Cyanide poisoning is poisoning that results from exposure to a number of forms of cyanide. Early symptoms include headache, dizziness, fast heart rate, shortness of breath, and vomiting. This may then be followed by seizures, slow heart rate, low blood pressure, loss of consciousness, and cardiac arrest. Onset of symptoms is usually within a few minutes. If a person survives, there may be long-term neurological problems.
|Other names||Cyanide toxicity, hydrocyanic acid poisoning|
|Specialty||Toxicology, critical care medicine|
|Symptoms||Early: headache, dizziness, fast heart rate, shortness of breath, vomiting|
Later: seizures, slow heart rate, low blood pressure, loss of consciousness, cardiac arrest
|Usual onset||Few minutes|
|Risk factors||House fire, metal polishing, certain insecticides, eating seeds from apples|
|Diagnostic method||Based on symptoms, high blood lactate|
|Treatment||Decontaminated, supportive care (100% oxygen), hydroxocobalamin|
Toxic cyanide-containing compounds include hydrogen cyanide gas and a number of cyanide salts. Poisoning is relatively common following breathing in smoke from a house fire. Other potential routes of exposure include workplaces involved in metal polishing, certain insecticides, the medication nitroprusside, and certain seeds such as those of apples and apricots. Liquid forms of cyanide can be absorbed through the skin. Cyanide ions interfere with cellular respiration, resulting in the body's tissues being unable to use oxygen.
Diagnosis is often difficult. It may be suspected in a person following a house fire who has a decreased level of consciousness, low blood pressure, or high blood lactate. Blood levels of cyanide can be measured but take time. Levels of 0.5–1 mg/L are mild, 1–2 mg/L are moderate, 2–3 mg/L are severe, and greater than 3 mg/L generally result in death.
If exposure is suspected, the person should be removed from the source of exposure and decontaminated. Treatment involves supportive care and giving the person 100% oxygen. Hydroxocobalamin (vitamin B12a) appears to be useful as an antidote and is generally first-line. Sodium thiosulphate may also be given. Historically cyanide has been used for mass suicide and by the Nazis for genocide.
Signs and symptomsEdit
If cyanide is inhaled it can cause a coma with seizures, apnea, and cardiac arrest, with death following in a matter of seconds. At lower doses, loss of consciousness may be preceded by general weakness, giddiness, headaches, vertigo, confusion, and perceived difficulty in breathing. At the first stages of unconsciousness, breathing is often sufficient or even rapid, although the state of the person progresses towards a deep coma, sometimes accompanied by pulmonary edema, and finally cardiac arrest. A cherry red skin color that changes to dark may be present as the result of increased venous hemoglobin oxygen saturation. Despite the similar name, cyanide does not directly cause cyanosis. A fatal dose for humans can be as low as 1.5 mg/kg body weight.
Exposure to lower levels of cyanide over a long period (e.g., after use of improperly processed cassava roots as a primary food source in tropical Africa) results in increased blood cyanide levels, which can result in weakness and a variety of symptoms, including permanent paralysis, nervous lesions, hypothyroidism, and miscarriages. Other effects include mild liver and kidney damage.
Acute hydrogen cyanide poisoning can result from inhalation of fumes from burning polymer products that use nitrile in their production, such as polyurethane, or vinyl. It can also be caused by breakdown of nitroprusside into nitric oxide and cyanide. Nitroprusside may be used during treatment of hypertensive crisis.
In addition to its uses as a pesticide and insecticide, cyanide is contained in tobacco smoke and smoke from building fires, and is present in many seeds or kernels such as those of almonds, apricots, apples, oranges, and in foods including cassava (also known as yuca or manioc), and bamboo shoots. Vitamin B12, in the form of hydroxocobalamin (also spelled hydroxycobalamin), may reduce the negative effects of chronic exposure, and a deficiency can lead to negative health effects following exposure.
Cyanide poisoning is a form of histotoxic hypoxia because the cells of an organism are unable to create ATP, primarily through the inhibition of the mitochondrial enzyme cytochrome c oxidase. Cyanide is quickly metabolized to 2-amino-2-thiazoline-4-carboxylic acid and thiocyanate with a half life of 10–30 minutes as a detoxifying mechanism. Within a few hours of single ingestion, no cyanide can be detected, since all of it is metabolized unless death occurs first. Thiocyanate has a long half life of >24hrs, and is typically eliminated through the kidneys. Thiocyanate possesses ~1/100th the toxicity of the cyanide parent molecule.
Old methods of detection involve colorimetric assays such as the Prussian Blue test, the pyridine-barbiturate assay, also known as the "Conway diffusion method" and the taurine fluorescence-HPLC but like all colorimetric assays these can be prone to false positives. Lipid peroxidation resulting in "TBARS," an artifact of heart attack produces dialdehydes that cross-react with the pyridine-barbiturate assay. Meanwhile, the taurine-fluorescence-HPLC assay used for cyanide detection is identical to the assay used to detect glutathione in spinal fluid. Recently, cyanide and thiocyanate assays have been run with mass spectrometry (LC/MS/MS), which are considered specific tests. Since cyanide has such a short half-life, the main metabolite, thiocyanate is typically measured to determine exposure.
Decontamination of people exposed to hydrogen cyanide gas only requires removal of the outer clothing and the washing of their hair. Those exposed to liquids or powders generally require full decontamination.
The United States standard cyanide antidote kit first uses a small inhaled dose of amyl nitrite, followed by intravenous sodium nitrite, followed by intravenous sodium thiosulfate. Hydroxocobalamin is newly approved in the US and is available in Cyanokit antidote kits. Sulfanegen TEA, which could be delivered to the body through an intra-muscular (IM) injection, detoxifies cyanide and converts the cyanide into thiocyanate, a less toxic substance. Alternative methods of treating cyanide intoxication are used in other countries.
|Nitrites||The nitrites oxidize some of the hemoglobin's iron from the ferrous state to the ferric state, converting the hemoglobin into methemoglobin.
Cyanide binds avidly to methemoglobin, forming cyanmethemoglobin, thus releasing cyanide from cytochrome oxidase. Treatment with nitrites is not innocuous as methemoglobin cannot carry oxygen, and severe methemoglobinemia may need to be treated in turn with methylene blue.[note 1]
|Thiosulfate||The evidence for sodium thiosulfate's use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the mitochondrial enzyme rhodanese (thiosulfate cyanide sulfurtransferase), which uses thiosulfate as a substrate. However, this reaction occurs too slowly in the body for thiosulfate to be adequate by itself in acute cyanide poisoning. Thiosulfate must therefore be used in combination with nitrites.|
|Hydroxocobalamin||Hydroxocobalamin, a form (or vitamer) of vitamin B12 made by bacteria, and sometimes denoted vitamin B12a, is used to bind cyanide to form the harmless cyanocobalamin form of vitamin B12.|
|4-Dimethylaminophenol||4-Dimethylaminophenol (4-DMAP) has been proposed[by whom?] in Germany as a more rapid antidote than nitrites with (reportedly) lower toxicity. 4-DMAP is used currently by the German military and by the civilian population. In humans, intravenous injection of 3 mg/kg of 4-DMAP produces 35 percent methemoglobin levels within 1 minute. Reportedly, 4-DMAP is part of the US Cyanokit, while it is not part of the German Cyanokit due to side effects (e. g. hemolysis).|
|Dicobalt edetate||Cobalt ions, being chemically similar to iron ions, can also bind cyanide. One current cobalt-based antidote available in Europe is dicobalt edetate or dicobalt-EDTA, sold as Kelocyanor. This agent chelates cyanide as the cobalticyanide. This drug provides an antidote effect more quickly than formation of methemoglobin, but a clear superiority to methemoglobin formation has not been demonstrated. Cobalt complexes are quite toxic, and there have been accidents reported in the UK where patients have been given dicobalt-EDTA by mistake based on a false diagnosis of cyanide poisoning. Because of its side effects, it should be reserved only for patients with the most severe degree of exposure to cyanide; otherwise, nitrite/thiosulfate is preferred.|
|Glucose||Evidence from animal experiments suggests that coadministration of glucose protects against cobalt toxicity associated with the antidote agent dicobalt edetate. For this reason, glucose is often administered alongside this agent (e.g. in the formulation 'Kelocyanor').|
It has also been anecdotally suggested that glucose is itself an effective counteragent to cyanide, reacting with it to form less toxic compounds that can be eliminated by the body. One theory on the apparent immunity of Grigori Rasputin to cyanide was that his killers put the poison in sweet pastries and madeira wine, both of which are rich in sugar; thus, Rasputin would have been administered the poison together with massive quantities of antidote. One study found a reduction in cyanide toxicity in mice when the cyanide was first mixed with glucose. However, as yet glucose on its own is not an officially acknowledged antidote to cyanide poisoning.
|3-Mercaptopyruvate prodrugs||The most widely studied cyanide-metabolizing pathway involves utilization of thiosulfate by the enzyme rhodanese, as stated above. In humans, however, rhodanese is concentrated in the kidneys (0.96 units/mg protein) and liver (0.15 u/mg), with concentrations in lung, brain, muscle and stomach not exceeding 0.03 U/ml. In all these tissues, it is found in the mitochondrial matrix, a site of low accessibility for ionized, inorganic species, such as thiosulfate. This compartmentalization of rhodanese in mammalian tissues leaves major targets of cyanide lethality, namely, the heart and central nervous system, unprotected. (Rhodanese is also found in red blood cells, but its relative importance has not been clarified.)
A different cyanide-metabolizing pathway, 3-mercaptopyruvate sulfurtransferase (3-MPST, EC 18.104.22.168), which is more widely distributed in mammalian tissues than rhodanese, is being explored. 3-MPST converts cyanide to thiocyanate, using the cysteine catabolite, 3-mercaptopyruvate (3-MP). However, 3-MP is extremely unstable chemically. Therefore, a prodrug, sulfanegen sodium (2, 5-dihydroxy-1,4-dithiane-2,5-dicarboxylic acid disodium salt), which hydrolyzes into 2 molecules of 3-MP after being administered orally or parenterally, is being evaluated in animal models.
|Oxygen therapy||Oxygen therapy is not a cure in its own right. However, the human liver is capable of metabolizing cyanide quickly in low doses (smokers breathe in hydrogen cyanide, but it is such a small amount and metabolized so fast that it does not accumulate).
The International Programme on Chemical Safety issued a survey (IPCS/CEC Evaluation of Antidotes Series) that lists the following antidotal agents and their effects: oxygen, sodium thiosulfate, amyl nitrite, sodium nitrite, 4-dimethylaminophenol, hydroxocobalamin, and dicobalt edetate ('Kelocyanor'), as well as several others. Other commonly-recommended antidotes are 'solutions A and B' (a solution of ferrous sulfate in aqueous citric acid, and aqueous sodium carbonate, respectively) and amyl nitrite.
The UK Health and Safety Executive (HSE) has recommended against the use of solutions A and B because of their limited shelf life, potential to cause iron poisoning, and limited applicability (effective only in cases of cyanide ingestion, whereas the main modes of poisoning are inhalation and skin contact). The HSE has also questioned the usefulness of amyl nitrite due to storage/availability problems, risk of abuse, and lack of evidence of significant benefits. It also states that the availability of Kelocyanor at the workplace may mislead doctors into treating a patient for cyanide poisoning when this is an erroneous diagnosis. The HSE no longer recommends a particular cyanide antidote. Qualified UK first aiders are now only permitted to apply oxygen therapy using a bag valve mask, providing they have been trained in its usage.
- On December 5, 2009, a fire in the night club Lame Horse (Khromaya Loshad) in the Russian city of Perm took the lives of 156 people. 111 people died on the spot and 45 later in hospitals. One of the main causes of death was poisoning from cyanide and other toxic gases released by the burning of plastic and polyurethane foam used in the construction of club interiors. Taking into account the number of deaths, this was the largest fire in post-Soviet Russia.[when?]
- On January 27, 2013, a fire at the Kiss nightclub in the city of Santa Maria, in the south of Brazil, caused the poisoning of hundreds of young people by cyanide released by the combustion of soundproofing foam made with polyurethane. By March 2013, 241 fatalities were confirmed.
In early 1942, Zyklon B which contains hydrogen cyanide, emerged as the preferred killing tool of Nazi Germany for use in extermination camps during the Holocaust. The chemical was used to kill roughly one million people in gas chambers installed in extermination camps at Auschwitz-Birkenau, Majdanek, and elsewhere. Most of the people who were killed were Jews, and by far the majority killed using this method died at Auschwitz.[a] Zyklon B was supplied to concentration camps at Mauthausen, Dachau, and Buchenwald by the distributor Heli, and to Auschwitz and Majdanek by Testa. Camps also occasionally bought Zyklon B directly from the manufacturers. Of the 729 tonnes of Zyklon B sold in Germany in 1942–44, 56 tonnes (about 8 percent of domestic sales) were sold to concentration camps. Auschwitz received 23.8 tonnes, of which 6 tonnes were used for fumigation. The remainder was used in the gas chambers or lost to spoilage (the product had a stated shelf life of only three months). Testa conducted fumigations for the Wehrmacht and supplied them with Zyklon B. They also offered courses to the SS in the safe handling and use of the material for fumigation purposes. In April 1941, the German agriculture and interior ministries designated the SS as an authorized applier of the chemical, and thus they were able to use it without any further training or governmental oversight.
Hydrogen cyanide gas has been used for judicial execution in some states of the United States, where cyanide was generated by reaction between potassium cyanide (or sodium cyanide) dropped into a compartment containing sulfuric acid, directly below the chair in the gas chamber.
Cyanide was stockpiled in chemical weapons arsenals in the United States in the 1950s and 1960s. However, as a military agent, hydrogen cyanide was not considered very effective, since it is lighter than air and needs a significant dose to incapacitate or kill.
Cyanide salts are sometimes used as fast-acting suicide devices. Cyanide reacts at a higher level with high stomach acidity.
- On January 26, 1904, company promoter and swindler Whitaker Wright committed suicide by ingesting cyanide in a court anteroom immediately after being convicted of fraud.
- In February 1937, the Uruguayan short story writer Horacio Quiroga committed suicide by drinking cyanide in a hospital at Buenos Aires.
- In 1937, polymer chemist Wallace Carothers committed suicide by cyanide.
- In the 1943 Operation Gunnerside to destroy the Vemork Heavy Water Plant in World War II (an attempt to stop or slow German atomic bomb progress), the commandos were given cyanide tablets (cyanide enclosed in rubber) kept in the mouth and were instructed to bite into them in case of German capture. The tablets ensured death within three minutes.
- Cyanide, in the form of pure liquid prussic acid (a historical name for hydrogen cyanide), was the favored suicide agent of the Third Reich. It was used to commit suicide by Erwin Rommel (1944), Adolf Hitler's wife, Eva Braun (1945), and by Nazi leaders Heinrich Himmler (1945), possibly Martin Bormann (1945), and Hermann Göring (1946).
- It is speculated that, in 1954, Alan Turing used an apple that had been injected with a solution of cyanide to commit suicide after being convicted of having a homosexual relationship — illegal at the time in the UK—and forced to undergo hormonal castration.
- Members of the Sri Lankan LTTE (Liberation Tigers of Tamil Eelam, whose insurgency lasted from 1983 to 2009), used to wear cyanide vials around their necks with the intention of committing suicide if captured by the government forces.
- On November 18, 1978, Jonestown. A total of 909 individuals died in Jonestown, many from apparent cyanide poisoning, in an event termed "revolutionary suicide" by Jones and some members on an audio tape of the event and in prior discussions. The poisonings in Jonestown followed the murder of five others by Temple members at Port Kaituma, including United States Congressman Leo Ryan, an act that Jones ordered. Four other Temple members committed murder-suicide in Georgetown at Jones' command.
- On June 6, 1985, serial killer Leonard Lake died in custody after having ingested cyanide pills he had sewn into his clothes.
- On June 28, 2012, Wall Street trader Michael Marin ingested a cyanide pill seconds after a guilty verdict was read in his arson trial in Phoenix, AZ; he died minutes after.
- On June 22, 2015, John B. McLemore, an horologist and the central figure of the podcast S-Town, died after ingesting cyanide.
- On November 29, 2017, Slobodan Praljak died from drinking potassium cyanide, after being convicted of war crimes by the International Criminal Tribunal for the former Yugoslavia.
Mining and industrialEdit
- In 2000, a spill at Baia Mare, Romania resulted in the worst environmental disaster in Europe since Chernobyl.
- In 2000, Allen Elias, CEO of Evergreen Resources was convicted of knowing endangerment for his role in the cyanide poisoning of employee Scott Dominguez. This was one of the first successful criminal prosecutions of a corporate executive by the Environmental Protection Agency.
- John Tawell, a murderer who in 1845 became the first person to be arrested as the result of telecommunications technology.
- Grigori Rasputin (1916; attempted, later killed by gunshot)
- Goebbels children (1945)
- Stepan Bandera (1959)
- Jonestown, Guyana, was the site of a large mass murder–suicide, in which over 900 members of the Peoples Temple drank potassium cyanide–laced Flavor Aid in 1978.
- Chicago Tylenol murders (1982)
- Ronald Clark O'Bryan (1944–1984)
- Bruce Nickell (June 5, 1986) Murdered by his wife who poisoned a bottle of Excedrin.
- Richard Kuklinski (1935–2006)
- Janet Overton (1942-1988) Her husband, Richard Overton was convicted of poisoning her, but Janet's symptoms did not match those of classic cyanide poisoning, the timeline was inconsistent with cyanide poisoning, and the amount found was just a trace. The diagnostic method used was prone to false positives. Richard Overton died in prison in 2009.
- Urooj Khan (1966-2012), won the lottery and was found dead a few days later. A blood diagnostic reported a lethal level of cyanide in his blood, but the body did not display any classic symptoms of cyanide poisoning, and no link to cyanide could be found in Urooj's social circle. The diagnostic method used was the Conway diffusion method, prone to false positives with artifacts of heart attack and kidney failure.
- Autumn Marie Klein (April 20, 2013), a prominent 41-year-old neuroscientist and physician, died from cyanide poisoning. Klein's husband, Robert J. Ferrante, also a prominent neuroscientist who used cyanide in his research, was convicted of murder and sentenced to life in prison for her death. However, Klein never exhibited symptoms of cyanide poisoning and the amount measured in relation to the timeline (2.2 mg/L at 15 hours after supposed ingestion but zero thiocyanate levels) suggest that the measurement was a false positive. Robert Ferrante is appealing his conviction.
- Mirna Salihin died in hospital on January 6, 2016 after drinking a Vietnamese iced coffee at a cafe in a shopping mall in Jakarta. Police reports claim that cyanide poisoning was to most likely cause of her death.
- Mei Xiang Li of Brooklyn, NY, collapsed and died in April 2017, with cyanide later reported to be in her blood. However, Mei never exhibited symptoms of cyanide poisoning and no link to cyanide could be found in her life.
- In 1995, a device was discovered in a restroom in the Kayabacho Tokyo subway station, consisting of bags of sodium cyanide and sulfuric acid with a remote controlled motor to rupture them in what was believed to be an attempt by the Aum Shinrikyo cult to produce toxic amounts of hydrogen cyanide gas.
- In 2003, Al Qaeda reportedly planned to release cyanide gas into the New York City Subway system. The attack was supposedly aborted because there would not be enough casualties.
Cobinamide is the final compound in the biosynthesis of cobalamin. It has greater affinity for the cyanide than cobalamin itself, which suggests that it could be a better option for emergency treatment.
- Soviet officials initially stated that over 4 million people were killed using Zyklon B at Auschwitz, but this figure was later proven to be greatly exaggerated.
- Waters, Brenda L. (2010). Handbook of Autopsy Practice (4 ed.). Springer Science & Business Media. p. 427. ISBN 9781597451277. Archived from the original on 8 September 2017.
- Anseeuw, K; Delvau, N; Burillo-Putze, G; De Iaco, F; Geldner, G; Holmström, P; Lambert, Y; Sabbe, M (February 2013). "Cyanide poisoning by fire smoke inhalation: a European expert consensus". European Journal of Emergency Medicine. 20 (1): 2–9. doi:10.1097/mej.0b013e328357170b. PMID 22828651.
- Hamel, J (February 2011). "A review of acute cyanide poisoning with a treatment update". Critical Care Nurse. 31 (1): 72–81, quiz 82. doi:10.4037/ccn2011799. PMID 21285466.
- Dorland's Illustrated Medical Dictionary (32 ed.). Elsevier Health Sciences. 2011. p. 1481. ISBN 978-1455709854. Archived from the original on 8 September 2017.
- Thompson, JP; Marrs, TC (December 2012). "Hydroxocobalamin in cyanide poisoning". Clinical Toxicology. 50 (10): 875–85. doi:10.3109/15563650.2012.742197. PMID 23163594.
- Hevesi, Dennis (26 March 1993). "Imported Bitter Apricot Pits Recalled as Cyanide Hazard". The New York Times. Archived from the original on 18 August 2017. Retrieved 2 June 2017.
- "Sodium Nitroprusside". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
- "Hydrogen Cyanide - Emergency Department/Hospital Management". CHEMM. 14 January 2015. Archived from the original on 14 November 2016. Retrieved 26 October 2016.
- "Cyanide [Technical document – Chemical/Physical Parameters]". Health Canada. 6 October 2008. Archived from the original on 4 February 2009.
- Soto-Blanco B, Maiorka PC, Gorniak SL (2002). "Effects of long-term low-dose cyanide administration to rats". Ecotoxicology and Environmental Safety. 53 (1): 37–41. doi:10.1006/eesa.2002.2189. PMID 12481854.
- Soto-Blanco B, Stegelmeier BL, Pfister JA, et al. (2008). "Comparative effects of prolonged administration of cyanide, thiocyanate and chokecherry (Prunus virginiana) to goats". Journal of Applied Toxicology. 28 (3): 356–63. doi:10.1002/jat.1286. PMID 17631662.
- Soto-Blanco B, Maiorka PC, Gorniak SL (2002). "Neuropathologic study of long term cyanide administration to goats". Food and Chemical Toxicology. 40 (11): 1693–1698. doi:10.1016/S0278-6915(02)00151-5. PMID 12176095.
- Soto-Blanco B, Gorniak SL (2004). "Prenatal toxicity of cyanide in goats—a model for teratological studies in ruminants". Theriogenology. 62 (6): 1012–26. doi:10.1016/j.theriogenology.2003.12.023. PMID 15289044.
- Soto-Blanco B, Pereira, Verechia FT; et al. (2009). "Fetal and maternal lesions of cyanide dosing to pregnant goats". Small Ruminant Research. 87 (1–3): 76–80. doi:10.1016/j.smallrumres.2009.09.029.CS1 maint: Multiple names: authors list (link)
- Sousa AB, Soto-Blanco B, Guerra JL, Kimura ET, Gorniak SL (2002). "Does prolonged oral exposure to cyanide promote hepatotoxicity and nephrotoxicity?". Toxicology. 174 (2): 87–95. doi:10.1016/S0300-483X(02)00041-0. PMID 11985886.
- Manzano H, de Sousa AB, Soto-Blanco B, et al. (2007). "Effects of long-term cyanide ingestion by pigs". Veterinary Research Communications. 31 (1): 93–104. doi:10.1007/s11259-006-3361-x. PMID 17180454.
- McKenna, Sean Thomas; Hull, Terence Richard (21 April 2016). "The fire toxicity of polyurethane foams". Fire Science Reviews. 5 (1). doi:10.1186/s40038-016-0012-3.
- Physicians, [ed. by] David M. Cline [et al.]; American College of Emergency (7 June 2012). Tintinalli's emergency medicine manual (7th ed.). New York: McGraw-Hill Medical. p. 604. ISBN 9780071781848.
- Crampton RF, Gaunt IF, Harris R, et al. (1979). "Effects of low cobalamin diet and chronic cyanide toxicity in baboons". Toxicology. National Library of Medicine. 12 (3): 221–34. doi:10.1016/0300-483X(79)90068-4. PMID 494304.
- Forensic Toxicology: Principles and Concepts By Nicholas T Lappas, Courtney M Lappas, Chapter 10.
- Toxicity, Cyanide~overview at eMedicine
- Toxicity, Cyanide~treatment at eMedicine
- "Archived copy". Archived from the original on 5 March 2016. Retrieved 14 January 2017.CS1 maint: Archived copy as title (link)[full citation needed]
- Leybell, Inna. "Cyanide Toxicity". Medscape. Archived from the original on 29 December 2008.
- Hanzlik, PJ (4 February 1933). "Methylene blue as an antidote for cyanide poisoning". JAMA. 100 (5): 357. doi:10.1001/jama.1933.02740050053028.
- Dart, Richard, ed. (2004). Medical Toxicology (Third ed.). Lippincott Williams & Wilkins. p. 221. ISBN 9780781728454. Archived from the original on 8 September 2017.
- Nagler J, Provoost RA, Parizel G (1978). "Hydrogen cyanide poisoning: Treatment with cobalt EDTA". Journal of Occupational Medicine. 20 (6): 414–6. PMID 209160.
- Gerardo I, Ilsen R, Ernesto I, Egar S, Magaly T, Marcelo G (2005). "Valoración de la glucosa como antídoto en la intoxicación por cianuro" [Rating glucose as an antidote in cyanide poisoning]. Retel (in Spanish) (7). Archived from the original on 22 January 2012.
- Aminlari, Mahmoud; Malekhusseini, Ali; Akrami, Fatemeh; Ebrahimnejad, Hadi (2006). "Cyanide-metabolizing enzyme rhodanese in human tissues: Comparison with domestic animals". Comparative Clinical Pathology. 16: 47–51. doi:10.1007/s00580-006-0647-x.
- Baskin SI, Horowitz AM, Nealley EW (April 1992). "The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning". J Clin Pharmacol. 32 (4): 368–75. doi:10.1002/j.1552-4604.1992.tb03849.x. PMID 1569239.
- Alexander K, Procell LR, Kirby SD, Baskin SI (1989). "The inactivation of rhodanese by nitrite and inhibition by other anions in vitro". J. Biochem. Toxicol. 4 (1): 29–33. doi:10.1002/jbt.2570040106. PMID 2769694.
- Crankshaw DL, Goon DJ, Briggs JE, et al. (December 2007). "A novel paradigm for assessing efficacies of potential antidotes against neurotoxins in mice". Toxicol. Lett. 175 (1–3): 111–7. doi:10.1016/j.toxlet.2007.10.001. PMC 2171362. PMID 18024011.
- Nagasawa HT, Goon DJ, Crankshaw DL, Vince R, Patterson SE (December 2007). "Novel, orally effective cyanide antidotes". J. Med. Chem. 50 (26): 6462–4. doi:10.1021/jm7011497. PMC 2274902. PMID 18038966.
- "Antidotes for Poisoning by Cyanide: 6. AMYL NITRITE". IPCS/CEC Evaluation of Antidotes Series; Volume 2. Archived from the original on 18 April 2007.
- "Cyanide poisoning – New recommendations on first aid treatment". Health and Safety Executive. Archived from the original on 20 October 2009.
- "Número de pessoas mortas em incêndio em boate em Santa Maria, no RS, é revisado para 232" (in Portuguese). Retrieved 7 August 2013.
- Haynes and Prada. "U.S. rushing treatment for Brazil fire victims". Reuters. Archived from the original on 14 February 2013. Retrieved 28 June 2013.
- Longerich 2010, pp. 281–282.
- Hayes 2004, pp. 2, 272.
- Piper 1994, p. 161.
- Hayes 2004, p. 272.
- Steinbacher 2005, pp. 132–133.
- Hayes 2004, pp. 288–289.
- Hayes 2004, p. 296.
- Hayes 2004, pp. 294–297, chpt. Degesch and Zyklon B. "The SS learned in 1944 that the expiration dates on the Zyklon tins were not hard and fast. All in all, it seems reasonable to assume that the SS over- rather than underdosed ..." (Peter Hayes).
- Hayes 2004, p. 283.
- Hayes 2004, p. 284.
- "Archived copy". Archived from the original on 28 June 2015. Retrieved 3 July 2015.CS1 maint: Archived copy as title (link) second paragraph
- "Archived copy". Archived from the original on 5 July 2015. Retrieved 3 July 2015.CS1 maint: Archived copy as title (link)
- "Gas Chamber Executions". About.com. Archived from the original on 20 February 2009.
- "Operation Gunnerside" in the book Bomb: The Race to Build – and Steal – the World's Most Dangerous Weapon
- "Michael Marin, former Wall Street trader, took cyanide after arson conviction, says autopsy". CBS News. Archived from the original on 27 July 2012.
- "Who is John B. McLemore, figure in new 'S-Town' podcast? (spoilers)". Alabama Local News. Archived from the original on 6 April 2017. Retrieved 1 April 2017.
- "Preliminary results autopsy Slobodan Praljak". Openbaar Ministerie. Retrieved 1 December 2017.
- "Death of a river" Archived 9 January 2009 at the Wayback Machine, BBC, February 15, 2000
- "Mr. Allen Elias". Archived from the original on 5 March 2016. Retrieved 1 February 2015.
- Kenworthy, Tom (13 December 1999). "A Life 'Trashed' in Cyanide Tank Long Prison Term Predicted in Environmental Crime". The Washington Post. Archived from the original on 2 February 2015. Retrieved 1 February 2015.
- Dugoni, Robert; Hilldorfer, Joseph (21 September 2004). The Cyanide Canary. Simon & Schuster. pp. 1–352. ISBN 9780743246521.
- "Was It Murder or Suicide: A Forum". Alternative Considerations of Jonestown & Peoples Temple. Archived from the original on 26 March 2016. Retrieved 12 June 2016.
- http://articles.latimes.com/1995-05-09/news/mn-64088_1_richard-overton. Missing or empty
- "Archived copy". Archived from the original on 13 February 2017. Retrieved 13 February 2017.CS1 maint: Archived copy as title (link)
- Parascandola, Kerry Burke, Rocco. "Sunset Park family reeling after they learn their matriarch had high levels of cyanide in her blood when she died - NY Daily News". nydailynews.com. Retrieved 11 July 2018.
- "Chronology of Aum Shinrikyo's CBW Activities" (PDF). Monterey Institute of International Studies. 2001. Archived from the original (PDF) on 26 November 2011.
- Suskind, Ron (19 June 2006). "The Untold Story of al-Qaeda's Plot to Attack the Subway". Time magazine. Archived from the original on 10 January 2007. Retrieved 20 January 2007.
- Suman, Sigridur G.; Gretarsdottir, Johanna M. (2019). "Chapter 14. Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide". In Sigel, Astrid; Freisinger, Eva; Sigel, Roland K. O.; Carver, Peggy L. (Guest editor) (eds.). Essential Metals in Medicine:Therapeutic Use and Toxicity of Metal Ions in the Clinic. Metal Ions in Life Sciences. 19. Berlin: de Gruyter GmbH. pp. 359–391. doi:10.1515/9783110527872-020. ISBN 978-3-11-052691-2.
- Longerich, Peter (2010). Holocaust: The Nazi Persecution and Murder of the Jews. Oxford; New York: Oxford University Press. ISBN 978-0-19-280436-5.
- Hayes, Peter (2004). From Cooperation to Complicity: Degussa in the Third Reich. Cambridge; New York; Melbourne: Cambridge University Press. ISBN 978-0-521-78227-2.
- Piper, Franciszek (1994). "Gas Chambers and Crematoria". In Gutman, Yisrael; Berenbaum, Michael (eds.). Anatomy of the Auschwitz Death Camp. Bloomington, Indiana: Indiana University Press. pp. 157–182. ISBN 978-0-253-32684-3.