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Dysautonomia or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does not work properly. This may affect the functioning of the heart, bladder, intestines, sweat glands, pupils, and blood vessels. Dysautonomia has many causes, not all of which may be classified as neuropathic.[4] A number of conditions can feature dysautonomia, such as Parkinson's disease, HIV/AIDS, multiple system atrophy, autonomic failure, postural orthostatic tachycardia syndrome, Ehlers-Danlos syndrome,[5] autoimmune autonomic ganglionopathy, and autonomic neuropathy.[citation needed]

Other namesAutonomic dysfunction
The Autonomic Nervous System.jpg
The autonomic nervous system
CausesInadequacy of sympathetic, or parasympathetic, components of autonomic nervous system[1]
Risk factorsAlcoholism and Diabetes[2]
Diagnostic methodAmbulatory Blood pressure, as well as EKG monitoring[3]
TreatmentSymptomatic and supportive[1]

The diagnosis is achieved through functional testing of the ANS, focusing on the affected organ system. Investigations may be performed to identify underlying disease processes that may have led to the development of symptoms or autonomic neuropathy. Symptomatic treatment is available for many symptoms associated with dysautonomia, and some disease processes can be directly treated.[6]

Signs and symptomsEdit

The symptoms of dysautonomia, which are numerous and vary widely for each individual, are due to inefficient or unbalanced efferent signals sent via both systems. The primary symptoms in individuals with dysautonomia include



Dysautonomia may be due to inherited or degenerative neurologic diseases (primary dysautonomia)[4] or it may occur due to injury of the autonomic nervous system from an acquired disorder (secondary dysautonomia).[7][9] The most common causes of dysautonomia include

In the sympathetic nervous system (SNS), predominant dysautonomia is common along with fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis, raising the possibility that such dysautonomia could be their common clustering underlying pathogenesis.[12]

In addition to sometimes being a symptom of dysautonomia, anxiety can sometimes physically manifest symptoms resembling autonomic dysfunction.[13][14][15] A thorough investigation ruling out physiological causes is crucial, but in cases where relevant tests are performed and no causes are found or symptoms do not match any known disorders, a primary anxiety disorder is possible, but should not be presumed.[16] For such patients, the anxiety sensitivity index may have better predictivity for anxiety disorders, while the Beck anxiety inventory may misleadingly suggest anxiety for patients with dysautonomia.[17]


The autonomic nervous system is a component of the peripheral nervous system and comprises two branches: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PSNS). The SNS controls the more active responses such as increasing heart rate and blood pressure. The PSNS slows down the heart rate and aids in digestion, for example. Symptoms typically arise from abnormal responses of either the sympathetic or parasympathetic systems based on situation or environment.[4][18]


Valsalva maneuver

The diagnosis of dysautonomia depends on the overall function of three autonomic functions – cardiovagal, adrenergic, and sudomotor. A diagnosis should, at a bare minimum, include measurements of blood pressure and heart rate while lying flat, and after at least 3 minutes of standing. The best way to achieve a diagnosis includes a range of testing, notably an autonomic reflex screen, tilt table test, and testing of the sudomotor response (QSART or thermoregulatory sweat test).[19]

Additional tests and examinations to determine a diagnosis of dysautonomia include

Tests to elucidate the cause of dysautonomia can include:

Vegetative-vascular dystoniaEdit

Particularly in the Russian literature,[20] a subtype of dysautonomia which particularly affects the vascular system has been called vegetative-vascular dystonia.[21][22][23][24][25] The term "vegetative" reflects an older name for the autonomic nervous system: the vegetative nervous system.[citation needed]


H2- receptor antagonist

The treatment of dysautonomia can be difficult; since it is made up of many different symptoms, a combination of drug therapies is often required to manage individual symptomatic complaints. Therefore, if an autoimmune neuropathy is the case, then treatment with immunomodulatory therapies is done, or if diabetes mellitus is the cause, control of blood glucose is important.[7] Treatment can include proton-pump inhibitors and H2 receptor antagonists used for digestive symptoms such as acid reflux.[26]

For the treatment of genitourinary autonomic neuropathy medications may include sildenafil (a guanine monophosphate type-5 phosphodiesterase inhibitor). For the treatment of hyperhidrosis, anticholinergic agents such as trihexyphenidyl or scopolamine can be used, also intracutaneous injection of botulinum toxin type A can be used for management in some cases.[27]

Balloon angioplasty, a procedure referred to as transvascular autonomic modulation, is specifically not approved for the treatment of autonomic dysfunction.[28]


The prognosis of dysautonomia depends on several factors; individuals with chronic, progressive, generalized dysautonomia in the setting of central nervous system degeneration such as Parkinson's disease or multiple system atrophy have a generally poorer long-term prognosis. Consequently, dysautonomia could be fatal due to pneumonia, acute respiratory failure, or sudden cardiopulmonary arrest.[4]

Autonomic dysfunction symptoms such as orthostatic hypotension, gastroparesis, and gustatory sweating are more frequently identified in mortalities.[29]

See alsoEdit


  1. ^ a b "Dysautonomia Information Page | National Institute of Neurological Disorders and Stroke". Retrieved 2 January 2018.
  2. ^ "Dysautonomia | Autonomic Nervous System Disorders | MedlinePlus". NIH. Retrieved 2 January 2018.
  3. ^ a b c d e f g h i j k l m n o p "Autonomic Neuropathy. Information about AN. Patient | Patient". Patient. Retrieved 2016-02-21.
  4. ^ a b c d e "Dysautonomia". NINDS. Archived from the original on 2016-12-02. Retrieved 2012-04-03.
  5. ^ Castori, M; Voermans, NC (6 October 2014). "Neurological manifestations of Ehlers-Danlos syndrome(s): A review". Iranian Journal of Neurology. 13 (4): 190–208. PMC 4300794. PMID 25632331.
  6. ^ Iodice, V; Sandroni, Paola; Vernino, Steven (2009). "Efficacy of immunotherapy in seropositive and seronegative putative autoimmune autonomic ganglionopathy". Neurology. 72 (23): 2002–8. doi:10.1212/WNL.0b013e3181a92b52. PMC 2837591. PMID 19506222.
  7. ^ a b c d e f g h i j k l "Autonomic Neuropathy Clinical Presentation: History, Physical, Causes". Retrieved 2016-02-21.
  8. ^ a b c d e f g h i j "Autonomic neuropathy: MedlinePlus Medical Encyclopedia". Retrieved 2016-02-20.
  9. ^ KIRK, KATHERINE A; SHOYKHET, MICHAEL; JEONG, JONG H; TYLER-KABARA, ELIZABETH C; HENDERSON, MARYANNE J; BELL, MICHAEL J; FINK, ERICKA L (2012-08-01). "Dysautonomia after pediatric brain injury". Developmental Medicine and Child Neurology. 54 (8): 759–764. doi:10.1111/j.1469-8749.2012.04322.x. ISSN 0012-1622. PMC 3393822. PMID 22712762.
  10. ^ De Wandele I, Rombaut L, Leybaert L, Van, de Borne P, De Backer T, Malfait F, De Paepe A, Calders P (2014). "Dysautonomia and its underlying mechanisms in the hypermobility type of Ehlers-Danlos syndrome". Semin. Arthritis Rheum. 44 (1): 93–100. doi:10.1016/j.semarthrit.2013.12.006. PMID 24507822.CS1 maint: multiple names: authors list (link)
  11. ^ "Paraneoplastic syndromes of the nervous system". Mayo Clinic. Mayo Clinic. Retrieved 13 September 2016.
  12. ^ Martínez-Martínez LA, Mora T, Vargas A, Fuentes-Iniestra M, Martínez-Lavín M (Apr 2014). "Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies" (PDF). J Clin Rheumatol. 20 (3): 146–50. doi:10.1097/RHU.0000000000000089. PMID 24662556.
  13. ^ "Medscape Log In". Retrieved 2017-06-02.
  14. ^ Ackerman, Kurt; DiMartini, Andrea F. (2015). Psychosomatic Medicine. Oxford University Press, Incorporated. ISBN 9780199329311.
  15. ^ Carr, Alan; McNulty, Muireann (2016-03-31). The Handbook of Adult Clinical Psychology: An Evidence Based Practice Approach. Routledge. ISBN 9781317576143.
  16. ^ Tasman, Allan; Kay, Jerald; First, Michael B.; Lieberman, Jeffrey A.; Riba, Michelle (2015-03-30). Psychiatry, 2 Volume Set. John Wiley & Sons. ISBN 9781118845479.
  17. ^ Raj, V; Haman, K L; Raj, S R; Byrne, D; Blakely, R D; Biaggioni, I; Robertson, D; Shelton, R C (2009). "Psychiatric profile and attention deficits in postural tachycardia syndrome". Journal of Neurology, Neurosurgery & Psychiatry. 80 (3): 339–344. doi:10.1136/jnnp.2008.144360. PMC 2758320. PMID 18977825. Retrieved 2017-06-02.
  18. ^ Information, National Center for Biotechnology; Pike, U. S. National Library of Medicine 8600 Rockville; MD, Bethesda; Usa, 20894. "Autonomic Nervous System - National Library of Medicine". PubMed Health. Retrieved 2016-02-21.
  19. ^ a b c d e f g h i Mustafa, Hossam I.; Fessel, Joshua P.; Barwise, John; Shannon, John R.; Raj, Satish R; Diedrich, André; Biaggioni, Italo; Robertson, David (2012-01-01). "Dysautonomia: Perioperative Implications". Anesthesiology. 116 (1): 205–215. doi:10.1097/ALN.0b013e31823db712. ISSN 0003-3022. PMC 3296831. PMID 22143168.
  20. ^ Loganovsky, Konstantin (1999). "Vegetative-Vascular Dystonia and Osteoalgetic Syndrome or Chronic Fatigue Syndrome as a Characteristic After-Effect of Radioecological Disaster". Journal of Chronic Fatigue Syndrome. 7 (3): 3–16. doi:10.1300/J092v07n03_02.
  21. ^ Ivanova, ES; Mukharliamov, FIu; Razumov, AN; Uianaeva, AI (2008). "State-of-the-art corrective and diagnostic technologies in medical rehabilitation of patients with vegetative vascular dystonia". Voprosy Kurortologii, Fizioterapii, I Lechebnoi Fizicheskoi Kultury (1): 4–7. PMID 18376477.
  22. ^ Malysheva, OA; Shirinskiĭ, VS (1998). "Seasonal changes of secondary immunodeficiency in patients with vascular dystonia". Klinicheskaia Meditsina. 76 (5): 34–6. PMID 9644934.
  23. ^ Lobzin, VS; Poliakova, LA; Shiman, AG; Zavodnik, AI (1989). "Treatment of autonomic vascular dystonia by combined physiotherapy methods". Vrachebnoe Delo (3): 22–3. PMID 2750110.
  24. ^ Solov'Eva, AD; Kolosova, OA; Loseva, MM; Mindlina, GE; Ginzburg, LI (1985). "Thermography in healthy subjects and in the syndrome of vegetative-vascular dystonia". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova. 85 (6): 905–10. PMID 4024817.
  25. ^ Isaev, DN; Efremov, KD (1983). "Psychogenic factors participating in the development of vegetovascular dystonia of the hypertensive type in children". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova. 83 (10): 1548–52. PMID 6659792.
  26. ^ "H2 Blockers. Reducing stomach acid with H2 Blockers. | Patient". Patient. Retrieved 2016-02-21.
  27. ^
  28. ^ "Safety Alerts for Human Medical Products - Balloon angioplasty devices to treat autonomic dysfunction: FDA Safety Communication - FDA concern over experimental procedures". Retrieved 9 March 2017.
  29. ^ Vinik, Aaron I.; Maser, Raelene E.; Mitchell, Braxton D.; Freeman, Roy (2003-05-01). "Diabetic Autonomic Neuropathy". Diabetes Care. 26 (5): 1553–1579. doi:10.2337/diacare.26.5.1553. ISSN 0149-5992. PMID 12716821.

Further readingEdit


  • Brading, Alison (1999). The autonomic nervous system and its effectors. Oxford: Blackwell Science. ISBN 978-0632026241.
  • Goldstein, David (2016). Principles of Autonomic Medicine (PDF) (free online version ed.). Bethesda, Maryland: National Institute of Neurological Disorders and Stroke, National Institutes of Health. ISBN 9780824704087.
  • Jänig, Wilfrid (2008). Integrative action of the autonomic nervous system : neurobiology of homeostasis (Digitally printed version. ed.). Cambridge: Cambridge University Press. ISBN 978-0521067546.

Journal articlesEdit

External linksEdit