ZW10 interactor (Zwint-1) is a protein that in humans is encoded by the ZWINT gene.[5]

ZWINT
Identifiers
AliasesZWINT, HZwint-1, KNTC2AP, ZWINT1, SIP30, ZW10 interacting kinetochore protein
External IDsOMIM: 609177; MGI: 1289227; HomoloGene: 48496; GeneCards: ZWINT; OMA:ZWINT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005413
NM_001005414
NM_007057
NM_032997

NM_001293683
NM_001293684
NM_025635

RefSeq (protein)

NP_001005413
NP_008988
NP_127490

NP_001280612
NP_001280613
NP_079911

Location (UCSC)Chr 10: 56.36 – 56.36 MbChr 10: 72.49 – 72.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

Interactions

edit

ZWINT has been shown to interact with MIS12.[6][7] ZWINT has also been shown to interact with RAB3C[8]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122952Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019923Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ZWINT ZW10 interactor".
  6. ^ Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
  7. ^ Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nature Cell Biology. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
  8. ^ van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232. S2CID 30206840.

Further reading

edit
edit