User:BIOL3485LKF2020/sandbox

C17orf78
Identifiers
Aliases	C17orf78, chromosome 17 open reading frame 78
External IDs	MGI: 3650287; HomoloGene: 82346; GeneCards: C17orf78; OMA:C17orf78 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	37,392,708 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	84,058,302 bp
RNA expression pattern
	Top expressed in
	duodenum; ; testicle; ; left testis; ; right testis; ; endometrium; ; corpus callosum; ; lymph node; ; apex of heart; ; ganglionic eminence; ; muscle of thigh;
	Top expressed in
	jejunum; ; ileum; ; colon; ; duodenum; ; liver; ; uterus;
	More reference expression data
	n/a
Orthologs
	284099
	628813
	ENSG00000278505; ENSG00000278145
	ENSMUSG00000051452
	Q8N4C9
	Q5QR91
	NM_173625; NM_001321399
	NM_001037932
	NP_001308328; NP_775896
	NP_001033021
	Wikidata
View/Edit Human	View/Edit Mouse

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Gene

Add: The info box at the beginning of the page

Add: C17orf78 is located on the plus strand of chromosome 17^[5]

Add: It neighbors the TADA2A, DUSP14, and ACACA genes.^[6]

Transcripts

Move: the transcript information from the protein section and make a new section. Have the mRNA information here

Protein

Localization

Change: there is a nuclear localization signal predicted on PSORT^[7]

Add: Percentages of localization predictions. Nuclear: 52.2 %^[7]

Add: Fetal expression lowers with development in all tissues except the intestines, which has increasing expression over time^[8]^[9]

Structure

mRNA

delete this section and move the stem-loop information to the mRNA regulation section

Protein

add: It is also predicted to have several beta sheets^[10]

Regulation

DNA

change: the promoter region starts where they have it listed but the end of the promoter is at 37376025 according to Genomatix (use their citation)

mRNA

add: this section

move: the stem-loop information from above to here

add: potentially miRNA and protein information? not sure if this is too speculative

Evolution rate of C17orf78

Homology/Evolution

Change: C17orf78 has orthologs in mammals, birds, and reptiles. It is a rapidly evolving gene, with around 40 base pairs mutating every 100 million years. There are no known paralogs for C17orf78 in humans.^[5] (They listed the gene as being only found in mammals)

Add: The evolution rate graph

Replace: The old ortholog table with mine-will complete on the actual page when I am editing


Genus and Species	Common Name	Taxonomic Group	Date of Divergence (MYA)	Accession Number	Protein Length (aa)	Identity	Simiarity
Homo sapiens
Mus musculus
Sus scrofa

References

^ ^a ^b ^c ENSG00000278145 GRCh38: Ensembl release 89: ENSG00000278505, ENSG00000278145 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051452 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "C17orf78 chromosome 17 open reading frame 78 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-10-21.
^ "AceView: Gene:C17orf78, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2020-10-21.
^ ^a ^b "PSORT II Prediction". psort.hgc.jp. Retrieved 2020-12-17.
^ "C17orf78 Gene Expression - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-12-17.
^ Szabo, Linda; Morey, Robert; Palpant, Nathan J.; Wang, Peter L.; Afari, Nastaran; Jiang, Chuan; Parast, Mana M.; Murry, Charles E.; Laurent, Louise C.; Salzman, Julia (2015-06-16). "Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development". Genome Biology. 16: 126. doi:10.1186/s13059-015-0690-5. ISSN 1474-760X. PMC 4506483. PMID 26076956.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Bioinformatics Toolkit". toolkit.tuebingen.mpg.de. Retrieved 2020-12-17.

[refGRCh38Ensembl-1] ENSG00000278145 GRCh38: Ensembl release 89: ENSG00000278505, ENSG00000278145 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051452 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] "C17orf78 chromosome 17 open reading frame 78 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-10-21.

[:1-6] "AceView: Gene:C17orf78, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2020-10-21.

[:2-7] "PSORT II Prediction". psort.hgc.jp. Retrieved 2020-12-17.

[8] "C17orf78 Gene Expression - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-12-17.

[9] Szabo, Linda; Morey, Robert; Palpant, Nathan J.; Wang, Peter L.; Afari, Nastaran; Jiang, Chuan; Parast, Mana M.; Murry, Charles E.; Laurent, Louise C.; Salzman, Julia (2015-06-16). "Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development". Genome Biology. 16: 126. doi:10.1186/s13059-015-0690-5. ISSN 1474-760X. PMC 4506483. PMID 26076956.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[10] "Bioinformatics Toolkit". toolkit.tuebingen.mpg.de. Retrieved 2020-12-17.

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