Sodium nitrite

Sodium nitrite is an inorganic compound with the chemical formula NaNO2. It is a white to slightly yellowish crystalline powder that is very soluble in water and is hygroscopic. From an industrial perspective, it is the most important nitrite salt. It is a precursor to a variety of organic compounds, such as pharmaceuticals, dyes, and pesticides, but it is probably best known as a food additive used in processed meats and (in some countries) in fish products.[3]

Sodium nitrite
Sodium nitrite
The nitrite anion (space-filling model)
The sodium cation
Natriumnitrit Elementarzelle.png
Unit cell of sodium nitrite under standard conditions.
  • 7632-00-0 checkY
3D model (JSmol)
ECHA InfoCard 100.028.687 Edit this at Wikidata
EC Number
  • 231-555-9
E number E250 (preservatives)
RTECS number
  • RA1225000
UN number 1500
  • InChI=1S/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1 checkY
  • InChI=1/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1
  • N(=O)[O-].[Na+]
Molar mass 68.9953 g/mol
Appearance white or slightly yellowish solid
Density 2.168 g/cm3
Melting point 271 °C (520 °F; 544 K) (decomposes at 320 °C)
71.4 g/100 mL (0 °C)
84.8 g/100 mL (25 °C)
160 g/100 mL (100 °C)
Solubility soluble in methanol (4.4 g/100 mL)
slightly soluble in diethyl ether (0.3 g/100 mL)
very soluble in ammonia
Acidity (pKa) ~9
−14.5·10−6 cm3/mol
a = 3.5653(8) Å, b = 5.5728(7) Å, c = 5.3846(13) Å
106 J/mol K
−359 kJ/mol[2]
−295 kJ/mol
V03AB08 (WHO)
Safety data sheet External MSDS
GHS03: Oxidizing GHS06: Toxic GHS09: Environmental hazard
R-phrases (outdated) R8, R25, R50
S-phrases (outdated) (S1/2), S45, S61
NFPA 704 (fire diamond)
489 °C (912 °F; 762 K)
Lethal dose or concentration (LD, LC):
180 mg/kg (rats, oral)
Related compounds
Other anions
Sodium nitrate
Other cations
Potassium nitrite
Ammonium nitrite
Lithium nitrite
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references


Industrial chemistryEdit

The main use of sodium nitrite is for the industrial production of organonitrogen compounds. It is a reagent for conversion of amines into diazo compounds, which are key precursors to many dyes, such as diazo dyes. Nitroso compounds are produced from nitrites. These are used in the rubber industry.[3]

It is used in a variety of metallurgical applications, for phosphatizing and detinning.[3]

Sodium nitrite is an effective corrosion inhibitor and is used as an additive in industrial greases,[4] as an aqueous solution in closed loop cooling systems, and in a molten state as a heat transfer medium.[5]


Sodium nitrite is an efficient drug in case of cyanide poisoning. It is used together with sodium thiosulfate.[6] It is on the World Health Organization's List of Essential Medicines.[7]

Food additive and preservativeEdit

Sodium nitrite is used to speed up the curing of meat and also impart an attractive pink color.[8][9] Nitrite reacts with the meat myoglobin to cause color changes, first converting to nitrosomyoglobin (bright red), then, on heating, to nitrosohemochrome (a pink pigment).[10]

The meat-packing industry has falsely claimed nitrite is used to prevent botulism (see also Inhibition of microbial growth).[8] Several large meat processors produce processed meats without relying on nitrite or nitrate.[11][8]

Historically, salt has been used for the preservation of meat. The salt-preserved meatproduct was usually brownish-gray in color. When sodium nitrite is added with the salt, the meat develops a red, then pink color, which is associated with cured meats such as ham, bacon, hot dogs, and bologna.[12]

In the early 1900s, irregular curing was commonplace. This led to further research surrounding the use of sodium nitrite as an additive in food, standardizing the amount present in foods to minimize the amount needed while maximizing its food additive role.[13] Through this research, sodium nitrite has been found to give taste and color to the meat; inhibit lipid oxidation that leads to rancidity; with varying degrees of effectiveness for controlling growth of disease-causing microorganisms.[13] The ability of sodium nitrite to address the above-mentioned issues has led to production of meat with extended storage life and has improved desirable color/taste. According to scientists working for the meat industry,[14] nitrite has improved food safety.[13] However, this view is widely disputed in the light of its ineffectiveness against botulism and the carcinogenic effects caused by adding nitrites to meat.[8]

Nitrite has the E number E250. Potassium nitrite (E249) is used in the same way. It is approved for usage in the EU,[15][16] USA[17] and Australia and New Zealand.[18]

In meat-processing, sodium nitrite is never used in a pure state but only ever mixed with common salt. This mixture is known as nitrited salt, curing salt or nitrited curing salt. In Europe, nitrited curing salt contains between 99.1% and 99.5% common salt and between 0.5% and 0.9% nitrite. In the USA, nitrited curing salt is dosed at 6% and must be remixed with salt before use.[19]

Color and tasteEdit

The appearance and taste of meat is an important component of consumer acceptance.[13] Sodium nitrite is responsible for the desirable red color (or shaded pink) of meat.[13] Very little nitrite is needed to induce this change.[13] It has been reported that as little as 2 to 14 parts per million (ppm) is needed to induce this desirable color change.[20] However, to extend the lifespan of this color change, significantly higher levels are needed.[20] The mechanism responsible for this color change is the formation of nitrosylating agents by nitrite, which has the ability to transfer nitric oxide that subsequently reacts with myoglobin to produce the cured meat color.[20] The unique taste associated with cured meat is also affected by the addition of sodium nitrite.[13] However, the mechanism underlying this change in taste is still not fully understood.[20]

Inhibition of microbial growthEdit

A 2018 study by the British Meat Producers Association determined that legally permitted levels of nitrite have no effect on the growth of the Clostridium botulinum bacteria which causes botulism, in line with the UK’s Advisory Committee on the Microbiological Safety of Food opinion that nitrites are not required to prevent C. botulinum growth and extend shelf life.[21] In some countries, cured-meat products are manufactured without nitrate or nitrite, and without nitrite from vegetable source. Parma ham, produced without nitrite since 1993, was reported in 2018 to have caused no cases of botulism.[8]

Sodium nitrite has had varying degrees of effectiveness for controlling growth of other spoilage or disease causing microorganisms.[13] Even though the inhibitory mechanisms for sodium nitrite are not well known, its effectiveness depends on several factors including residual nitrite level, pH, salt concentration, reductants present and iron content.[20] Furthermore, the type of bacteria also affects sodium nitrites effectiveness.[20] It is generally agreed upon that sodium nitrite is not considered effective for controlling gram-negative enteric pathogens such as Salmonella and Escherichia coli.[20]

Other food additives (such as lactate and sorbate) provide similar protection against bacteria, but do not provide the desired pink color.[22][23]

Inhibition of lipid peroxidationEdit

Sodium nitrite is also able to effectively delay the development of oxidative rancidity.[20] Lipid peroxidation is considered to be a major reason for the deterioration of quality of meat products (rancidity and unappetizing flavors).[20] Sodium nitrite acts as an antioxidant in a mechanism similar to the one responsible for the coloring effect.[20] Nitrite reacts with heme proteins and metal ions, neutralizing free radicals by nitric oxide (one of its byproducts).[20] Neutralization of these free radicals terminates the cycle of lipid oxidation that leads to rancidity.[20]


Sodium nitrite is toxic.[24] The LD50 in rats is 180 mg/kg and in human LDLo is 71 mg/kg.[25] Yet, death by sodium nitrite ingestion can happen at lower dose.[26][27] Sodium nitrite is sometimes used for homicide[28][29] and for suicide attempts.[30][31][32][33] Since 2019, eBay prohibits globally the sale of sodium nitrite as a chemical.[34] To prevent intoxication, sodium nitrite (blended with salt) sold as a food additive in the USA is dyed bright pink to avoid mistaking it for plain salt or sugar. In other countries, nitrited curing salt is not dyed but is strictly regulated.[35]

Occurrence in vegetablesEdit

Nitrites are not naturally occurring in vegetables in significant quantities.[36] However, nitrates are found in commercially available vegetables and a study in an intensive agricultural area in northern Portugal found residual nitrate levels in 34 vegetable samples, including different varieties of cabbage, lettuce, spinach, parsley and turnips ranged between 54 and 2440 mg/kg, e.g. curly kale (302.0 mg/kg) and green cauliflower (64 mg/kg).[37][38] Boiling vegetables lowers nitrate but not nitrite.[37] Fresh meat contains 0.4–0.5 mg/kg nitrite and 4–7 mg/kg of nitrate (10–30 mg/kg nitrate in cured meats).[36]

The presence of nitrite in animal tissue is a consequence of metabolism of nitric oxide, an important neurotransmitter.[39] Nitric oxide can be created de novo from nitric oxide synthase utilizing arginine or from ingested nitrate or nitrite.[40]


Because of sodium nitrite's high level of toxicity to swine (Sus scrofa) it is now being developed in Australia to control feral pigs and wild boar.[41][42] The sodium nitrite induces methemoglobinemia in swine, i.e. it reduces the amount of oxygen that is released from hemoglobin, so the animal will feel faint and pass out, and then die in a humane manner after first being rendered unconscious.[43] The Texas Parks and Wildlife Department operates a research facility at Kerr Wildlife Management Area, where they examine feral pig feeding preferences and bait tactics to administer sodium nitrite.[44]


Carcinogenicity is the ability or tendency of a chemical to induce tumors, increase their incidence or malignancy, or shorten the time of tumor occurrence.[45]

Adding nitrites to meat has been shown to generate known carcinogens such as nitrosamines; the World Health Organization (WHO) advises that each 50 g (1.8 oz) of "processed meats" eaten a day would raise the risk of getting bowel cancer by 18% over a lifetime. The World Health Organization's review of more than 400 studies concluded, in 2015, that there was sufficient evidence that "processed meats" caused cancer, particularly colon cancer; the WHO's International Agency for Research on Cancer (IARC) classified "processed meats" as carcinogenic to humans (Group 1); "processed meat" meaning meat that has been transformed through salting, curing, fermentation, smoking, or other processes to enhance flavour or improve preservation.).[8][46]

Nitrosamines can be formed during the curing process used to preserve meats, when sodium nitrite-treated meat is cooked, and also from the reaction of nitrite with secondary amines under acidic conditions (such as occurs in the human stomach). Dietary sources of nitrosamines include US cured meats preserved with sodium nitrite as well as the dried salted fish eaten in Japan. In the 1920s, a significant change in US meat curing practices resulted in a 69% decrease in average nitrite content. This event preceded the beginning of a dramatic decline in gastric cancer mortality.[47] Around 1970, it was found that ascorbic acid (vitamin C), an antioxidant, inhibits nitrosamine formation.[48] Consequently, the addition of at least 550 ppm of ascorbic acid is required in meats manufactured in the United States. Manufacturers sometimes instead use erythorbic acid, a cheaper but equally effective isomer of ascorbic acid. Additionally, manufacturers may include α-tocopherol (vitamin E) to further inhibit nitrosamine production. α-Tocopherol, ascorbic acid, and erythorbic acid all inhibit nitrosamine production by their oxidation-reduction properties. Ascorbic acid, for example, forms dehydroascorbic acid when oxidized, which when in the presence of nitrosonium, a potent nitrosating agent formed from sodium nitrite, reduces the nitrosonium into nitric oxide.[49] The nitrosonium ion formed in acidic nitrite solutions is commonly[50][51] mislabeled nitrous anhydride, an unstable nitrogen oxide that cannot exist in vitro.[52]

Nitrate or nitrite (ingested) under conditions that result in endogenous nitrosation has been classified as "probably carcinogenic to humans" by International Agency for Research on Cancer (IARC).[53][54] The World Health Organization's review of more than 400 studies concluded, in 2015, that there was that there was sufficient evidence that "processed meats" caused cancer, particularly colon cancer.[8]

Sodium nitrite consumption has also been linked to the triggering of migraines in individuals who already suffer from them.[55]

One study has found a correlation between highly frequent ingestion of meats cured with pink salt and the COPD form of lung disease. The study's researchers suggest that the high amount of nitrites in the meats was responsible; however, the team did not prove the nitrite theory. Additionally, the study does not prove that nitrites or cured meat caused higher rates of COPD, merely a link. The researchers did adjust for many of COPD's risk factors, but they commented they cannot rule out all possible unmeasurable causes or risks for COPD.[56][57]


Industrial production of sodium nitrite follows one of two processes, the reduction of nitrate salts, or the oxidation of lower nitrogen oxides.

One method uses molten sodium nitrate as the salt, and lead which is oxidized, while a more modern method uses scrap iron filings to reduce the nitrate.[3][58]

A more commonly used method involves the general reaction of nitrogen oxides in alkaline aqueous solution, with the addition of a catalyst. The exact conditions depend on which nitrogen oxides are used, and what the oxidant is, as the conditions need to be carefully controlled to avoid over oxidation of the nitrogen atom.[3]

Sodium nitrite has also been produced by reduction of nitrate salts by exposure to heat, light, ionizing radiation, metals, hydrogen, and electrolytic reduction.[59]

Chemical reactionsEdit

In the laboratory, sodium nitrite can be used to destroy excess sodium azide.[60][61]

2 NaN3 + 2 NaNO2 + 4 H+ → 3 N2 + 2 NO + 4 Na+ + 2 H2O

Above 330 °C sodium nitrite decomposes (in air) to sodium oxide, nitric oxide and nitrogen dioxide.[62]

2 NaNO2 → Na2O + NO + NO2

Sodium nitrite can also be used in the production of nitrous acid:

+ H
→ 2 HNO
+ Na

The nitrous acid then, under normal conditions, decomposes:

+ NO + H

The resulting nitrogen dioxide hydrolyzes to a mixture of nitric and nitrous acids:

+ H

Isotope labelling 15NEdit

15N isotope enriched NaNO2

In organic synthesis isotope enriched sodium nitrite-15N can be used instead of normal sodium nitrite as their reactivity is nearly identical in most reactions.

The obtained products carry isotope 15N and hence Nitrogen NMR can be efficiently carried out.[63]


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Further readingEdit

External linksEdit