User:Meodipt/2010 talk archive

Happy New Year

I just wanted to take the time to say that I hope that you and your family have a Happy New Year Meodipt! Thank you for all of the work you do for the encyclopedia.--Literaturegeek | T@1k? 01:21, 2 January 2010 (UTC)

File:Noopept structure.png missing description details

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The problem is that I wasn't sure WHAT it was a chemical structure for...

BTW If you use {{information}} fully filled out, it helps when the image gets moved (as it will do) to Wikimedia Commons. Sfan00 IMG (talk) 00:15, 13 February 2010 (UTC)

Chemical Diagrams

Thank you for uploading free images/media to Wikipedia! As you may know, there is another Wikimedia Foundation project called Wikimedia Commons, a central media repository for all free media. In future, please upload media there instead (see m:Help:Unified login). That way, all of the other language Wikipedias can use them too, as well as our many sister projects. This will also allow our visitors to search for, view and use our media in one central location. If you wish to move previous uploads to Commons, see Wikipedia:Moving images to the Commons (you may view previous uploads by going to your user contributions on the left and choosing the 'file' namespace from the drop down box (or see [1]). Please note that non-free content, such as images claimed as fair use, cannot be uploaded to the Wikimedia Commons. Help us spread the word about Commons by informing other users, and please continue uploading! Sfan00 IMG (talk) 00:15, 13 February 2010 (UTC)

A question

Hey Meodipt, a lady is on my talk page asking a question about regulation of melatonin. Maybe you know something about this? If you have time perhaps you could read over and see. She edits sleep disorder related articles thus has an interest in melatonin. :)--Literaturegeek | T@1k? 19:44, 17 February 2010 (UTC)

The "lady" has answered you on Lg's talk page. - Hordaland (talk) 17:10, 21 February 2010 (UTC)

Rubidium

Okie doke I'll move it. By the way you can call me Kobie :-) el3ctr0nika (Talk | Contribs) 08:34, 12 March 2010 (UTC)

F-15,559

Thanks for fixing the messed up structure I didn't realize it was drawn wrong. Still trying to get used to ChemDraw. By the way I missed you on Facebook the other day. el3ctr0nika (Talk | Contribs) 06:54, 19 March 2010 (UTC)

File copyright problem with File:14-Hydroxydihydrocodine.png

Thank you for uploading File:14-Hydroxydihydrocodine.png. However, it currently is missing information on its copyright status. Wikipedia takes copyright very seriously. It may be deleted soon, unless we can determine the license and the source of the file. If you know this information, then you can add a copyright tag to the image description page.

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AN/I

Hello. In the interest of fairness, I want to tell you that I mentioned your name on AN/I, in this thread about User:Yid, and then struck out my remark. My apologies. Beyond My Ken (talk) 05:56, 22 May 2010 (UTC)

File:HU-210_structure.png

Hi Meodipt, I was reading this paper about HU 210 and noticed that the structure for the - isomer given in figure 1 is different to your drawing. Could you take a look and modify the diagram if necessary? Thanks Smartse (talk) 13:42, 26 August 2010 (UTC)

Hi Smartse. There is some confusion between sources as to the correct enantiomer, which is not helped by different drawing styles (some show it without the hydrogens and the carbon bonds going into or out of the page, some with hydrogens shown to illustrate stereochemistry). Personally I feel it is clearer with the hydrogens shown, but this then takes a bit of mental visualisation to compare it to a structure drawn in the other style! Also some sources show the opposite enantiomer (i.e. HU-211) as HU-210 so obviously they cannot all be correct, but I tried to make my drawing correspond to what the majority of sources show, and be the opposite to HU-211 (which is a much less common compound, and so more likely that drawings in the literature are correct). Eventually the experts at the CAS number verification project will get around to reviewing this page and confirm the enantiomer shown is the correct one, but I'm fairly sure my drawing is correct... Meodipt (talk) 22:38, 28 August 2010 (UTC)

Ok, I'll take your word for it as you're much more likely to know than me. Out of interest, do you know if HU-211 has been found in any synthetic cannabis products? It's a while since I did any chemistry but isn't it hard not to produce both? By the way, somebody's asked a question at the science reference desk today that you might be able to help. Smartse (talk) 00:05, 29 August 2010 (UTC)

I'm not aware of HU-211 having been found in any "herbal smoking blends", but in the one product verified to have contained HU-210, I think they just used GCMS to confirm identity which doesn't distinguish isomers anyway. Your speculation is probably correct as the (C8)-CP 47,497 that was used by the same company in the original Spice product turned out to be a racemic mix of isomers rather than the pure active enantiomer, so most likely their "HU-210" was also a racemic mix of HU-210 and HU-211. Certainly HU-211 has been added to the controlled drugs list in a couple of jurisdictions, presumably on the basis of structural similarity given its lack of cannabinoid effects! Meodipt (talk) 01:00, 29 August 2010 (UTC)

Oh, and the question on the science reference desk seems to be mainly along the lines of "which synthetic cannabinoid should I use in my home made herbal smoking blend", and I don't think that is really the kind of thing wikipedia is intended for...besides the research hasn't been done yet to answer the other questions raised, though current speculation seems to be that the difference in subjective effects between THC and the synthetic cannabinoids is most likely due to differential activation of second messenger pathways inside the neuron following CB₁ binding (cf. lisuride vs LSD), though off-target effects may well also be significant for some compounds. Meodipt (talk) 01:08, 29 August 2010 (UTC)

Thanks for the info, it'll be interesting to see papers come out in the future. I agree that the refdesk question isn't what we're here for - hence the forum links. Thanks also for the revert on mephedrone, organic chemistry nomenclature is way too complicated for me! Smartse (talk) 12:00, 30 August 2010 (UTC)

Well to be fair the metabolic route for mephedrone shown in that paper shows 4-methylnorephedrine as a metabolite, not 4-methylephedrine, so saying this may be responsible for the vasoconstriction probably is an impermissible synthesis (which is frowned upon here for the same reasons as original research, just not so strictly)...I'll reword this bit when I have a chance to think about how to phrase it better! Meodipt (talk) 22:47, 30 August 2010 (UTC)

I've just added a ref to THC#Biosynthesis, which says that CBD and THC are enantiomers - looking at their structures this seems to be wrong, but I just wanted to check to see if you know either way. Smartse (talk) 10:24, 31 August 2010 (UTC)

No they are not enantiomers, THC and CBD readily interconvert by a reversible ring-opening - ring-closing reaction called a ring-chain tautomerism, between the double bond on the isopropenyl side chain of the cyclohexyl ring of CBD and the adjacent phenol OH, so the middle carbon of the isopropenyl is attacked by the OH and turns into the gem dimethyl bit of the pyran ring of THC and the OH turns into the ether bridge...hmm might be easier to draw it! See e.g. pp 191-195 of Raj K. Razdan's The Total Synthesis of Cannabinoids. ISBN 978-0-471-05460-3. Note that midazolam undergoes a similar tautomerism between ring-opened and ring-closed forms depending on pH, and there are other examples also, but THC / CBD is something of a special case as both tautomers have distinct pharmacological activity, and both are stable enough that there are usually large amounts of both forms present at once. Meodipt (talk) 11:07, 31 August 2010 (UTC)

Gabapentin enacarbil

Hi Meodipt,

I noticed your creation of XP-13512 and addition of it to the Template:Anticonvulsants. Thanks for adding new articles to Wikipedia. Perhaps you would be interested going for a Did You Know? A brief Google showed that this drug has been granted the INN of Gabapentin enacarbil (see Recommended INN List 56). I also see that it failed FDA approval in Feb this year (see this for example), which is a setback that should be mentioned in the article along with the reasons why.

We generally use the INN for the drug article name (see WP:MEDMOS) so that should be the page where the article sits and XP-13512 could be a redirect. I see that Gabapentin enacarbil is a redirect so I'm not sure how easy it is to swap the articles (I believe you are meant to do that rather than just swap the content, so that the history and proper editor-attribution is kept, but since you are the only editor so far, and the history isn't very long, perhaps you can get away with just swapping the text over?) If you want to move/swap the articles and can't figure out how to do this, you could ask an admin.

Secondly, I wonder if you would please remove this drug from the Template:Anticonvulsants. I would do so myself but I see from the history that I did a similar removal of a drug added by you almost exactly a year ago. So I think it best if you consider this or else ask for another opinion as I don't want to edit war with you, even if very slowly :-) The reason for removing it is that I think that template should only be used for drugs that have seen clinical use as anticonvulsants. Lots of drugs have anticonvulsant properties but aren't used for such. I have tried searching for Gabapentin enacarbil wrt use as an anticonvulsant but have not found anything. So although it seems very likely to be an anticonvulsant (since it is just a prodrug of one) I don't think that's why it was created or how it will be used.

Cheers,

Colin°^Talk 16:21, 12 September 2010 (UTC)

Hi there. Yeah that sounds fine, I was unsure if gabapentin enacarbil had been assigned as the INN name or if that was just the name of the ester and they were planning to give it another official name, but will change those over. Added it to the anticonvulsants template mainly because it is a prodrug for a drug whose primary mechanism of action is an anticonvulsant (though I wonder whether gabapentin's use in neuropathic pain is now more widespread than its use as an anticonvulsant), but to be honest more I just needed a redlink to click on to create the page and it seemed the most appropriate template to add it to. So far as I can see the main use gabapentin enacarbil has been researched for is for restless legs syndrome, but we don't have a template for "drugs for the treatment of restless legs syndrome" yet... Meodipt (talk) 04:58, 13 September 2010 (UTC)

Oh and feel free to nominate it for a Did You Know entry if you want, one of my other pages for a sildenafil analogue that had been sold in "herbal aphrodisiac" products was in that a while back as I recall. Meodipt (talk) 05:05, 13 September 2010 (UTC)

Edoxaban

Hi! You beat me in creating this stub by about five minutes. I hope you don't mind that I replaced your structure drawing with my SVG. Cheers! --ἀνυπόδητος (talk) 11:37, 23 September 2010 (UTC)

Commons

Hi Meodipt. I would appreciate if you could upload the chemical structures to Commons instead of to English Wikipedia. Like this, they can be used by other Wikimedia projects such as Wikibooks or Wikipedias in other languages. If you would like to, you can use the prefilled form found at Commons:COM:CHEM. Thank you. --Leyo 00:06, 4 October 2010 (UTC) PS. You may want to merge your accounts.

{{pd-chem}}

May I suggest you use {{pd-chem}} instead of {{pd-self}} for your structural formula images.--ARTEST4ECHO ^{(talk|contribs)} 17:26, 19 October 2010 (UTC)

For his first structural formula images uploaded to Commons (thank you), he used both templates. ;-) Personally, I prefer “PD-chem”, but it is up to the uploader to choose. --Leyo 17:41, 19 October 2010 (UTC)

Wikipedia:Articles for deletion/Substituted phenethylamines

If you see it in time, you might want to comment at this AfD. Smartse (talk) 11:15, 29 October 2010 (UTC)

File:4,5-MDO-DMT.png listed for deletion

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File:Butallylonal.png listed for deletion

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File:LY503430.svg missing description details

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File:L-838,417.svg missing description details

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File:3C-P.png missing description details

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--ARTEST4ECHO ^{(talk|contribs)} 15:38, 9 November 2010 (UTC)

File:5-Me-MDA.png missing description details

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File:BK-MBDB.png missing description details

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File:11-COOH-THC.png missing description details

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File:DOTFM.png missing description details

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