Herpesviridae is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word herpein ("to creep"), referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster (shingles). In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established Herpesvirus as a genus with 23 viruses among four groups. Latent, recurring infections are typical of this group of viruses, though the family name does not refer to latency. Herpesviridae can cause latent or lytic infections.
At least five species of the Herpesviridae – HSV-1 and HSV-2 (both of which can cause orolabial herpes and genital herpes), varicella zoster virus (the cause of chickenpox and shingles), Epstein–Barr virus (implicated in several diseases, including mononucleosis and some cancers), and cytomegalovirus – are extremely widespread among humans. More than 90% of adults have been infected with at least one of these, and a latent form of the virus remains in almost all humans.
Nine herpesvirus types are known to infect humans: herpes simplex viruses 1 and 2 (HSV-1 and HSV-2, also known as HHV1 and HHV2), varicella-zoster virus (VZV, which may also be called by its ICTV name, HHV-3), Epstein–Barr virus (EBV or HHV-4), human cytomegalovirus (HCMV or HHV-5), human herpesvirus 6A and 6B (HHV-6A and HHV-6B), human herpesvirus 7 (HHV-7), and Kaposi's sarcoma-associated herpesvirus (KSHV, also known as HHV-8). In total, more than 130 herpesviruses are known, some of them from mammals, birds, fish, reptiles, amphibians, and mollusks.
Herpesviruses all share a common structure— relatively large, double-stranded, linear DNA genomes encoding 100-200 genes encased within an icosahedral protein cage called the capsid, which is itself wrapped in a protein layer called the tegument containing both viral proteins and viral mRNAs and a lipid bilayer membrane called the envelope. This whole particle is known as a virion.
|Genus||Structure||Symmetry||Capsid||Genomic arrangement||Genomic segmentation|
Infection is initiated when a viral particle contacts a cell with specific types of receptor molecules on the cell surface. Following binding of viral envelope glycoproteins to cell membrane receptors, the virion is internalized and dismantled, allowing viral DNA to migrate to the cell nucleus. Within the nucleus, replication of viral DNA and transcription of viral genes occurs.
During symptomatic infection, infected cells transcribe lytic viral genes. In some host cells, a small number of viral genes termed latency-associated transcript (LAT) accumulate, instead. In this fashion, the virus can persist in the cell (and thus the host) indefinitely. While primary infection is often accompanied by a self-limited period of clinical illness, long-term latency is symptom-free.
Reactivation of latent viruses has been implicated in a number of diseases (e.g. shingles, pityriasis rosea). Following activation, transcription of viral genes transitions from LAT to multiple lytic genes; these lead to enhanced replication and virus production. Often, lytic activation leads to cell death. Clinically, lytic activation is often accompanied by emergence of nonspecific symptoms, such as low-grade fever, headache, sore throat, malaise, and rash, as well as clinical signs such as swollen or tender lymph nodes and immunological findings such as reduced levels of natural killer cells.
|Genus||Host details||Tissue tropism||Entry details||Release details||Replication site||Assembly site||Transmission|
|Iltovirus||Birds: galliform: psittacine||None||Cell receptor endocytosis||Budding||Nucleus||Nucleus||Oral-fecal, aerosol|
|Cytomegalovirus||Humans; monkeys||Epithelial mucosa||Glycoproteins||Budding||Nucleus||Nucleus||Urine, saliva|
|Mardivirus||Chickens; turkeys; quail||None||Cell receptor endocytosis||Budding||Nucleus||Nucleus||Aerosol|
|Rhadinovirus||Humans; mammals||B-lymphocytes||Glycoproteins||Budding||Nucleus||Nucleus||Sex, saliva|
|Roseolovirus||Humans||T-cells; B-cells; NK-cell; monocytes; macrophages; epithelial||Glycoproteins||Budding||Nucleus||Nucleus||Respiratory contact|
|Simplexvirus||Humans; mammals||Epithelial mucosa||Cell receptor endocytosis||Budding||Nucleus||Nucleus||Saliva|
|Scutavirus||Sea turtles||None||Cell receptor endocytosis||Budding||Nucleus||Nucleus||Aerosol|
The herpesvirus was first isolated from the blue wildebeest in 1960 by veterinary scientist Walter Plowright. The genus Herpesvirus was established in 1971 in the first report of the International Committee on Taxonomy of Viruses (ICTV). This genus consisted of 23 viruses and 4 groups of viruses. In the second ICTV report in 1976 this genus was elevated to family level – the Herpetoviridae. Because of possible confusion with viruses derived from reptiles this name was changed in the third report in 1979 to Herpesviridae. In this report the family Herpesviridae was divided into 3 subfamilies (Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae) and 5 unnamed genera: 21 viruses were listed. In 2009 the family Herpesviridae was elevated to the order Herpesvirales. This elevation was necessitated by the discovery that the herpes viruses of fish and molluscs were only distantly related to those of birds and mammals. Two new families were created – the family Alloherpesviridae which incorporates bony fish and frog viruses and the family Malacoherpesviridae which contains those of molluscs.
This order currently has 3 families, 3 subfamilies plus 1 unassigned, 17 genera, 90 species and plus 48 as yet unassigned viruses.
The system of naming herpes viruses was originated in 1973 and has been elaborated considerably since. The recommended naming system specified that each herpes virus should be named after the taxon (family or subfamily) to which its primary natural host belongs. The subfamily name is used for viruses from members of the family Bovidae or from primates (the virus name ending in –ine, e.g. bovine) and the host family name for other viruses (ending in –id, e.g. equid). Human herpes viruses have been treated as an exception (human rather than hominid). Following the host-derived term, the word herpes virus is added, followed by an Arabic numeral (1,2,3,...). These last two additions bear no implied meaning about taxonomic or biological properties of the virus.
Some exceptions to this system exist. A number of viruses' names (e.g. Epstein–Barr virus) are so widely used that it is impractical to attempt to insist on their replacement. This has led to a dual nomenclature in the literature for some herpes viruses. All herpes viruses described since this system was adopted have been named in accordance with it.
The three mammalian subfamilies – Alpha, Beta and Gamma – arose approximately 180 to 220 mya. The major sublineages within these subfamilies were probably generated before the mammalian radiation of 80 to 60 mya. Speciations within sublineages took place in the last 80 million years probably with a major component of cospeciation with host lineages.
All the currently known bird and reptile species are alphaherpesviruses. Although the branching order of the herpes viruses has not yet been resolved, because herpes viruses and their hosts tend to coevolve this is suggestive that the alphaherpesviruses may have been the earliest branch.
The date of evolution of the iltovirus genus has been estimated to be 200 mya while those of the mardivirus and simplex genera have been estimated to be between 150 and 100 mya.
Immune system evasionsEdit
Herpesviruses are known for their ability to establish lifelong infections. One way this is possible is through immune evasion. Herpesviruses have many different ways of evading the immune system. One such way is by encoding a protein mimicking human interleukin 10 (hIL-10) and another is by downregulation of the major histocompatibility complex II (MHC II) in infected cells.
Research conducted on cytomegalovirus (CMV) indicates that the viral human IL-10 homolog, cmvIL-10, is important in inhibiting pro-inflammatory cytokine synthesis. The cmvIL-10 protein has 27% identity with hIL-10 and only one conserved residue out of the nine amino acids that make up the functional site for cytokine synthesis inhibition on hIL-10. There is, however, much similarity in the functions of hIL-10 and cmvIL-10. Both have been shown to down regulate IFN-γ, IL-1α, GM-CSF, IL-6 and TNF-α, which are all pro-inflammatory cytokines. They have also been shown to play a role in downregulating MHC I and MHC II and up regulating HLA-G (non-classical MHC I). These two events allow for immune evasion by suppressing the cell-mediated immune response and natural killer cell response, respectively. The similarities between hIL-10 and cmvIL-10 may be explained by the fact that hIL-10 and cmvIL-10 both use the same cell surface receptor, the hIL-10 receptor. One difference in the function of hIL-10 and cmvIL-10 is that hIL-10 causes human peripheral blood mononuclear cells (PBMC) to both increase and decrease in proliferation whereas cmvIL-10 only causes a decrease in proliferation of PBMCs. This indicates that cmvIL-10 may lack the stimulatory effects that hIL-10 has on these cells.
It was found that cmvIL-10 functions through phosphorylation of the Stat3 protein. It was originally thought that this phosphorylation was a result of the JAK-STAT pathway. However, despite evidence that JAK does indeed phosphorylate Stat3, its inhibition has no significant influence on cytokine synthesis inhibition. Another protein, PI3K, was also found to phosphorylate Stat3. PI3K inhibition, unlike JAK inhibition, did have a significant impact on cytokine synthesis. The difference between PI3K and JAK in Stat3 phosphorylation is that PI3K phosphorylates Stat3 on the S727 residue whereas JAK phosphorylates Stat3 on the Y705 residue. This difference in phosphorylation positions seems to be the key factor in Stat3 activation leading to inhibition of pro-inflammatory cytokine synthesis. In fact, when a PI3K inhibitor is added to cells, the cytokine synthesis levels are significantly restored. The fact that cytokine levels are not completely restored indicates there is another pathway activated by cmvIL-10 that is inhibiting cytokine system synthesis. The proposed mechanism is that cmvIL-10 activates PI3K which in turn activates PKB (Akt). PKB may then activate mTOR, which may target Stat3 for phosphorylation on the S727 residue.
Another one of the many ways in which herpes viruses evade the immune system is by down regulation of MHC I and MHC II. This is observed in almost every human herpesvirus. Down regulation of MHC I and MHC II can come about by many different mechanisms, most causing the MHC to be absent from the cell surface. As discussed above, one way is by a viral chemokine homolog such as IL-10. Another mechanism to down regulate MHCs is to encode viral proteins that detain the newly formed MHC in the endoplasmic reticulum (ER). The MHC cannot reach the cell surface and therefore cannot activate the T cell response. The MHCs can also be targeted for destruction in the proteasome or lysosome. The ER protein TAP also plays a role in MHC down regulation. Viral proteins inhibit TAP preventing the MHC from picking up a viral antigen peptide. This prevents proper folding of the MHC and therefore the MHC does not reach the cell surface.
Human herpesvirus typesEdit
|Name||Synonym||Subfamily||Primary Target Cell||Pathophysiology||Site of Latency||Means of Spread|
|HHV‑1||Herpes simplex virus-1 (HSV-1)||α (Alpha)||Mucoepithelial||Oral and Herptic whitlow and/or genital herpes (predominantly orofacial), as well as other herpes simplex infections||Neuron||Close contact (oral or sexually transmitted infection)|
|HHV-2||Herpes simplex virus-2 (HSV-2)||α||Mucoepithelial||Oral and/or genital herpes (predominantly genital), as well as other herpes simplex infections||Neuron||Close contact (oral or sexually transmitted disease)|
|HHV-3||Varicella zoster virus (VZV)||α||Mucoepithelial||Chickenpox and shingles||Neuron||Respiratory and close contact (including sexually transmitted disease)|
|HHV-4||Epstein–Barr virus (EBV), lymphocryptovirus||γ (Gamma)||B cells and epithelial cells||Epstein-Barr virus-associated lymphoproliferative diseases, a large group of benign, pre-malignant, and malignant diseases including Epstein-Barr virus-positive reactive lymphoid hyperplasia, severe mosquito bite allergy, Epstein-Barr virus-positive reactive lymphoid hyperplasia, Infectious mononucleosis, Burkitt's lymphoma, Epstein–Barr virus-positive Hodgkin lymphoma, extranodal NK/T cell lymphoma, nasal type, Epstein–Barr virus-associated aggressive NK cell leukemia, CNS lymphoma in AIDS patients, post-transplant lymphoproliferative syndrome (PTLD), nasopharyngeal carcinoma, HIV-associated hairy leukoplakia||B cell||Close contact, transfusions, tissue transplant, and congenital|
|HHV-5||Cytomegalovirus (CMV)||β (Beta)||Monocytes and epithelial cells||Infectious mononucleosis-like syndrome, retinitis||Monocyte, and ?||Saliva, urine, blood, breast milk|
|HHV-6A and 6B||Roseolovirus, Herpes lymphotropic virus||β||T cells and ?||Sixth disease (roseola infantum or exanthem subitum)||T cells and ?||Respiratory and close contact?|
|HHV-7||β||T cells and ?||drug-induced hypersensitivity syndrome, encephalopathy, hemiconvulsion-hemiplegia-epilepsy syndrome, hepatitis infection, postinfectious myeloradiculoneuropathy, pityriasis rosea, and the reactivation of HHV-4, leading to "mononucleosis-like illness"||T cells and ?||?|
|HHV-8||Kaposi's sarcoma-associated herpesvirus
(KSHV), a type of rhadinovirus
|γ||Lymphocyte and other cells||Kaposi's sarcoma, primary effusion lymphoma, some types of multicentric Castleman's disease||B cell||Close contact (sexual), saliva?|
|Macaque monkey||CeHV-1||Cercopithecine herpesvirus-1, (monkey B virus)||α||Very unusual, with only approximately 25 human cases reported. Untreated infection is often deadly; sixteen of the 25 cases resulted in fatal encephalomyelitis. At least four cases resulted in survival with severe neurologic impairment. Symptom awareness and early treatment are important for laboratory workers facing exposure.|
|Mouse||MuHV‑4||Murid herpesvirus 68 (MHV-68)||γ||Zoonotic infection found in 4.5% of general population and more common in laboratory workers handling infected mice. ELISA tests show factor-of-four (x4) false positive results, due to antibody cross-reaction with other Herpes viruses.|
In animal virology, the best known herpesviruses belong to the subfamily Alphaherpesvirinae. Research on pseudorabies virus (PrV), the causative agent of Aujeszky's disease in pigs, has pioneered animal disease control with genetically modified vaccines. PrV is now extensively studied as a model for basic processes during lytic herpesvirus infection, and for unraveling molecular mechanisms of herpesvirus neurotropism, whereas bovine herpesvirus 1, the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis, is analyzed to elucidate molecular mechanisms of latency. The avian infectious laryngotracheitis virus is phylogenetically distant from these two viruses and serves to underline similarity and diversity within the Alphaherpesvirinae.
- Subfamily Alphaherpesvirinae
- Genus Simplexvirus
- Ateline herpesvirus 1, spider monkey herpesvirus.
- Bovine herpesvirus 2 causes bovine mammillitis and pseudo-lumpyskin disease.
- Cercopithecine herpesvirus 1, also known as Herpes B virus, causes a herpes simplex-like disease in macaques, usually fatal if symptomatic and untreated in humans.
- Fruit bat alphaherpesvirus 1
- Leporid herpesvirus 4
- Macacine herpesvirus 1
- Macropodid herpesvirus 2
- Papiine herpesvirus 2
- Genus Varicellovirus
- Bovine herpesvirus 1 causes infectious bovine rhinotracheitis, vaginitis, balanoposthitis, and abortion in cattle.
- Bovine herpesvirus 5 causes encephalitis in cattle.
- Bubaline herpesvirus 1
- Caprine herpesvirus 1 causes conjunctivitis and respiratory disease in goats.
- Canine herpesvirus 1 causes a severe hemorrhagic disease in puppies.
- Cercopithecine herpesvirus 9
- Cervid herpesvirus 1
- Cervid herpesvirus 2
- Elk herpesvirus 1
- Equine herpesvirus 1 causes respiratory disease, neurological disease/paralysis, and spontaneous abortion in horses.
- Equine herpesvirus 3 causes coital exanthema in horses.
- Equine herpesvirus 4 causes rhinopneumonitis in horses.
- Equine herpesvirus 8
- Equine herpesvirus 9
- Feline herpesvirus 1 causes feline viral rhinotracheitis and keratitis in cats.
- Suid herpesvirus 1 causes Aujeszky's disease, also called pseudorabies.
- Genus Mardivirus
- Genus Iltovirus
- Genus Simplexvirus
- Caretta caretta herpesvirus
- Chelonid herpesvirus 1
- Chelonid herpesvirus 2
- Chelonid herpesvirus 3
- Chelonid herpesvirus 4
- Chelonia mydas herpesvirus
- Coober herpesvirus
- Emydid herpesvirus 1
- Emydid herpesvirus 2
- Fibropapilloma associated herpes virus
- Gerrhosaurid herpesvirus 1
- Gerrhosaurid herpesvirus 2
- Gerrhosaurid herpesvirus 3
- Glyptemis herpesvirus 1
- Glyptemys herpesvirus 2
- Iguanid herpesvirus 1
- Iguanid herpesvirus 2
- Loggerhead orocutaneous herpesvirus
- Lung-eye-trachea associated herpesvirus
- Pelomedusid herpesvirus 1
- Red eared slider herpes virus
- Terrapene herpesvirus 1
- Terrapene herpesvirus 2
- Testudinid herpesvirus 1
- Testudinid herpesvirus 2
- Testudinid herpesvirus 3
- Testudinid herpesvirus 4
- Varanid herpesvirus 1
- Subfamily Betaherpesvirinae
- Subfamily Gammaherpesvirinae
- Phascolarctid gammaherpesvirus 1
- Vombatid gammaherpesvirus 1
- Genus Macavirus
- Genus Percavirus
- Genus Rhadinovirus
- Alcelaphine herpesvirus 1 causes bovine malignant catarrhal fever.
- Alcelaphine herpesvirus 2 causes an antelope and hartebeest version of MCF
- Ateline herpesvirus 2
- Bovine herpesvirus 4
- Cercopithecine herpesvirus 17
- Equine herpesvirus 2 causes equine cytomegalovirus infection.
- Equine herpesvirus 5
- Equine herpesvirus 7
- Japanese macaque rhadinovirus
- Leporid herpesvirus 1
- Murid herpesvirus 4 Also known as Murine gammaherpesvirus-68 (MHV-68)
Research is currently ongoing into a variety of side-effect or co-conditions related to the herpesviruses. These include:
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|Wikispecies has information related to Herpesviridae|
|Wikimedia Commons has media related to Herpesviridae.|
- ICTV International Committee on Taxonomy of Viruses (official site)
- Viralzone: Herpesviridae
- Animal viruses
- Article on Cercopithecine herpesvirus
- National B Virus Resource Center
- Pityriasis Rosea overview
- Herpes simplex: Host viral protein interactions.A database of Host/HSV-1 interactions
- Virus Pathogen Database and Analysis Resource (ViPR): Herpesviridae