C17orf78 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | C17orf78, chromosome 17 open reading frame 78 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | MGI: 3650287; HomoloGene: 82346; GeneCards: C17orf78; OMA:C17orf78 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene
editAdd: The info box at the beginning of the page
Add: C17orf78 is located on the plus strand of chromosome 17[5]
Transcripts
editMove: the transcript information from the protein section and make a new section. Have the mRNA information here
Protein
editLocalization
editChange: there is a nuclear localization signal predicted on PSORT[7]
Add: Percentages of localization predictions. Nuclear: 52.2 %[7]
Add: Fetal expression lowers with development in all tissues except the intestines, which has increasing expression over time[8][9]
Structure
editmRNA
editdelete this section and move the stem-loop information to the mRNA regulation section
Protein
editadd: It is also predicted to have several beta sheets[10]
Regulation
editDNA
editchange: the promoter region starts where they have it listed but the end of the promoter is at 37376025 according to Genomatix (use their citation)
mRNA
editadd: this section
move: the stem-loop information from above to here
add: potentially miRNA and protein information? not sure if this is too speculative
Homology/Evolution
editChange: C17orf78 has orthologs in mammals, birds, and reptiles. It is a rapidly evolving gene, with around 40 base pairs mutating every 100 million years. There are no known paralogs for C17orf78 in humans.[5] (They listed the gene as being only found in mammals)
Add: The evolution rate graph
Replace: The old ortholog table with mine-will complete on the actual page when I am editing
Genus and Species | Common Name | Taxonomic Group | Date of Divergence (MYA) | Accession Number | Protein Length (aa) | Identity | Simiarity |
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Homo sapiens | |||||||
Mus musculus | |||||||
Sus scrofa | |||||||
References
edit- ^ a b c ENSG00000278145 GRCh38: Ensembl release 89: ENSG00000278505, ENSG00000278145 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051452 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "C17orf78 chromosome 17 open reading frame 78 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-10-21.
- ^ "AceView: Gene:C17orf78, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2020-10-21.
- ^ a b "PSORT II Prediction". psort.hgc.jp. Retrieved 2020-12-17.
- ^ "C17orf78 Gene Expression - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-12-17.
- ^ Szabo, Linda; Morey, Robert; Palpant, Nathan J.; Wang, Peter L.; Afari, Nastaran; Jiang, Chuan; Parast, Mana M.; Murry, Charles E.; Laurent, Louise C.; Salzman, Julia (2015-06-16). "Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development". Genome Biology. 16: 126. doi:10.1186/s13059-015-0690-5. ISSN 1474-760X. PMC 4506483. PMID 26076956.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - ^ "Bioinformatics Toolkit". toolkit.tuebingen.mpg.de. Retrieved 2020-12-17.