Tissue factor pathway inhibitor

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

TFPI
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
External IDsOMIM: 152310; MGI: 1095418; HomoloGene: 4579; GeneCards: TFPI; OMA:TFPI - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177319
NM_001177320
NM_011576
NM_001355271
NM_001355273

RefSeq (protein)

NP_001170790
NP_001170791
NP_035706
NP_001342200
NP_001342202

Location (UCSC)Chr 2: 187.46 – 187.57 MbChr 2: 84.26 – 84.31 Mb
PubMed search[3][4]
Wikidata
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Genetics

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The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. A similar gene, termed TFPI2, has been identified on chromosome 7, at locus 7q21.3; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.

Protein structure

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TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.

TFPI consists of a highly negatively charged amino-terminus, three tandemly linked Kunitz domains, and a highly positively charged carboxy-terminus. With its Kunitz domains, TFPI exhibits significant homology with human inter-alpha-trypsin inhibitor and bovine basic pancreatic trypsin inhibitor.

Interactions

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Tissue factor pathway inhibitor has been shown to interact with Factor X.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000003436Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027082Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Broze, G J; Warren L A; Novotny W F; Higuchi D A; Girard J J; Miletich J P (Feb 1988). "The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action". Blood. 71 (2). UNITED STATES: 335–43. doi:10.1182/blood.V71.2.335.335. ISSN 0006-4971. PMID 3422166.
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Further reading

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