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Parasitism

  (Redirected from Ectoparasites)
A Lithognathus fish with a parasitic isopod, Cymothoa exigua, a fish parasite replacing its tongue

In evolutionary biology, parasitism is a relationship between species, where one organism, the parasite, lives on or in another organism, the host, causing it some harm, and is adapted structurally to this way of life.[1] The entomologist E. O. Wilson has characterised parasites as "predators that eat prey in units of less than one".[2] Parasites include protozoans such as the agents of malaria, sleeping sickness, and amoebic dysentery; animals such as hookworms, lice, mosquitoes, and vampire bats; fungi such as honey fungus and the agents of ringworm; and plants such as mistletoe, dodder, and the broomrapes. There are six major parasitic strategies of exploitation of animal hosts, namely parasitic castration, directly transmitted parasitism (by contact), trophically transmitted parasitism (by being eaten), vector-transmitted parasitism, parasitoidism, and micropredation.

Like predation, parasitism is a type of consumer-resource interaction,[3] but unlike predators, parasites, with the exception of parasitoids, are typically much smaller than their hosts, do not kill them, and often live in or on their hosts for an extended period. Parasites of animals are highly specialised, and reproduce at a faster rate than their hosts. Classic examples include interactions between vertebrate hosts and tapeworms, flukes, the malaria-causing Plasmodium species, and fleas.

Parasites reduce host fitness by general or specialised pathology, from parasitic castration to modification of host behaviour. Parasites increase their own fitness by exploiting hosts for resources necessary for their survival, in particular by feeding on them and by using intermediate (secondary) hosts to assist in their transmission from one definitive (primary) host to another. Although parasitism is often unambiguous, it is part of a spectrum of interactions between species, grading via parasitoidism into predation, through evolution into mutualism, and in some fungi, shading into being saprophytic.

People have known about parasites such as roundworms and tapeworms since ancient Egypt, Greece, and Rome. In Early Modern times, Antonie van Leeuwenhoek observed Giardia lamblia in his microscope in 1681, while Francesco Redi described internal and external parasites including sheep liver fluke and ticks. Modern parasitology developed in the 19th century. In human culture, parasitism has negative connotations. These were exploited to satirical effect in Jonathan Swift's 1733 poem "On Poetry: A Rhapsody", comparing poets to hyperparasitical "vermin". In fiction, Bram Stoker's 1897 Gothic horror novel Dracula and its many later adaptations featured a blood-drinking parasite. Ridley Scott's 1979 film Alien was one of many works of science fiction to feature a terrifying[4] parasitic alien species.

Contents

EtymologyEdit

First used in English in 1539, the word parasite comes from the Medieval French parasite, from the Latin parasitus, the latinisation of the Greek παράσιτος (parasitos), "one who eats at the table of another"[5] and that from παρά (para), "beside, by"[6] + σῖτος (sitos), "wheat", hence "food".[7] The related term parasitism appears in English from 1611.[8]

Evolutionary strategiesEdit

Basic conceptsEdit

Parasitism is a kind of symbiosis, a close and persistent long-term biological interaction between the parasite and its host. Unlike commensalism and mutualism, the parasitic relationship harms the host, either feeding on it or, as in the case of intestinal parasites, consuming some of its food.[9] Because parasites interact with other species, they are well placed to act as vectors of pathogens, microscopic parasites that cause disease.[10] Predation is not generally considered a symbiosis as the interaction is brief, but the entomologist E. O. Wilson has characterised parasites as "predators that eat prey in units of less than one".[2]

Within that scope are many possible ways of life. Parasites are classified in a variety of different but overlapping schemes, based on their interactions with their hosts and on their life cycles, which are sometimes very complex. An obligate parasite is totally dependent on the host to complete its life cycle, while a facultative parasite is not. A parasite with a direct life cycle has only one host while those with indirect life cycles have a definitive host and one or more intermediate hosts.[11][12] An endoparasite is one that lives inside the host's body; an ectoparasite lives outside, on the host's surface.[10] Mesoparasites like some copepods enter an opening in the host's body and remain partly embedded there.[13] It is possible for parasites to be generalists, feeding on a wide range of hosts, but many parasites, and the majority of protozoans and helminths that parasitise animals, are specialists and extremely host-specific.[10] An early basic, functional division of parasites was that of microparasites and macroparasites. These each had a mathematical model assigned in order to analyse the population movements of the host-parasite groupings.[14] The microorganisms and viruses that can reproduce and complete their life cycle within the host are known as microparasites. Macroparasites are the multicellular organisms that reproduce and complete their life cycle outside of the host or on the host's body.[14][15]

Much of the thinking on types of parasitism has focussed on terrestrial animal parasites of animals, such as helminths. Those in other environments and with other hosts often have analogous strategies. For example, the snubnosed eel is probably a facultative endoparasite that opportunistically burrows into and eats sick and dying fish.[16] Plant-eating insects such as scale insects, aphids, and caterpillars are much like ectoparasites, attacking much larger plants; they serve as vectors of bacteria, fungi and viruses which cause plant diseases. As female scale insects are unable to move, they are obligate parasites, permanently attached to their hosts.[14]

Major strategiesEdit

There are six major parasitic strategies, namely parasitic castration, directly transmitted parasitism, trophically transmitted parasitism, vector-transmitted parasitism, parasitoidism, and micropredation. These apply to parasites whose hosts are plants as well as animals.[17][14] These strategies represent adaptive peaks; intermediate strategies are possible, but organisms in many different groups have consistently converged on these six, which are evolutionarily stable.[17] A perspective on the evolutionary options can be gained by considering four questions: the effect on the fitness of a parasite's hosts; the number of hosts they have per life stage; whether the host is prevented from reproducing; and whether the effect depends on intensity (number of parasites per host). From this analysis, the major evolutionary strategies of parasitism emerge, alongside predation.[18]

Evolutionary strategies in parasitism and predation[18]
(Intensity-dependent: green, roman;
       Intensity-independent: purple, italics)
Host fitness Single host, stays alive Single host, dies Multiple hosts
Able to
reproduce
(fitness > 0)
Conventional parasite
   Pathogen
Trophically transmitted parasite[a]
   Trophically transmitted pathogen
Micropredator
   Micropredator
Unable to
reproduce
(fitness = 0)
-----
   Parasitic castrator
Trophically transmitted parasitic castrator
   Parasitoid
Social predator[b]
   Solitary predator
 
The parasitic castrator Sacculina carcini (highlighted) attached to its crab host

Parasitic castratorsEdit

Parasitic castrators partly or completely destroy their host's ability to reproduce, diverting the energy that would have gone into reproduction into host and parasite growth, sometimes causing gigantism in the host. The host's other systems are left intact, allowing it to survive and sustain the parasite.[17][19] Parasitic crustaceans such as those in the specialised barnacle genus Sacculina specifically cause damage to the gonads of their many species[20] of host crabs. In the case of Sacculina, the testes of over two-thirds of their crab hosts degenerate sufficiently for these male crabs to have gained female secondary sex characteristics such as broader abdomens, smaller claws and egg-grasping appendages. Various species of helminth castrate their hosts (such as insects and snails). This may be directly, whether mechanically by feeding on their gonads, or by secreting a chemical that destroys reproductive cells; or indirectly, whether by secreting a hormone or by diverting nutrients. For example, the trematode Zoogonus lasius, whose sporocysts lack mouths, castrates the intertidal marine snail Tritia obsoleta chemically, developing in its gonad and killing its reproductive cells.[19][21]

 
Human head lice are directly-transmitted obligate ectoparasites.

Directly transmittedEdit

Directly transmitted parasites, not requiring a vector to reach their hosts, include parasites of terrestrial vertebrates such as lice and mites; marine parasites such as copepods and cyamid amphipods; monogeneans; and many species of nematodes, fungi, protozoans, bacteria, and viruses. Whether endoparasites or ectoparasites, each has a single host species. Within that species, most individuals are free or almost free of parasites, while a minority carry a large number of parasites; this highly uneven distribution is described as aggregated.[17]

Trophically transmittedEdit

 
Clonorchis sinensis, the Chinese liver fluke, is trophically transmitted.

Trophically transmitted parasites are transmitted by being eaten by a host. They include trematodes (all except schistosomes), cestodes, acanthocephalans, pentastomids, many round worms, and many protozoa such as Toxoplasma.[17] They have complex life cycles involving hosts of two or more species. In their juvenile stages, they infect and often encyst in the intermediate host. When this animal is eaten by a predator, the definitive host, the parasite survives the digestion process and matures into an adult; some live as intestinal parasites. Many trophically transmitted parasites modify the behaviour of their intermediate hosts, increasing their chances of being eaten by a predator. Like directly transmitted parasites, the distribution of trophically transmitted parasites among host individuals is aggregated.[17] Coinfection by multiple parasites is common.[22] Autoinfection, where (by exception) the whole of the parasite's life cycle takes place in a single primary host, can sometimes occur in helminths such as Strongyloides stercoralis.[23]

Vector-transmittedEdit

 
The vector-transmitted protozoan endoparasite Trypanosoma among human red blood cells

Vector-transmitted parasites rely on a third party, an intermediate host, where the parasite does not reproduce sexually[10] to carry them from one definitive host to another.[17] These parasites are microorganisms, namely protozoa, bacteria, or viruses, often intracellular pathogens (causing disease).[17] Their vectors are mostly hematophagic arthropods such as fleas, lice, ticks, and mosquitoes.[17][24] For example, the deer tick Ixodes scapularis acts as a vector for diseases including Lyme disease, babesiosis, and anaplasmosis.[25] Protozoan endoparasites, such as the malarial parasites in the genus Plasmodium and sleeping sickness parasites in the genus Trypanosoma, infective stages in the host's blood are transported to new hosts by biting insects.[26]

ParasitoidsEdit

Parasitoids are insects which sooner or later kill their hosts, placing their relationship close to predation.[27] Most parasitoids are hymenopterans, parasitoid wasps; others include dipterans such as phorid flies. They can be divided into two groups, idiobionts and koinobionts, differing in their treatment of their hosts.[28]

Idiobiont parasitoids sting their often large prey on capture, either killing them outright or paralysing them immediately. The immobilised prey is then carried to a nest, sometimes alongside other prey if it is not large enough to support a parasitoid throughout its development. An egg is laid on top of the prey, and the nest is then sealed. The parasitoid develops rapidly through its larval and pupal stages, feeding on the provisions left for it.[28]

Koinobiont parasitoids, which include flies as well as wasps, lay their eggs inside young hosts, usually larvae. These are allowed to go on growing, so the host and parasitoid develop together for an extended period, ending when the parasitoids emerge as adults, leaving the prey dead, eaten from inside. Some koinobionts regulate their host's development, for example preventing it from pupating or making it moult whenever the parasitoid is ready to moult. They may do this by producing hormones that mimic the host's moulting hormones (ecdysteroids), or by regulating the host's endocrine system.[28]

MicropredatorsEdit

 
Mosquitoes are micropredators, and important vectors of disease.

A micropredator attacks more than one host, reducing each host's fitness at least a small amount, and is only in contact with any one host intermittently. This makes them suitable as vectors as they can pass smaller parasites from one host to another.[17][29][18] Most micropredators are hematophagic, feeding on blood. They include annelids such as leeches, crustaceans such as branchiurans and gnathiid isopods, various dipterans such as mosquitoes and tsetse flies, other arthropods such as fleas and ticks, vertebrates such as lampreys, and mammals such as vampire bats.[17]

Transmission strategiesEdit

 
Life cycle of Entamoeba histolytica, an anaerobic parasitic protozoan transmitted by the fecal-oral route

Parasites use a variety of methods to infect animal hosts, including physical contact, the fecal-oral route, free-living infectious stages, and vectors, suiting their differing hosts, life-cycles, and ecological contexts.[30] Examples to illustrate some of the many possible combinations are given in the table.

VariationsEdit

Among the many variations on parasitic strategies are hyperparasitism,[32] social parasitism,[33] brood parasitism,[34] kleptoparasitism,[35] sexual parasitism,[36] and adelphoparasitism.[37]

HyperparasitismEdit

Hyperparasites feed on another parasite, as exemplified by protozoa living in helminth parasites,[32] or facultative or obligate parasitoids whose hosts are either conventional parasites or parasitoids.[17][28] Levels of parasitism beyond secondary also occur, especially among facultative parasitoids. In oak gall systems, there can be up to five levels of parasitism.[38]

Hyperparasites can control their hosts' populations, and are used for this purpose in agriculture and to some extent in medicine. The controlling effects can be seen in the way that the CHV1 virus helps to control the damage that chestnut blight, Cryphonectria parasitica, does to American chestnut trees, and in the way that bacteriophages can limit bacterial infections. It is likely, though little researched, that most pathogenic microparasites have hyperparasites which may prove widely useful in both agriculture and medicine.[39]

Social parasitismEdit

Social parasites take advantage of interspecific interactions between members of social animals such as ants, termites, and bumblebees. Examples include the large blue butterfly, Phengaris arion, its larvae employing ant mimicry to parasitise certain ants,[33] Bombus bohemicus, a bumblebee which invades the hives of other bees and takes over reproduction while their young are raised by host workers, and Melipona scutellaris, a eusocial bee whose virgin queens escape killer workers and invade another colony without a queen.[40] An extreme example of interspecific social parasitism is found in the ant Tetramorium inquilinum, an obligate parasite which lives exclusively on the backs of other Tetramorium ants.[41] Emery's rule notes that social parasites tend to be closely related to their hosts, often being in the same genus.[42][43]

Intraspecific social parasitism occurs in parasitic nursing, where some individual young take milk from unrelated females. In wedge-capped capuchins, higher ranking females sometimes take milk from low ranking females without any reciprocation.[44]

Brood parasitismEdit

In brood parasitism, the hosts act as parents as they raise the young as their own. Brood parasites include birds in different families such as cowbirds, whydahs, cuckoos, and black-headed ducks. These do not build nests of their own, but leave their eggs in nests of other species. The eggs of some brood parasites mimic those of their hosts, while some cowbird eggs have tough shells, making them hard for the hosts to kill by piercing, both mechanisms implying selection by the hosts against parasitic eggs.[34][45][46] The adult female European cuckoo further mimics a predator, the European sparrowhawk, giving her time to lay her eggs in the host's nest unobserved.[47]

KleptoparasitismEdit

In kleptoparasitism (from Greek κλέπτης (kleptēs), "thief"), parasites steal food gathered by the host. The parasitism is often on close relatives, whether within the same species or between species in the same genus or family. For instance, the many lineages of cuckoo bees lay their eggs in the nest cells of other bees in the same family.[35] Kleptoparasitism is uncommon generally but conspicuous in birds; some such as skuas are specialised in pirating food from other seabirds, relentlessly chasing them down until they disgorge their catch.[48]

Sexual parasitismEdit

A unique approach is seen in some species of anglerfish, such as Ceratias holboelli, where the males are reduced to tiny sexual parasites, wholly dependent on females of their own species for survival, permanently attached below the female's body, and unable to fend for themselves. The female nourishes the male and protects him from predators, while the male gives nothing back except the sperm that the female needs to produce the next generation.[36]

AdelphoparasitismEdit

Adelphoparasitism, (from Greek ἀδελφός (adelphós), brother[49]), also known as sibling-parasitism, occurs where the host species is closely related to the parasite, often in the same family or genus.[37] In the citrus blackfly parasitoid, Encarsia perplexa, unmated females of which may lay haploid eggs in the fully developed larvae of their own species, producing male offspring,[50] while the marine worm Bonellia viridis has a similar reproductive strategy, although the larvae are planktonic.[51]

IllustrationsEdit

Examples of the major variant strategies are illustrated.

Taxonomic rangeEdit

 
Head (scolex) of tapeworm Taenia solium, an intestinal parasite, has hooks and suckers to attach to its host.

A wide range of organisms is parasitic, from animals, plants, and fungi to protozoans, bacteria, and viruses.[52]

AnimalsEdit

Parasitism is widespread in the animal kingdom,[55] and has evolved independently from free-living forms hundreds of times.[17] Many types of helminth including flukes and cestodes have complex life cycles involving two or more hosts. By far the largest group is the parasitoid wasps in the Hymenoptera.[17] The phyla and classes with the largest numbers of parasitic species are listed in the table. Numbers are conservative minimum estimates. The columns for Endo- and Ecto-parasitism refer to the definitive host, as documented in the Vertebrate and Invertebrate columns.[53]

PlantsEdit

 
Cuscuta (a dodder), a stem holoparasite, on an acacia tree

A hemiparasite or partial parasite, such as mistletoe derives some of its nutrients from another living plant, and a holoparasite such as dodder derives all of its nutrients from another plant.[56] Parasitic plants make up about one per cent of angiosperms and are in almost every biome in the world.[57][58] All these plants have modified roots, haustoria, which penetrate the host plants, connecting them to the conductive system – either the xylem, the phloem, or both. This provides them with the ability to extract water and nutrients from the host. A parasitic plant is classified depending on where it latches onto the host, either the stem or the root, and the amount of nutrients it requires. Since holoparasites have no chlorophyll and therefore cannot make food for themselves by photosynthesis, they are always obligate parasites, deriving all their food from their hosts.[57] Some parasitic plants can locate their host plants by detecting chemicals in the air or soil given off by host shoots or roots, respectively. About 4,500 species of parasitic plant in approximately 20 families of flowering plants are known.[59][57]

Species within Orobanchaceae (broomrapes) are some of the most economically destructive of all plants. Species of Striga (witchweeds) are estimated to cost billions of dollars a year in crop yield loss, infesting over 50 million hectares of cultivated land within Sub-Saharan Africa alone. Striga infects both grasses and grains, including corn, rice and sorghum, undoubtedly some of the most important food crops. Orobanche also threatens a wide range of other important crops, including peas, chickpeas, tomatoes, carrots, and varieties of cabbage. Yield loss from Orobanche can be total; despite extensive research, no method of control has been entirely successful.[60]

Many plants and fungi exchange carbon and nutrients in mutualistic mycorrhizal relationships. Some 400 species of myco-heterotrophic plants, mostly in the tropics, however effectively cheat by taking carbon from a fungus rather than exchanging it for minerals. They have much reduced roots, as they do not need to absorb water from the soil; their stems are slender with few vascular bundles, and their leaves are reduced to small scales, as they do not photosynthesize. Their seeds are very small and numerous, so they appear to rely on being infected by a suitable fungus soon after germinating.[61]

 
The honey fungus, Armillaria mellea, is a parasite of trees, and a saprophyte feeding on the trees it has killed.

FungiEdit

Parasitic fungi derive some or all of their nutritional requirements from plants, other fungi, or animals. Unlike mycorrhizal fungi which have a mutualistic relationship with their host plants, they are pathogenic. For example, the honey fungi in the genus Armillaria grow in the roots of a wide variety of trees, and eventually kill them. They then continue to live in the dead wood, feeding saprophytically.[62] Fungal infection (mycosis) is widespread in animals including humans; it kills some 1.6 million people each year.[63] Microsporidia are obligate intracellular parasitic fungi that can also be hyperparasites. They largely affect insects, but some affect vertebrates including humans, where they can cause the intestinal infection microsporidiosis.[64]

 
Borrelia burgdorferi, the bacterium that causes Lyme disease, is transmitted by Ixodes ticks.

ProtozoaEdit

Protozoa such as Plasmodium, Trypanosoma, and Entamoeba,[65] are endoparasitic. They cause serious diseases in vertebrates including humans – in these examples, malaria, sleeping sickness, and amoebic dysentery – and have complex life-cycles.[26]

BacteriaEdit

Many bacteria are parasitic, though they are more generally thought of as pathogens causing disease.[66] Parasitic bacteria are extremely diverse, and infect their hosts by a variety of routes. To give a few examples, Bacillus anthracis, the cause of anthrax, is spread by contact with infected domestic animals; its spores, which can survive for years outside the body, can enter a host through an abrasion or may be inhaled. Borrelia, the cause of Lyme disease and relapsing fever, is transmitted by a vector, ticks of the genus Ixodes, from the diseases' reservoirs in animals such as deer. Campylobacter jejuni, a cause of gastroenteritis, is spread by the fecal-oral route from animals, or by eating insufficiently cooked poultry, or by contaminated water. Haemophilus influenzae, an agent of bacterial meningitis and respiratory tract infections such as influenza and bronchitis, is transmitted by droplet contact. Treponema pallidum, the cause of syphilis, is spread by sexual activity.[67]

 
Enterobacteria phage T4 is a bacteriophage virus. It infects its host, Escherichia coli, by injecting its DNA through its tail, which attaches to the bacterium's surface.

VirusesEdit

Viruses are obligate intracellular parasites, characterised by extremely limited biological function, to the point where, while they are evidently able to infect all other organisms from bacteria and archaea to animals, plants and fungi, it is unclear whether they can themselves be described as living. Viruses can be either RNA or DNA viruses consisting of a single or double strand of genetic material (RNA or DNA) respectively, covered in a protein coat and sometimes a lipid envelope. They thus lack all the usual machinery of the cell such as enzymes, relying entirely on the host cell's ability to replicate DNA and synthesise proteins. Most viruses are bacteriophages, infecting bacteria.[68][69][70][71]

Evolutionary ecologyEdit

 
Restoration of a Tyrannosaurus with holes possibly caused by a Trichomonas-like parasite

Parasitism is a major aspect of evolutionary ecology; for example, almost all free-living animals are host to at least one species of parasite. Vertebrates, the best-studied group, are hosts to between 75,000 and 300,000 species of helminths and an uncounted number of parasitic microorganisms. On average, a mammal species hosts four species of nematode, two of trematodes, and two of cestodes.[72] Humans have 342 species of helminth parasites, and 70 species of protozoan parasites.[73] Some three-quarters of the links in food webs include a parasite, important in regulating host numbers. Perhaps 40 percent of described species are parasitic.[72] This is harder to demonstrate from the fossil record, but for example holes in the mandibles of several specimens of Tyrannosaurus may have been caused by Trichomonas-like parasites.[74]

CoevolutionEdit

As hosts and parasites evolve together, their relationships often change. When a parasite is in a sole relationship with a host, selection drives the relationship to become more benign, even mutualistic, as the parasite can reproduce for longer if its host lives longer.[75] But where parasites are competing, selection favours the parasite that reproduces fastest, leading to increased virulence. There are thus varied possibilities in host-parasite coevolution.[76]

Coevolution favouring mutualismEdit

 
Wolbachia bacteria within an insect cell

Long-term coevolution sometimes leads to a relatively stable relationship tending to commensalism or mutualism, as, all else being equal, it is in the evolutionary interest of the parasite that its host thrives. A parasite may evolve to become less harmful for its host or a host may evolve to cope with the unavoidable presence of a parasite—to the point that the parasite's absence causes the host harm. For example, although animals parasitised by worms are often clearly harmed, such infections may also reduce the prevalence and effects of autoimmune disorders in animal hosts, including humans.[75] In a more extreme example, some nematode worms cannot reproduce, or even survive, without infection by Wolbachia bacteria.[77]

Lynn Margulis and others have argued, following Peter Kropotkin's 1902 Mutual Aid: A Factor of Evolution, that natural selection drives relationships from parasitism to mutualism when resources are limited. This process may have been involved in the symbiogenesis which formed the eukaryotes from an intracellular relationship between archaea and bacteria, though the sequence of events remains largely undefined.[78][79]

Competition favoring virulenceEdit

Competition between parasites can be expected to favour faster reproducing and therefore more virulent parasites, by natural selection.[76][80] Parasites whose life cycle involves the death of the host, in order to leave it and to sometimes enter the next host, evolve to be more virulent, and may alter the behavior or other properties of the host to make it more vulnerable to predators.[81] Conversely, parasites whose reproduction is largely tied to their host's reproductive success tend to become less virulent or mutualist, so that their hosts reproduce more effectively.[81]

 
Biologists long suspected cospeciation of flamingos and ducks with their parasitic lice, which were similar in the two families. Cospeciation did occur, but it led to flamingos and grebes, with a later host switch of flamingo lice to ducks.

Among competing parasitic insect-killing bacteria of the genera Photorhabdus and Xenorhabdus, virulence depended on the relative potency of the antimicrobial toxins (bacteriocins) produced by the two strains involved. When only one bacterium could kill the other, the other strain was excluded by the competition. But when caterpillars were infected with bacteria both of which had toxins able to kill the other strain, neither strain was excluded, and their virulence was less than when the insect was infected by a single strain.[76]

CospeciationEdit

A parasite sometimes undergoes cospeciation with its host, resulting in the pattern described in Fahrenholz's rule, that the phylogenies of the host and parasite come to mirror each other.[82]

An example is between the simian foamy virus (SFV) and its primate hosts. The phylogenies of SFV polymerase and the mitochondrial cytochrome c oxidase subunit II from African and Asian primates were found to be closely congruent in branching order and divergence times, implying that the simian foamy viruses cospeciated with Old World primates for at least 30 million years.[83]

The presumption of a shared evolutionary history between parasites and hosts can help elucidate how host taxa are related. For instance, there has been a dispute about whether flamingos are more closely related to storks or ducks. The fact that flamingos share parasites with ducks and geese was initially taken as evidence that these groups were more closely related to each other than either is to storks. However, evolutionary events such as the duplication, or the extinction of parasite species (without similar events on the host phylogeny) often erode similarities between host and parasite phylogenies. In the case of flamingos, they have similar lice to those of grebes. Flamingos and grebes do have a common ancestor, implying cospeciation of birds and lice in these groups. Flamingo lice then switched hosts to ducks, creating the situation which had confused biologists.[84]

 
The protozoan Toxoplasma gondii facilitates its transmission by inducing behavioral changes in rats through infection of neurons in their central nervous system.

Parasites infect sympatric hosts (those within their same geographical area) more effectively, as has been shown with digenetic trematodes infecting lake snails.[85] This is in line with the Red Queen hypothesis, which states that interactions between species lead to constant natural selection for coadaptation. Parasites track the locally common hosts' phenotypes, so the parasites are less infective to allopatric hosts, those from different geographical regions.[85]

Modifying host behaviourEdit

Some parasites modify host behaviour in order to increase their transmission between hosts, often in relation to predator and prey (parasite increased trophic transmission). For example, in the California coastal salt marsh, the fluke Euhaplorchis californiensis reduces the ability of its killifish host to avoid predators.[86] This parasite matures in egrets, which are more likely to feed on infected killifish than on uninfected fish. Another example is the protozoan Toxoplasma gondii, a parasite that matures in cats but can be carried by many other mammals. Uninfected rats avoid cat odors, but rats infected with T. gondii are drawn to this scent, which may increase transmission to feline hosts.[87] The malaria parasite modifies the skin odour of its human hosts, increasing their attractiveness to mosquitoes and hence improving the chance that the parasite will be transmitted.[31]

 
Trait loss: bed bug, Cimex lectularius, is flightless, like many insect ectoparasites.

Trait lossEdit

Parasites can exploit their hosts to carry out a number of functions that they would otherwise have to carry out for themselves. Parasites which lose those functions then have a selective advantage, as they can divert resources to reproduction. Many insect ectoparasites including bedbugs, batbugs, lice and fleas have lost their ability to fly, relying instead on their hosts for transport.[88] Trait loss more generally is widespread among parasites.[89]

Host defencesEdit

Hosts have evolved a variety of defensive measures against their parasites, including physical barriers like the skin of vertebrates,[90] the immune system of mammals,[91] insects actively removing parasites,[92] and defensive chemicals in plants.[93]

The evolutionary biologist W. D. Hamilton suggested that sexual reproduction could have evolved to help to defeat multiple parasites by enabling genetic recombination, the shuffling of genes to create varied combinations. Hamilton showed by mathematical modelling that sexual reproduction would be evolutionarily stable in different situations, and that the theory's predictions matched the actual ecology of sexual reproduction.[94][95] However, there may be a trade-off between immunocompetence and breeding male vertebrate hosts' secondary sex characteristics, such as the plumage of peacocks and the manes of lions. This is because the male hormone testosterone encourages the growth of secondary sex characteristics, favouring such males in sexual selection, at the price of reducing their immune defences.[96]

VertebratesEdit

 
The dry skin of vertebrates such as the short-horned lizard prevents the entry of many parasites.

The physical barrier of the tough and often dry and waterproof skin of reptiles, birds and mammals keeps invading microorganisms from entering the body. Human skin also secretes sebum, which is toxic to most microorganisms.[90] On the other hand, larger parasites such as trematodes detect chemicals produced by the skin to locate their hosts when they enter the water. Vertebrate saliva and tears contain lysozyme, an enzyme which breaks down the cell walls of invading bacteria.[90] Should the organism pass the mouth, the stomach with its hydrochloric acid, toxic to most microorganisms, is the next line of defence.[90] Some intestinal parasites have a thick, tough outer coating which is digested slowly or not at all, allowing the parasite to pass through the stomach alive, at which point they enter the intestine and begin the next stage of their life. Once inside the body, parasites must overcome the immune system's serum proteins and pattern recognition receptors, intracellular and cellular, that trigger the adaptive immune system's lymphocytes such as T cells and antibody-producing B cells. These have receptors that recognise parasites.[91]

InsectsEdit

 
Leaf spot on oak. The spread of the parasitic fungus is limited by defensive chemicals produced by the tree, resulting in circular patches of damaged tissue.

Insects often adapt their nests to reduce parasitism. For example, one of the key reasons why the wasp Polistes canadensis nests across multiple combs, rather than building a single comb like much of the rest of its genus, is to avoid infestation by tineid moths. The tineid moth lays its eggs within the wasps' nests and then these eggs hatch into larvae that can burrow from cell to cell and prey on wasp pupae. Adult wasps attempt to remove and kill moth eggs and larvae by chewing down the edges of cells, coating the cells with an oral secretion that gives the nest a dark brownish appearance.[92]

PlantsEdit

Plants respond to parasite attack with a series of chemical defences, such as polyphenol oxidase, under the control of the jasmonic acid-insensitive (JA) and salicylic acid (SA) signalling pathways.[93][97] The different biochemical pathways are activated by different attacks, and the two pathways can interact positively or negatively. In general, plants can either initiate a specific or a non-specific response.[98][97] Specific responses involve recognition of a parasite by the plant's cellular receptors, leading to a strong but localised response: defensive chemicals are produced around the area where the parasite was detected, blocking its spread, and avoiding wasting defensive production where it is not needed.[98] Nonspecific defensive responses are systemic, meaning that the responses are not confined to an area of the plant, but spread throughout the plant, making them costly in energy. These are effective against a wide range of parasites.[98] When damaged, such as by lepidopteran caterpillars, leaves of plants including maize and cotton release increased amounts of volatile chemicals such as terpenes that signal they are being attacked; one effect of this is to attract parasitoid wasps, which in turn attack the caterpillars.[99]

Biology and conservationEdit

Ecology and parasitologyEdit

Parasitism and parasite evolution were until the twentyfirst century studied by parasitologists, in a science dominated by medicine, rather than by ecologists or evolutionary biologists. Even though parasite-host interactions were plainly ecological and important in evolution, the history of parasitology caused what the evolutionary ecologist Robert Poulin called a "takeover of parasitism by parasitologists", leading ecologists to ignore the area. This was in his opinion "unfortunate", as parasites are "omnipresent agents of natural selection" and significant forces in evolution and ecology.[100] In his view, the long-standing split between the sciences limited the exchange of ideas, with separate conferences and separate journals. The technical languages of ecology and parasitology sometimes involved different meanings for the same words. There were philosophical differences, too: Poulin notes that, influenced by medicine, "many parasitologists accepted that evolution led to a decrease in parasite virulence, whereas modern evolutionary theory would have predicted a greater range of outcomes".[100]

 
The rescuing from extinction of the California condor was a successful if very expensive project, but its ectoparasite, the louse Colpocephalum californici, became extinct.

Their complex relationships make parasites difficult to place in food webs: a trematode with multiple hosts for its various life-cycle stages would occupy many positions in a food web simultaneously, and would set up loops of energy flow, confusing the analysis. Further, since nearly every animal has (multiple) parasites, parasites would occupy the top levels of every food web.[73]

Rationale for conservationEdit

Although parasites are widely considered to be harmful, the eradication of all parasites would not be beneficial. Parasites account for at least half of life's diversity; they perform important ecological roles; and without parasites, organisms might tend to asexual reproduction, diminishing the diversity of traits brought about by sexual reproduction.[101] Parasites provide an opportunity for the transfer of genetic material between species, facilitating evolutionary change.[81] Many parasites require multiple hosts of the different species to complete their life cycles and rely on predator-prey or other stable ecological interactions to get from one host to another. The presence of parasites thus indicates that an ecosystem is healthy.[102]

A well-known case was that of an ectoparasite, the California condor louse, Colpocephalum californici. Any lice found were "deliberately killed" during the major and very costly captive breeding program to rescue its host, the Californian condor. The result was that one species, the condor, was saved and returned to the wild, while another species, the parasite, became extinct.[103]

Although parasites are often omitted in depictions of food webs, they usually occupy the top position. Parasites can function like keystone species, reducing the dominance of superior competitors and allowing competing species to co-exist.[73][104][105]

 
Parasites are distributed very unevenly among their hosts, most hosts having no parasites, and a few hosts harbouring most of the parasite population. This distribution makes sampling difficult and requires careful use of statistics.

Quantitative ecologyEdit

A single parasite species usually has an aggregated distribution across host animals, which means that most hosts carry few parasites, while a few hosts carry the vast majority of parasite individuals. This poses considerable problems for students of parasite ecology, as it renders parametric statistics as commonly used by biologists invalid. Log-transformation of data before the application of parametric test, or the use of non-parametric statistics is recommended by several authors, but this can give rise to further problems, so quantitative parasitology is based on more advanced biostatistical methods.[106]

HistoryEdit

AncientEdit

Human parasites including roundworms, the Guinea worm, threadworms and tapeworms are mentioned in Egyptian papyrus records from 3000 BC onwards; the Ebers papyrus describes hookworm. In ancient Greece, parasites including the bladder worm are described in the Hippocratic Corpus, while the comic playwright Aristophanes called tapeworms "hailstones". The Roman physicians Celsus and Galen documented the roundworms Ascaris lumbricoides and Enterobius vermicularis.[107]

MedievalEdit

 
A plate from Francesco Redi's Osservazioni intorno agli animali viventi che si trovano negli animali viventi (Observations on living animals found inside living animals), 1684

In his Canon of Medicine, completed in 1025, the Persian physician Avicenna recorded human and animal parasites including roundworms, threadworms, the Guinea worm and tapeworms.[107]

In his 1397 book Traité de l'état, science et pratique de l'art de la Bergerie (Account of the state, science and practice of the art of shepherding), Jehan de Brie (fr) wrote the first description of a trematode endoparasite, the sheep liver fluke Fasciola hepatica.[108][109]

Early ModernEdit

In the Early Modern period, Francesco Redi's 1668 book Esperienze Intorno alla Generazione degl'Insetti (Experiences of the Generation of Insects), explicitly described ecto- and endoparasites, illustrating ticks, the larvae of nasal flies of deer, and sheep liver fluke.[110] Redi noted that parasites develop from eggs, contradicting the theory of spontaneous generation.[111] In his 1684 book Osservazioni intorno agli animali viventi che si trovano negli animali viventi (Observations on Living Animals found in Living Animals), Redi described and illustrated over 100 parasites including the large roundworm in humans that causes ascariasis.[110] Redi was the first to name the cysts of Echinococcus granulosus seen in dogs and sheep as parasitic; a century later, in 1766, Peter Simon Pallas correctly suggested that these were the larvae of tapeworms.[107]

In 1681, Antonie van Leeuwenhoek observed and illustrated the protozoan parasite Giardia lamblia, and linked it to "his own loose stools". This was the first protozoan parasite of humans to be seen under a microscope.[107] A few years later, in 1687, the Italian biologists Cosimo Bonomo (it) and Diacinto Cestoni described scabies as caused by the parasitic mite Sarcoptes scabiei, marking it as the first disease of humans with a known microscopic causative agent.[112]

 
Ronald Ross won the 1902 Nobel Prize for showing that the malaria parasite is transmitted by mosquitoes. This 1897 notebook page records his first observations of the parasite in mosquitoes.

ParasitologyEdit

Modern parasitology developed in the 19th century with accurate observations and experiments by many researchers and clinicians;[108] the term was first used in 1870.[113] In 1828, James Annersley described amoebiasis, protozoal infections of the intestines and the liver, though the pathogen, Entamoeba histolytica, was not discovered until 1873 by Friedrich Lösch. James Paget discovered the intestinal nematode Trichinella spiralis in humans in 1835. James McConnell described the human liver fluke, Clonorchis sinensis, in 1875.[107] Algernon Thomas and Rudolf Leuckart independently made the first discovery of the life cycle of a trematode, the sheep liver fluke, by experiment in 1881–1883.[108] In 1877 Patrick Manson discovered the life cycle of the filarial worms, that cause elephantiatis transmitted by mosquitoes. Manson further predicted that the malaria parasite, Plasmodium, had a mosquito vector, and persuaded Ronald Ross to investigate. Ross confirmed that the prediction was correct in 1897–1898. At the same time, Giovanni Battista Grassi and others described the malaria parasite's life cycle stages in Anopheles mosquitoes. Ross was controversially awarded the 1902 Nobel prize for his work, while Grassi was not.[107] In 1903, David Bruce identified the protozoan parasite and the tsetse fly vector of African trypanosomiasis.[114]

VaccineEdit

Given the importance of malaria, with some 220 million people infected annually, many attempts have been made to interrupt its transmission. Various methods of malaria prophylaxis have been tried including the use of antimalarial drugs to kill off the parasites in the blood, the eradication of its mosquito vectors with organochlorine and other insecticides, and the development of a malaria vaccine. All of these have proven problematic, with drug resistance, insecticide resistance among mosquitoes, and repeated failure of vaccines as the parasite mutates.[115] The first and as of 2015 the only licensed vaccine for any parasitic disease of humans is RTS,S for Plasmodium falciparum malaria.[116]

ResistanceEdit

Poulin observes that the widespread prophylactic use of anthelmintic drugs in domestic sheep and cattle constitutes a worldwide uncontrolled experiment in the life-history evolution of their parasites. The outcomes depend on whether the drugs decrease the chance of a helminth larva reaching adulthood. If so, natural selection can be expected to favour the production of eggs at an earlier age. If on the other hand the drugs mainly affects adult parasitic worms, selection could cause delayed maturity and increased virulence. Such changes appear to be under way: the nematode Teladorsagia circumcincta is changing its adult size and reproductive rate in response to drugs.[117]

Cultural significanceEdit

 
"An Old Parasite in a New Form": an 1881 Punch cartoon by Edward Linley Sambourne compares a crinoletta bustle to a parasitic insect's exoskeleton

Classical timesEdit

In the classical era, the concept of the parasite was not strictly pejorative: the parasitus was an accepted role in Roman society, in which a person could live off the hospitality of others, in return for "flattery, simple services, and a willingness to endure humiliation".[118][119]

SocietyEdit

Parasitism has a derogatory sense in popular usage. According to the immunologist John Playfair,[120]

In everyday speech, the term 'parasite' is loaded with derogatory meaning. A parasite is a sponger, a lazy profiteer, a drain on society.[120]

The satirical cleric Jonathan Swift refers to hyperparasitism in his 1733 poem "On Poetry: A Rhapsody", comparing poets to "vermin" who "teaze and pinch their foes":[121]

The vermin only teaze and pinch
Their foes superior by an inch.
So nat'ralists observe, a flea
Hath smaller fleas that on him prey;
And these have smaller fleas to bite 'em.
And so proceeds ad infinitum.
Thus every poet, in his kind,
Is bit by him that comes behind:

FictionEdit

 
Parasites by Katrin Alvarez. Oil on canvas, 2011

In Bram Stoker's 1897 Gothic horror novel Dracula, and its many film adaptations, the eponymous Count Dracula is a blood-drinking parasite. The critic Laura Otis argues that as a "thief, seducer, creator, and mimic, Dracula is the ultimate parasite. The whole point of vampirism is sucking other people's blood—living at other people's expense."[122]

Disgusting and terrifying parasitic alien species are widespread in science fiction,[123][124] as for instance in Ridley Scott's 1979 film Alien.[125][126] In one scene, a Xenomorph bursts out of the chest of a dead man, with blood squirting out under high pressure assisted by explosive squibs. Animal organs were used to reinforce the shock effect. The scene was filmed in a single take, and the startled reaction of the actors was genuine.[4][127]

NotesEdit

  1. ^ Trophically transmitted parasites are transmitted to their definitive host, a predator, when their intermediate host is eaten. These parasites often modify the behaviour of their intermediate hosts, causing them to behave in a way that makes them likely to be eaten, such as by climbing to a conspicuous point: this gets the parasites transmitted at the cost of the intermediate host's life.
  2. ^ The wolf is a social predator, hunting in packs; the cheetah is a solitary predator, hunting alone. Neither strategy is conventionally considered parasitic.

ReferencesEdit

  1. ^ Poulin 2007, pp. 4–5.
  2. ^ a b Wilson, Edward O. (2014). The Meaning of Human Existence. W. W. Norton & Company. p. 112. ISBN 978-0-87140-480-0. Parasites, in a phrase, are predators that eat prey in units of less than one. Tolerable parasites are those that have evolved to ensure their own survival and reproduction but at the same time with minimum pain and cost to the host. 
  3. ^ Getz, W. M. (2011). "Biomass transformation webs provide a unified approach to consumer-resource modelling". Ecological Letters. 14 (2): 113–124. doi:10.1111/j.1461-0248.2010.01566.x. PMC 3032891 . PMID 21199247. 
  4. ^ a b "The Making of Alien's Chestburster Scene". The Guardian. 13 October 2009. Archived from the original on 30 April 2010. Retrieved 29 May 2010. 
  5. ^ παράσιτος, Liddell, Henry George; Scott, Robert, A Greek-English Lexicon, on Perseus Digital Library
  6. ^ παρά, Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus Digital Library
  7. ^ σῖτος, Liddell, Henry George; Scott, Robert, A Greek-English Lexicon, on Perseus Digital Library
  8. ^ σιτισμός, Liddell, Henry George; Scott, Robert, A Greek-English Lexicon, on Perseus Digital Library
  9. ^ Martin, Bradford D.; Schwab, Ernest (2013). "Current usage of symbiosis and associated terminology". International Journal of Biology. 5 (1): 32–45. doi:10.5539/ijb.v5n1p32. 
  10. ^ a b c d "Overview of Parasitology". Australian Society of Parasitology and Australian Research Council/National Health and Medical Research Council) Research Network for Parasitology. July 2010. ISBN 978-1-8649999-1-4. Retrieved 9 April 2018. 
  11. ^ "A Classification of Animal-Parasitic Nematodes". plpnemweb.ucdavis.edu. 
  12. ^ Garcia, L. S. (1999). "Classification of Human Parasites, Vectors, and Similar Organisms" (PDF). Clinical Infectious Diseases. 29 (4): 734–746. doi:10.1086/520425. PMID 10589879. 
  13. ^ Vecchione, Anna; Aznar, Francisco Javier (2008). "The mesoparasitic copepod Pennella balaenopterae and its significance as a visible indicator of health status in dolphins (Delphinidae): a review" (PDF). Journal of Marine Animals and Their Ecology. 7 (1): 4–11. 
  14. ^ a b c d Poulin, Robert (2011). Rollinson, D.; Hay, S. I., eds. The Many Roads to Parasitism: A Tale of Convergence. Advances in Parasitology. Academic Press. pp. 27–28. ISBN 978-0-12-385897-9. 
  15. ^ "Parasitism | The Encyclopedia of Ecology and Environmental Management". Blackwell Science. Retrieved 8 April 2018. 
  16. ^ Caira, J. N.; Benz, G. W.; Borucinska, J.; Kohler, N. E. (1997). "Pugnose eels, Simenchelys parasiticus (Synaphobranchidae) from the heart of a shortfin mako, Isurus oxyrinchus (Lamnidae)". Environmental Biology of Fishes. 49: 139–144. doi:10.1023/a:1007398609346. 
  17. ^ a b c d e f g h i j k l m n o Poulin, Robert; Randhawa, Haseeb S. (February 2015). "Evolution of parasitism along convergent lines: from ecology to genomics". Parasitology. 142 (Suppl 1): S6–S15. doi:10.1017/S0031182013001674. PMC 4413784 . PMID 24229807. 
  18. ^ a b c Lafferty, K. D.; Kuris, A. M. (2002). "Trophic strategies, animal diversity and body size". Trends Ecol. Evol. 17: 507–513. doi:10.1016/s0169-5347(02)02615-0. 
  19. ^ a b Poulin 2007, p. 111.
  20. ^ Elumalai, V.; Viswanathan, C.; Pravinkumar, M.; Raffi, S. M. (2013). "Infestation of parasitic barnacle Sacculina spp. in commercial marine crabs". Journal of Parasitic Diseases. Springer Nature. 38 (3): 337–339. doi:10.1007/s12639-013-0247-z. PMC 4087306 . 
  21. ^ Cheng, Thomas C. (2012). General Parasitology. Elsevier Science. pp. 13–15. ISBN 978-0-323-14010-2. 
  22. ^ Cox, F. E. (2001). "Concomitant infections, parasites and immune responses". Parasitology. 122. Supplement: S23–38. doi:10.1017/s003118200001698x. PMID 11442193. 
  23. ^ "Helminth Parasites". Australian Society of Parasitology. Retrieved 9 October 2017. 
  24. ^ "Pathogenic Parasitic Infections". PEOI. Retrieved 2013-07-18. 
  25. ^ Steere AC (July 2001). "Lyme disease". New England Journal of Medicine. 345 (2): 115–125. doi:10.1056/NEJM200107123450207. PMID 11450660. 
  26. ^ a b Pollitt, Laura C.; MacGregor, Paula; Matthews, Keith; Reece, Sarah E. (2011). "Malaria and trypanosome transmission: different parasites, same rules?". Trends in Parasitology. 27 (5): 197–203. doi:10.1016/j.pt.2011.01.004. 
  27. ^ Stevens, Alison N. P. (2010). "Predation, Herbivory, and Parasitism". Nature Education Knowledge. 3 (10): 36. Retrieved 12 February 2018. Predation, herbivory, and parasitism exist along a continuum of severity in terms of the extent to which they negatively affect an organism's fitness. ... In most situations, parasites do not kill their hosts. An exception, however, occurs with parasitoids, which blur the line between parasitism and predation. 
  28. ^ a b c d Gullan, P. J.; Cranston, P. S. (2010). The Insects: An Outline of Entomology (4th ed.). Wiley. pp. 308, 365–367, 375, 440–441. ISBN 978-1-118-84615-5. 
  29. ^ Wilson, Anthony J.; et al. (March 2017). "What is a vector?". Philosophical Transactions of the Royal Society B: Biological Sciences. The Royal Society. 372 (1719): 20160085. doi:10.1098/rstb.2016.0085. PMC 5352812 . 
  30. ^ a b Godfrey, Stephanie S. (December 2013). "Networks and the ecology of parasite transmission: A framework for wildlife parasitology". Wildlife. 2: 235–245. doi:10.1016/j.ijppaw.2013.09.001. 
  31. ^ a b de Boer, Jetske G.; Robinson, Ailie; Powers, Stephen J.; Burgers, Saskia L. G. E.; Caulfield, John C.; Birkett, Michael A.; Smallegange, Renate C.; van Genderen, Perry J. J.; Bousema, Teun; Sauerwein, Robert W.; Pickett, John A.; Takken, Willem; Logan, James G. (August 2017). "Odours of Plasmodium falciparum-infected participants influence mosquito-host interactions". Scientific Reports. 7 (1). doi:10.1038/s41598-017-08978-9. 
  32. ^ a b Dissanaike, A. S. (1957). "On Protozoa hyperparasitic in Helminth, with some observations on Nosema helminthorum Moniez, 1887". J. Helminthology. 31 (1–2): 47–64. doi:10.1017/s0022149x00033290. PMID 13429025. 
  33. ^ a b Thomas, J. A.; Schönrogge, K.; Bonelli, S.; Barbero, F.; Balletto, E. (2010). "Corruption of ant acoustical signals by mimetic social parasites: Maculinea butterflies achieve elevated status in host societies by mimicking the acoustics of queen ants". Commun Integr Biol. 3 (2): 169–171. doi:10.4161/cib.3.2.10603. PMC 2889977 . PMID 20585513. 
  34. ^ a b Payne, R. B. (1997). Clayton, D. H.; Moore, J., eds. Avian brood parasitism. Host-parasite evolution: General principles and avian models. Oxford University Press. pp. 338–369. ISBN 978-0198548928. 
  35. ^ a b Slater, Peter J. B.; Rosenblatt, Jay S.; Snowdon, Charles T.; Roper, Timothy J.; Brockmann, H. Jane; Naguib, Marc (30 January 2005). Advances in the Study of Behavior. Academic Press. p. 365. ISBN 978-0-08-049015-1. 
  36. ^ a b Pietsch, Theodore W. (25 August 2005). "Dimorphism, parasitism, and sex revisited: modes of reproduction among deep-sea ceratioid anglerfishes (Teleostei: Lophiiformes)". Ichthyological Research. 52 (3): 207–236. doi:10.1007/s10228-005-0286-2. 
  37. ^ a b Rochat, Jacques; Gutierrez, Andrew Paul (May 2001). "Weather-mediated regulation of olive scale by two parasitoids". Journal of Animal Ecology. 70 (3): 476–490. doi:10.1046/j.1365-2656.2001.00505.x. 
  38. ^ Askew, R. R. (1961). "On the biology of the inhabitants of oak galls of Cynipidae (Hymenoptera) in Britain". Transactions of the Society for British Entomology. 14: 237–268. 
  39. ^ Parratt, Steven R.; Laine, Anna-Liisa (January 2016). "The role of hyperparasitism in microbial pathogen ecology and evolution". The ISME Journal. 10 (8): 1815–1822. doi:10.1038/ismej.2015.247. PMC 5029149 . 
  40. ^ Van Oystaeyen, Annette; Araujo Alves, Denise; Caliari Oliveira, Ricardo; Lima do Nascimento, Daniela; Santos do Nascimento, Fábio; Billen, Johan; Wenseleers, Tom (September 2013). "Sneaky queens in Melipona bees selectively detect and infiltrate queenless colonies". Animal Behaviour. 86 (3): 603–609. doi:10.1016/j.anbehav.2013.07.001. 
  41. ^ "Social Parasites in the Ant Colony". Antkeepers. Retrieved 4 April 2016. 
  42. ^ Deslippe, Richard (2010). "Social Parasitism in Ants". Nature Education Knowledge. Retrieved 29 October 2010. 
  43. ^ Emery, C. (1909). "Über den Ursprung der dulotischen, parasitischen und myrmekophilen Ameisen". Biologisches Centralblatt. 29: 352–362. 
  44. ^ O'Brien, Timothy G. (1988). "Parasitic nursing behavior in the wedge-capped capuchin monkey (Cebus olivaceus)". American Journal of Primatology. 16 (4): 341–344. doi:10.1002/ajp.1350160406. 
  45. ^ Rothstein, S. I. (1990). "A model system for coevolution: avian brood parasitism". Annual Review of Ecology and Systematics. 21: 481–508. doi:10.1146/annurev.ecolsys.21.1.481. 
  46. ^ De Marsico, M. C.; Gloag, R.; Ursino, C. A.; Reboreda, J. C. (March 2013). "A novel method of rejection of brood parasitic eggs reduces parasitism intensity in a cowbird host". Biology Letters. 9 (3): 20130076–20130076. doi:10.1098/rsbl.2013.0076. PMC 3645041 . 
  47. ^ Welbergen, J.; Davies, N. B. (2011). "A parasite in wolf's clothing: hawk mimicry reduces mobbing of cuckoos by hosts". Behavioral Ecology. 22 (3): 574–579. doi:10.1093/beheco/arr008. 
  48. ^ Furness, R. W. (1978). "Kleptoparasitism by great skuas (Catharacta skua Brünn.) and Arctic skuas (Stercorarius parasiticus L.) at a Shetland seabird colony". Animal Behaviour. Elsevier. 26: 1167–1177. doi:10.1016/0003-3472(78)90107-0. 
  49. ^ Maggenti, Armand R.; Maggenti, Mary Ann; Gardner, Scott Lyell (2005). Online Dictionary of Invertebrate Zoology (PDF). University of Nebraska. p. 22. 
  50. ^ "Featured Creatures. Encarsia perplexa". University of Florida. Retrieved 6 January 2018. 
  51. ^ Berec, Ludek; Schembri, Patrick J.; Boukal, David S. (2005). "Sex determination in Bonellia viridis (Echiura: Bonelliidae): population dynamics and evolution". Oikos. 108 (3): 473–484. doi:10.1111/j.0030-1299.2005.13350.x. 
  52. ^ Rollinson, D.; Hay, S. I. (2011). Advances in parasitology. Oxford: Elsevier Science. pp. 4–7. ISBN 978-0123858979. 
  53. ^ a b Poulin 2007, p. 6.
  54. ^ Sekar, Sandhya (22 May 2015). "Parasitoid wasps may be the most diverse animal group". BBC. Retrieved 14 February 2018. 
  55. ^ Morand, Serge; Krasnov, Boris R.; Littlewood, D. Timothy J. (2015). Parasite Diversity and Diversification. Cambridge University Press. p. 44. ISBN 978-1-107-03765-6. 
  56. ^ Rastogi, V. B. (1997). "Modern Biology". Pitambar Publishing. 
  57. ^ a b c Heide-Jørgensen, Henning S. (2008). Parasitic flowering plants. Brill. ISBN 978-9004167506. 
  58. ^ Nickrent, Daniel L. (2002). "Parasitic Plants of the World" (PDF). Archived (PDF) from the original on 6 March 2016. Retrieved 10 April 2018.  which appeared in Spanish as Chapter 2, pp. 7–27 in: J. A. López-Sáez, P. Catalán and L. Sáez [eds.], Parasitic Plants of the Iberian Peninsula and Balearic Islands.
  59. ^ Nickrent, D. L.; Musselman, L. J. (2004). "Introduction to Parasitic Flowering Plants". The Plant Health Instructor. doi:10.1094/PHI-I-2004-0330-01. 
  60. ^ Westwood, James H.; Yoder, John I.; Timko, Michael P.; dePamphilis, Claude W. (2010). "The evolution of parasitism in plants". Trends in Plant Science. 15 (4): 227–235. doi:10.1016/j.tplants.2010.01.004. 
  61. ^ Leake, J. R. (1994). "The biology of myco-heterotrophic ('saprophytic') plants". New Phytologist. 127: 171–216. doi:10.1111/j.1469-8137.1994.tb04272.x. 
  62. ^ "What is honey fungus?". Royal Horticultural Society. Retrieved 12 October 2017. 
  63. ^ "Stop neglecting fungi". Nature Microbiology. 2 (8). 25 July 2017. doi:10.1038/nmicrobiol.2017.120. 
  64. ^ Didier, E. S.; Stovall, M. E.; Green, L. C.; Brindley, P. J.; Sestak, K.; Didier, P. J. (9 December 2004). "Epidemiology of microsporidiosis: sources and modes of transmission". Veterinary parasitology. 126 (1–2): 145–66. doi:10.1016/j.vetpar.2004.09.006. PMID 15567583. 
  65. ^ Esch, K. J.; Petersen, C. A. (January 2013). "Transmission and epidemiology of zoonotic protozoal diseases of companion animals". Clinical Microbiology Reviews. 26 (1): 58–85. doi:10.1128/CMR.00067-12. PMC 3553666 . PMID 23297259. 
  66. ^ McFall-Ngai, Margaret (January 2007). "Adaptive Immunity: Care for the community". Nature. 445 (7124): 153–153. doi:10.1038/445153a. 
  67. ^ Fisher, Bruce; Harvey, Richard P.; Champe, Pamela C. (2007). Lippincott's Illustrated Reviews: Microbiology (Lippincott's Illustrated Reviews Series). Lippincott Williams & Wilkins. pp. 332–353. ISBN 0-7817-8215-5. 
  68. ^ Koonin, E. V.; Senkevich, T. G.; Dolja, V. V. (2006). "The ancient Virus World and evolution of cells". Biology Direct. 1: 29. doi:10.1186/1745-6150-1-29. PMC 1594570 . PMID 16984643. 
  69. ^ Breitbart, M.; Rohwer, F. (2005). "Here a virus, there a virus, everywhere the same virus?". Trends in Microbiology. 13 (6): 278–284. doi:10.1016/j.tim.2005.04.003. PMID 15936660. 
  70. ^ Lawrence, C. M.; Menon, S.; Eilers, B. J.; et al. (2009). "Structural and functional studies of archaeal viruses". The Journal of Biological Chemistry. 284 (19): 12599–603. doi:10.1074/jbc.R800078200. PMC 2675988 . PMID 19158076. 
  71. ^ Edwards, R. A.; Rohwer, F. (2005). "Viral metagenomics". Nature Reviews Microbiology. 3 (6): 504–510. doi:10.1038/nrmicro1163. PMID 15886693. 
  72. ^ a b Dobson, A.; Lafferty, K. D.; Kuris, A. M.; Hechinger, R. F.; Jetz, W. (2008). "Homage to Linnaeus: How many parasites? How many hosts?". Proceedings of the National Academy of Sciences. 105 (Supplement 1): 11482–11489. doi:10.1073/pnas.0803232105. 
  73. ^ a b c Sukhdeo, Michael V.K. (2012). "Where are the parasites in food webs?". Parasites & Vectors. 5 (1): 239. doi:10.1186/1756-3305-5-239. 
  74. ^ Wolff, Ewan D. S.; Salisbury, Steven W.; Horner, John R.; Varrichio, David J. (2009). "Common Avian Infection Plagued the Tyrant Dinosaurs". PLoS ONE. 4 (9): e7288. doi:10.1371/journal.pone.0007288. PMC 2748709 . PMID 19789646. 
  75. ^ a b Rook, G. A. (2007). "The hygiene hypothesis and the increasing prevalence of chronic inflammatory disorders". Transactions of the Royal Society of Tropical Medicine and Hygiene. 101 (11): 1072–1074. doi:10.1016/j.trstmh.2007.05.014. PMID 17619029. 
  76. ^ a b c Massey, R. C.; Buckling, A.; ffrench-Constant, R. (2004). "Interference competition and parasite virulence". Proceedings of the Royal Society B: Biological Sciences. 271 (1541): 785–788. doi:10.1098/rspb.2004.2676. PMC 1691666 . PMID 15255095. 
  77. ^ Werren, John H. (February 2003). "Invasion of the Gender Benders: by manipulating sex and reproduction in their hosts, many parasites improve their own odds of survival and may shape the evolution of sex itself". Natural History. 112 (1): 58. OCLC 1759475. Archived from the original on 8 July 2012. Retrieved 15 November 2008. 
  78. ^ Margulis, Lynn; Sagan, Dorion; Eldredge, Niles (1995). What Is Life?. Simon and Schuster. ISBN 978-0684810874. 
  79. ^ Sarkar, Sahotra; Plutynski, Anya (2008). A Companion to the Philosophy of Biology. John Wiley & Sons. p. 358. ISBN 978-0-470-69584-5. 
  80. ^ Rigaud, T.; Perrot-Minnot, M.-J.; Brown, M. J. F. (2010). "Parasite and host assemblages: embracing the reality will improve our knowledge of parasite transmission and virulence". Proceedings of the Royal Society B: Biological Sciences. 277 (1701): 3693–3702. doi:10.1098/rspb.2010.1163. 
  81. ^ a b c Claude Combes, The Art of being a Parasite, University of Chicago Press, 2005
  82. ^ Page, Roderic D. M. (2006-01-27). Cospeciation. John Wiley. doi:10.1038/npg.els.0004124. ISBN 0-470-01617-5. 
  83. ^ Switzer, William M.; Salemi, Marco; Shanmugam, Vedapuri; Gao, Feng; Cong, Mian-er; Kuiken, Carla; Bhullar, Vinod; Beer, Brigitte E.; Vallet, Dominique; Gautier-Hion, Annie; Tooze, Zena; Villinger, Francois; Holmes, Edward C.; Heneine, Walid (2005). "Ancient co-speciation of simian foamy viruses and primates". Nature. 434 (7031): 376–380. doi:10.1038/nature03341. 
  84. ^ Johnson, K. P.; Kennedy, M.; McCracken, K. G (2006). "Reinterpreting the origins of flamingo lice: cospeciation or host-switching?". Biology Letters. 2 (2): 275–278. doi:10.1098/rsbl.2005.0427. PMC 1618896 . PMID 17148381. 
  85. ^ a b Lively, C. M.; Dybdahl, M. F. (2000). "Parasite adaptation to locally common host genotypes". Nature. 405 (6787): 679–81. doi:10.1038/35015069. PMID 10864323. 
  86. ^ Lafferty, K. D.; Morris, A. K. (1996). "Altered behavior of parasitized killifish increases susceptibility to predation by bird final hosts". Ecology. 77: 1390. doi:10.2307/2265536. 
  87. ^ Berdoy, M.; Webster, J. P.; Macdonald, D. W. (2000). "Fatal attraction in rats infected with Toxoplasma gondii". Proc. Biol. Sci. 267 (1452): 1591–4. doi:10.1098/rspb.2000.1182. PMC 1690701 . PMID 11007336. 
  88. ^ Alexander, David E. (2015). On the Wing: Insects, Pterosaurs, Birds, Bats and the Evolution of Animal Flight. Oxford University Press. p. 119. ISBN 978-0-19-999679-7. 
  89. ^ Poulin, Robert (September 1995). "Evolution of parasite life history traits: myths and reality". Parasitology Today. 11 (9): 342–345. doi:10.1016/0169-4758(95)80187-1. PMID 15275316. 
  90. ^ a b c d "Host-Parasite Interactions Innate Defenses of the Host" (PDF). University of Colorado. 
  91. ^ a b Maizels, R. M. (2009). "Parasite immunomodulation and polymorphisms of the immune system". J. Biol. 8 (7): 62. doi:10.1186/jbiol166. PMC 2736671 . PMID 19664200. 
  92. ^ a b Jeanne, Robert L. (1979). "Construction and Utilization of Multiple Combs in Polistes canadensis in Relation to the Biology of a Predaceous Moth". Behavioral Ecology and Sociobiology. 4 (3): 293–310. doi:10.1007/bf00297649. 
  93. ^ a b Runyon, J. B.; Mescher, M. C.; De Moraes, C. M. (2010). "Plant defenses against parasitic plants show similarities to those induced by herbivores and pathogens". Plant Signal Behav. 5 (8): 929–31. doi:10.4161/psb.5.8.11772. PMC 3115164 . PMID 20495380. 
  94. ^ Hamilton, W. D.; Axelrod, R.; Tanese, R. (May 1990). "Sexual reproduction as an adaptation to resist parasites (a review)". Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. 87 (9): 3566–3573. doi:10.1073/pnas.87.9.3566. 
  95. ^ Ebert, Dieter; Hamilton, William D. (1996). "Sex against virulence: the coevolution of parasitic diseases". Trends in Ecology & Evolution. Elsevier BV. 11 (2): 79–82. doi:10.1016/0169-5347(96)81047-0. 
  96. ^ Folstad, Ivar; Karter, Andrew John (1992). "Parasites, Bright Males, and the Immunocompetence Handicap". The American Naturalist. 139 (3): 603–622. doi:10.1086/285346. 
  97. ^ a b Thaler, Jennifer S.; Karban, Richard; Ullman, Diane E.; Boege, Karina; Bostock, Richard M. (2002). "Cross-talk between jasmonate and salicylate plant defense pathways: effects on several plant parasites". Oecologia. Springer Nature. 131 (2): 227–235. doi:10.1007/s00442-002-0885-9. 
  98. ^ a b c Frank, S. A. (2000). "Specific and non-specific defense against parasitic attack". J. Theor. Biol. 202 (4): 283–304. doi:10.1006/jtbi.1999.1054. PMID 10666361. 
  99. ^ Paré, Paul W.; Tumlinson, James H. (1999-10-01). "Plant Volatiles as a Defense against Insect Herbivores". Plant Physiology. American Society of Plant Biologists (ASPB). 121 (2): 325–332. doi:10.1104/pp.121.2.325. 
  100. ^ a b Poulin 2007, pp. x, 1–2.
  101. ^ Holt, R. D. (2010). "IJEE Soapbox". Israel Journal of Ecology and Evolution. 56 (3): 239–250. doi:10.1560/IJEE.56.3-4.239. 
  102. ^ Hudson, Peter J.; Dobson, Andrew P.; Lafferty, Kevin D. (2006). "Is a healthy ecosystem one that is rich in parasites?". Trends in Ecology & Evolution. 21 (7): 381–385. doi:10.1016/j.tree.2006.04.007. 
  103. ^ Stringer, Andrew Paul; Linklater, Wayne (2014). "Everything in Moderation: Principles of Parasite Control for Wildlife Conservation". BioScience. 64 (10): 932–937. doi:10.1093/biosci/biu135 . 
  104. ^ Lafferty, Kevin D.; Allesina, Stefano; Arim, Matias; Briggs, Cherie J.; et al. (2008). "Parasites in food webs: the ultimate missing links". Ecology Letters. 11 (6): 533–546. doi:10.1111/j.1461-0248.2008.01174.x. 
  105. ^ Chase, Jonathan (2013). "Parasites in Food Webs: Untangling the Entangled Bank". PLoS Biology. 11 (6): e1001580. doi:10.1371/journal.pbio.1001580. 
  106. ^ Rózsa, L.; Reiczigel, J.; Majoros, G. (2000). "Quantifying parasites in samples of hosts". J. Parasitol. 86 (2): 228–32. doi:10.1645/0022-3395(2000)086[0228:QPISOH]2.0.CO;2. PMID 10780537. 
  107. ^ a b c d e f Cox, Francis E. G. (June 2004). "History of human parasitic diseases". Infectious Disease Clinics of North America. 18 (2): 173–174. doi:10.1016/j.idc.2004.01.001. PMID 15145374. 
  108. ^ a b c Cheng, Thomas C. (1973). General Parasitology. Academic Press. pp. 120–134. ISBN 978-0-12-170750-7. The 19th century might be thought of as the genesis of modern parasitology. 
  109. ^ Humphrey-Smith, Ian, ed. (1993). Sept siècles de parasitologie en France [The French School of Parasitology] (in French). Société Française de Parasitologie. pp. 26–29. 
  110. ^ a b Ioli, A.; Petithory, J. C.; Theodorides, J. (1997). "Francesco Redi and the birth of experimental parasitology". Hist Sci Med. 31 (1): 61–66. PMID 11625103. 
  111. ^ Bush, A. O.; Fernández, J. C.; Esch, G. W.; Seed, J. R. (2001). Parasitism: The Diversity and Ecology of Animal Parasites. Cambridge University Press. p. 4. ISBN 0521664470. 
  112. ^ "Acarus as the cause of scabies". University of Cagliari. Retrieved 11 April 2018. 
  113. ^ "Parasitology". Merriam-Webster. Retrieved 13 April 2018. 
  114. ^ Ellis, Harold (March 2006). "Sir David Bruce, a pioneer of tropical medicine". British Journal of Hospital Medicine. 67 (3): 158. doi:10.12968/hmed.2006.67.3.20624. PMID 16562450. 
  115. ^ "Malaria and Malaria Vaccine Candidates". The College of Physicians of Philadelphia. 19 April 2017. Retrieved 11 February 2018. 
  116. ^ Walsh, Fergus (24 July 2015). "Malaria vaccine gets 'green light'". BBC. Retrieved 25 July 2015. 
  117. ^ Poulin 2007, pp. 265–266.
  118. ^ Matyszak, Philip (2017). 24 Hours in Ancient Rome: A Day in the Life of the People Who Lived There. Michael O'Mara. p. 252. ISBN 978-1-78243-857-1. 
  119. ^ Damon, Cynthia (1997). "5". The Mask of the Parasite: A Pathology of Roman Patronage. University of Michigan Press. p. 148. ISBN 978-0472107605. A satirist seeking to portray client misery naturally focuses on the relationship with the greatest dependency, that in which a client gets his food from his patron, and for this the prefabricated persona of the parasite proved itself extremely useful. 
  120. ^ a b Playfair, John (2007). Living with Germs: In health and disease. Oxford University Press. p. 19. ISBN 978-0-19-157934-9.  Playfair is comparing the popular usage to a biologist's view of parasitism, which he calls (heading the same page) "an ancient and respectable view of life".
  121. ^ Swift, Jonathan (1733). On Poetry: A Rapsody. And sold by J. Huggonson, next to Kent's Coffee-house, near Serjeant's-inn, in Chancery-lane; [and] at the bookseller's and pamphletshops. 
  122. ^ Otis, Laura (2001). Networking: Communicating with Bodies and Machines in the Nineteenth Century. University of Michigan Press. p. 216. ISBN 0-472-11213-9. 
  123. ^ "Parasitism and Symbiosis". The Encyclopedia of Science Fiction. 10 January 2016. 
  124. ^ Dove, Alistair (9 May 2011). "This is clearly an important species we're dealing with". Deep Sea News. 
  125. ^ Pappas, Stephanie (29 May 2012). "5 Alien Parasites and Their Real-World Counterparts". Live Science. 
  126. ^ Sercel, Alex (19 May 2017). "Parasitism in the Alien Movies". Signal to Noise Magazine. 
  127. ^ Nordine, Michael (25 April 2017). "'Alien' Evolution: Explore Every Stage in the Xenomorph's Gruesome Life Cycle. Celebrate Alien Day with a look at the past, present and future of cinema's most terrifying extraterrestrial". IndieWire. Nothing speaks to the xenomorph's visceral terror quite like the fact that this stage of its life cycle – which, true to its name, finds the creature literally bursting through its host's ribcage – isn't even its final form. For every alien that is born, another being (usually a human) is violently killed. And there's a reason the other actors look utterly terrified by what's happening in that infamous scene: Scott intentionally withheld key details from them in order to elicit genuine reactions. 

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