Lancelot Thomas Hogben FRS FRSE (9 December 1895 – 22 August 1975) was a British experimental zoologist and medical statistician. He developed the African clawed frog (Xenopus laevis) as a model organism for biological research in his early career, attacked the eugenics movement in the middle of his career, and popularised books on science, mathematics and language in his later career.
Lancelot Thomas Hogben
|Died||22 August 1975 (aged 79)|
|Alma mater||Trinity College, Cambridge|
|Occupation||experimental zoologist, medical statistician|
Hogben was born and raised in Southsea near Portsmouth in Hampshire. His parents were Plymouth Brethren; he broke young from the family religion. He attended Tottenham County School in London, his family having moved to Stoke Newington, where his mother had grown up, in 1907, and then as a medical student studied physiology at Trinity College, Cambridge. He took his degree in 1915, graduating with an Ordinary degree. He had acquired socialist convictions, changing the name of the university's Fabian Society to Socialist Society and went on to become an active member of the Independent Labour Party. Later in life he preferred to describe himself as 'a scientific humanist'.
First World WarEdit
In the First World War he was a pacifist. He worked for six months with the Red Cross in France, under the auspices of the Friends' War Victims Relief Service and then the Friends' Ambulance Unit. He then returned to Cambridge, and was imprisoned in Wormwood Scrubs as a conscientious objector in 1916. His health collapsed and he was released in 1917. His brother George was also a conscientious objector, serving with the Friends' Ambulance Unit.
After a year's convalescence he took lecturing positions in London universities, moving in 1922 to the University of Edinburgh and its Animal Breeding Research Department. In 1923 he was elected a Fellow of the Royal Society of Edinburgh. His proposers were James Hartley Ashworth, James Cossar Ewart, Francis Albert Eley Crew and John Stephenson. He won the Society's Keith Prize for the period 1933–35.
He then went to McGill University, and in 1927 took a zoology chair at the University of Cape Town. He worked in endocrinology, studying chameleon properties of the Xenopus frog. The frog's adult color depended on its early environment; wild frogs became brownish-green, while frogs raised in a dark environment became black, and in a light environment, light-colored. Hogben theorized that the frog's ability to develop differences in color was related to the pituitary gland. After removing the pituitary gland, the frogs became white regardless of their environment.
The frogs also developed a side effect that Hogben tried to counteract by injecting the frogs with pituitary extract from an ox. He noticed that female Xenopus frogs ovulated within hours of being injected with the extract. In this way, Hogben serendipitously discovered a human pregnancy test. He knew that the ox extract chemically resembled human chorionic gonadotropin (HCG), a hormone released by pregnant women. He confirmed that female Xenopus frogs, when injected with urine from a pregnant woman, ovulated within hours.
Hogben found the job in South Africa attractive, but his antipathy to the country's racial policies drove him to leave. In 1930 Hogben moved to the London School of Economics, in a chair for social biology. There he continued to develop the Hogben Pregnancy Test. Previous pregnancy tests required several days to carry out and resulted in the deaths of mice or rabbits. Hogben's pregnancy test took hours and could be carried out without harm to the frogs, which could be reused for future tests. It became the major, international pregnancy test for about fifteen years, from the mid-1930s through the 1940s.
Distinguished for his work in Experimental Zoology, especially in respect of the mechanism of colour change in Amphibia and Reptilia. He has published a series of important papers on the effect of hormones on the pigmentary effector system and on the reproductive cycle of vertebrates, and has worked on many branches of comparative physiology. More recently he has made substantial contributions to genetics, especially with regard to man.
The social biology position at the London School of Economics was funded by the Rockefeller Foundation, and when it withdrew funding Hogben moved to Aberdeen, becoming Regius Professor of Natural History at the University of Aberdeen in 1937.
Hogben was awarded the Neill Prize, and a gold medal, for his work in mathematical genetics.
Xenopus pregnancy test controversyEdit
Hogben's claim to have discovered the Xenopus pregnancy test was disputed by two South African researchers, Hillel Shapiro and Harry Zwarenstein. Shapiro had been Hogben's student in Cape Town, and he acknowledged that Hogben had suggested that Xenopus was a suitable subject for general research. The pregnancy test itself was discovered by Shapiro and his co-researcher, Harry Zwarenstein, and their results and report had been widely published in medical journals and text books in South Africa and the United Kingdom; in their report published by Royal Society of South Africa in October 1933, Shapiro and Zwarenstein announced that in the previous month they had successfully used Xenopus in 35 pregnancy tests. The following spring Nature carried their report. Shapiro and Zwarenstein's letter published in the British Medical Journal on 16 November 1946 clarified that Hogben was retrospectively wrongly claiming credit for discovering the pregnancy test. Nobel laureate John B. Gurdon of the Wellcome CRC Institute and Nick Hopwood of the Department of History and Philosophy of Science, University of Cambridge, elaborated on this in detail in their comprehensive article published in The International Journal of Developmental Biology, pointing out that although Hogben had demonstrated in principle that Xenopus might be used for testing the presence of gonadotrophins in a pregnant woman's urine, his reporting had not mentioned pregnancy testing at all; he seemed to have had other research directions.
While Chair for Social Biology at the London School of Economics, Hogben unleashed a relentless attack on the British eugenics movement, which was at its apex in the 1920s and 1930s. In contrast to eugenicists, who commonly drew a strict line between heredity (or nature) and environment (or nurture), Hogben highlighted the 'interdependence of nature and nurture'. Hogben's appeal to this interdependence of nature and nurture marked the first time gene-environment interaction (or 'gene-environment interplay') was used to undermine statistical attempts to partition the contributions of nature and nurture, as well as the eugenic implications drawn from those statistics. Hogben's foil throughout this period was R.A. Fisher, the leading scientist-eugenicist of the day (Tabery 2008).
In an interview for the book Twentieth Century Authors, Hogben stated:
"I like Scandinavians, skiing, swimming and socialists who realize it is our business to promote social progress by peaceful methods. I dislike football, economists, eugenicists, Fascists, Stalinists, and Scottish conservatives. I think that sex is necessary and bankers are not".
Society for Experimental BiologyEdit
In 1923, Hogben was a founder of the Society for Experimental Biology and its organ the British Journal of Experimental Biology (renamed Journal of Experimental Biology in 1930), along with Julian Huxley and geneticist Francis Albert Eley Crew (1886–1973). According to Gary Werskey, Hogben was the only one of the founders not holding any eugenic ideas.
Inspired by the example of The Outline of History by H. G. Wells, Hogben began to work on books designed to popularize mathematics and science for the general public. Hogben produced two best-selling works of popular science, Mathematics for the Million (1936) and Science for the Citizen (1938). Mathematics for the Million received widespread praise, with H. G. Wells saying that "Mathematics for the Million is a great book, a book of first-class importance". The book was also lauded by Albert Einstein, Bertrand Russell and Julian Huxley.Mathematics for the Million was reprinted after Hogben's death. While at Aberdeen, Hogben developed an interest in language. Besides editing The Loom of Language by his friend Frederick Bodmer, he created an international language, Interglossa, as 'a draft of an auxiliary for a democratic world order'.
Above all, we cannot play ducks and drakes with a native battery of idioms which prescribes egregious collocations of vocables (...)— Orwell (1946), quoting Hogben, Interglossa (1943)
Professor Hogben plays ducks and drakes with a battery which is able to write prescriptions (...)— Orwell, Politics and the English Language (1946)
During World War II Hogben had responsibility for the British Army's medical statistics. He was Mason Professor of Zoology at the University of Birmingham 1941–1947 and professor of medical statistics there 1947–1961, when he retired. In 1963, he became the first Vice-Chancellor of the University of Guyana, a post he abandoned in April 1964, resigning in 1965.
In the 1950s Hogben settled at Glyn Ceiriog in north Wales, where he bought a cottage. That decade his marriage to Enid broke down; the couple separated in 1953 and divorced in 1957. Later that year Hogben married (Mary) Jane Roberts (née Evans), a local widowed retired school headmistress, who was seven years younger. Widowed by the death of Jane in 1974, he died at the War Memorial Hospital at Wrexham in 1975 aged 79 and was cremated at nearby Pentre Bychan. He was an atheist.
Hogben's research has left a lasting impression on the history of biology. The African clawed frog (Xenopus laevis), which Hogben first developed as a model organism, is now one of the most widely used model organisms in biological research. Likewise, his emphasis on the interdependence of nature and nurture has affected and continues to affect scientific practice and scientific debate. In terms of scientific practice, modern research on phenotypic plasticity, gene-environment interaction, and developmental systems theory all owes much to the legacy of Hogben's initial emphasis on understanding nature and nurture interdependently rather than in dichotomy. In terms of scientific debate, the dispute between Hogben and R.A. Fisher over gene-environment interaction was the first of many subsequent disputes over the extent to which the primacy of the gene can be understood independently of its developmental relationship with the environment. The debate on nature and nurture, the race and intelligence controversy, the heritability wars, concerns over the geneticisation of complex human traits, and arguments over the promises and perils of the human genome project all incorporate some element of disagreement over the primacy of the gene. Hogben's attack on that primacy by appeal to the interdependence of nature and nurture has been echoed in each successive dispute.
The Hogben ArchiveEdit
The Lancelot Thomas Hogben papers are held in Special Collections, University of Birmingham. Archive highlights include a draft of his autobiography (later edited and published by his son Adrian Hogben and his wife), correspondence, hand drawn diagrams for his books, and reflections on his life and works. (For a review of the Hogben Archive, see Tabery 2006).
- A Short Life of Alfred Russel Wallace (1823-1913), p. 64 (London, Society for Promoting Christian Knowledge, 1918)
- Exiles of the Snow, and Other Poems (1918)
- An Introduction to Recent Advances in Comparative Physiology (1924) with Frank R. Winton
- The Pigmentary Effector System. A review of the physiology of colour response (1924)
- Comparative Physiology (1926)
- Comparative Physiology of Internal Secretion (1927)
- The Nature of Living Matter (1930)
- Genetic Principles in Medical and Social Science (1931)
- Nature or Nurture - The William Withering Lectures for 1933 (1933)
- Mathematics for the Million: A Popular Self-Educator (London, George Allen & Unwin, 1936), illustrated by Frank Horrabin, Primers for the Age of Plenty - No. 1. Re-issued in the United States by W. W. Norton & Company, Inc. (1937).
- The Retreat from Reason (1936) Conway Memorial Lecture 20 May 1936, chaired by Julian Huxley.
- Science for the Citizen: A Self-Educator Based on the Social Background of Scientific Discovery (London, George Allen & Unwin, 1938), illustrated by Frank Horrabin, Primers for the Age of Plenty - No. 2.
- Political Arithmetic: A Symposium of Population Studies (1938) editor
- Dangerous Thoughts (1939)
- Author in Transit (1940)
- Principles of Animal Biology (1940)
- Interglossa: A Draft of an Auxiliary for a Democratic world order, Being an Attempt to Apply Semantic Principles to Language Design (1943)
- The Loom of Language: A Guide To Foreign Languages For The Home Student by Frederick Bodmer (1944), edited by Hogben, Primers for the Age of Plenty - No. 3.
- An Introduction to Mathematical Genetics (1946)
- History of the Homeland: The Story of the British Background by Henry Hamilton (1947), edited by Hogben, Primers for the Age of Plenty - No. 4.
- The New Authoritarianism (1949) Conway Memorial Lecture 1949
- From Cave Painting To Comic Strip: A Kaleidoscope of Human Communication (1949)
- Chance and Choice by Cardpack and Chessboard (1950)
- Man Must Measure: The Wonderful World of Mathematics (1955)
- Statistical theory. The relationship of probability, credibility and error. An examination of the contemporary crisis in statistical theory from a behaviorist viewpoint (1957)
- The Wonderful World Of Energy (1957)
- The Signs of Civilisation (1959)
- The Wonderful World of Communication (1959)
- Mathematics in the Making (1960)
- Essential World English (1963) with Jane Hogben and Maureen Cartwright
- Science in Authority: Essays (1963)
- The Mother Tongue (1964)
- Wales for the Welsh — A Tale of War and Peace with Notes for those who Teach or Preach (1967)
- Beginnings and Blunders or Before Science Began (1970)
- The Vocabulary Of Science (1970) with Maureen Cartwright
- Astronomer Priest and Ancient Mariner (1972)
- Maps, Mirrors and Mechanics (1973)
- Columbus, the Cannon Ball and the Common Pump (1974)
- How The World Was Explored, editor, with Marie Neurath and Joseph Albert Lauwerys
- Hogben, Anne; Hogben, Lancelot Thomas; Hogben, Adrian. Lancelot Hogben: scientific humanist: an unauthorised autobiography (1998)
- Leslie Hogben, granddaughter of Lancelot
- Wells, G. P. (1978). "Lancelot Thomas Hogben. 9 December 1895-22 August 1975". Biographical Memoirs of Fellows of the Royal Society. 24: 183–21. doi:10.1098/rsbm.1978.0007. PMID 11615739.
- Sarkar, S. (1996). "Lancelot Hogben, 1895-1975". Genetics. 142 (3): 655–660. PMC 1207007. PMID 8849876.
- Bud, Robert (2004). "Lancelot Hogben". Oxford Dictionary of National Biography. 1 (online ed.). Oxford University Press. doi:10.1093/ref:odnb/31244. (Subscription or UK public library membership required.)
- Tabery, J. (2008). "R. A. Fisher, Lancelot Hogben, and the origin(s) of genotype-environment interaction". Journal of the History of Biology. 41 (4): 717–761. doi:10.1007/s10739-008-9155-y. PMID 19244846. S2CID 46322531.
- Tabery, J. (2007). "Biometric and developmental gene–environment interactions: Looking back, moving forward". Development and Psychopathology. 19 (4): 961–976. doi:10.1017/S0954579407000478. PMID 17931428.
- Keynes, M. (1999). "Lancelot Hogben, F.R.S. (1895-1975): A review of his autobiography. Review of: Hogben, A; Hogben, A.: Lancelot Hogben - scientific humanist. Woodbridge, Suffolk: Merlin Press, 1998". Notes and Records of the Royal Society of London. 53 (3): 361–369. doi:10.1098/rsnr.1999.0088. PMID 11624011. S2CID 72372017.
- Hogben, L. (1996). "Fifty years ago: Lancelot Hogben reviews Bradford Hill. 1948". Journal of Epidemiology and Community Health. 50 (1): 3, discussion 3–4. doi:10.1136/jech.50.1.3. PMC 1060894. PMID 8815153.
- "Lancelot Hogben". Lancet. 2 (7934): 565. 1975. doi:10.1016/s0140-6736(75)90955-1. PMID 51402. S2CID 208786843.
- Kunitz, Stanley J. and Haycraft, Howard Twentieth Century Authors, A Biographical Dictionary of Modern Literature, (Third Edition). New York, The H.W. Wilson Company, 1950, (pp. 658–59)
- Biographical Index of Former Fellows of the Royal Society of Edinburgh 1783–2002 (PDF). The Royal Society of Edinburgh. July 2006. ISBN 0-902-198-84-X.
- Kean, Sam (2017). "The Birds, the Bees, and the Froggies". Distillations. 3 (2): 5. Retrieved 17 April 2018.
- University of Cape Town (CAPETOWN); SAPEIKA, Norman; SHAPIRO, Hillel Abbe; ZWARENSTEIN, Harry (1946). Xenopus laevis. A bibliography. Compiled by H. Zwarenstein ... N. Sapeika ... H.A. Shapiro. African Bookman: Cape Town. OCLC 558736058.
- Shapiro Zwarenstein, Hillel Harry (March 1935). "A test fr the early diagnosis of pregnancy on the South African clawed toad (Xenopus leaves)" (PDF). South African Medical Journal. 9: 202.
- SHAPIRO, H. A.; ZWARENSTEIN, H. (19 May 1934). "A Rapid Test for Pregnancy on Xenopus lævis". Nature. 133 (3368): 762. Bibcode:1934Natur.133..762S. doi:10.1038/133762a0. ISSN 0028-0836. S2CID 4123060.
- Christophers, S. R. (16 November 1946). "The Government Lymph Establishment". Br Med J. 2 (4480): 752. doi:10.1136/bmj.2.4480.752. ISSN 0007-1447. PMC 2054716.
- Gurdon, J B; Hopwood, N (1 February 2003). "The introduction of Xenopus laevis into developmental biology: of empire, pregnancy testing and ribosomal genes". International Journal of Developmental Biology. 44 (1). ISSN 0214-6282.
- Bowler, Peter J. Science for All : The Popularization of Science in Early Twentieth-Century Britain Chicago, Ill. : Univ. of Chicago Press, 2009. ISBN 9780226068633 (pp. 110-112)
- "Mathematics for the Million...praised by Einstein, H. G. Wells and others, it was reprinted in paperback in 1993." De Smith, Michael John, Maths for the Mystified : An Exploration of the History of Mathematics and Its Relationship to Modern-Day Science and Computing.Leicester : Matador, 2006. (p.192)
- "Archived copy". Archived from the original on 15 July 2010. Retrieved 15 July 2010.CS1 maint: archived copy as title (link)
- "Death Notice". Shropshire Star (Wrexham edition). 25 August 1975. p. 2.
- "A reader who has suffered me so far will have realised how much of my mental energy had been hitherto absorbed in a fruitless search for an intellectually compelling rationale to rescue some fragments from the wreckage of my family faith. The mood of liberation I experienced when I finally discarded the last remnant of theism was no less exhilarating than that of Bunyan's Pilgrim when the burden of sin fell from his back. [...] In retrospect, the final steps seem as sudden as they were painless. [...] As I looked upward [at the night sky], I realised that the sole prospect was limitless expanse of unthreatening and impersonal emptiness — but for unapproachable galaxies — of a universe without purpose of punishment or reward for a lately arrived animal species, free to make or mar its own destiny without help or hindrance from above." Lancelot Hogben, Lancelot Hogben: Scientific Humanist: An Unauthorised Autobiography, edited by Adrian and Ann Hogben. Merlin Press, 1998.
- Tabery, James (1 December 2008). "R. A. Fisher, Lancelot Hogben, and the Origin(s) of Genotype–Environment Interaction". Journal of the History of Biology. 41 (4): 717–761. doi:10.1007/s10739-008-9155-y. ISSN 1573-0387. PMID 19244846. S2CID 46322531.
- Milo Keynes. "Lancelot Hogben, FRS (1895-1975)". Galton Institute December 2001 Newsletter. Archived from the original on 24 September 2015. Retrieved 16 December 2014.Reprinted from Notes and Records of the Royal Society, London, 1999; vol. 53: pp. 361-369, part 2 Archived 24 September 2015 at the Wayback Machine
- Phillip Gething, "Forum: A whiff of optimism – Whatever happened to self-improvement?", New Scientist, 21 July 1990. Retrieved 6 January 2019.
- "1936 Lancelot Hogben: The Retreat From Reason". Conway Hall Ethical Society. Archived from the original on 16 December 2014. Retrieved 16 December 2014.
- "1949 Lancelot Hogben: The New Authoritarianism". Conway Hall Ethical Society. Archived from the original on 16 December 2014. Retrieved 16 December 2014.
- Gale, Floyd C. (September 1958). "Galaxy's 5 Star Shelf". Galaxy Science Fiction. p. 104.
- Hogben, Anne; Hogben, Lancelot Thomas; Hogben, Adrian (1998). Lancelot Hogben: scientific humanist: an unauthorised autobiography. London: Merlin. ISBN 978-0-85036-470-5.
- Erlingsson, Steindór J., "The Early History of the SEB and the BJEB." Society For Experimental Biology Bulletin, March, pp. 10–11, 2006. The article can be accessed here
- Tabery, James (2006). "Looking Back on Lancelot's Laughter". The Mendel Newsletter. 15: 10–17. External link in
- Werskey, Gary (1978). The Visible College. London: Allen Lane. ISBN 978-0-7139-0826-8.
- Lancelot Hogben biography at the Galton Institute
- Scientific Humanism in Time Magazine (11 March 1940)
- Max Perutz on Lancelot Hogben and his autobiography in Times Higher Education (31 July 1998)
- Details of research on Xenopus
- Royal Society certificate of election
- Royal Society photograph[permanent dead link]
- First part of Interglossa (there is a photograph of the author on p. 2.)
- Brief excerpts from Interglossa
- Full text and diagrams from Interglossa
- Scientists' Nightstand: David Mumford - a tribute to Mathematics for the Million from Fields Medallist David Mumford
- Correspondence of Sir R.A. Fisher: Calendar of Correspondence with Lancelot Hogben