Talk:Ethanol metabolism

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Important OmissionsEdit

Needs to include the role of CYP450 proteins (esp CYP2E1) in the ethanol - acetaldehyde reaction. This is very relevant to anyone more interested in clinical significant over organic chemistry — Preceding unsigned comment added by 108.162.182.183 (talk) 18:20, 17 January 2012 (UTC)

Writing StyleEdit

Somebody needs to translate this into English. It's the worst article on Wiki I've ever read. —Preceding unsigned comment added by 83.104.48.201 (talk) 19:58, 3 October 2009 (UTC)

This article seems written like a wikibook 70.83.165.112 03:37, 3 December 2007 (UTC)

It seems to me that this is a copy of a lab report. 71.167.118.89 (talk) 12:36, 7 January 2008 (UTC)
Yeah, this is honestly really poorly written (in the sense of organization and Wikipedia). I'm going to mark this for later review so I can maybe make some sense of this. Slavakion (talk) 03:01, 9 February 2008 (UTC)

i agree merge this with ‘microsomal ethanol-oxidising system as well, keep all the data on the topic in one place 125.253.101.232 (talk) 02:04, 27 March 2013 (UTC) I made a couple edits to make this article more like one that belongs on Wikipedia, but it still needs a bit of work. I tagged it appropriately. Andrew Nutter  Talk | Contribs  15:47, 20 April 2009 (UTC)

"all the way back to single cell bacteria." ?Is there any other type of bacteria? --Thebesius (talk) 06:18, 2 November 2012 (UTC)

References & Original ResearchEdit

This article at least seems to be fairly well cited. Do we really need that tag? What exactly is the information in question? Andrew Nutter  Talk | Contribs  15:47, 20 April 2009 (UTC) I think the line in question may be: "If the body had no mechanism for catabolizing the alcohols, they would build up in the body and become toxic. This could be an evolutionary rationale for alcohol catabolism" maybe a few other places? Editsbyabigail (talk) 23:52, 12 November 2013 (UTC)

glycolysis mapEdit

Ethanol doesn't even get used in glycolysis ... the whole glycolysis map is really misleading because the conversion of acetic acid into acetyl-CoA is an aerobic step, not an anaerobic one. I suggest we remove it and replace it with a simpler schema. It doesn't add anything that we don't already know through the "thermodynamic considerations" section. John Riemann Soong (talk) 14:08, 16 August 2009 (UTC)

ExcretionEdit

a section is needed on excretion. i.e., proportion excreted by the kidneys unchanged, as acetaldehyde, etc.Toyokuni3 (talk) 15:17, 9 June 2010 (UTC)

Way to test for enzyme?Edit

Is there a way to test someone to see if they have the enzyme or not? — Preceding unsigned comment added by 140.147.236.194 (talk) 16:06, 25 May 2012 (UTC)

Energy CalculationsEdit

Step 3 is missing in the energy calculation section. I do not know enough about wikipedia formatting or biochemistry to fix it. — Preceding unsigned comment added by 71.197.187.251 (talk) 06:32, 5 February 2013 (UTC)

Energy calculation error: it seems to me that the maximum has to be the total of the full pathway, 47.2 - 215.1 - 1 325.3 = -1493.2 and the minimum still requires the first endothermic step 47.2 - 215.1 = -167.9 I have made this adjustment, although I am happy to be proven wrong as I am an engineer not a biochemist. Mike163 (talk) 14:53, 2 January 2016 (UTC)

My bad: reviewing the calculations, I didn't see the Sigma initially.Mike163 (talk) 15:13, 2 January 2016 (UTC)

Biologically accessible energyEdit

Most of the −1325.6 kJ/mol calculated here will be turned into heat. Wouldn't it be more useful to list the biologically available energy produced per ethanol?

Step NADH FADH2 ATP/GTP
Step 1 +1 0 0
Step 2 +1 0 0
Step 3 0 0 -1
CAC +3 +1 +1
Total +5 +1 0

Given that NADH oxidation in the ETC cycle produces ~2.5ATP/NADH and ~1.5ATP/FADH2, this makes ~15 ATP available per ethanol. In comparison, glycolysis produces ~32 ATP/glucose. --Quantum7 13:25, 26 July 2017 (UTC)

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