ANP is synthesized as an inactive preprohormone, encoded by the human NPPA gene located on the short arm of chromosome 1.[1] The NPPA gene is expressed primarily in atrial myocytes and comprises of 2 introns and 3 exons, with translation of this gene yielding a high molecular mass 151 amino acid polypeptide known as preproANP.[2] The preprohormone is activated via post-translational modification that involves cleavage of the 25 amino acid signal sequence to produce proANP, a 126 amino acid peptide that is the major form of ANP stored in intracellular granules of the atria.[3] Following stimulation of atrial cells, proANP is released and rapidly converted to the 28-amino-acid C-terminal mature ANP on the cell surface by the cardiac transmembrane serine protease corin.[4][5]
- ^ Potter, Lincoln R.; Yoder, Andrea R.; Flora, Darcy R.; Antos, Laura K.; Dickey, Deborah M. (2009), "Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications", cGMP: Generators, Effectors and Therapeutic Implications, Springer Berlin Heidelberg, pp. 341–366, doi:10.1007/978-3-540-68964-5_15, ISBN 9783540689607, PMC 4855512, PMID 19089336, retrieved 2018-11-05
{{citation}}: CS1 maint: PMC format (link) - ^ Stryjewski, PJ; Nessler, B; Cubera, K; Nessler, J (2013). "[Natriuretic peptides. History of discovery, chemical structure, mechanism of action and the removal routes. Basis of diagnostic and therapeutic use]". Przeglad lekarski. 70 (7). ISSN 0033-2240.
- ^ Stryjewski, PJ; Nessler, B; Cubera, K; Nessler, J (2013). "[Natriuretic peptides. History of discovery, chemical structure, mechanism of action and the removal routes. Basis of diagnostic and therapeutic use]". Przeglad lekarski. 70 (7). ISSN 0033-2240.
- ^ Yan, Wei; Sheng, Ning; Seto, Marian; Morser, John; Wu, Qingyu (1999-05-21). "Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel cDNA from Human Heart". Journal of Biological Chemistry. 274 (21): 14926–14935. doi:10.1074/jbc.274.21.14926. ISSN 0021-9258. PMID 10329693.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Yan, Wei; Wu, Faye; Morser, John; Wu, Qingyu (2000-07-18). "Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme". Proceedings of the National Academy of Sciences. 97 (15): 8525–8529. doi:10.1073/pnas.150149097. ISSN 0027-8424. PMC 26981. PMID 10880574.
{{cite journal}}: CS1 maint: PMC format (link)