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Y linkage, also known as sex linkage, or Holandric Inheritance, describes traits that are produced by genes located on the Y chromosome.

Y linkage can be difficult to detect. This is partly because the Y chromosome is small and contains fewer genes than the autosomal chromosomes or the X chromosome. It is estimated to contain about 200 genes. Earlier, the human Y chromosome was thought to have little importance;[1] . The Y-chromosome is sex-determining in humans and some other species: not all genes that play a role in sex determination are Y-linked. The Y-chromosome, generally does not undergo genetic recombination and only small regions called pseudoautosomal regions exhibit recombination. The majority of the Y-chromosome genes that do not recombine are located in the "non-recombining region".[2]

For a trait to be considered Y linkage, it must exhibit these characteristics:

  • occurs only in males
  • appears in all sons of males who exhibit that trait
  • is absent from daughters of trait carriers; instead the daughtersthat are phenotypically normal and do not have affected offspring.[3]

These requirements were established by the pioneer of Y linkage, Curt Stern. Stern detailed in his paper genes he suspected to be y-linked.[3] His requirements at first made Y linkage hard to prove. In the 1950s using human pedigrees, many genes were incorrectly determined to be Y-linked.[4] Later research adopted more advanced techniques and more sophisticated statistical analysis.[5] Hairy ears are an example of a gene once thought to be Y-linked in humans; however, that hypothesis was discredited.[4] Due to advancements in DNA sequencing, Y linkage is getting easier to determine and prove. The Y-chromosome is almost entirely mapped, revealing many y-linked traits.

Y linkage is similar to, but different than X linkage; although, both are forms of sex linkage. X linkage can be genetically linked and sex-linked, while Y linkage can only be genetically linked. This is because males' cells have only one copy of the Y-chromosome. X-chromosomes have two copies, one from each parent permitting recombination. The X chromosome contains more genes and is substantially larger.

Some ostensibly Y-linked have not been confirmed. One example is hearing impairment. Hearing impairment was tracked in one specific family and through seven generations all males were affected by this trait. However, this trait occurs rarely and has not been entirely resolved.[6]

Pedigree tree showing the inheritance of a Y-linked trait

Y-chromosome deletions are a frequent genetic cause of male infertility.

Contents

AnimalsEdit

GuppiesEdit

In guppies, Y-linked genes help determine sex selection. This is done indirectly by traits that allow the guppy to appear more attractive to a prospective mate. These traits were shown to be on the Y-chromosome and thus Y-linked.[7] Also in guppies, it appears that the four measures of sexual activity is Y-linked.[8]

RatsEdit

Hypertension, or high blood pressure, appears to be Y-linked in the hypertensive rat. One loci was autosomal. However, the second component appeared to be Y-linked. This held through the third generation of rats. Male offspring with a hypertensive father had significantly higher blood pressure than male offspring with a hypertensive mother indicating that a component of the trait was Y-linked. The results were not the same in females as in males, further hinting at a Y-component.[9]

Hairy earsEdit

Hairy ears were thought to be a Y-linked trait,[10] but this was disproven.[4]

Genes known to be contained on the human Y chromosomeEdit

See alsoEdit

ReferencesEdit

  1. ^ Sayres, Wilson (2012). "Gene survival and death on the human Y chromosome". Mol Biol Evol. 30: 781–87. doi:10.1093/molbev/mss267. PMC 3603307. PMID 23223713.
  2. ^ Skaletsky, Helen (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423: 825–837. doi:10.1038/nature01722.
  3. ^ a b Curt, Stern (1957). "The Problem of Complete Y-Linkage in Man". American Journal of Human Genetics. 9.3: 147–166 – via Google Scholar.
  4. ^ a b c Lee, Andrew (2004). "Molecular evidence for absence of Y-linkage of the Hairy Ears trait". European Journal of Human Genetics. 112: 1077–1079. doi:10.1038/sj.ejhg.5201271.
  5. ^ Ott, J (1986). "Y-linkage and pseudoautosomal linkage". Am J Hum Genet. 38: 891–7. PMC 1684847. PMID 3728465.
  6. ^ Wang, Qiuju (2013). "Genetic Basis of Y-Linked Hearing Impairment". Am J Hum Genet. 92: 301–6. doi:10.1016/j.ajhg.2012.12.015. PMC 3567277. PMID 23352258.
  7. ^ Postma, Erik (2011). "SEX-DEPENDENT SELECTION DIFFERENTIALLY SHAPES GENETIC VARIATION ON AND OFF THE GUPPY Y CHROMOSOME". Society for the Study of Evolution. 65: 2145–2156. doi:10.1111/j.1558-5646.2011.01314.x.
  8. ^ Farr, James (1983). "The Inheritance of Quantitative Fitness Traits in Guppies, Poecilia reticulata". Evolution. 37: 1193–1209. doi:10.2307/2408841.
  9. ^ Ely, D. (1990). "Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome". American Heart Association.
  10. ^ Stern, Curt (1964). "New Data on the Problem of Y-Linkage of Hairy Pinnae". Am J Hum Genet. 16: 455–71. PMC 1932324. PMID 14250426.
  11. ^ "Y-linked gene definition - Medical Dictionary: Definitions of Popular Terms Defined on MedTerms". Medterms.com. 2012-09-20. Retrieved 2014-06-29.

External linksEdit