Mihir Mishra played the role of Rohit who is Pooja's husband opposite Riva Bubber in BSNL Cellone. He played the role of a senior doctor whose name is Dr. Sinha in Zindagi Wins on Bindass. He did various TV commercials such as Red Tape, Sony Handycam, Sunsilk, BSNL, VICCO, MC Cain Foods India and Tata AIA Life. He played the role of Mr. Rawal who is Leela's father in Jaane Kya Hoga Rama Re on Life OK.
- "Mihir Mishra at Smoke House Delhi". The Times of India.
- "Mihir Mishra to act in a new channel Me Home". www.filmibeat.com.
- "Mihir Mishra & Papiya Sengupta in Fear Files". The Times of India.
- "Mihir Mishra to enter Ek Hazzaron me meri behena hai". Times Of India. Retrieved 10 October 2014.
- "Mihir Mishra & Manini De got eliminated". DNA Syndication. Retrieved 10 October 2014.
- "Mihir Mishra in Adaalat". Times of India.
- "Mihir Mishra The Mystery Man on Ek Hasina Thi". Times of India. Retrieved 10 October 2014.
- "Social dad: As good as mom or even dad!". Times of India. Retrieved 10 October 2014.
- "Mihir Mishra's first time in a mythological avatar". The Times of India.