| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 US 6
|
149.00 | 239.79 | I-80 / I-94 / US 6 at Illinois state line | US 6 at Ohio state line | 1931 | current | ||
 US 12
|
45.16 | 72.68 | US 12 / US 20 / US 41 at Illinois state line | US 12 at Michigan state line | 1926 | current | ||
 US 20
|
155.50 | 250.25 | US 12 / US 20 / US 41 at Illinois state line | US 20 at Ohio state line | 1926 | current | ||
 US 24
|
– | [convert: invalid number] | US 24 at Illinois state line | US 24 at Ohio state line | 1926 | current | ||
 US 27
|
117.78 | 189.55 | US 27 at Ohio state line | I-69 / US 24 / US 30 / SR 3 in Fort Wayne | 1926 | current | ||
 US 30
|
155.96 | 250.99 | US 30 at Illinois state line | US 30 at Ohio state line | 1926 | current | ||
 US 31
|
266.02 | 428.12 | US 31 at Kentucky state line | US 31 at Michigan state line | 1926 | current | ||
 US 33
|
94.72 | 152.44 | US 33 at Ohio state line | US 20 in Elkhart | 1937 | current | ||
 US 35
|
204.91 | 329.77 | I-70 / US 35 at Ohio state line | US 20 in Michigan City | 1934 | current | ||
 US 36
|
138.99 | 223.68 | US 36 at Illinois state line | US 36 at Ohio state line | 1926 | current | ||
 US 40
|
149.80 | 241.08 | I-70 / US 40 at Illinois state line | US 40 at Ohio state line | 1926 | current | ||
 US 41
|
279.79 | 450.28 | US 41 at Kentucky state line | US 12 / US 20 / US 41 at Illinois state line | 1926 | current | ||
 US 50
|
171.83 | 276.53 | US 50 at Illinois state line | US 50 at Ohio state line | 1926 | current | ||
 US 52
|
171.03 | 275.25 | US 52 at Illinois state line | US 52 at Ohio state line | 1926 | current | ||
 US 131
|
0.67 | 1.08 | Indiana Toll Road / I-80 / I-90 / SR 13 north of Middebury | US 131 at Michigan state line | 1961 | current | ||
 US 136
|
75.30 | 121.18 | US 136 at Illinois | I-74 / I-465 in Speedway | 1952 | current | ||
 US 150
|
177.17 | 285.13 | US 150 at Illinois state line | US 150 at Kentucky state line | 1926 | current | ||
 US 224
|
39.63 | 63.78 | US 24 in Huntington | US 24 at Ohio state line | 1934 | current | ||
 US 231
|
285.82 | 459.98 | US 231 at Kentucky state line | US 41 in St. John | 1954 | current | ||
 US 421
|
232.00 | 373.37 | US 421 at Kentucky state line | US 20 in Michigan City | 1951 | current | ||
