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On 21 February 1517 he became a canon of the cathedral chapter of St. Peter's Basilica. He was elected bishop of Cassano on 23 March 1523 when his uncle resigned the see in his favor. He later became an auditor of the Roman Rota. From October 1534 to December 1536, he was a datary. On 23 August 1535 he was named to a commission charged with studying reform of the Roman Curia.
Pope Paul III created him a cardinal priest in the consistory of 22 December 1536. He received the red hat on 23 December 1536, and the titular church of Sant'Anastasia on 15 January 1537. On 6 September 1537 he opted for the titular church of Sant'Eustachio, a deaconry raised pro illa vice to title, though he maintained his former titular church in commendam.
On 10 December 1537 he, along with Cardinal Rodolfo Pio da Carpi, was named papal legate to restore the peace between Charles V, Holy Roman Emperor and Francis I of France (though the cardinals were not informed of the legation until the consistory celebrated in Piacenza on 30 April 1538). On 21 April 1539 he was made legate to Perugia and Umbria.
He died in Perugia on 7 October 1540 and was buried there.
|Catholic Church titles|
| Bishop of Cassano all'Jonio
Antoine du Prat
| Cardinal-Priest of Sant'Anastasia
Robert de Lenoncourt (cardinal)
| Cardinal-Priest of Sant'Eustachio
Guido Ascanio Sforza di Santa Fiora