Malaise is a feeling of general discomfort, uneasiness, or pain, often the first sign of an infection or other disease.[1][2] The word has existed in the French language since at least the 12th century.

Other namesdiscomfort, uneasiness
SpecialtyFamily medicine, Psychiatry, Clinical psychology
Symptomsfeeling of uneasiness or discomfort.
Diagnostic methodbased on symptoms
Differential diagnosispain, anxiety, depressed

The term is also often used figuratively in other contexts.


Malaise is a non-specific symptom and can be present in the slightest ailment, such as an emotion (causing fainting, a vasovagal response) or hunger (light hypoglycemia[3]), to the most serious conditions (cancer, stroke, heart attack, internal bleeding, etc.).

Malaise expresses a patient's uneasiness that "something is not right" that may need a medical examination to determine the significance.

Malaise is thought to be caused by the activation of an immune response, and the associated pro-inflammatory cytokines.[4]

Figurative useEdit

"Economic malaise" refers to an economy that is stagnant or in recession (compare depression). The term is particularly associated with the US 1973–75 recession.[5] A speech made by President Jimmy Carter in 1979 is commonly referred to as the "malaise" speech, although the term was not in the speech.[6]

See alsoEdit

Notes and referencesEdit

  1. ^ "Malaise: MedlinePlus Medical Encyclopedia". Archived from the original on 2016-09-16.
  2. ^ "Well". Archived from the original on 2018-04-24 – via
  3. ^ Sommerfield, Andrew J.; Deary, Ian J.; McAulay, Vincent; Frier, Brian M. (1 February 2003). "Short-Term, Delayed, and Working Memory Are Impaired During Hypoglycemia in Individuals With Type 1 Diabetes". Diabetes Care. 26 (2): 390–396. doi:10.2337/diacare.26.2.390. PMID 12547868. Archived from the original on 13 September 2016 – via
  4. ^ Dantzer, Robert (1 December 2016). "Cytokine, Sickness Behavior, and Depression". Immunology and allergy clinics of North America. 29 (2): 247–264. doi:10.1016/j.iac.2009.02.002. ISSN 0889-8561. PMC 2740752. PMID 19389580.
  5. ^ One example can be found in The Next 200 Years: A Scenario for America and the World, by Herman Kahn et al., published in 1976, p. 2.
  6. ^ ""Crisis of Confidence" Speech (July 15, 1979)". Miller Center, University of Virginia. Archived from the original (text and video) on July 21, 2009.

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