Cannabigerolic acid (CBGA) is the acidic form of cannabigerol (CBG). It is a dihydroxybenzoic acid that is olivetolic acid in which the hydrogen at position 3 is substituted by a geranyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the Cannabis plant. It is a dihydroxybenzoic acid, a diterpenoid, a polyketide, a member of resorcinols and a phytocannabinoid. It derives from an olivetolic acid. It is a conjugate acid of a cannabigerolate.
|Preferred IUPAC name
|Molar mass||360.494 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
In the Cannabis plant, olivetolic acid and geranyl diphosphate are synthesized into CBGA. CBGA is converted in the plant by CBCA synthase, cannabidiolic acid synthase (CBDA synthase) and tetrahydrocannabinolic acid synthase (THCA synthase) into CBCA, CBDA and tetrahydrocannabinolic acid (THCA). THCA can be decarboxylated into THC by drying and heating plant material.
- "Compound Summary – cannabigerolic acid". PubChem. United States National Library of Medicine. Retrieved April 7, 2020.
- Thomas, Brian F.; ElSohly, Mahmoud A. (2015). The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations. Emerging Issues in Analytical Chemistry. Elsevier Science. ISBN 978-0-12-804670-8.
- Degenhardt, F.; Stehle, F.; Kayser, O. (2016). "The biosynthesis of cannabinoids". In Preedy, Victor R. (ed.). Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Academic Press. pp. 13–23. ISBN 978-0128008270.
- Havelka, Jacqueline (September 9, 2019). "What is CBGA (Cannabigerolic Acid) & what does this cannabinoid do?". Leafly.