TFPI2

TFPI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZR0
Identifiers
Aliases	TFPI2, PP5, REF1, TFPI-2, tissue factor pathway inhibitor 2
External IDs	OMIM: 600033 MGI: 108543 HomoloGene: 38194 GeneCards: TFPI2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	93,890,753 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	3,988,919 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; parietal pleura; ; islet of Langerhans; ; retinal pigment epithelium; ; germinal epithelium; ; pericardium; ; placenta; ; peritoneum; ; palpebral conjunctiva; ; left uterine tube;
	Top expressed in
	left lobe of liver; ; kidney; ; atrioventricular valve; ; yolk sac; ; calvaria; ; ileum; ; dermis; ; proximal tubule; ; uterus; ; Paneth cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; extracellular matrix structural constituent; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; extracellular matrix; extracellular space;
Biological process	hemostasis; negative regulation of peptidase activity; blood coagulation; negative regulation of endopeptidase activity; cellular response to fluid shear stress;
	Sources:Amigo / QuickGO
Orthologs
	7980
	21789
	ENSG00000105825
	ENSMUSG00000029664
	P48307
	O35536
	NM_006528; NM_001271003; NM_001271004
	NM_009364; NM_001381907; NM_001381908
	NP_001257932; NP_001257933; NP_006519
	NP_033390; NP_001368836; NP_001368837
	Wikidata
View/Edit Human	View/Edit Mouse

Tissue factor pathway inhibitor 2 is a protein that in humans is encoded by the TFPI2 gene.^[5]^[6]^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105825 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029664 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyagi Y, Koshikawa N, Yasumitsu H, Miyagi E, Hirahara F, Aoki I, Misugi K, Umeda M, Miyazaki K (Apr 1995). "cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2". J Biochem. 116 (5): 939–42. doi:10.1093/oxfordjournals.jbchem.a124648. PMID 7896752.
^ Miyagi Y, Yasumitsu H, Mizushima H, Koshikawa N, Matsuda Y, Itoh H, Hori TA, Aoki I, Misugi K, Miyazaki K (Jan 1997). "Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6". DNA Cell Biol. 15 (11): 947–54. doi:10.1089/dna.1996.15.947. PMID 8945635.
^ "Entrez Gene: TFPI2 tissue factor pathway inhibitor 2".

Further reading edit

Bützow R, Huhtala ML, Bohn H, et al. (1988). "Purification and characterization of placental protein 5". Biochem. Biophys. Res. Commun. 150 (1): 483–90. doi:10.1016/0006-291X(88)90546-3. PMID 3276312.
Takayama M, Soma H, Saito T, et al. (1983). "Circulating levels of placental protein 5 in normal and abnormal pregnancies". Gynecol. Obstet. Invest. 16 (1): 13–26. doi:10.1159/000299207. PMID 6884838.
Sprecher CA, Kisiel W, Mathewes S, Foster DC (1994). "Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3353–7. Bibcode:1994PNAS...91.3353S. doi:10.1073/pnas.91.8.3353. PMC 43575. PMID 8159751.
Petersen LC, Sprecher CA, Foster DC, et al. (1996). "Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor". Biochemistry. 35 (1): 266–72. doi:10.1021/bi951501d. PMID 8555184.
Miyagi Y, Yasumitsu H, Eki T, et al. (1996). "Assignment of the human PP5/TFPI-2 gene to 7q22 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis". Genomics. 35 (1): 267–8. doi:10.1006/geno.1996.0353. PMID 8661135.
Rao CN, Reddy P, Liu Y, et al. (1996). "Extracellular matrix-associated serine protease inhibitors (Mr 33,000, 31,000, and 27,000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2". Arch. Biochem. Biophys. 335 (1): 82–92. doi:10.1006/abbi.1996.0484. PMID 8914837.
Iino M, Foster DC, Kisiel W (1998). "Quantification and characterization of human endothelial cell-derived tissue factor pathway inhibitor-2". Arterioscler. Thromb. Vasc. Biol. 18 (1): 40–6. doi:10.1161/01.ATV.18.1.40. PMID 9445254.
Udagawa K, Miyagi Y, Hirahara F, et al. (1998). "Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization". Placenta. 19 (2–3): 217–23. doi:10.1016/S0143-4004(98)90011-X. PMID 9548189.
Shinoda E, Yui Y, Hattori R, et al. (1999). "Tissue factor pathway inhibitor-2 is a novel mitogen for vascular smooth muscle cells". J. Biol. Chem. 274 (9): 5379–84. doi:10.1074/jbc.274.9.5379. hdl:2433/181716. PMID 10026147.
Liu Y, Stack SM, Lakka SS, et al. (1999). "Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin". Arch. Biochem. Biophys. 370 (1): 112–8. doi:10.1006/abbi.1999.1371. PMID 10496984.
Kamei S, Kazama Y, Kuijper JL, et al. (2001). "Genomic structure and promoter activity of the human tissue factor pathway inhibitor-2 gene". Biochim. Biophys. Acta. 1517 (3): 430–5. doi:10.1016/S0167-4781(00)00298-0. PMID 11342222.
Crawley JT, Goulding DA, Ferreira V, et al. (2002). "Expression and localization of tissue factor pathway inhibitor-2 in normal and atherosclerotic human vessels". Arterioscler. Thromb. Vasc. Biol. 22 (2): 218–24. doi:10.1161/hq0102.101842. PMID 11834519.
Konduri SD, Osman FA, Rao CN, et al. (2002). "Minimal and inducible regulation of tissue factor pathway inhibitor-2 in human gliomas". Oncogene. 21 (6): 921–8. doi:10.1038/sj.onc.1204983. PMID 11840337.
Udagawa K, Yasumitsu H, Esaki M, et al. (2002). "Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts". Placenta. 23 (2–3): 145–53. doi:10.1053/plac.2001.0774. PMID 11945080.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hubé F, Reverdiau P, Iochmann S, et al. (2003). "Demonstration of a tissue factor pathway inhibitor 2 messenger RNA synthesis by pure villous cytotrophoblast cells isolated from term human placentas". Biol. Reprod. 68 (5): 1888–94. doi:10.1095/biolreprod.102.011858. PMID 12606321. S2CID 32145819.
George J, Gondi CS, Dinh DH, Gujrati M, Rao JS (2007). "Restoration of TFPI-2 in a Human Glioblastoma Cell Line Triggers Caspase Mediated Pathway and Apoptosis". Clin. Cancer Res. 13 (12): 3507–3517. doi:10.1158/1078-0432.CCR-06-3023. PMC 1905856. PMID 17575213.
Rao CN, Segawa T, Navari JR, et al. (2003). "Methylation of TFPI-2 gene is not the sole cause of its silencing". Int. J. Oncol. 22 (4): 843–8. doi:10.3892/ijo.22.4.843. PMID 12632077.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105825 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029664 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7896752-5] Miyagi Y, Koshikawa N, Yasumitsu H, Miyagi E, Hirahara F, Aoki I, Misugi K, Umeda M, Miyazaki K (Apr 1995). "cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2". J Biochem. 116 (5): 939–42. doi:10.1093/oxfordjournals.jbchem.a124648. PMID 7896752.

[pmid8945635-6] Miyagi Y, Yasumitsu H, Mizushima H, Koshikawa N, Matsuda Y, Itoh H, Hori TA, Aoki I, Misugi K, Miyazaki K (Jan 1997). "Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6". DNA Cell Biol. 15 (11): 947–54. doi:10.1089/dna.1996.15.947. PMID 8945635.

[7] "Entrez Gene: TFPI2 tissue factor pathway inhibitor 2".

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[6]

[7]

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