Talk:List of opioids

Priority opioids for inclusion to Wikipedia.

Genomorphine / Morphine-N-oxide as an active metabolite of Morphine, should be high up on the importance scale of opioids next in line to have articles made for them here on Wikipedia. Nagelfar (talk) 11:40, 15 November 2011 (UTC)

Done. Nagelfar (talk) 13:50, 18 November 2011 (UTC)

6,14-Endoethenotetrahydrooripavine should be created, seeing as it is the parent compound to the entire orvinol series of opioids. Nagelfar (talk) 17:28, 18 November 2011 (UTC)

Apparently naloxone can be N-deallylated using what's called Wilkinson's catalyst and reacted with methyl iodide which makes 14-methoxymorphone which is around 600× the potency of morphine and in the range of subjective effect colloquially similar to its cousin oxymorphone. 14-methoxymorphone seems like a worthy substance to add for the morphinan family. Nagelfar (talk) 03:14, 29 December 2012 (UTC)

Neutral antagonists (e.g. 6β-naltrexol)

There doesn't seem to be many articles on Wikipedia for opioid 'neutral antagonists' of which 6β-naltrexol is one (as opposed to inverse-agonists dubbed "antagonists" such as naloxone & naltrexone). Perhaps this could be a focus of those doing work on opioid type compounds in Wikipedia. Nagelfar (talk) 13:49, 18 November 2011 (UTC)

active (non-prodrug) morphinan di-esters.

It seems drugs like 3-O-acetylmorphine-6-O-sulfate (mentioned on the 3-MAM article page) and acetorphine have analgesic properties even having the 3-position masked behind a branch. It simply appears that there must be a 6-position substituent which is more "substantial" than the #3 in some manner for there to be activity with a #3 as well. This makes me wonder if they have selective mu³ subtype affinity over other mu-types, considering the role played in mu³ agonism by 6-position branches otherwise. Nagelfar (talk) 16:11, 21 November 2011 (UTC)

Non-existing names

I found out that some listed here are not found anywhere. I've added cas or other info visible on edited. One item is giving me trouble finding: in Ethylmorphine reads: "Ethylmorphine also has a hydromorphone analogue (ethyldihydromorphinone or 3-ethoxy-7,8-dihydro-morphin-6-one)." Cid mentioned was for "Methyldi..." and I think it should be "3-ethoxy-7,8-dihydro-morphinan-6-one". Help,pls.--RicHard-59 (talk) 12:12, 26 December 2011 (UTC)

section for corrections.

6-nicotinoyldihydromorphine is listed under the "3,6-di-esters of morphine" yet it is only a 6-position ester, not a 3,6-diester. This should be categorized into its proper section. 66.96.79.223 (talk) 22:38, 26 November 2013 (UTC)

 Done. Fixed, thanks for pointing it out. --Tryptofish (talk) 01:01, 27 November 2013 (UTC)

The veracity of the 3-(3-Methoxyphenyl)-3-ethoxycarbonyltropane "opioid" that has so little beyond original/primary sourcing.

Although if you search the web you get the purported reference of NIDA Research Monography. See vol. 81 from 1988. around page 520. "NIH 10479: ortho-MeO", "NIH 10480: ortho-OH" & "NIH 10481: no substituents at the Ph" at most… …if you notice the enigmatic "phenyltropane opioid" has within it the chemical formula "OC₂H₅" found in Tetraethyl orthosilicate, which appears very "politically affiliated" to fall back upon shallow innuendo, and for this reason I for one question if such a compound is not, therefore, just a bad joke after all? Can someone find that citation if it were indeed true? My doubts have been piqued. 66.96.79.217 (talk) 00:08, 6 April 2015 (UTC)

However, on the other hand, many Bentley compound opioids have alcohols with substitutions that go out in quadrant formations much as that 'tetraethyl', so for me the jury is out on exactly what to think. 66.96.79.217 (talk) 02:45, 7 April 2015 (UTC)

back into a template

Can we turn this back into a template which can be added to articles alongside "Opioidergics"? This would be helpful to a much larger spectrum of readers. — Preceding unsigned comment added by 69.95.162.198 (talk) 20:23, 16 February 2016 (UTC)

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Question about a section heading

The following heading reads like a typo, of sorts, but I have no real information on this -- Crude opiate extracts whole opium products

Could there be a missing word such as: Crude opiate extracts (of) whole opium products OR Crude opiate extracts (and) whole opium products? Arbalest Mike (talk) 19:40, 19 April 2018 (UTC)