ExPASy is a bioinformatics resource portal operated by the Swiss Institute of Bioinformatics (SIB) and in particular the SIB Web Team. It is an extensible and integrative portal accessing many scientific resources, databases and software tools in different areas of life sciences. Scientists can access a wide range of resources in many different domains, such as proteomics, genomics, phylogenetics/evolution, systems biology, population genetics, and transcriptomics. The individual resources (databases, web-based and downloadable software tools) are hosted in a decentralised way by different groups of the SIB Swiss Institute of Bioinformatics and partner institutions. Specifically, a single web portal provides a common entry point to a wide range of resources developed and operated by many different SIB groups and external institutions. The portal features a search function across selected resources. Internally, the availability and usage of resources are monitored. The portal is aimed for both expert users and for people who are not familiar with a specific domain in life sciences: in particular, the new web interface provides visual guidance for newcomers to ExPASy.
Originally, ExPASy was called ExPASy (Expert Protein Analysis System) and acted as a proteomics server to analyze protein sequences and structures and two-dimensional gel electrophoresis (2-D Page electrophoresis). Among others, ExPASy hosted the protein sequence knowledgebase, UniProtKB/Swiss-Prot, and its computer annotated supplement, UniProtKB/TrEMBL, before these moved to the UniProt website.