Though Sen is mainly popular as a film and television actress, she started as a theatre artist. In 1984, she made her acting debut in a local theatre group. In 1985, she acted in a play named Baluchari, which was staged at the Star Theatre, Kolkata and continued for 500 shows. Besides acting, she has written plays. A play, Swarger Kache, was staged by Bengali theatre group Rangmahal.
In 1994, she started her own theatre group, Shyambazar Apalak.
In 1995–1996, Sen was first cast in a television serial, Jodi Emon Hoto. She has worked in serials like Janmabhumi, Roopkotha, Labonyer Sangsar, Swaragini-Jodein Rishton Ke Sur and Pandemonium.
- Baluchari (1985)
- Kacher Putul
- Ghar- Jamai (1989)
- Swarger Kache (playwright)
- Gogoler Kirti
- Obhishopto Nighty
- Classmate (2012) (Unreleased) actor
- Pather Sesh Kothay (2012) director, producer, story
- Prem By Chance (2010) actor
- Bondhu Eso Tumi (2010) actor
- Brake Fail (2009) actor
- Premer Phande Kakatua (2009) actor
- Bor Aasbe Ekhuni (2008) actor
- Jinon Rang Berang (2008)
- ghawre and bayire
- Labonyer Sangsar
- Bibi Chowdhurani
- Swaragini - Jodein Rishton Ke Sur (Colors)
- Premer Phande (Zee Bangla)
- Devi Chaudhurani (TV Show) (Star Jalsha)
- Soudaminir Songshar (Zee Bangla)
- Ranna Banna (Anchor now replaced by (Aparajita Auddy)along with Raktim Mitra) (Star Jalsha)
- Firki (Zee Bangla)
- Zee Bangla award for 1) "Dhyattarika" and 2) "Labonnoyer Sansar" (twice)
- Uttam Kumar Smriti Award (twice)
- Hemanta Kumar Smriti (memorial) award.
- Shyamal Mitra Smriti (memorial) award.
- Shubendu Smriti (memorial) award.
- Pramathesh Barua Smriti (memorial) award.
- Vivek Samman award.
- Dishari Award for her roles in theatre.
- "Tanima Sen bio". gomolo. Retrieved 11 August 2012.
- "Tanima Sen – about". Archived from the original on 12 May 2012. Retrieved 11 August 2012.
- Sengupta, Reshmi (25 August 2008). "Comedy of errors". Telegraph Calcutta. Calcutta, India. Retrieved 11 August 2012.
- "Hostel ha-ha". Telegraph Calcutta. Calcutta, India. 8 September 2008. Retrieved 11 August 2012.