This article needs additional citations for verification. (January 2009) (Learn how and when to remove this template message)
Hypotension is low blood pressure, especially in the arteries of the systemic circulation. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. A systolic blood pressure of less than 90 millimeters of mercury (mm Hg) or diastolic of less than 60 mm Hg is generally considered to be hypotension. However, in practice, blood pressure is considered too low only if noticeable symptoms are present.
|Specialty||Critical care medicine|
Hypotension is the opposite of hypertension, which is high blood pressure. It is best understood as a physiological state, rather than a disease. Severely low blood pressure can deprive the brain and other vital organs of oxygen and nutrients, leading to a life-threatening condition called shock.
For some people who exercise and are in top physical condition, low blood pressure is a sign of good health and fitness. For many people, excessively low blood pressure can cause dizziness and fainting or indicate serious heart, endocrine or neurological disorders.
Treatment of hypotension may include the use of intravenous fluids or vasopressors. When using vasopressors, trying to achieve a mean arterial pressure (MAP) of greater than 70 mmHg does not appear to result in better outcomes than trying to achieve a MAP of greater than 65 mm Hg in adults.
Signs and symptomsEdit
If the blood pressure is sufficiently low, fainting may occur.
Low blood pressure is sometimes associated with certain symptoms, many of which are related to causes rather than effects of hypotension:
- chest pain
- shortness of breath
- irregular heartbeat
- fever higher than 38.3 °C (101 °F)
- stiff neck
- severe upper back pain
- cough with sputum
- Prolonged diarrhea or vomiting
- dyspepsia (indigestion)
- dysuria (painful urination)
- acute, life-threatening allergic reaction
- loss of consciousness
- profound fatigue
- temporary blurring or loss of vision
- Black tarry stools
Reduced blood volume, hypovolemia, is the most common cause of hypotension. This can result from hemorrhage; insufficient fluid intake, as in starvation; or excessive fluid losses from diarrhea or vomiting. Hypovolemia is often induced by excessive use of diuretics. Low blood pressure may also be attributed to heat stroke. The body may have enough fluid but does not retain electrolytes. Absence of perspiration, light headedness and dark coloured urine are also indicators.
Other medications can produce hypotension by different mechanisms. Chronic use of alpha blockers or beta blockers can lead to hypotension. Beta blockers can cause hypotension both by slowing the heart rate and by decreasing the pumping ability of the heart muscle.
Decreased cardiac output despite normal blood volume, due to severe congestive heart failure, large myocardial infarction, heart valve problems, or extremely low heart rate (bradycardia), often produces hypotension and can rapidly progress to cardiogenic shock. Arrhythmias often result in hypotension by this mechanism.
Some heart conditions can lead to low blood pressure, including extremely low heart rate (bradycardia), heart valve problems, heart attack and heart failure. These conditions may cause low blood pressure because they prevent the body from being able to circulate enough blood.
Excessive vasodilation, or insufficient constriction of the resistance blood vessels (mostly arterioles), causes hypotension. This can be due to decreased sympathetic nervous system output or to increased parasympathetic activity occurring as a consequence of injury to the brain or spinal cord or of dysautonomia, an intrinsic abnormality in autonomic system functioning. Excessive vasodilation can also result from sepsis, acidosis, or medications, such as nitrate preparations, calcium channel blockers, or AT1 receptor antagonists (Angiotensin II acts on AT1 receptors). Many anesthetic agents and techniques, including spinal anesthesia and most inhalational agents, produce significant vasodilation.
Lower blood pressure is a side effect of certain herbal medicines, which can also interact with hypotensive medications. An example is the theobromine in Theobroma cacao, which lowers blood pressure through its actions as both a vasodilator and a diuretic, and has been used to treat high blood pressure.
Orthostatic hypotension, also called postural hypotension, is a common form of low blood pressure. It occurs after a change in body position, typically when a person stands up from either a seated or lying position. It is usually transient and represents a delay in the normal compensatory ability of the autonomic nervous system. It is commonly seen in hypovolemia and as a result of various medications. In addition to blood pressure-lowering medications, many psychiatric medications, in particular antidepressants, can have this side effect. Simple blood pressure and heart rate measurements while lying, seated, and standing (with a two-minute delay in between each position change) can confirm the presence of orthostatic hypotension. Orthostatic hypotension is indicated if there is a drop in 20 mmHg of systolic pressure (and a 10 mmHg drop in diastolic pressure in some facilities) and a 20 beats per minute increase in heart rate.
Vasovagal syncope is a form of dysautonomia characterized by an inappropriate drop in blood pressure while in the upright position. Vasovagal syncope occurs as a result of increased activity of the vagus nerve, the mainstay of the parasympathetic nervous system .
Another, but rarer form, is postprandial hypotension, a drastic decline in blood pressure that occurs 30 to 75 minutes after eating substantial meals. When a great deal of blood is diverted to the intestines (a kind of "splanchnic blood pooling") to facilitate digestion and absorption, the body must increase cardiac output and peripheral vasoconstriction to maintain enough blood pressure to perfuse vital organs, such as the brain. Postprandial hypotension is believed to be caused by the autonomic nervous system not compensating appropriately, because of aging or a specific disorder.
Blood pressure is continuously regulated by the autonomic nervous system, using an elaborate network of receptors, nerves, and hormones to balance the effects of the sympathetic nervous system, which tends to raise blood pressure, and the parasympathetic nervous system, which lowers it. The vast and rapid compensation abilities of the autonomic nervous system allow normal individuals to maintain an acceptable blood pressure over a wide range of activities and in many disease states.
The diagnosis of hypotension is made by first obtaining a blood pressure, either non-invasively with a sphygmomanometer or invasively with an arterial catheter (mostly in an intensive care setting). If the MAP (Mean Arterial Pressure) is <65mmHg, this is generally considered hypotension.
Evaluation of vasovagal syncope is done with a tilt table test.
The treatment for hypotension depends on its cause. Chronic hypotension rarely exists as more than a symptom. Asymptomatic hypotension in healthy people usually does not require treatment. Adding electrolytes to a diet can relieve symptoms of mild hypotension. A morning dose of caffeine can also be effective. In mild cases, where the patient is still responsive, laying the person in dorsal decubitus (lying on the back) position and lifting the legs increases venous return, thus making more blood available to critical organs in the chest and head. The Trendelenburg position, though used historically, is no longer recommended.
Hypotensive shock treatment always follows the first four following steps. Outcomes, in terms of mortality, are directly linked to the speed that hypotension is corrected. Still-debated methods are in parentheses, as are benchmarks for evaluating progress in correcting hypotension. A study on septic shock provided the delineation of these general principles. However, since it focuses on hypotension due to infection, it is not applicable to all forms of severe hypotension.
- Volume resuscitation (usually with crystalloid)
- Blood pressure support with a vasopressor (all seem equivalent with respect to risk of death, with norepinephrine possibly better than dopamine). Trying to achieve a mean arterial pressure (MAP) of greater than 70 mmHg does not appear to result in better outcomes than trying to achieve a MAP of greater than 65 mm Hg in adults.
- Ensure adequate tissue perfusion (maintain SvO2 >70 with use of blood or dobutamine)
- Address the underlying problem (i.e., antibiotic for infection, stent or CABG (coronary artery bypass graft surgery) for infarction, steroids for adrenal insufficiency, etc...)
Medium-term (and less well-demonstrated) treatments of hypotension include:
- Blood sugar control (80–150 by one study)
- Early nutrition (by mouth or by tube to prevent ileus)
- Steroid support
Hypotension, from Ancient Greek hypo-, meaning "under" or "less" + English tension, meaning "'strain" or "tightness". This refers to the under-constriction of the blood vessels and arteries which leads to low blood pressure.
- TheFreeDictionary > hypotension. Citing: The American Heritage Science Dictionary Copyright 2005
- "Diseases and Conditions Index – Hypotension". National Heart Lung and Blood Institute. September 2008. Retrieved September 16, 2008.
- Mayo Clinic staff (May 23, 2009). "Low blood pressure (hypotension) — Definition". MayoClinic.com. Mayo Foundation for Medical Education and Research. Retrieved October 19, 2010.
- Mayo Clinic staff (May 23, 2009). "Low blood pressure (hypotension) — Causes". MayoClinic.com. Mayo Foundation for Medical Education and Research. Retrieved October 19, 2010.
- "Low blood pressure (hypotension)". BUPA.co.uk.
- Hylands, M; Moller, MH; Asfar, P; Toma, A; Frenette, AJ; Beaudoin, N; Belley-Côté, É; D'Aragon, F; Laake, JH; Siemieniuk, RA; Charbonney, E; Lauzier, F; Kwong, J; Rochwerg, B; Vandvik, PO; Guyatt, G; Lamontagne, F (July 2017). "A systematic review of vasopressor blood pressure targets in critically ill adults with hypotension". Canadian journal of anaesthesia = Journal canadien d'anesthesie. 64 (7): 703–715. doi:10.1007/s12630-017-0877-1. PMID 28497426.
- "What Are the Signs and Symptoms of Hypotension?". nhlbi.nih.gov. National Institutes of Health. November 1, 2010. Retrieved February 17, 2014.
- Joel A. DeLisa, Bruce M. Gans, Nicholas E. Walsh (editors) (2005). "19. Complementary and Alternative Medicine". Physical Medicine and Rehabilitation: Principles and Practice. 1. Lippincott Williams & Wilkins. p. 468.
- Tabassum, Nahida; Feroz Ahmad (2011). "Role of natural herbs in the treatment of hypertension". Pharmacognosy Review. 5 (9): 30–40. doi:10.4103/0973-7847.79097. PMC . PMID 22096316.
- Mitchell ES, Slettenaar M, vd Meer N, Transler C, Jans L, Quadt F, Berry M.; Slettenaar; Vd Meer; Transler; Jans; Quadt; Berry (2011). "Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure". Physiol. Behav. 104 (5): 816–22. doi:10.1016/j.physbeh.2011.07.027. PMID 21839757.
Theobromine ... lowered blood pressure relative to placebo
- William Marias Malisoff (1943). Dictionary of Bio-Chemistry and Related Subjects. Philosophical Library. pp. 311, 530, 573.
- Theobromine Chemistry – Theobromine in Chocolate. Chemistry.about.com (May 12, 2013). Retrieved on 2013-05-30.
- Kelly, Caleb J (2005). "Effects of theobromine should be considered in future studies". American Journal of Clinical Nutrition. 82 (2): 486–7; author reply 487–8. PMID 16087999.
- Merck Manual Home Edition. "Postprandial Hypotension." Last accessed October 26, 2011.
- Konieczka Katarzyna, Rich Robert; et al. (2014). "Flammer syndrome". EPMA Journal. 5: 11.
- Mookherjee, S. Lai, C., Rennke, St. The UCSF Hospitalist Handbook.
- Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ; Bakris; Black; Cushman; Green; Izzo Jr; Jones; Materson; Oparil; Wright Jr; Roccella; Joint National Committee On Prevention; National High Blood Pressure Education Program Coordinating Committee (December 2003). "Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure". Hypertension. 42 (6): 1206–52. doi:10.1161/01.HYP.0000107251.49515.c2. PMID 14656957. Retrieved November 3, 2009.
- Kettaneh, Nicolas (October 30, 2008). "BestBets: Use of the Trendelenburg Position to Improve Hemodynamics During Hypovolemic Shock". Grand Rapids Medical Education & Research/Michigan State University.
- Rivers, E; Nguyen, B; Havstad, S; Ressler, J; Muzzin, A; Knoblich, B; Peterson, E; Tomlanovich, M; Early Goal-Directed Therapy Collaborative, Group (8 November 2001). "Early goal-directed therapy in the treatment of severe sepsis and septic shock". The New England Journal of Medicine. 345 (19): 1368–77. doi:10.1056/nejmoa010307. PMID 11794169.
- Gamper, G; Havel, C; Arrich, J; Losert, H; Pace, NL; Müllner, M; Herkner, H (15 February 2016). "Vasopressors for hypotensive shock". Cochrane Database of Systematic Reviews. 2: CD003709. doi:10.1002/14651858.CD003709.pub4. PMID 26878401.
- Bentzer, P; Griesdale, DE; Boyd, J; MacLean, K; Sirounis, D; Ayas, NT (27 September 2016). "Will This Hemodynamically Unstable Patient Respond to a Bolus of Intravenous Fluids?". JAMA. 316 (12): 1298–309. doi:10.1001/jama.2016.12310. PMID 27673307.
- "Online Etymology Dictionary". etymonline.com. Retrieved 2017-12-10.