|Alma mater||Dartmouth College|
Panero was born in New York City, and grew up on the Upper West Side of Manhattan. He attended the preparatory school Trinity in Manhattan. Panero graduated from Dartmouth in 1998, where he majored in classics. In his sophomore year he was appointed editor-in-chief of The Dartmouth Review.
Panero joined the editorial staff of National Review upon graduation. In 1999 he worked in Gstaad, Switzerland as a writing assistant to William F. Buckley Jr on his novel Spytime: The Undoing of James Jesus Angleton (Harcourt, 2000).
Before joining The New Criterion in 2001, Panero was a graduate student in the History of Art and Architecture department at Brown University, where he was awarded the University Scholarship. His area of focus was late-nineteenth-century French modernism.
Panero has written for New York Magazine, The New York Times Book Review, The Wall Street Journal, City Journal, Philanthropy Magazine, Forbes, The International Herald Tribune, Humanities Magazine, National Review, The Weekly Standard, The Claremont Review, The University Bookman, and The Dartmouth Alumni Magazine. In 2007, he became a regular writer for Art & Antiques Magazine.
Panero is the co-editor of The Dartmouth Review Pleads Innocent, an anthology of the newspaper published by the Intercollegiate Studies Institute in Spring 2006.
He is a contributor to Counterpoints: 25 Years of The New Criterion on Culture and the Arts (Ivan R. Dee, 2007), The State of Art Criticism, edited by James Elkins and Michael Newman (Routledge, 2008), and "Future Tense: The Lessons of Culture in an Age of Upheaval" (Encounter Books, 2012).
He is married to the writer and teacher Dara Mandle.
- "The Joe Bonham Project: An Exhibition Curated by James Panero": wartime illustrators document the rehabilitation of wounded warriors. On view at Storefront gallery, Bushwick, Brooklyn, September 1 through September 18, 2011.
- Future Tense: The Lessons of Culture in an Age of Upheaval (Roger Kimball, editor, James Panero, contributing writer on "What's a Museum?") ISBN 978-1594036347
- "The State of Art Criticism (The Art Seminar)" (James Elkins, editor; James Panero, contributing writer) ISBN 978-0415977876
- "Re-Enchantment (The Art Seminar)" (James Elkins and David Morgan, editors; James Panero, contributing writer) ISBN 978-0415977876
- The Dartmouth Review Pleads Innocent (James Panero and Stefan Beck, editors) ISBN 978-1-932236-93-4
- Jeffrey Collins, interview with James Panero for "Who's Afraid of Red, Yellow, and Blue"
- Reason TV: Ai WeiWei, Pussy Riot and the Power of Punk Art: An Interview with James Panero
- The Brian Lehrer Show What's a Museum?: James Panero discusses his new piece and how the idea of a museum has changed over the last several generations.
- "James Kalm Rough Cuts with James Panero, curator of The Joe Bonham Project.
- "FineArtViews Interview: James Panero -- Art Critic and Managing Editor for The New Criterion" 
- Lipinski, Jed (2011-12-24). "Via YouTube, Leading Tours of the City's Art Scene". The New York Times. Retrieved 2012-01-27.
- "Editor Profile: James Panero". The New Criterion. 2012-01-01. Retrieved 2012-01-27.
- Panero, James (2012-01-02). "Gstaad with Bill". Supreme Fiction. Retrieved 2012-01-27.
- Allen, Jonathan (2011-12-28). "Abstract painter Helen Frankenthaler dies at 83". Reuters. Retrieved 2012-01-27.
- Panero, James (2008-03-24). "An Old Master in Ruins". New York Magazine. Retrieved 2012-01-27.
- Panero, James (2008-06-29). "O Brother, Who Art Thou?". New York Times Book Review. Retrieved 2012-01-27.
- Panero, James (2011-03-23). "Behind the Veil: Questions about Art Authentication". The Wall Street Journal. Retrieved 2012-01-27.
- Panero, James (2011-04-01). "The Hudson River Destruction Project". City Journal. Retrieved 2012-01-27.
- Panero, James (2011-08-01). "Outsmarting Albert Barnes". Philanthropy Magazine. Retrieved 2012-01-27.
- Panero, James (2010-11-01). "Why Paris?". Humanities Magazine. Retrieved 2012-01-27.
- The New Criterion (2009-08-26). "Biography of James Panero". Retrieved 2009-08-26.
- "William and Barbara Edwards Media Fellows". The Hoover Institution. 2013-04-23. Archived from the original on 2013-05-11. Retrieved 2013-04-23.
- The New York Times (2006-08-27). "Dara Mandle, James Panero". Retrieved 2012-01-27.
- "Tucker Carlson equates the metric system with 'tyranny,' so someone should probably tell the US military". Task & Purpose. 2019-06-06. Retrieved 2019-06-08.
- Selvin, Claire (2019-06-06). "Art Critic James Panero Discusses the Metric System with Far-Right Pundit Tucker Carlson". ARTnews. Retrieved 2019-06-08.
- Panero, James (2011-09-09). "Introducing The Joe Bonham Project". The New Criterion. Retrieved 2012-01-27.
- Collins, Jeffrey (2012-12-14). "Interview with James Panero". Who's Afraid of Red, Yellow and Blue. Retrieved 2013-03-05.
- Reason TV (2011-09-22). "Ai WeiWei, Pussy Riot and the Power of Punk Art: An Interview with James Panero". Reason TV. Retrieved 2013-03-05.
- The Brian Lehrer Show (2012-03-29). "What's a Museum?: James Panero discusses his new piece and how the idea of a museum has changed over the last several generations". The Brian Lehrer Show. Retrieved 2013-03-05.
- Kalm, James (2011-09-22). "The Joe Bonham Project". James Kalm Rough Cuts. Retrieved 2012-01-27.
- Sherwin, Brian (2011-10-13). "FineArtViews Interview: James Panero -- Art Critic and Managing Editor for The New Criterion". FineArtViews. Retrieved 2012-01-27.