Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

In enzymology, a trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) is an enzyme that catalyzes the chemical reaction

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Identifiers
EC no.1.3.1.20
CAS no.37255-32-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
trans-1,2-dihydrobenzene-1,2-diol + NADP+ catechol + NADPH + H+

Thus, the two substrates of this enzyme are trans-1,2-dihydrobenzene-1,2-diol and NADP+, whereas its three products are catechol, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase. This enzyme is also called dihydrodiol dehydrogenase. This enzyme participates in metabolism of xenobiotics by cytochrome p450.

Structural studies

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As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2HDJ, 2IPJ, 2O48, 2O4U, and 2POQ.

References

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  • AYENGAR PK, HAYAISHI O, NAKAJIMA M, TOMIDA I (1959). "Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol". Biochim. Biophys. Acta. 33 (1): 111–9. doi:10.1016/0006-3002(59)90504-9. PMID 13651190.