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Centre for Cellular and Molecular Biology

The Centre for Cellular and Molecular Biology (Hindi: कोशिकीय एवं आणविक जीवविज्ञान केंद्र, IAST: Kośikīya evam āṇavik jīvavijñāna kendra) or CCMB is an Indian biotechnology research establishment located in Hyderabad that operates under the aegis of the Council of Scientific and Industrial Research. CCMB is a designated "Center of Excellence" by the Global Molecular and Cell Biology Network, UNESCO.[1][2] The Republic of India's national biosafety level – 4 containment facility for human infectious diseases is located on the campus of CCMB.[3][4]

Centre for Cellular and Molecular Biology
CCMB hyderabad india.jpg
Motto Dedicated to the Nation
Type Autonomous, Govt, CSIR
Established 1977
Director Rakesh K. Mishra
Location Hyderabad, Telangana, India
Campus Urban, 6 acres (24,000 m2)
Website ccmb.res.in
CCMB Logo

The center collaborates with the University of Nebraska Medical Center for translational research on glaucoma[5] In addition, the centre receives funding for specific collaborative projects from establishments outside India, such as the National Institutes of Health, Harvard Medical School and the Massachusetts Institute of Technology in the United States,[6][7] the Imperial Cancer Research Fund and Cambridge University in the United Kingdom,[8] the India-Japan Science Council and the University of Ryukyus in Japan,[9][10] Centre Nationale de la Recherche Scientifique and the Pasteur Institute in France and the Volkswagen Foundation in Germany.[11][12]

Contents

HistoryEdit

CCMB was set up initially as a semi-autonomous Centre on April 1, 1977 with the Biochemistry Division of the then Regional Research Laboratory (presently, Indian Institute of Chemical Technology, IICT) Hyderabad forming its nucleus and Dr P M Bhargava heading the new Centre. Earlier, the Governing Board of the Council of Scientific and Industrial Research (CSIR) New Delhi, the apex body which constituted 44 research institutions in the country, approved the proposal in 1976 to establish such a Centre in view of the importance of research in the frontier and multi-disciplinary areas of modern biology. During 1981-82, the CCMB was accorded the status of a full-fledged national laboratory with its own Executive Committee and Scientific Advisory Council. With major expansion plans, it was decided to relocate the Centre to a spacious campus. 

Former directorsEdit

The list of former directors.[13][14]

Name From To
P. M. Bhargava April 1977 February 1990
Sharat Chandra March 1990 May 1992
Balasubramanian May 1992 May 1998
Lalji Singh May 1998 July 2009
Ch. Mohan Rao July 2009 January 2016
Rakesh Kumar Mishra May 2016 till date

ResearchEdit

The ongoing research programmes at the CCMB are in three major categories – high quality basic research in the frontier areas of modern biology, research relevant to societal needs, and application-oriented research towards commercialisation. These include the areas of biomedicine & diagnostics, evolution & development, gene regulation in prokaryotes and eukaryotes, host-parasite interactions, membrane biology, protein structure, bio informatics, functional genomics, theoretical biology, etc.

In recognition for its contribution to modern biology, CCMB has been chosen as a Centre of Excellence by UNESCO Global Network for Molecular and Cell Biology MCBN and has been designated as a South Centre for Excellence for Research and Training by the Third World Academy of Sciences TWAS, Italy. Many prestigious international and national awards have come to CCMB including the CSIR Technology Award (four times) and FICCI Award for outstanding achievements in Science & Technology.

CCMB is accredited by Jawaharlal Nehru University to offer Doctor of Philosophy programme and post doctoral research.[15]

Technological achievementsEdit

  • Discovered the heart disease mutation, carried by sixty million people among Indians.[16]
  • Developed the first genetically engineered, gene knockout mouse in India.[17]
  • Developed the first artificial insemination technology in India, to deliver extinct ruminant mammals, like deer.[18]
  • Developed a systematic screening and validation programme for anti cancer drugs in India.[19]
  • Discovered the origin of Andaman tribes, through DNA Fingerprinting technology[20]
  • Commercially delivered, recombinant DNA technology based diagnostic kit for detection of pathogens causing ophthalmic infections.[21]
  • Discovered high yielding disease resistant rice.[22]
  • Discovered native bacteria, Indibacter alkaliphilus used to generate Enzymes and Bio-molecules in the Industrial Biotechnology sector.[23]
  • Discovered the functionality of microsatellites (simple sequence repeats) among non-coding DNA.[24]
  • Discovered the gene CPA1, which causes chronic pancreatitis, in collaboration with Asian Institute of Gastroenterology.[25]

Annexe I – LaCONESEdit

CCMB is involved in the dissemination of modern biological information through popularisation of science, science education in schools, and has been a meeting point for art and science. The Laboratory for conservation of endangered species is an annexe with the aim to conserve the Indian wildlife by using modern biological techniques and assisted reproductive technologies.

Annexe II – Clinical Research Laboratory and Innovation ComplexEdit

CCMB has started clinical research and Regenerative medicine services at its clinical research facility in collaboration with physicians from Nizam's Institute of Medical Sciences to conduct bone marrow transplantation. A new 37 acre Innovation complex is going to be set up as an extension to CRF, which aims to conduct translational research for stem cell therapy and Agri biotech.[26][27][28]

See alsoEdit

Notes and referencesEdit

  1. ^ "CCMB develops DNA test to identify animal species". The Hindu Business Line. 2003-04-30. Retrieved 2012-08-22. 
  2. ^ TNN May 10, 2006, 01.54am IST (2006-05-10). "CCMB identifies milk gene". The Times of India. Retrieved 2012-08-22. 
  3. ^ "BSL 4" (PDF). Retrieved 2012-08-22. 
  4. ^ "Business Line : Today's Paper / ECONOMY : Stone laid for stem cell research lab in Hyderabad". The Hindu Business Line. 2007-11-06. Retrieved 2012-08-22. 
  5. ^ "Glaucoma Research" (PDF) (Press release). Retrieved 2012-12-01. 
  6. ^ "Harvard School of Public Health » HSPH News » New research reveals the ancestral populations of India and their relationships to modern groups". Hsph.harvard.edu. 2009-09-23. Retrieved 2013-04-16. 
  7. ^ "caste system existed from 'Founder' race: CCMB-Harvard-MIT study". News.webindia123.com. 2009-09-24. Retrieved 2013-04-16. 
  8. ^ "Modern man went into the world via India". Epaper.timesofindia.com. 2009-01-21. Retrieved 2013-04-16. 
  9. ^ http://cdn.intechopen.com/pdfs/20874/InTech-Japanese_encephalitis_an_emerging_and_spreading_arbovirosis.pdf
  10. ^ Ndhlovu, LC; Leal, FE; Hasenkrug, AM; Jha, AR; Carvalho, KI; Eccles-James, IG; Bruno, FR; Vieira, RG; York, VA; Chew, GM; Jones, RB; Tanaka, Y; Neto, WK; Sanabani, SS; Ostrowski, MA; Segurado, AC; Nixon, DF; Kallas, EG (2011). "HTLV-1 Tax Specific CD8+ T Cells Express Low Levels of Tim-3 in HTLV-1 Infection: Implications for Progression to Neurological Complications". PLoS Negl Trop Dis. 5: e1030. PMC 3082508 . PMID 21541358. doi:10.1371/journal.pntd.0001030. 
  11. ^ "Research > Research Partners". Ccmb.res.in. Archived from the original on 2013-12-18. Retrieved 2013-04-16. 
  12. ^ "Education Plus : Opening new vistas of research in biology". Chennai, India: The Hindu. 2011-05-31. Retrieved 2013-04-16. 
  13. ^ "Archived copy". Archived from the original on 2012-07-22. Retrieved 2014-02-23. 
  14. ^ "Dr Rakesh Mishra appointed as the new Director of CCMB, Hyderabad". Bio Voice. May 21, 2016. Retrieved October 10, 2016. 
  15. ^ "Academics" (Press release). Archived from the original on August 1, 2010. Retrieved 2012-12-01. 
  16. ^ The worst luck in the world? - Wellcome Trust Sanger Institute
  17. ^ "Scientists complete work on gene knockout technology". The Hindu. Chennai, India. 2006-05-10. 
  18. ^ CCMB implements artificial insemination in deer - India - DNA
  19. ^ "CCMB scientists develop new drug assay system - The Times of India". The Times Of India. 2001-11-03. 
  20. ^ "DNA fingerprinting has come a long way, says Lalji Singh". The Hindu. Chennai, India. 2013-02-17. 
  21. ^ "CCMB scientists develop new method to test cancer - The Times of India". The Times Of India. 2001-11-04. 
  22. ^ "CCMB grows pest-resistant Samba Masuri rice strain - The Times of India". The Times Of India. 2011-11-29. 
  23. ^ Mallikarjun, Y. (2011-11-13). "New found bacteria get Indian nomenclatures". The Hindu. Chennai, India. 
  24. ^ DNA: CCMB scientists achieve breakthrough - The New Indian Express
  25. ^ Scientists from CCMB and AIG Discovered Gene Causing Chronic Pancreatitis
  26. ^ Eenadu daily, Innovation complex for CCMB, Page 11, November 21, 2012.
  27. ^ TNN Nov 26, 2011, 04.56AM IST (2011-11-26). "Stem cell therapy facility at Centre for Cellular and Molecular Biology". The Times of India. Retrieved 2012-08-22. 
  28. ^ Business Standard (2012-08-09). "CCMB sets up clinical research facility in Hyderabad". Business-standard.com. Retrieved 2012-08-22. 

External linksEdit