Contested deletion

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This page should not be speedily deleted because... this is not restoration of the previous article. What I do, is translation of the article of "Хронология исследования старения" from Russian wikipedia that what created independently (this is not reverse translation). I know that my English is not great (sorry) but I hope that some person soon clean up my grammatical bugs in the article. --Lady3mlnm (talk) 16:36, 4 May 2021 (UTC)Reply

Items to add from the year in science articles and the need for ex/inclusion-criteria and/or layout changes

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2019
  • 22 August – Research by Norwegian scientists adds to a growing body of evidence that too much sitting is related to a higher risk of early death, and that even a small amount of regular activity can lengthen lifespan.[1]
    • (I would not include that one)
  • 16 September – Scientists at the Mayo Clinic report the first successful use of senolytics, a new class of drug with potential anti-aging benefits, to remove senescent cells from human patients with a kidney disease.[2][3]
  • 16 October – Researchers at Harvard Medical School identify a link between neural activity and human longevity. Neural excitation is linked to shorter life, while suppression of overactivity appears to extend lifespan.[5]
  • 13 November – Scientists in Japan use single-cell RNA analysis to find that supercentenarians have an excess of cytotoxic CD4 T-cells, a type of immune cell.[6]
2020
  • 4 March – Researchers report that their review indicates that the unguarded X hypothesis may be valid: according to this hypothesis one reason for why the average lifespan of males isn't as long as that of females – by 18% on average according to the study – is that they have a Y chromosome which can't protect an individual from harmful genes expressed on the X chromosome, while a duplicate X chromosome, as present in female organisms, can ensure harmful genes aren't expressed.[7][8]
    • (I would not include that one)
  • 10 July – Scientists report that after mice exercise their livers secrete the protein GPLD1, which is also elevated in elderly humans who exercise regularly, that this is associated with improved cognitive function in aged mice and that increasing the amount of GPLD1 produced by the mouse liver in old mice could yield many benefits of regular exercise for their brains – such as increased BDNF-levels, neurogenesis, and improved cognitive functioning in tests.[11][12]
    • (This was removed from the list and simply nobody undid the removal.)
  • 17 July – Scientists report that yeast cells of the same genetic material and within the same environment age in two distinct ways, describe a biomolecular mechanism that can determine which process dominates during aging and genetically engineer a novel aging route with substantially extended lifespan.[13][14]
2021

Here are some items that I considered for inclusion in the year in science articles but found they may only be suitable for inclusion here:

Note that all very major items should probably also be included in their respective "year in science" articles.


I propose creating subsections for years starting with 2019 so that more items can be incorporated and the increased number of significant results are properly taken into consideration. Then this timeline could then also be added to this template (to Fields):

It would be good to start formalizing ex/inclusion criteria. One could also change the layout of the list to be a table and have categories for types of entries or importance. One of the advantages of this is that the list could then be sorted or filtered (the latter requires some changes to the MediaWiki code for table functionalities that are already possible on the Wikipedia Watchlist and which I proposed on phabricator). One could also keep the list-style layout but add e.g. colored tags for different categories of items (like "achievement", "conclusion [about aging-mechanics]", "policy", "meta", etc for types and categories about how significant things are [like items making it into the main tiles of my monthly "Science Summary" being a different category than the shortly summarized items] – having a separate category for less significant findings allows readers to easily skip or filter these out).


@Lady3mlnm: and anybody else interested in this topic: What do you think about including these, developing some exclusion criteria and making some layout changes like new sections?

--Prototyperspective (talk) 11:01, 25 June 2021 (UTC)Reply

  • @Prototyperspective: I will be very glad if the article develops, but I can't take active participation in this.
Small comment: "2019, 22 August … too much sitting is related to a higher risk of early death" - that is healthy lifestyle, not senescence research directly. I would also not include such things.
--Lady3mlnm (talk) 12:09, 25 June 2021 (UTC)Reply

References

  1. ^ Even a Little Exercise Means a Lot for Life Span webmd.com Retrieved 22 August 2019.
  2. ^ "Mayo researchers demonstrate senescent cell burden is reduced in humans by senolytic drugs". Mayo Clinic. Mayo Clinic. 18 September 2019. Retrieved 20 September 2019.
  3. ^ "Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease". EBioMedicine. EBioMedicine. 20 September 2019. Retrieved 20 September 2019.
  4. ^ "Fruit flies live longer with combination drug treatment". University College London. 30 September 2019. Retrieved 2 October 2019.
  5. ^ "In a first, scientists pinpoint neural activity's role in human longevity". Science Daily. 16 October 2019. Retrieved 28 October 2019.
  6. ^ "Could cytotoxic T-cells be a key to longevity?". Science Daily. 13 November 2019. Retrieved 19 November 2019.
  7. ^ "Why men (and other male animals) die younger: It's all in the Y chromosome". phys.org. Retrieved 5 April 2020.
  8. ^ Xirocostas, Zoe A.; Everingham, Susan E.; Moles, Angela T. (25 March 2020). "The sex with the reduced sex chromosome dies earlier: a comparison across the tree of life". Biology Letters. 16 (3): 20190867. doi:10.1098/rsbl.2019.0867. PMC 7115182. PMID 32126186.
  9. ^ "Blood iron levels could be key to slowing ageing, gene study shows". phys.org. Retrieved 18 August 2020.
  10. ^ Timmers, Paul R. H. J.; Wilson, James F.; Joshi, Peter K.; Deelen, Joris (16 July 2020). "Multivariate genomic scan implicates novel loci and haem metabolism in human ageing". Nature Communications. 11 (1): 3570. Bibcode:2020NatCo..11.3570T. doi:10.1038/s41467-020-17312-3. ISSN 2041-1723. PMC 7366647. PMID 32678081.
  11. ^ "Brain benefits of exercise can be gained with a single protein". medicalxpress.com. Retrieved 18 August 2020.
  12. ^ Horowitz, Alana M.; Fan, Xuelai; Bieri, Gregor; Smith, Lucas K.; Sanchez-Diaz, Cesar I.; Schroer, Adam B.; Gontier, Geraldine; Casaletto, Kaitlin B.; Kramer, Joel H.; Williams, Katherine E.; Villeda, Saul A. (10 July 2020). "Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain". Science. 369 (6500): 167–173. doi:10.1126/science.aaw2622. ISSN 0036-8075. Retrieved 18 August 2020.
  13. ^ "Researchers discover 2 paths of aging and new insights on promoting healthspan". phys.org. Retrieved 17 August 2020.
  14. ^ Li, Yang; Jiang, Yanfei; Paxman, Julie; O'Laughlin, Richard; Klepin, Stephen; Zhu, Yuelian; Pillus, Lorraine; Tsimring, Lev S.; Hasty, Jeff; Hao, Nan (2020). "A programmable fate decision landscape underlies single-cell aging in yeast". Science. 369 (6501): 325–329. Bibcode:2020Sci...369..325L. doi:10.1126/science.aax9552. PMC 7437498. PMID 32675375.
  15. ^ "Researchers Find Powerful Protein Doubles Running Capacity, Improves Physical Performance". NBC Los Angeles. Retrieved 13 February 2021.
  16. ^ "'Exercise protein' doubles running capacity, restores function and extends healthy lifespans in older mice". medicalxpress.com. Retrieved 13 February 2021.
  17. ^ Reynolds, Joseph C.; Lai, Rochelle W.; Woodhead, Jonathan S. T.; Joly, James H.; Mitchell, Cameron J.; Cameron-Smith, David; Lu, Ryan; Cohen, Pinchas; Graham, Nicholas A.; Benayoun, Bérénice A.; Merry, Troy L.; Lee, Changhan (20 January 2021). "MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis". Nature Communications. 12 (1): 470. Bibcode:2021NatCo..12..470R. doi:10.1038/s41467-020-20790-0. ISSN 2041-1723. PMC 7817689. PMID 33473109.   Available under CC BY 4.0.
  18. ^ "Study reveals immune driver of brain aging". medicalxpress.com. Retrieved 13 February 2021.
  19. ^ Minhas, Paras S.; Latif-Hernandez, Amira; McReynolds, Melanie R.; Durairaj, Aarooran S.; Wang, Qian; Rubin, Amanda; Joshi, Amit U.; He, Joy Q.; Gauba, Esha; Liu, Ling; Wang, Congcong; Linde, Miles; Sugiura, Yuki; Moon, Peter K.; Majeti, Ravi; Suematsu, Makoto; Mochly-Rosen, Daria; Weissman, Irving L.; Longo, Frank M.; Rabinowitz, Joshua D.; Andreasson, Katrin I. (February 2021). "Restoring metabolism of myeloid cells reverses cognitive decline in ageing". Nature. 590 (7844): 122–128. Bibcode:2021Natur.590..122M. doi:10.1038/s41586-020-03160-0. ISSN 1476-4687. PMID 33473210. Retrieved 13 February 2021.
  20. ^ "Do people aged 105 and over live longer because they have more efficient DNA repair?". eLife. May 4, 2021. Retrieved May 7, 2021.
  21. ^ Garagnani, Paolo; et al. (2021-05-04). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi:10.7554/eLife.57849. ISSN 2050-084X. PMC 8096429. PMID 33941312. Retrieved 13 June 2021.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  22. ^ "Mothers can influence offspring's height, lifespan and disease risk through mitochondria". phys.org. Retrieved 14 June 2021.
  23. ^ Yonova-Doing, Ekaterina; Calabrese, Claudia; Gomez-Duran, Aurora; Schon, Katherine; Wei, Wei; Karthikeyan, Savita; Chinnery, Patrick F.; Howson, Joanna M. M. (2021-05-17). "An atlas of mitochondrial DNA genotype–phenotype associations in the UK Biobank". Nature Genetics: 1–12. doi:10.1038/s41588-021-00868-1. ISSN 1546-1718. PMID 34002094. Retrieved 14 June 2021.
  24. ^ "Humans Could Live up to 150 Years, New Research Suggests". Scientific American. May 25, 2021. Retrieved May 28, 2021.
  25. ^ "Gero scientists found a way to break the limit of human longevity". EurekAlert!. May 25, 2021. Retrieved May 28, 2021.
  26. ^ "Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit". Nature. May 25, 2021. Retrieved May 28, 2021.   Available under CC BY 4.0.