# Product (chemistry)

Products are the species formed from chemical reactions.[1] During a chemical reaction reactants are transformed into products after passing through a high energy transition state. This process results in the consumption of the reactants. It can be a spontaneous reaction or mediated by catalysts which lower the energy of the transition state, and by solvents which provide the chemical environment necessary for the reaction to take place. When represented in chemical equations products are by convention drawn on the right-hand side, even in the case of reversible reactions.[2] The properties of products such as their energies help determine several characteristics of a chemical reaction such as whether the reaction is exergonic or endergonic. Additionally the properties of a product can make it easier to extract and purify following a chemical reaction, especially if the product has a different state of matter than the reactants. Reactants are molecular materials used to create chemical reactions. The atoms aren't created or destroyed. The materials are reactive and reactants are rearranging during a chemical reaction. Here is an example of reactants: CH4 + O2. A non-example is CO2 + H2O or "energy".

Much of chemistry research is focused on the synthesis and characterization of beneficial products, as well as the detection and removal of undesirable products. Synthetic chemists can be subdivided into research chemists who design new chemicals and pioneer new methods for synthesizing chemicals, as well as process chemists who scale up chemical production and make it safer, more environmentally sustainable, and more efficient.[3] Other fields include natural product chemists who isolate products created by living organisms and then characterize and study these products.

## Determination of reaction

The products of a chemical reaction influence several aspects of the reaction. If the products are lower in energy than the reactants, then the reaction will give off excess energy making it an exergonic reaction. Such reactions are thermodynamically favorable and tend to happen on their own. If the kinetics of the reaction are high enough, however, then the reaction may occur too slowly to be observed, or not even occur at all. This is the case with the conversion of diamond to lower energy graphite at atmospheric pressure, in such a reaction diamond is considered metastable and will not be observed converting into graphite.[4][5]

If the products are higher in chemical energy than the reactants then the reaction will require energy to be performed and is therefore an endergonic reaction. Additionally if the product is less stable than a reactant, then Leffler's assumption holds that the transition state will more closely resemble the product than the reactant.[6] Sometimes the product will differ significantly enough from the reactant that it is easily purified following the reaction such as when a product is insoluble and precipitates out of solution while the reactants remained dissolved.

## History

Ever since the mid nineteenth century chemists have been increasingly preoccupied with synthesizing chemical products.[7] Disciplines focused on isolation and characterization of products, such as natural products chemists, remain important to the field, and the combination of their contributions alongside synthetic chemists has resulted in much of the framework through which chemistry is understood today.[7]

Much of synthetic chemistry is concerned with the synthesis of new chemicals as occurs in the design and creation of new drugs, as well as the discovery of new synthetic techniques. Beginning in the early 2000s (decade) though process chemistry began emerging as a distinct field of synthetic chemistry focused on scaling up chemical synthesis to industrial levels, as well as finding ways to make these processes more efficient, safer, and environmentally responsible.[3]

## Biochemistry

Conversation of the disaccharide sugar lactose (substrate) to monosaccharide sugars (products) by lactase (enzyme)

In biochemistry, enzymes act as biological catalysts to convert substrate to product.[8] For example, the products of the enzyme lactase are galactose and glucose, which are produced from the substrate lactose.

${\displaystyle S+E\rightarrow P+E}$
• Where S is substrate, P is product and E is enzyme.

### Product promiscuity

Some enzymes display a form of promiscuity where they convert a single substrate into multiple different products. It occurs when the reaction occurs via a high energy transition state that can be resolved into a variety of different chemical products.[9]

### Product inhibition

Some enzymes are inhibited by the product of their reaction binds to the enzyme and reduces its activity.[10] This can be important in the regulation of metabolism as a form of negative feedback controlling metabolic pathways.[11] Product inhibition is also an important topic in biotechnology, as overcoming this effect can increase the yield of a product.[12]

## References

1. ^ McNaught, A. D.; Wilkinson, A. (2006). [product] Compendium of Chemical Terminology, 2nd ed. (the "Gold Book". Blackwell Scientific Publications, Oxford. doi:10.1351/goldbook. ISBN 978-0-9678550-9-7.
2. ^ McNaught, A. D.; Wilkinson, A. (2006). [chemical reaction equation] Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Blackwell Scientific Publications, Oxford. doi:10.1351/goldbook. ISBN 978-0-9678550-9-7.
3. ^ a b Henry, Celia M. "DRUG DEVELOPMENT". Chemical and Engineering News. Retrieved 13 September 2014.
4. ^ McNaught, A. D.; Wilkinson, A. (2006). [diamond] Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Blackwell Scientific Publications, Oxford. doi:10.1351/goldbook. ISBN 978-0-9678550-9-7.
5. ^ McNaught, A. D.; Wilkinson, A. (2006). [metastability] Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Blackwell Scientific Publications, Oxford. doi:10.1351/goldbook. ISBN 978-0-9678550-9-7.
6. ^ McNaught, A. D.; Wilkinson, A. (2006). [metastability] Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Blackwell Scientific Publications, Oxford. doi:10.1351/goldbook. ISBN 978-0-9678550-9-7.
7. ^ a b Yeh, Brian J; Lim, Wendell A (2007). "Synthetic biology: lessons from the history of synthetic organic chemistry". Nature Chemical Biology. 3 (9): 521–525. doi:10.1038/nchembio0907-521. PMID 17710092.
8. ^ Cornish-Bowden, A (2 September 2013). "The origins of enzyme kinetics". FEBS Letters. 587 (17): 2725–30. doi:10.1016/j.febslet.2013.06.009. PMID 23791665.
9. ^ Yoshikuni, Y; Ferrin, TE; Keasling, JD (20 April 2006). "Designed divergent evolution of enzyme function". Nature. 440 (7087): 1078–82. Bibcode:2006Natur.440.1078Y. doi:10.1038/nature04607. PMID 16495946.
10. ^ Walter C, Frieden E (1963). The prevalence and significance of the product inhibition of enzymes. Adv. Enzymol. Relat. Areas Mol. Biol. Advances in Enzymology - and Related Areas of Molecular Biology. 25. pp. 167–274. doi:10.1002/9780470122709.ch4. ISBN 978-0-470-12270-9. PMID 14149677.
11. ^ Hutson NJ, Kerbey AL, Randle PJ, Sugden PH (1979). "Regulation of pyruvate dehydrogenase by insulin action". Prog. Clin. Biol. Res. 31: 707–19. PMID 231784.
12. ^ Schügerl K, Hubbuch J (2005). "Integrated bioprocesses". Curr. Opin. Microbiol. 8 (3): 294–300. doi:10.1016/j.mib.2005.01.002. PMID 15939352.